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Gene: Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) Rattus norvegicus
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Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Description: Exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including cellular response to copper ion; response to estradiol; and response to lipopolysaccharide. Localizes to intracellular membrane-bounded organelle. Biomarker of mental depression. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2); PARTICIPATES IN caffeine pharmacokinetics pathway; clomipramine pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-artemisinin; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cholesterol 25-hydroxylase; CYPD45; CYPIA2; cytochrome P-448; cytochrome P-450d; cytochrome P450 1A2; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450, 1a2; Cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450-D; hydroperoxy icosatetraenoate dehydratase; P-448; P-450d; P450-D; RATCYPD45
Orthologs:
Homo sapiens (human) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)  HGNC  Alliance
Mus musculus (house mouse) : Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102010322 (cytochrome P450 1A2)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)
Canis lupus familiaris (dog) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101969421 (cytochrome P450 1A2)
Sus scrofa (pig) : CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2)
Chlorocebus sabaeus (African green monkey) : CYP1A2 (cytochrome P450 family 1 subfamily A member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0862,451,360 - 62,458,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,451,329 - 62,458,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,228,271 - 62,235,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,439,062 - 61,447,861 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1861,458,143 - 61,464,586 (-)NCBI
Celera857,541,217 - 57,547,956 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations