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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDochratoxin A results in increased expression of CYP1A2 mRNA; ochratoxin A results in increased expression of CYP1A2 proteinPMID:30291945
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDochratoxin A results in increased expression of CYP1A2 mRNA; ochratoxin A results in increased expression of CYP1A2 proteinPMID:21834667 PMID:30291945
Cyp1a2increases response to substanceISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased susceptibility to ochratoxin APMID:11189750 PMID:21781659 PMID:8542584
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