GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a2 | affects metabolic processing | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | CYP1A2 protein affects the metabolism of tizanidine | PMID:15592331 PMID:16198659 | Cyp1a2 | increases metabolic processing | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | CYP1A2 protein results in increased metabolism of tizanidine | PMID:17618427 | Cyp1a2 | multiple interactions | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | [[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine] | PMID:15592331 PMID:15834531 PMID:16198659 PMID:16934051 | |
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