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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases expressionEXP 6480464CTDobeticholic acid results in decreased expression of CYP1A2 mRNAPMID:35267068
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDobeticholic acid results in decreased activity of CYP1A2 proteinPMID:27939613
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDobeticholic acid results in decreased expression of CYP1A2 mRNAPMID:27939613
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 proteinPMID:35267068
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDobeticholic acid inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]PMID:27939613
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