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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:81522
Term: 2,3,3',4,4',5-Hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C087667
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityEXP 6480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein

PMID:15659567
Cyp1a2decreases activityISORGD:7357116480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein

PMID:15659567
Cyp1a2increases activityISORGD:104386480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in increased activity of CYP1A2 protein

PMID:10986007
Cyp1a2increases expressionISORGD:104386480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl results in increased expression of CYP1A2 mRNA

PMID:23674508
Cyp1a2multiple interactionsISORGD:7357116480464CTD2 3 3' 4 4' 5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

PMID:18493746
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