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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34565
Term: benzo[b]fluoranthene
Definition: An ortho- and peri-fused polycyclic arene that consists of a benzene ring fused with a acephenanthrylene ring.
Chemical ID: MESH:C006703
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CYP1A2 mRNA; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A2 mRNAPMID:18711122 PMID:37189300
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDbenzo(b)fluoranthene results in decreased activity of CYP1A2 proteinPMID:11162773
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDbenzo(b)fluoranthene results in increased expression of CYP1A2 mRNAPMID:12117779
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDbenzo(b)fluoranthene results in increased expression of CYP1A2 mRNAPMID:16269432 PMID:17253728 PMID:30293151
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNAPMID:7750161
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CYP1A2 mRNA; [propiconazole co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A2 mRNAPMID:17690111 PMID:30293151
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