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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTDEthanol results in increased expression of CYP1A2 mRNA; Ethanol results in increased expression of CYP1A2 proteinPMID:23273579 PMID:26747958 PMID:35301062
Cyp1a2multiple interactionsEXP 6480464CTD[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein; Corticosterone promotes the reaction [Ethanol results in increased expression of CYP1A2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]PMID:26747958 PMID:35301062
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDEthanol results in increased expression of CYP1A2 mRNAPMID:35301062
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CYP1A2 mRNAPMID:30517762
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