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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingEXP 6480464CTDCYP1A2 protein affects the metabolism of CaffeinePMID:15619608
Cyp1a2increases activityEXP 6480464CTDCaffeine results in increased activity of CYP1A2 proteinPMID:15822860
Cyp1a2multiple interactionsEXP 6480464CTD[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of CaffeinePMID:12706856 PMID:15659567 PMID:26599973
Cyp1a2affects bindingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein binds to CaffeinePMID:9334905
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolitePMID:1302044 PMID:14586384 PMID:14586387 PMID:15022032 PMID:15199075 PMID:15286053 PMID:15327588 PMID:15980104
Cyp1a2decreases activityISOCyp1a2 (Mus musculus)6480464CTDCaffeine results in decreased activity of CYP1A2 proteinPMID:18420780
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDCaffeine results in decreased activity of CYP1A2 proteinPMID:11465391 PMID:24211539
Cyp1a2decreases methylationISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in decreased methylation of CaffeinePMID:11376689
Cyp1a2decreases methylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in decreased methylation of CaffeinePMID:11145498 PMID:12433797
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of CaffeinePMID:11907490 PMID:19215233 PMID:20716633
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNAPMID:28843594
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]PMID:11145498 PMID:11907490 PMID:15659567 PMID:15856409 PMID:16934051 PMID:19215233 PMID:20716633 PMID:31132250
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