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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16664
Term: albendazole
Definition: A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.
Chemical ID: MESH:D015766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of AlbendazolePMID:12920490
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDAlbendazole results in increased expression of CYP1A2 mRNAPMID:12451431
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