HCK (HCK proto-oncogene, Src family tyrosine kinase)

Gene: HCK (HCK proto-oncogene, Src family tyrosine kinase) Chlorocebus sabaeus

Analyze

Symbol:

HCK

Name:

HCK proto-oncogene, Src family tyrosine kinase

RGD ID:

18663962

Description:

ENCODES a protein that exhibits lipid binding (ortholog); phosphotyrosine residue binding (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); intracellular signal transduction (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autoimmune disease (ortholog); Autoinflammation with Pulmonary and Cutaneous Vasculitis (ortholog); FOUND IN actin filament (ortholog); caveola (ortholog); cytoplasmic side of plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tyrosine-protein kinase HCK

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	36,441,185 - 36,490,205 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	36,460,495 - 36,490,190 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	90,424,019 - 90,473,182 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

autoimmune disease (ISO)

Autoinflammation with Pulmonary and Cutaneous Vasculitis (ISO)

COVID-19 (ISO)

disease of cellular proliferation (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

defense response to Gram-positive bacterium (ISO)

innate immune response (IEA)

intracellular signal transduction (ISO)

negative regulation of apoptotic process (ISO)

phagocytosis (ISO)

positive regulation of cell population proliferation (ISO)

regulation of actin cytoskeleton organization (ISO)

regulation of cell shape (ISO)

regulation of phagocytosis (ISO)

regulation of podosome assembly (ISO)

Cellular Component

actin filament (ISO)

caveola (ISO)

cytoplasm (IEA)

cytoplasmic side of plasma membrane (ISO)

cytosol (IEA)

extrinsic component of cytoplasmic side of plasma membrane (IEA)

focal adhesion (ISO)

intracellular membrane-bounded organelle (ISO)

lysosome (ISO)

plasma membrane (ISO)

Molecular Function

ATP binding (IEA)

lipid binding (ISO)

non-membrane spanning protein tyrosine kinase activity (IEA)

phosphotyrosine residue binding (ISO)

protein binding (ISO)

protein tyrosine kinase activity (IEA)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway (ISO)

ephrin - ephrin receptor bidirectional signaling axis (ISO)

glypican signaling pathway (ISO)

interleukin-6 signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HCK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	36,441,185 - 36,490,205 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	36,460,495 - 36,490,190 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	90,424,019 - 90,473,182 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HCK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	32,052,242 - 32,101,856 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	32,052,197 - 32,101,856 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	30,640,045 - 30,689,659 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	30,103,718 - 30,153,320 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	30,103,717 - 30,153,316	NCBI
Celera	20	27,396,349 - 27,446,028 (+)	NCBI		Celera
Cytogenetic Map	20	q11.21	NCBI
HuRef	20	27,428,653 - 27,478,333 (+)	NCBI		HuRef
CHM1_1	20	30,543,895 - 30,593,543 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	33,776,868 - 33,826,471 (+)	NCBI		T2T-CHM13v2.0

Hck
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	152,950,388 - 152,993,361 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	152,950,388 - 152,993,361 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	153,108,468 - 153,151,441 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	153,108,468 - 153,151,441 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	152,934,204 - 152,977,177 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	152,799,949 - 152,842,877 (+)	NCBI		MGSCv36	mm8
Celera	2	158,934,831 - 158,977,872 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	75.41	NCBI

Hck
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	162,031,833 - 162,074,933 (+)	NCBI		GRCr8
mRatBN7.2	3	141,571,587 - 141,614,696 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	141,571,587 - 141,614,693 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	145,476,301 - 145,519,337 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	154,060,107 - 154,103,139 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	151,799,366 - 151,842,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	148,579,917 - 148,623,026 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	148,579,920 - 148,623,033 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	154,982,909 - 155,025,529 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	143,447,697 - 143,490,281 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	143,353,318 - 143,395,900 (+)	NCBI
Celera	3	140,318,662 - 140,361,702 (+)	NCBI		Celera
RH 3.4 Map	3	1263.9	RGD
Cytogenetic Map	3	q41	NCBI

Hck
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	28,932,653 - 28,986,998 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	28,934,512 - 28,986,998 (-)	NCBI	ChiLan1.0	ChiLan1.0

HCK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	37,749,456 - 37,798,596 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	37,742,549 - 37,791,693 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	28,346,244 - 28,395,370 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	29,474,737 - 29,523,399 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	29,474,737 - 29,523,399 (+)	Ensembl	panpan1.1		panPan2

HCK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	21,473,424 - 21,513,673 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	21,473,305 - 21,513,564 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	21,120,196 - 21,159,815 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	22,159,696 - 22,200,184 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	22,159,611 - 22,200,164 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	21,438,409 - 21,478,679 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	21,543,401 - 21,583,860 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	21,974,379 - 22,014,637 (+)	NCBI		UU_Cfam_GSD_1.0

Hck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	170,546,975 - 170,587,555 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	18,978,412 - 19,017,908 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	18,996,016 - 19,017,908 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HCK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	35,709,349 - 35,751,582 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	35,708,549 - 35,751,590 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	40,639,128 - 40,680,366 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hck
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	455,696 - 493,821 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	456,186 - 494,207 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium		19
Low	36	1	60
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008020387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000010762 ⟹ ENSCSAP00000008851

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	2	36,460,495 - 36,490,190 (+)	Ensembl

RefSeq Acc Id:

XM_008020387 ⟹ XP_008018578

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	36,441,185 - 36,490,205 (+)	NCBI
Vero_WHO_p1.0	NW_023666050	90,424,019 - 90,473,182 (-)	NCBI

Sequence:

show sequence

TAGCATCGCTCAGGGCGCGGCTAAAGCGCCCAGATGGCCTGCGGGCACCACCGCGTCCCTGGTC
CCAGTCCGGGAGCACGTCGGAGGCTTAGAGGCGAGTGGGAAGGGACCCAGACAGTGCAGGGCGA
GACACGCCCGCGGCACCAAAGCCCCTCCGAGCGCCGCCCCCGCCTCTAGTTCTAGAAAGTCAGT
TTCCCAGCACTGGCACCCCGGAACCTCGGGGGCTGCCGAGCTGGGGGGGCGCTCGAGCTGCGAG
GATCCGGGCTGCCCGCGAGACCAGGAGCGGGCGCCCAGGATGGGGTGCATGAAGTCCAAGTTCC
TCCAGGCCGGAGGCAATACATTCTCCAAAACTGAAACCAGCGCCAACCCACACTGCCCTGTGTA
CGTGCCGGATCCCACATCCACCATCAAGCCGGGGCCTAATAGCAACAACAGGAACACACCAGGA
ATTGGGGAGGGCTCTGAGGACATCATCGTGGTTGCCCTGTATGATTATGAGGCCATTCACCATG
AAGACCTCAGCTTCCAGAAGGGGGACCAGATGGTCGTCCTAGAGGAATCCGGGGAGTGGTGGAA
GGCTCGATCCCTAGCCACCCGGAAGGAGGGCTACATCCCAAGCAATTATGTTGCCCGCGTTGAC
TCTCTGGAGACAGAGGAGTGGTTCTTCAAGGGCATCGGCCGGAAGGACGCAGAGCGCCAACTCC
TGGCTCCCGGCAACATGCTGGGCTCCTTCATGATCCGGGATAGCGAGACCACTAAAGGAAGCTA
CTCTTTGTCCGTGCGAGACTACGACCCTCGGCAGGGAGATACTGTGAAACATTACAAAATCCGG
ACCCTGGACAACGGGGGCTTCTACATATCCCCCCGAAGCACCTTCAGCACCCTGCAGGAGCTGG
TGGACCACTACAAGAAGGGGAGTGATGGGCTCTGCCAGAAACTGTCGGTGCCCTGCATGTCTTC
CAAGCCCCAGAAGCCTTGGGAGAAAGATGCCTGGGAGATCCCTCGGGAATCCCTCAAGCTGGAG
AAGAAACTTGGAGCCGGGCAGTTTGGGGAAGTCTGGATGGCCACCTACAACAAGCACACCAAGG
TGGCAGTGAAGACAATGAAGCCAGGGAGCATGTCGGTGGAGGCCTTCCTGGCAGAGGCCAACCT
GATGAAAACTCTACAGCATGACAAGCTAGTCAAACTTCATGCGGTGGTTACCAAGGAGCCCATC
TACATCATCACGGAGTTCATGGCCAAAGGAAGCCTGCTGGACTTTCTGAAAAGTGATGAGGGCA
GCAAGCAGCCCTTGCCAAAACTCATTGATTTCTCAGCCCAGATTGCAGAAGGCATGGCCTTCAT
CGAGCAGAGGAACTACATCCACCGAGACCTCCGAGCCGCCAACATCTTGGTCTCTGCATCCTTG
GTGTGTAAGATTGCTGACTTTGGCCTGGCCCGGATCATTGAGGACAATGAGTACACAGCTCGGG
AAGGGGCCAAATTCCCCATCAAGTGGACAGCTCCTGAAGCCATCAACTTTGGCTCCTTCACCAT
CAAGTCAGACGTCTGGTCCTTTGGTATCCTGCTGATGGAGATCGTCACCTACGGCCGCATCCCT
TACCCAGGGATGTCAAACCCCGAAGTGATCCGAGCTCTGGAGCGTGGATACCGGATGCCTCGCC
CGGAGAACTGCCCAGAGGAGCTTTACAACATCATGATGCGCTGCTGGAAGAACCGTCCGGAGGA
GCGGCCGACCTTCGAATACATCCAGAGTGTGCTGGATGACTTCTACACGGCCACAGAGAGCCAA
TACCAACAGCAGCCATGATGGGGAGGACCAGGGTAGGGCCAGGGGGTGCCCAGGTGGTGGCTGC
AAGGTGGCTCCAGCACCATCCACTAGGGCCCACGCCCCCTCCCTACTCCCAGACACCCACCCTC
GCTTCAGCCACGGTTTCCTCATCTATCCAGTGAGTGGGTTGGACTGGAAAATCTCTTTTTGACT
CTCGCAATCCACAATCTGACATTCTCAGGAAGCCCCCAAGTTGATATTTCTATTTCCTGGAATG
GTTGGATTTTAGTTACAGCTGTGATTTGGAAGAGAAACTTTCAAAATAGTGAAATGAATATTTA
AATAAAAGATATAAATGCCAAAGTCTTTACCAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008018578	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008851
	ENSCSAP00000008851.1

RefSeq Acc Id:	XP_008018578 ⟸ XM_008020387
- UniProtKB:	A0A0D9RJR2 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000008851 ⟸ ENSCSAT00000010762

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012669	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010762.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	HCK_SH2	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
NCBI Gene	HCK	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE HCK	UniProtKB/TrEMBL
Pfam	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A0D9RJR2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)