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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects methylationEXP 6480464CTDAtrazine affects the methylation of CYP1A2 genePMID:35440735
Cyp1a2increases activityEXP 6480464CTDAtrazine results in increased activity of CYP1A2 proteinPMID:9711812
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDAtrazine results in increased activity of CYP1A2 proteinPMID:22310298
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDAtrazine results in increased expression of CYP1A2 mRNAPMID:26775023
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDAtrazine results in increased expression of CYP1A2 mRNAPMID:22310298
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Lycopene co-treated with Atrazine] results in increased expression of CYP1A2 mRNA; Lycopene inhibits the reaction [Atrazine results in increased expression of CYP1A2 mRNA]PMID:26775023 PMID:36216167
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