Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISORGD:7357116480464CTDisoliquiritigenin results in decreased activity of CYP1A2 protein

PMID:29753067
Cyp1a2multiple interactionsISORGD:7357116480464CTDisoliquiritigenin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of CYP1A2 mRNA], isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]

PMID:25110319
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.