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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:5138
Term: fluvoxamine
Definition: A 5-methoxyvalerophenone O-(2-aminoethyl)oxime that has formula C15H21F3N2O2.
Chemical ID: MESH:D016666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityEXP 6480464CTDFluvoxamine results in decreased activity of CYP1A2 protein

PMID:26599973
Cyp1a2multiple interactionsEXP 6480464CTD[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine

PMID:26599973
Cyp1a2decreases activityISORGD:7357116480464CTDFluvoxamine results in decreased activity of CYP1A2 protein

PMID:11763009 PMID:15545309 PMID:15845683 PMID:18816299 PMID:21915887 PMID:26599973
Cyp1a2increases response to substanceISORGD:7357116480464CTDCYP1A2 protein results in increased susceptibility to Fluvoxamine

PMID:18809730
Cyp1a2multiple interactionsISORGD:7357116480464CTD[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite CYP1A2 protein binds to and affects the metabolism of Fluvoxamine Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine] Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine] Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline] Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen] Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of clozapine N-oxide] Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine] Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]

PMID:15545309 PMID:15905806 PMID:18809730 PMID:21277363 PMID:21915887 PMID:26599973 PMID:9029748
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