Hck (HCK proto-oncogene, Src family tyrosine kinase)

Gene: Hck (HCK proto-oncogene, Src family tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Hck

Name:

HCK proto-oncogene, Src family tyrosine kinase

RGD ID:

2785

Description:

Predicted to enable several functions, including lipid binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including innate immune response; regulation of organelle organization; and regulation of phagocytosis. Predicted to act upstream of or within defense response to Gram-positive bacterium and phagocytosis. Predicted to be located in several cellular components, including caveola; cytoplasmic side of plasma membrane; and focal adhesion. Predicted to colocalize with actin filament. Orthologous to human HCK (HCK proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

HCTK; hematopoietic cell kinase; hemopoietic cell kinase; hemopoietic cell tyrosine kinase; p56-HCK; p56Hck; p59Hck; tyrosine-protein kinase HCK

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	162,031,833 - 162,074,933 (+)	NCBI		GRCr8
mRatBN7.2	3	141,571,587 - 141,614,696 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	141,571,587 - 141,614,693 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	145,476,301 - 145,519,337 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	154,060,107 - 154,103,139 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	151,799,366 - 151,842,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	148,579,917 - 148,623,026 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	148,579,920 - 148,623,033 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	154,982,909 - 155,025,529 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	143,447,697 - 143,490,281 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	143,353,318 - 143,395,900 (+)	NCBI
Celera	3	140,318,662 - 140,361,702 (+)	NCBI		Celera
RH 3.4 Map	3	1263.9	RGD
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

autoimmune disease (ISO)

Autoinflammation with Pulmonary and Cutaneous Vasculitis (ISO)

COVID-19 (ISO)

disease of cellular proliferation (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-di-tert-butyl-4-methylphenol (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acetylsalicylic acid (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amosite asbestos (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

ATP (ISO)

bathocuproine disulfonic acid (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clothianidin (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

curcumin (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

dichromium trioxide (ISO)

diclofenac (ISO)

diethyl malate (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethylparaben (ISO)

folic acid (ISO)

gentamycin (EXP)

ionomycin (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

mercury dichloride (ISO)

methotrexate (ISO)

N-formyl-L-methionyl-L-leucyl-L-phenylalanine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

oxycodone (EXP)

ozone (EXP,ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

ponatinib (ISO)

pyrrolidine dithiocarbamate (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-nitroso-N-acetyl-D-penicillamine (EXP)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

streptozocin (EXP)

sulforaphane (ISO)

T-2 toxin (EXP)

tamibarotene (ISO)

testosterone (EXP)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenylstannane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA,IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IBA,IEA)

defense response to Gram-positive bacterium (ISO)

exocytosis (IEA)

inflammatory response (IEA)

innate immune response (IBA,IEA)

intracellular signal transduction (IEA,ISO)

negative regulation of apoptotic process (IEA,ISO)

phagocytosis (ISO)

positive regulation of cell population proliferation (IEA,ISO,ISS)

regulation of actin cytoskeleton organization (IEA,ISO,ISS)

regulation of cell shape (IEA,ISO,ISS)

regulation of phagocytosis (IEA,ISO,ISS)

regulation of podosome assembly (IEA,ISO,ISS)

Cellular Component

actin filament (IEA,ISO,ISS)

caveola (IEA,ISO)

cell projection (IEA)

cytoplasmic side of plasma membrane (IEA,ISO,ISS)

cytosol (IEA,ISO)

extrinsic component of cytoplasmic side of plasma membrane (IEA)

focal adhesion (IEA,ISO)

Golgi apparatus (IEA)

intracellular membrane-bounded organelle (ISO)

lysosome (IEA,ISO,ISS)

nucleus (IEA)

plasma membrane (IBA,ISO)

transport vesicle (IEA)

Molecular Function

ATP binding (IEA)

lipid binding (ISO)

non-membrane spanning protein tyrosine kinase activity (IBA,IEA)

phosphotyrosine residue binding (IEA,ISO)

protein binding (ISO)

protein tyrosine kinase activity (IEA,ISO,ISS)

signaling receptor binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

eicosanoid signaling pathway (ISO)

ephrin - ephrin receptor bidirectional signaling axis (ISO)

Fc gamma receptor mediated signaling pathway (IEA)

glypican signaling pathway (ISO)

interleukin-6 signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5.	Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.	Lock P, etal., Mol Cell Biol 1991 Sep;11(9):4363-70.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Identification of rat cDNA encoding hck tyrosine kinase from megakaryocytes.	Okano Y, etal., Biochem Biophys Res Commun 1991 Dec 31;181(3):1137-44.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:7791757	PMID:8125254	PMID:10092522	PMID:10861086	PMID:11904303	PMID:14551197	PMID:15489334	PMID:15998323	PMID:16921024	PMID:17535448	PMID:20624904	PMID:27053350

Genomics

Comparative Map Data

Hck
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	162,031,833 - 162,074,933 (+)	NCBI		GRCr8
mRatBN7.2	3	141,571,587 - 141,614,696 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	141,571,587 - 141,614,693 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	145,476,301 - 145,519,337 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	154,060,107 - 154,103,139 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	151,799,366 - 151,842,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	148,579,917 - 148,623,026 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	148,579,920 - 148,623,033 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	154,982,909 - 155,025,529 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	143,447,697 - 143,490,281 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	143,353,318 - 143,395,900 (+)	NCBI
Celera	3	140,318,662 - 140,361,702 (+)	NCBI		Celera
RH 3.4 Map	3	1263.9	RGD
Cytogenetic Map	3	q41	NCBI

HCK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	32,052,242 - 32,101,856 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	32,052,197 - 32,101,856 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	30,640,045 - 30,689,659 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	30,103,718 - 30,153,320 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	30,103,717 - 30,153,316	NCBI
Celera	20	27,396,349 - 27,446,028 (+)	NCBI		Celera
Cytogenetic Map	20	q11.21	NCBI
HuRef	20	27,428,653 - 27,478,333 (+)	NCBI		HuRef
CHM1_1	20	30,543,895 - 30,593,543 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	33,776,868 - 33,826,471 (+)	NCBI		T2T-CHM13v2.0

Hck
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	152,950,388 - 152,993,361 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	152,950,388 - 152,993,361 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	153,108,468 - 153,151,441 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	153,108,468 - 153,151,441 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	152,934,204 - 152,977,177 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	152,799,949 - 152,842,877 (+)	NCBI		MGSCv36	mm8
Celera	2	158,934,831 - 158,977,872 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	75.41	NCBI

Hck
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	28,932,653 - 28,986,998 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	28,934,512 - 28,986,998 (-)	NCBI	ChiLan1.0	ChiLan1.0

HCK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	37,749,456 - 37,798,596 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	37,742,549 - 37,791,693 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	28,346,244 - 28,395,370 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	29,474,737 - 29,523,399 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	29,474,737 - 29,523,399 (+)	Ensembl	panpan1.1		panPan2

HCK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	21,473,424 - 21,513,673 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	21,473,305 - 21,513,564 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	21,120,196 - 21,159,815 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	22,159,696 - 22,200,184 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	22,159,611 - 22,200,164 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	21,438,409 - 21,478,679 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	21,543,401 - 21,583,860 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	21,974,379 - 22,014,637 (+)	NCBI		UU_Cfam_GSD_1.0

Hck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	170,546,975 - 170,587,555 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	18,978,412 - 19,017,908 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	18,996,016 - 19,017,908 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HCK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	35,709,349 - 35,751,582 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	35,708,549 - 35,751,590 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	40,639,128 - 40,680,366 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HCK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	36,441,185 - 36,490,205 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	36,460,495 - 36,490,190 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	90,424,019 - 90,473,182 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hck
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	455,696 - 493,821 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	456,186 - 494,207 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hck
286 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	121
Count of miRNA genes:	98
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000012432
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	140069424	146976080	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat

Markers in Region

J03023

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	141,614,468 - 141,614,623 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	148,622,799 - 148,622,953	NCBI	Rnor6.0
Rnor_5.0	3	155,025,302 - 155,025,456	UniSTS	Rnor5.0
RGSC_v3.4	3	143,490,054 - 143,490,208	UniSTS	RGSC3.4
Celera	3	140,361,475 - 140,361,629	UniSTS
Cytogenetic Map	3	q41	UniSTS

RH94532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	141,614,453 - 141,614,623 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	148,622,784 - 148,622,953	NCBI	Rnor6.0
Rnor_5.0	3	155,025,287 - 155,025,456	UniSTS	Rnor5.0
RGSC_v3.4	3	143,490,039 - 143,490,208	UniSTS	RGSC3.4
Celera	3	140,361,460 - 140,361,629	UniSTS
RH 3.4 Map	3	1263.9	UniSTS
Cytogenetic Map	3	q41	UniSTS

RH137385

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	141,614,503 - 141,614,659 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	148,622,834 - 148,622,989	NCBI	Rnor6.0
Rnor_5.0	3	155,025,337 - 155,025,492	UniSTS	Rnor5.0
RGSC_v3.4	3	143,490,089 - 143,490,244	UniSTS	RGSC3.4
Celera	3	140,361,510 - 140,361,665	UniSTS
RH 3.4 Map	3	1275.0	UniSTS
Cytogenetic Map	3	q41	UniSTS

UniSTS:498385

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	141,614,236 - 141,614,639 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	148,622,567 - 148,622,969	NCBI	Rnor6.0
Rnor_5.0	3	155,025,070 - 155,025,472	UniSTS	Rnor5.0
RGSC_v3.4	3	143,489,822 - 143,490,224	UniSTS	RGSC3.4
Celera	3	140,361,243 - 140,361,645	UniSTS
Cytogenetic Map	3	q41	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		10	4	17	4					3	11
Low	1	35	47	37	2	37	8	11	72	35	34		8
Below cutoff		8							2		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU760053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M83666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S74141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012432 ⟹ ENSRNOP00000012432

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	141,571,587 - 141,614,693 (+)	Ensembl
Rnor_6.0 Ensembl	3	148,579,920 - 148,623,033 (+)	Ensembl

RefSeq Acc Id:

NM_013185 ⟹ NP_037317

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	162,031,833 - 162,074,933 (+)	NCBI
mRatBN7.2	3	141,571,587 - 141,614,696 (+)	NCBI
Rnor_6.0	3	148,579,917 - 148,623,026 (+)	NCBI
Rnor_5.0	3	154,982,909 - 155,025,529 (+)	NCBI
RGSC_v3.4	3	143,447,697 - 143,490,281 (+)	RGD
Celera	3	140,318,662 - 140,361,702 (+)	NCBI

Sequence:

show sequence

GATGGCCAGTGAGCACCACCGGGTTGCCGCTCCCCGCTTGCACTTTACGGTTGCGGCTCTCAGA
CGGGTGGGAGGGAACCAAAGTCGCCGGTAAAGGCGGCTCTGACCCGCTCGGAGCGCCAACGCAG
CCTCCGTAGCCCGCAAGTCTTCGTCGCTTGCTCCGGGCTCTCGAGTCCGGGGCCACCAGGGGCC
GCGGCGCTGGGGGGTCGTTCGAGCTGCGAGGATCCGGGCTGCCCGCGAGGCGAAGGGCGGGTGC
CCAGGATGGGATGTGTGAAGTCCAGGTTCCTCCGAGAAGGAAGCAAGGCCTCAAAAATAGAGCC
AAATGCCAACCAGAAAGGCCCTGTGTATGTGCCGGATCCCACGTCCCCTAAGAAGCTGGGACCG
AACAGCATCAACAGCCTGCCCCCGGGGGTCGTGGAGGGCTCTGAGGACACCATTGTGGTCGCAC
TGTACGACTATGAGGCCATTCACCGTGAAGACCTCAGCTTCCAGAAGGGAGACCAGATGGTGGT
TCTGGAGGAGTCTGGGGAGTGGTGGAAGGCCCGTTCCCTGGCTACCAAGAAAGAAGGCTATATC
CCAAGCAATTATGTAGCTCGAGTTAACTCTTTGGAGACTGAGGAGTGGTTCTTCAAGGGTATCA
GCCGGAAGGATGCAGAGCGCCACCTGCTGGCTCCCGGGAACATGCTGGGCTCCTTCATGATCCG
GGACAGTGAGACCACCAAAGGGAGCTACTCACTTTCTGTTCGAGACTTTGACCCCCAGCACGGA
GACACGGTGAAGCATTATAAAATCCGGACACTGGACAGTGGAGGCTTCTACATCTCTCCGAGGA
GCACCTTCAGCAGCCTGCAGGAACTTGTCGTCCACTACAAGAAGGGGAAGGATGGGCTCTGCCA
GAAGCTGTCAGTGCCCTGTGTGTCTCCCAAACCCCAGAAGCCATGGGAGAAAGATGCCTGGGAG
ATTCCTCGAGAATCCCTCCAGATGGAGAAGAAACTGGGAGCCGGGCAGTTTGGAGAAGTGTGGA
TGGCCACCTACAACAAGCACACCAAAGTGGCGGTGAAGACAATGAAGCCAGGGAGCATGTCTGT
GGAGGCCTTCCTGGCAGAGGCCAACCTGATGAAGACGTTACAGCATGATAAACTGGTGAAGCTG
CACGCCGTGGTCTCTCAGGAGCCCATCTTTATTGTCACCGAGTTCATGGCCAAAGGAAGCCTGC
TGGACTTTCTCAAGAGTGAAGAAGGCAGCAAGCAGCCACTGCCAAAACTCATTGACTTCTCAGC
CCAGATTTCAGAGGGCATGGCTTTCATTGAGCAGAGGAACTACATCCACCGAGACCTCCGGGCT
GCCAACATCTTGGTTTCTGCATCACTGGTGTGTAAGATCGCTGACTTTGGACTGGCACGGATCA
TCGAGGACAATGAGTACACAGCTCGGGAAGGAGCCAAGTTCCCCATCAAGTGGACAGCTCCTGA
AGCCATCAACTTTGGCTCCTTCACCATCAAGTCAGATGTCTGGTCCTTTGGTATCCTGCTGATG
GAAATCGTCACCTACGGCCGGATCCCTTACCCAGGTATGTCAAACCCAGAGGTGATTCGAGCAC
TAGAGCATGGGTACCGTATGCCTCGACCAGATAACTGCCCAGAGGAGCTCTACAGTATCATGAT
CCGCTGCTGGAAGAACCGTCCAGAGGAACGGCCCACTTTCGAATACATCCAGAGCGTGCTGGAT
GACTTCTACACGGCCACTGAGAGCCAGTATCAGCAGCAACCTTGATGGGCCGGAAGAACATGAG
CACAGCCAGAAGCCCCATCAGGGCCTTGACATGCTCGACCTGCTGGGCCCACTCTCAGACGCCC
CCTCCCCCACATTCCAGCTGTCGAGTGGAGGGAGAGGACTTCACAATCTCTTTTTGACTCTAGT
CATCTGCAATCTGCCATTCTCAGGGCCTCCAAGTTAGTGTTTCTCATTTGCCTGGAATGAACTG
AATTCAATCTATAGCTGTGATTTAAGTGGGAAGCTGTTAAAATAGTATTTAAATAAAAGATGTG
AGTGTCAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_037317	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41312	(Get FASTA)	NCBI Sequence Viewer
	AAB20754	(Get FASTA)	NCBI Sequence Viewer
	AAH78890	(Get FASTA)	NCBI Sequence Viewer
	EDL86018	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012432
	ENSRNOP00000012432.7
GenBank Protein	P50545	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037317 ⟸ NM_013185

- UniProtKB:

Q64647 (UniProtKB/Swiss-Prot), Q6AYV7 (UniProtKB/Swiss-Prot), P50545 (UniProtKB/Swiss-Prot), A0A8L2UIG7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGGRSSCEDPGCPRGEGRVPRMGCVKSRFLREGSKASKIEPNANQKGPVYVPDPTSPKKLGPNS
INSLPPGVVEGSEDTIVVALYDYEAIHREDLSFQKGDQMVVLEESGEWWKARSLATKKEGYIPS
NYVARVNSLETEEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDT
VKHYKIRTLDSGGFYISPRSTFSSLQELVVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIP
RESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHA
VVSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAAN
ILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEI
VTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSVLDDF
YTATESQYQQQP

hide sequence

RefSeq Acc Id:

ENSRNOP00000012432 ⟸ ENSRNOT00000012432

Protein Domains

Protein kinase SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50545-F1-model_v2	AlphaFold	P50545	1-524	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692557

Promoter ID:

EPDNEW_R3082

Type:

initiation region

Name:

Hck_1

Description:

HCK proto-oncogene, Src family tyrosine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	148,579,924 - 148,579,984	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2785	AgrOrtholog
BioCyc Gene	G2FUF-47229	BioCyc
Ensembl Genes	ENSRNOG00000009331	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012432	ENTREZGENE
	ENSRNOT00000012432.7	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7121407	IMAGE-MGC_LOAD
InterPro	HCK_SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25734	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93602	IMAGE-MGC_LOAD
NCBI Gene	25734	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE HCK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hck	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009331	RatGTEx
SMART	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TyrKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC222854
UniProt	A0A8L2UIG7	ENTREZGENE, UniProtKB/TrEMBL
	A6KHT7_RAT	UniProtKB/TrEMBL
	HCK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q64647	ENTREZGENE
	Q6AYV7	ENTREZGENE
UniProt Secondary	Q64647	UniProtKB/Swiss-Prot
	Q6AYV7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-11	Hck	HCK proto-oncogene, Src family tyrosine kinase	Hck	hemopoietic cell kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Hck	Hemopoietic cell tyrosine kinase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed predominantly myeloid and B-lymphoid lineage cells	1298942
gene_product	member of the src family of tyrosine kinases	1298942
gene_protein	503 amino acids	728421
gene_transcript	1911 nucleotides	728421

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)