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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:3687
Term: chrysophanol
Definition: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
Chemical ID: MESH:C027113
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISORGD:7357116480464CTDchrysophanic acid results in decreased activity of CYP1A2 protein

PMID:27633141
Cyp1a2increases metabolic processingISORGD:7357116480464CTDCYP1A2 protein results in increased metabolism of chrysophanic acid

PMID:29698620
Cyp1a2multiple interactionsISORGD:7357116480464CTD[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

PMID:29698620
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