Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) - Rat Genome Database

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Gene: Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) Mus musculus
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Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
RGD ID: 10438
MGI Page MGI
Description: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including cellular response to cadmium ion; dibenzo-p-dioxin metabolic process; and hydrogen peroxide biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aromatic compound inducible; cholesterol 25-hydroxylase; CP1; CP12; Cyp1a1; CYPIA2; cytochrome P450 1A2; cytochrome P450 family 1 subfamily a polypeptide 1; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450-P2; cytochrome P450-P3; hydroperoxy icosatetraenoate dehydratase; P450-; P450-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,584,220 - 57,590,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,584,220 - 57,590,986 (-)EnsemblGRCm39 Ensembl
GRCm38957,676,937 - 57,683,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,676,937 - 57,683,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,524,744 - 57,531,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,475,074 - 57,481,792 (-)NCBIMGSCv36mm8
Celera954,913,185 - 54,919,903 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP,ISO)
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-schisandrin B  (ISO)
(+/-)-Aegeline  (EXP)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1E,4E,8E)-alpha-humulene  (ISO)
(2-hydroxyphenyl)acetic acid  (ISO)
(E,E)-germacrone  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(RS)-coclaurine  (EXP)
(RS)-norcoclaurine  (EXP)
(S)-coclaurine  (EXP)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP)
1,2,3,7,8-Pentachlorodibenzofuran  (EXP)
1,2,4,5-tetrachlorobenzene  (ISO)
1,2,4-trichlorobenzene  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-dimethylnaphthalene  (ISO)
1,3,7-trimethyluric acid  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dimethylnaphthalene  (ISO)
1,4-naphthoquinone  (ISO)
1,6-dimethylnaphthalene  (ISO)
1,6-Dinitropyrene  (ISO)
1,7-dimethylxanthine  (ISO)
1,7-phenanthroline  (ISO)
1,8-Dinitropyrene  (ISO)
1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol  (ISO)
1-Aminopyrene  (ISO)
1-benzofuran  (ISO)
1-hydroxyanthraquinone  (ISO)
1-methyl-7H-xanthine  (ISO)
1-methylnaphthalene  (ISO)
1-Methylpyrene  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2'-deoxyguanosine  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,3-dihydrobenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-Triphenyl-1-hexene  (EXP)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrophenol  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-benzoxazolinone  (ISO)
2-chlorobiphenyl  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxychrysophanol  (ISO)
2-Methoxynaphthalene  (ISO)
2-methyl-1H-indole  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-methylnaphthalene  (ISO)
2-naphthol  (ISO)
2-naphthylamine  (ISO)
2-nitroanisole  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP,ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-xylenol  (ISO)
3-(Methylthio)-1-propene  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (ISO)
3-methylquinoline  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenoxybenzoic acid  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(methylsulfinyl)phenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-chlorobiphenyl  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxybenzyl isothiocyanate  (ISO)
4-hydroxychalcone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-Ipomeanol  (ISO)
4-Methylchrysene  (ISO)
4-nitroaniline  (ISO)
4-nitrophenol  (ISO)
4-phenoxyphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxyindole  (EXP)
5-Methylchrysene  (ISO)
5-methyltryptamine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chrysenamine  (ISO)
6-Methylchrysene  (ISO)
6-Nitrobenzo[a]pyrene  (ISO)
6-Nitrochrysene  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (ISO)
7-Nitrobenz[a]anthracene  (ISO)
7H-Dibenzo[c,g]carbazole  (ISO)
9-phenanthrol  (ISO)
acenaphthene  (EXP)
acenaphthylene  (EXP,ISO)
acenocoumarol  (ISO)
acephate  (EXP)
acetamide  (ISO)
acetone  (ISO)
Acetyl tributyl citrate  (EXP)
aconitine  (ISO)
acridines  (ISO)
actinomycin D  (ISO)
Aescin  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
alachlor  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (EXP)
alizarin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allocryptopine  (ISO)
almotriptan  (ISO)
Aloe emodin  (ISO)
alpha-linolenic acid  (ISO)
alpha-methyltryptamine  (ISO)
alpha-naphthoflavone  (EXP,ISO)
ametryn  (ISO)
amiodarone  (ISO)
amitraz  (ISO)
amitriptyline  (ISO)
amitriptylinoxide  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
angelicin  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (ISO)
anthracene  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aranidipine  (ISO)
arecoline  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Artemisin  (ISO)
asenapine  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
atovaquone  (ISO)
atrazine  (EXP,ISO)
Avasimibe  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
benidipine  (ISO)
benoxaprofen  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (ISO)
benzo[c]phenanthrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP,ISO)
benzofurans  (ISO)
benzyl isothiocyanate  (ISO)
benzylideneacetone  (ISO)
berberine  (EXP)
bergomottin  (EXP)
Besigomsin  (EXP)
beta-carboline  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (EXP)
bilobalide  (ISO)
binimetinib  (ISO)
biochanin A  (ISO)
biphenyl  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromfenac  (ISO)
bromodichloromethane  (ISO)
brucine  (ISO)
bucladesine  (EXP)
Bufuralol  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
canadine  (EXP)
cannabidiol  (EXP,ISO)
canthaxanthin  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbendazim  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP)
Carnosol  (ISO)
carotenoid  (ISO)
caryophyllene oxide  (ISO)
catechols  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chelidonine  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorotoluron  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
chlorzoxazone  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysene  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clenbuterol  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clopidogrel  (ISO)
clothianidin  (ISO)
clotrimazole  (ISO)
clozapine  (EXP,ISO)
Clozapine N-oxide  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cyclobarbital  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP)
dabrafenib  (ISO)
dacarbazine  (ISO)
daidzein  (EXP)
dantrolene  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (EXP)
desogestrel  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazinon  (ISO)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofuran  (EXP,ISO)
dibenzofurans  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
dichloromethane  (EXP)
diclofenac  (ISO)
dicofol  (ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP,ISO)
diflubenzuron  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
Dihydrotanshinone I  (ISO)
dimethocaine  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dimethylmercury  (ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipropyl phthalate  (ISO)
diuron  (ISO)
domperidone  (ISO)
dopamine  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
Elemicin  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enfuvirtide  (ISO)
enilconazole  (ISO)
enoxacin  (ISO)
epoxiconazole  (EXP)
Erucin  (ISO)
estragole  (EXP,ISO)
estrone  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylisopropylamiloride  (ISO)
ethylparaben  (ISO)
etodolac  (ISO)
etoposide  (ISO)
etoricoxib  (ISO)
eugenol  (ISO)
farnesol  (ISO)
farrerol  (ISO)
felbamate  (ISO)
felodipine  (ISO)
fenarimol  (EXP)
fenbendazole  (EXP)
fenitrothion  (ISO)
fenofibrate  (ISO)
fenproporex  (ISO)
fenvalerate  (ISO)
ferulic acid  (ISO)
finasteride  (ISO)
fipronil  (ISO)
flavanone  (ISO)
flavone  (ISO)
flavonol  (ISO)
fluconazole  (EXP)
fludioxonil  (ISO)
flumequine  (EXP)
fluoranthene  (EXP,ISO)
fluorene  (EXP)
flutamide  (ISO)
fluvoxamine  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formononetin  (ISO)
Frangulin A  (ISO)
Frangulin B  (ISO)
fructose  (EXP)
Furafylline  (EXP,ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
galangin  (ISO)
gallocatechin  (EXP)
gamma-decalactone  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-valerolactone  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (ISO)
gestodene  (ISO)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucoerucin  (ISO)
glucoerucin(1-)  (ISO)
glucoraphanin  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
griseofulvin  (EXP,ISO)
guanethidine  (ISO)
GW 3965  (ISO)
halocarban  (ISO)
hemin  (ISO)
heroin  (EXP)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexane  (ISO)
huperzine A  (ISO)
hydralazine  (ISO)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
iberin  (ISO)
ibuprofen  (ISO)
Icaritin  (ISO)
ifosfamide  (ISO)
imipramine  (ISO)
imipramine oxide  (ISO)
imiprothrin  (ISO)
imiquimod  (EXP,ISO)
imperatorin  (EXP)
indane  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP,ISO)
indolin-2-one  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
inulin  (EXP)
irilone  (ISO)
iron dextran  (EXP)
isocarbophos  (ISO)
isoimperatorin  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (EXP)
isoprenaline  (ISO)
isoproturon  (EXP,ISO)
Isosafrole  (EXP,ISO)
Isoxanthohumol  (ISO)
Isradipine  (ISO)
ivermectin  (EXP)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lansoprazole  (ISO)
laquinimod  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lefetamine  (ISO)
leflunomide  (ISO)
lentinan  (EXP)
Licochalcone A  (ISO)
lidocaine  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
loxapine  (ISO)
luteolin  (ISO)
Luteolin 7-methyl ether  (ISO)
lycopene  (EXP)
m-xylene  (ISO)
Magnolol  (EXP)
malathion  (ISO)
maneb  (ISO)
mangiferin  (ISO)
mebendazole  (ISO)
Meclizine  (EXP,ISO)
mefenamic acid  (ISO)
MeIQ  (EXP,ISO)
MeIQx  (EXP,ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
menadione  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
metolachlor  (ISO)
metronidazole  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
Mitragynine  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP)
morphine  (EXP)
musk xylene  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N,N-dimethyltryptamine  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-1,4-benzoquinone imine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desmethylclozapine  (EXP,ISO)
N-Desmethyltamoxifen  (ISO)
N-hydroxy-PhIP  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (ISO)
neomycin  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nifedipine  (EXP,ISO)
nimesulide  (ISO)
nisoldipine  (ISO)
nitroaniline  (ISO)
nitrofurantoin  (ISO)
nitroglycerin  (ISO)
nobiletin  (ISO)
Nonylphenol  (ISO)
norfloxacin  (ISO)
norgestimate  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (ISO)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (EXP)
octamethylcyclotetrasiloxane  (ISO)
ofloxacin  (ISO)
okadaic acid  (ISO)
okanin  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
Olivacine  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP,ISO)
Ondansetron  (ISO)
organophosphorus compound  (ISO)
organoselenium compound  (ISO)
orphenadrine  (ISO)
ortho-Aminoazotoluene  (EXP)
Oxadiazon  (EXP)
oxfendazole  (ISO)
oxolane  (EXP)
ozone  (EXP,ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
pantoprazole  (ISO)
papaverine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
pedalitin  (ISO)
pelargonidin  (ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
perampanel  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
permethrin  (ISO)
phenacetin  (EXP,ISO)
phenanthrene  (EXP,ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenthoate  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
physcion  (ISO)
pifithrin-?  (ISO)
pimobendan  (ISO)
pinocembrin  (ISO)
Pipermethystine  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(styrene)  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
primaquine  (ISO)
prochloraz  (ISO)
profenofos  (ISO)
propachlor  (ISO)
propiconazole  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
protopine  (ISO)
pterostilbene  (EXP,ISO)
pyrazinecarboxamide  (ISO)
pyrene  (EXP,ISO)
pyridine  (ISO)
pyrogallol  (EXP)
pyrrolidines  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinaldine  (ISO)
quinidine  (ISO)
quinine  (ISO)
quinizarin  (ISO)
quinoline  (ISO)
rabeprazole  (ISO)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
Retrorsine  (ISO)
Rhein  (ISO)
rifampicin  (EXP,ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
rubiadin  (ISO)
Rutecarpine  (ISO)
safrole  (EXP,ISO)
salicylamide  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
saracatinib  (ISO)
scutellarein  (ISO)
secobarbital  (EXP)
selenium atom  (ISO)
senecionine  (EXP,ISO)
Sesamex  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
simazine  (ISO)
sinensetin  (ISO)
skatole  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
sophoraflavanone B  (ISO)
sporidesmin A  (ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
Sudan I  (ISO)
Sudan III  (ISO)
sulfaphenazole  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
suramin  (ISO)
tacrine  (ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (EXP,ISO)
tegaserod  (ISO)
terbutryn  (ISO)
Tesaglitazar  (ISO)
tetrachloroethene  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (EXP)
tetrahydropalmatine  (EXP)
tetraphene  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
theobromine  (ISO)
theophylline  (EXP,ISO)
thiabendazole  (ISO)
thiacloprid  (ISO)
thioacetamide  (ISO)
thiophanate-methyl  (ISO)
thioridazine  (ISO)
ticlopidine  (ISO)
tizanidine  (ISO)
tofacitinib  (ISO)
tolcapone  (ISO)
tolfenamic acid  (ISO)
toluene  (ISO)
toxaphene  (EXP)
trabectedin  (ISO)
trans-1,2-dichloroethene  (ISO)
trans-chalcone  (ISO)
tranylcypromine  (ISO)
triadimefon  (ISO)
triamterene  (ISO)
triazines  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
triflumuron  (ISO)
trimethoprim  (ISO)
trimethylarsine oxide  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tryptamines  (ISO)
umbelliferone  (ISO)
vadimezan  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
veliparib  (ISO)
verapamil  (EXP)
versicolorin A  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (ISO)
warfarin  (ISO)
wortmannin  (ISO)
Wuweizisu C  (EXP)
xanthohumol  (ISO)
yohimbine  (EXP)
zafirlukast  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)
zolmitriptan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Al-Attas OS, etal., Environ Sci Pollut Res Int. 2015 Jul;22(13):10083-93. doi: 10.1007/s11356-015-4212-5. Epub 2015 Feb 18.
2. A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia. Basile VS, etal., Mol Psychiatry 2000 Jul;5(4):410-7.
3. Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A. Feng C, etal., Environ Toxicol Pharmacol. 2013 Aug 6;36(3):850-857. doi: 10.1016/j.etap.2013.07.017.
4. Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. Fukushima S, etal., World J Gastroenterol. 2008 Apr 28;14(16):2556-60.
5. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Gulyaeva LF, etal., Adv Exp Med Biol. 2008;617:359-66.
6. Effects of aescin on cytochrome P450 enzymes in rats. Huang Y, etal., J Ethnopharmacol. 2014;151(1):583-90. doi: 10.1016/j.jep.2013.11.016. Epub 2013 Nov 16.
7. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Jing H, etal., J Surg Res. 2012 Jul;176(1):63-73. doi: 10.1016/j.jss.2011.09.001. Epub 2011 Sep 29.
8. Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Kapitulnik J and Gonzalez FJ, Mol Pharmacol. 1993 May;43(5):722-5.
9. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
10. Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. Lee SH and Lee SM, Shock. 2005 Feb;23(2):144-9.
11. Global metabolic profiling for the study of Rhizoma Paridis saponins-induced hepatotoxicity in rats. Man S, etal., Environ Toxicol. 2017 Jan;32(1):99-108. doi: 10.1002/tox.22215. Epub 2015 Nov 21.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress. Minamiyama Y, etal., Free Radic Biol Med. 2006 Mar 1;40(5):808-16. doi: 10.1016/j.freeradbiomed.2005.10.038. Epub 2005 Oct 28.
16. Organic nitrate tolerance is induced by degradation of some cytochrome P450 isoforms. Minamiyama Y, etal., Redox Rep. 2002;7(5):339-42. doi: 10.1179/135100002125000947.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. Ryan DE, etal., J Biol Chem. 1980 Aug 25;255(16):7941-55.
24. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Vibhuti A, etal., Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. Epub 2010 Jan 18.
25. Shengmai Yin formula exerts cardioprotective effects on rats with chronic heart failure via regulating Linoleic Acid metabolism. Wang S, etal., Prostaglandins Other Lipid Mediat. 2022 Feb;158:106608. doi: 10.1016/j.prostaglandins.2021.106608. Epub 2021 Dec 24.
26. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. Wickliffe JK, etal., Mol Med. 2011 Mar-Apr;17(3-4):241-7. doi: 10.2119/molmed.2010.00130. Epub 2010 Oct 15.
27. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Xue X, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3074-81. doi: 10.1093/ndt/gfn262. Epub 2008 May 21.
28. The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis. Zhou M, etal., Int J Mol Med. 2008 Apr;21(4):423-8.
Additional References at PubMed
PMID:1313028   PMID:1335375   PMID:1452456   PMID:1794054   PMID:1794058   PMID:1889815   PMID:2425809   PMID:2505256   PMID:2512252   PMID:2572508   PMID:2576007   PMID:2885918  
PMID:3718958   PMID:3755821   PMID:3785172   PMID:3860967   PMID:3988744   PMID:4040754   PMID:4054433   PMID:6262772   PMID:6324134   PMID:6328503   PMID:6421814   PMID:6547952  
PMID:6548461   PMID:7490103   PMID:7508708   PMID:7750163   PMID:7761462   PMID:7781742   PMID:8001243   PMID:8137279   PMID:8215422   PMID:8274012   PMID:8297798   PMID:8406508  
PMID:8486527   PMID:8486528   PMID:8499946   PMID:8507983   PMID:8643688   PMID:8795463   PMID:8954808   PMID:9119402   PMID:9128719   PMID:9143510   PMID:9226375   PMID:9240455  
PMID:9295056   PMID:9441766   PMID:9461503   PMID:9464455   PMID:9559668   PMID:9585423   PMID:9615220   PMID:9772215   PMID:9784916   PMID:9875304   PMID:10094576   PMID:10445756  
PMID:10448125   PMID:10503904   PMID:10570017   PMID:10623596   PMID:10631128   PMID:11003706   PMID:11043581   PMID:11141507   PMID:11198052   PMID:11217851   PMID:11274970   PMID:11384210  
PMID:11915039   PMID:12372429   PMID:12398935   PMID:12438513   PMID:12464254   PMID:12466851   PMID:12477932   PMID:12745259   PMID:12958197   PMID:14637164   PMID:14681479   PMID:14980704  
PMID:15003330   PMID:15028720   PMID:15094312   PMID:15252868   PMID:15329440   PMID:15489334   PMID:15643613   PMID:15752708   PMID:15845371   PMID:16183037   PMID:16377763   PMID:16516144  
PMID:16636061   PMID:16684708   PMID:16876762   PMID:16916647   PMID:17052995   PMID:17166882   PMID:17560947   PMID:17569574   PMID:17997381   PMID:18372398   PMID:18722179   PMID:18814841  
PMID:19261855   PMID:19285097   PMID:19370779   PMID:19447165   PMID:19520064   PMID:19695277   PMID:20118626   PMID:20164109   PMID:20961953   PMID:21081470   PMID:21571617   PMID:21873635  
PMID:21880518   PMID:22086975   PMID:22260863   PMID:22935098   PMID:22982977   PMID:23776235   PMID:23956430   PMID:24349309   PMID:24497629   PMID:25174530   PMID:25601990   PMID:25680282  
PMID:25703676   PMID:25922528   PMID:26165599   PMID:27088858   PMID:29184146   PMID:29197979   PMID:30910785   PMID:30944282   PMID:31147315   PMID:32325033   PMID:32726451   PMID:33632817  
PMID:34242741   PMID:35734174   PMID:36379250   PMID:36740553   PMID:37453365   PMID:38081439  


Genomics

Comparative Map Data
Cyp1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,584,220 - 57,590,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,584,220 - 57,590,986 (-)EnsemblGRCm39 Ensembl
GRCm38957,676,937 - 57,683,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,676,937 - 57,683,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,524,744 - 57,531,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,475,074 - 57,481,792 (-)NCBIMGSCv36mm8
Celera954,913,185 - 54,919,903 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.3NCBI
CYP1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,748,845 - 74,756,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,748,845 - 74,756,607 (+)EnsemblGRCh38hg38GRCh38
GRCh371575,041,186 - 75,048,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,828,237 - 72,835,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,828,236 - 72,835,994NCBI
Celera1551,991,217 - 51,998,975 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,838,984 - 51,846,743 (+)NCBIHuRef
CHM1_11575,159,686 - 75,167,443 (+)NCBICHM1_1
T2T-CHM13v2.01572,618,749 - 72,626,513 (+)NCBIT2T-CHM13v2.0
Cyp1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,971,261 - 66,978,149 (-)NCBIGRCr8
mRatBN7.2858,075,367 - 58,082,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,075,367 - 58,082,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,608,316 - 63,615,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,885,882 - 61,892,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,750,429 - 59,757,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,451,360 - 62,458,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,451,329 - 62,458,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,228,271 - 62,235,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,439,062 - 61,447,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,458,143 - 61,464,586 (-)NCBI
Celera857,541,217 - 57,547,956 (-)NCBICelera
Cytogenetic Map8q24NCBI
LOC102010322
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,165,106 - 3,171,942 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,165,107 - 3,171,894 (-)NCBIChiLan1.0ChiLan1.0
CYP1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,978,105 - 63,985,853 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,142,637 - 68,148,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,692,877 - 53,699,279 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,311,720 - 73,319,447 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,311,720 - 73,319,447 (+)Ensemblpanpan1.1panPan2
CYP1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,818,400 - 37,824,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,799,140 - 37,824,135 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,751,388 - 37,757,086 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,023,809 - 38,029,593 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,023,809 - 38,029,586 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,976,275 - 37,981,991 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,002,364 - 38,008,076 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,258,389 - 38,264,108 (+)NCBIUU_Cfam_GSD_1.0
LOC101969421
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,856,553 - 115,861,413 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,703,792 - 33,709,484 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,704,616 - 33,709,455 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,779,475 - 58,786,100 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,779,529 - 58,786,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,468,129 - 63,474,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,727,996 - 8,733,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048132,898,379 - 132,904,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp1a2
167 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:85
Interacting mature miRNAs:93
Transcripts:ENSMUST00000034860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
1301287Feml2_mfemur length in high growth mice 2 (mouse)Not determined95750728363207282Mouse

Markers in Region
D9Mit101  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,680,247 - 57,680,587UniSTSGRCm38
MGSCv37957,528,054 - 57,528,394UniSTSGRCm37
Celera954,916,495 - 54,916,835UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
Whitehead Genetic929.5UniSTS
D9Mit101.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,680,594 - 57,680,732UniSTSGRCm38
MGSCv37957,528,401 - 57,528,539UniSTSGRCm37
Celera954,916,842 - 54,916,980UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
cM Map9 UniSTS
Whitehead Genetic929.5UniSTS
D9Mit101.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,680,203 - 57,680,377UniSTSGRCm38
MGSCv37957,528,010 - 57,528,184UniSTSGRCm37
Celera954,916,451 - 54,916,625UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
cM Map9 UniSTS
Whitehead Genetic929.5UniSTS
Whitehead_YAC9 UniSTS
D9Mit21  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,684,209 - 57,684,399UniSTSGRCm38
MGSCv37957,532,016 - 57,532,206UniSTSGRCm37
Celera954,920,457 - 54,920,633UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
Whitehead Genetic929.5UniSTS
Whitehead_YAC9 UniSTS
Cyp1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,681,085 - 57,682,074UniSTSGRCm38
MGSCv37957,528,892 - 57,529,881UniSTSGRCm37
Celera954,917,333 - 54,918,322UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
cM Map931.0UniSTS
cM Map931.0UniSTS
PMC291882P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,681,770 - 57,681,963UniSTSGRCm38
MGSCv37957,529,577 - 57,529,770UniSTSGRCm37
Celera954,918,018 - 54,918,211UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
Cyp1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,680,423 - 57,680,574UniSTSGRCm38
MGSCv37957,528,230 - 57,528,381UniSTSGRCm37
Celera954,916,671 - 54,916,822UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS
Cyp1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38957,678,518 - 57,678,715UniSTSGRCm38
MGSCv37957,526,325 - 57,526,522UniSTSGRCm37
Celera954,914,766 - 54,914,963UniSTS
Cytogenetic Map9BUniSTS
cM Map931.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB042202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ392393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X01682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034860   ⟹   ENSMUSP00000034860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl957,584,220 - 57,590,986 (-)Ensembl
GRCm38.p6 Ensembl957,676,937 - 57,683,703 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215792
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl957,588,204 - 57,589,319 (-)Ensembl
GRCm38.p6 Ensembl957,680,921 - 57,682,036 (-)Ensembl
RefSeq Acc Id: NM_009993   ⟹   NP_034123
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39957,584,220 - 57,590,938 (-)NCBI
GRCm38957,676,937 - 57,683,655 (-)ENTREZGENE
MGSCv37957,524,744 - 57,531,462 (-)RGD
Celera954,913,185 - 54,919,903 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034123   ⟸   NM_009993
- UniProtKB: Q9QWJ4 (UniProtKB/Swiss-Prot),   P00186 (UniProtKB/Swiss-Prot),   B6VGH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034860   ⟸   ENSMUST00000034860

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00186-F1-model_v2 AlphaFold P00186 1-513 view protein structure

Promoters
RGD ID:6848397
Promoter ID:MM_ACW:50698
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:CYP1A2.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36957,529,851 - 57,530,351 (-)MPROMDB
RGD ID:6844384
Promoter ID:MM_KWN:57551
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_009993
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36957,531,051 - 57,531,551 (-)MPROMDB
RGD ID:8669758
Promoter ID:EPDNEW_M12909
Type:multiple initiation site
Name:Cyp1a2_1
Description:Mus musculus cytochrome P450, family 1, subfamily a, polypeptide2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38957,683,652 - 57,683,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88589 AgrOrtholog
Ensembl Genes ENSMUSG00000032310 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034860 ENTREZGENE
  ENSMUST00000034860.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13077 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88589 ENTREZGENE
NCBI Gene 13077 ENTREZGENE
PANTHER CYTOCHROME P450 1A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP1A2 RGD
PhenoGen Cyp1a2 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B6VGH4 ENTREZGENE, UniProtKB/TrEMBL
  CP1A2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QWJ4 ENTREZGENE
UniProt Secondary Q9QWJ4 UniProtKB/Swiss-Prot