HCK (HCK proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: HCK (HCK proto-oncogene, Src family tyrosine kinase) Homo sapiens
Analyze
Symbol: HCK
Name: HCK proto-oncogene, Src family tyrosine kinase
RGD ID: 732471
HGNC Page HGNC
Description: Exhibits phosphotyrosine residue binding activity and protein tyrosine kinase activity. Involved in several processes, including protein phosphorylation; regulation of DNA-binding transcription factor activity; and regulation of organelle organization. Localizes to several cellular components, including caveola; extrinsic component of cytoplasmic side of plasma membrane; and focal adhesion. Colocalizes with actin filament.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hematopoietic cell kinase; hemopoietic cell kinase; JTK9; p59-HCK/p60-HCK; p59Hck; p61Hck; tyrosine-protein kinase HCK
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2032,052,188 - 32,101,856 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2032,052,197 - 32,101,856 (+)EnsemblGRCh38hg38GRCh38
GRCh382032,052,242 - 32,101,856 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,640,045 - 30,689,659 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,103,718 - 30,153,320 (+)NCBINCBI36hg18NCBI36
Build 342030,103,717 - 30,153,316NCBI
Celera2027,396,349 - 27,446,028 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,428,653 - 27,478,333 (+)NCBIHuRef
CHM1_12030,543,895 - 30,593,543 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amosite asbestos  (ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP)
bathocuproine disulfonic acid  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clothianidin  (EXP)
cobalt dichloride  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (EXP)
diclofenac  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
folic acid  (ISO)
gentamycin  (ISO)
ionomycin  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP,ISO)
methotrexate  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
oxycodone  (ISO)
ozone  (ISO)
panobinostat  (EXP)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
ponatinib  (EXP)
pyrrolidine dithiocarbamate  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
T-2 toxin  (ISO)
tamibarotene  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triphenylstannane  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:1373873   PMID:1572549   PMID:1689310   PMID:1720539   PMID:1875927   PMID:3453117   PMID:3496523   PMID:7588629   PMID:7682059   PMID:7782336   PMID:7791757   PMID:7859737  
PMID:8058772   PMID:8064233   PMID:8125298   PMID:8599760   PMID:8626374   PMID:8657103   PMID:8885868   PMID:8955135   PMID:8995358   PMID:9020138   PMID:9024658   PMID:9109402  
PMID:9178913   PMID:9195918   PMID:9218412   PMID:9268059   PMID:9400828   PMID:9407116   PMID:9571048   PMID:9656992   PMID:9705913   PMID:9742969   PMID:9778343   PMID:9790917  
PMID:9837776   PMID:9890970   PMID:10068673   PMID:10092522   PMID:10318861   PMID:10364375   PMID:10388555   PMID:10428862   PMID:10527858   PMID:10544125   PMID:10547288   PMID:10574946  
PMID:10586033   PMID:10642173   PMID:10749872   PMID:10799548   PMID:10849448   PMID:10858437   PMID:10861086   PMID:10918587   PMID:10934191   PMID:10967098   PMID:10973280   PMID:11071635  
PMID:11097855   PMID:11239464   PMID:11278465   PMID:11294897   PMID:11328823   PMID:11350938   PMID:11413142   PMID:11448168   PMID:11463741   PMID:11500821   PMID:11533201   PMID:11689697  
PMID:11741929   PMID:11780052   PMID:11896602   PMID:11904303   PMID:11940572   PMID:11976726   PMID:11994282   PMID:12029088   PMID:12033791   PMID:12076760   PMID:12138090   PMID:12181444  
PMID:12235133   PMID:12244095   PMID:12477932   PMID:12496276   PMID:12522270   PMID:12538589   PMID:12576423   PMID:12592324   PMID:12600646   PMID:12626508   PMID:12734187   PMID:12734410  
PMID:12748290   PMID:12769846   PMID:12900520   PMID:14506255   PMID:14551197   PMID:14551213   PMID:14702039   PMID:14969582   PMID:14993658   PMID:15010462   PMID:15078178   PMID:15144186  
PMID:15263807   PMID:15489334   PMID:15491611   PMID:15595833   PMID:15626739   PMID:15638726   PMID:15707590   PMID:15784897   PMID:15952790   PMID:15998323   PMID:16169070   PMID:16210316  
PMID:16271895   PMID:16273093   PMID:16344560   PMID:16374509   PMID:16454711   PMID:16636290   PMID:16684964   PMID:16849330   PMID:16921024   PMID:16964398   PMID:17024369   PMID:17081983  
PMID:17141806   PMID:17535448   PMID:17668209   PMID:17868192   PMID:17893228   PMID:18005690   PMID:18042718   PMID:18067320   PMID:18155796   PMID:18538446   PMID:18794796   PMID:19149577  
PMID:19211505   PMID:19234535   PMID:19490893   PMID:19585521   PMID:19807124   PMID:19807924   PMID:20056178   PMID:20181660   PMID:20488787   PMID:20624904   PMID:20670214   PMID:20702582  
PMID:20798061   PMID:20810664   PMID:20936779   PMID:21309750   PMID:21365684   PMID:21477083   PMID:21516116   PMID:21567396   PMID:21625496   PMID:21696586   PMID:21738584   PMID:21763503  
PMID:21832049   PMID:21873635   PMID:21878628   PMID:21886773   PMID:21988832   PMID:21993313   PMID:22021612   PMID:22110726   PMID:22185326   PMID:22345475   PMID:22364282   PMID:22393415  
PMID:22537596   PMID:22623531   PMID:22641034   PMID:22651890   PMID:22745667   PMID:22939624   PMID:22973453   PMID:22974441   PMID:23128233   PMID:23317503   PMID:23352142   PMID:23397142  
PMID:23439650   PMID:23559827   PMID:23576497   PMID:23601552   PMID:23847689   PMID:23896410   PMID:23986795   PMID:24051604   PMID:24162774   PMID:24229420   PMID:24396731   PMID:24451644  
PMID:24623722   PMID:24658140   PMID:24722985   PMID:24728074   PMID:24860872   PMID:25036101   PMID:25122770   PMID:25241761   PMID:25402006   PMID:25416956   PMID:25469238   PMID:25527710  
PMID:25624478   PMID:25666803   PMID:25745180   PMID:25807049   PMID:25814554   PMID:25825872   PMID:25972488   PMID:26440750   PMID:27143257   PMID:27485399   PMID:27531930   PMID:28319085  
PMID:28399411   PMID:29331674   PMID:29568343   PMID:29845934   PMID:29962266   PMID:30425250   PMID:31586073   PMID:31790499   PMID:31877324   PMID:31980649   PMID:32226298   PMID:32296183  
PMID:32484210   PMID:32591642  


Genomics

Comparative Map Data
HCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2032,052,188 - 32,101,856 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2032,052,197 - 32,101,856 (+)EnsemblGRCh38hg38GRCh38
GRCh382032,052,242 - 32,101,856 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,640,045 - 30,689,659 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,103,718 - 30,153,320 (+)NCBINCBI36hg18NCBI36
Build 342030,103,717 - 30,153,316NCBI
Celera2027,396,349 - 27,446,028 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,428,653 - 27,478,333 (+)NCBIHuRef
CHM1_12030,543,895 - 30,593,543 (+)NCBICHM1_1
Hck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,950,388 - 152,993,361 (+)NCBIGRCm39mm39
GRCm39 Ensembl2152,950,388 - 152,993,361 (+)Ensembl
GRCm382153,108,468 - 153,151,441 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,108,468 - 153,151,441 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,934,204 - 152,977,177 (+)NCBIGRCm37mm9NCBIm37
MGSCv362152,799,949 - 152,842,877 (+)NCBImm8
Celera2158,934,831 - 158,977,872 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Hck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,571,587 - 141,614,696 (+)NCBI
Rnor_6.0 Ensembl3148,579,920 - 148,623,033 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03148,579,917 - 148,623,026 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03154,982,909 - 155,025,529 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,447,697 - 143,490,281 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,353,318 - 143,395,900 (+)NCBI
Celera3140,318,662 - 140,361,702 (+)NCBICelera
RH 3.4 Map31263.9RGD
Cytogenetic Map3q41NCBI
Hck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,932,653 - 28,986,998 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,934,512 - 28,986,998 (-)NCBIChiLan1.0ChiLan1.0
HCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12029,474,737 - 29,523,399 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,474,737 - 29,523,399 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02028,346,244 - 28,395,370 (+)NCBIMhudiblu_PPA_v0panPan3
HCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,473,424 - 21,513,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,473,305 - 21,513,564 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,120,196 - 21,159,815 (+)NCBI
ROS_Cfam_1.02422,159,696 - 22,200,184 (+)NCBI
UMICH_Zoey_3.12421,438,409 - 21,478,679 (+)NCBI
UNSW_CanFamBas_1.02421,543,401 - 21,583,860 (+)NCBI
UU_Cfam_GSD_1.02421,974,379 - 22,014,637 (+)NCBI
Hck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,546,975 - 170,587,555 (+)NCBI
SpeTri2.0NW_00493648518,996,016 - 19,017,908 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,709,348 - 35,751,588 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,708,549 - 35,751,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,639,128 - 40,680,366 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,441,185 - 36,490,205 (+)NCBI
ChlSab1.1 Ensembl236,460,495 - 36,490,190 (+)Ensembl
Hck
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624741456,186 - 494,207 (-)NCBI

Position Markers
RH45427  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,689,404 - 30,689,597UniSTSGRCh37
Build 362030,153,065 - 30,153,258RGDNCBI36
Celera2027,445,773 - 27,445,966RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,478,078 - 27,478,271UniSTS
GeneMap99-GB4 RH Map20178.28UniSTS
RH92890  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,669,232 - 30,669,354UniSTSGRCh37
Build 362030,132,893 - 30,133,015RGDNCBI36
Celera2027,425,618 - 27,425,740RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,457,908 - 27,458,030UniSTS
GeneMap99-GB4 RH Map20179.8UniSTS
D20S512E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,689,270 - 30,689,328UniSTSGRCh37
Build 362030,152,931 - 30,152,989RGDNCBI36
Celera2027,445,639 - 27,445,697RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,477,944 - 27,478,002UniSTS
SHGC-112528  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,650,439 - 30,650,727UniSTSGRCh37
Build 362030,114,100 - 30,114,388RGDNCBI36
Celera2027,406,821 - 27,407,109RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,439,110 - 27,439,398UniSTS
AL031189  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,676,472 - 30,676,661UniSTSGRCh37
Build 362030,140,133 - 30,140,322RGDNCBI36
Celera2027,432,858 - 27,433,047RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,465,148 - 27,465,337UniSTS
SGC34341  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,689,139 - 30,689,290UniSTSGRCh37
Build 362030,152,800 - 30,152,951RGDNCBI36
Celera2027,445,508 - 27,445,659RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,477,813 - 27,477,964UniSTS
GeneMap99-GB4 RH Map20172.24UniSTS
Whitehead-RH Map20174.3UniSTS
NCBI RH Map20279.4UniSTS
D20S727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,689,323 - 30,689,656UniSTSGRCh37
Build 362030,152,984 - 30,153,317RGDNCBI36
Celera2027,445,692 - 27,446,025RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,477,997 - 27,478,330UniSTS
GeneMap99-GB4 RH Map20168.23UniSTS
Whitehead-YAC Contig Map20 UniSTS
NCBI RH Map20279.4UniSTS
G09843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,664,494 - 30,664,593UniSTSGRCh37
Build 362030,128,155 - 30,128,254RGDNCBI36
Celera2027,420,880 - 27,420,979RGD
Cytogenetic Map20q11-q12UniSTS
HuRef2027,453,170 - 27,453,269UniSTS
HCK_3380  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372030,689,189 - 30,689,769UniSTSGRCh37
Build 362030,152,850 - 30,153,430RGDNCBI36
Celera2027,445,558 - 27,446,138RGD
HuRef2027,477,863 - 27,478,443UniSTS
336XG5  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20q11-q12UniSTS
HuRef2027,434,882 - 27,435,163UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3429
Count of miRNA genes:812
Interacting mature miRNAs:924
Transcripts:ENST00000262651, ENST00000375852, ENST00000375862, ENST00000470092, ENST00000486475, ENST00000518730, ENST00000520553, ENST00000534862, ENST00000538448
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 209 209
Medium 636 1100 339 122 1349 82 1084 150 701 124 241 770 40 909 550 2 1
Low 1681 1650 1352 480 305 357 3070 1849 2911 249 1130 663 127 1 295 2117 2 1
Below cutoff 29 27 11 8 56 9 135 166 68 21 39 66 2 121

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001172133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK026432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW139272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC108930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC108931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA465978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262651   ⟹   ENSP00000262651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,242 - 32,101,849 (+)Ensembl
RefSeq Acc Id: ENST00000375852   ⟹   ENSP00000365012
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,242 - 32,101,843 (+)Ensembl
RefSeq Acc Id: ENST00000375862   ⟹   ENSP00000365022
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,197 - 32,101,519 (+)Ensembl
RefSeq Acc Id: ENST00000470092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,288 - 32,072,589 (+)Ensembl
RefSeq Acc Id: ENST00000486475   ⟹   ENSP00000420457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,242 - 32,101,660 (+)Ensembl
RefSeq Acc Id: ENST00000518730   ⟹   ENSP00000427757
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,261 - 32,101,519 (+)Ensembl
RefSeq Acc Id: ENST00000520553   ⟹   ENSP00000429848
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,242 - 32,101,856 (+)Ensembl
RefSeq Acc Id: ENST00000538448   ⟹   ENSP00000441169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,188 - 32,101,852 (+)Ensembl
RefSeq Acc Id: ENST00000629881   ⟹   ENSP00000486627
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2032,052,242 - 32,101,660 (+)Ensembl
RefSeq Acc Id: NM_001172129   ⟹   NP_001165600
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,101,856 (+)NCBI
GRCh372030,639,991 - 30,689,659 (+)ENTREZGENE
HuRef2027,428,653 - 27,478,333 (+)ENTREZGENE
CHM1_12030,543,895 - 30,593,543 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001172130   ⟹   NP_001165601
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,101,856 (+)NCBI
GRCh372030,639,991 - 30,689,659 (+)ENTREZGENE
HuRef2027,428,653 - 27,478,333 (+)ENTREZGENE
CHM1_12030,543,895 - 30,593,543 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001172131   ⟹   NP_001165602
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,101,856 (+)NCBI
GRCh372030,639,991 - 30,689,659 (+)ENTREZGENE
HuRef2027,428,653 - 27,478,333 (+)ENTREZGENE
CHM1_12030,543,895 - 30,593,543 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001172132   ⟹   NP_001165603
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,101,856 (+)NCBI
GRCh372030,639,991 - 30,689,659 (+)ENTREZGENE
HuRef2027,428,653 - 27,478,333 (+)ENTREZGENE
CHM1_12030,543,895 - 30,593,543 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001172133   ⟹   NP_001165604
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,101,856 (+)NCBI
GRCh372030,639,991 - 30,689,659 (+)ENTREZGENE
HuRef2027,428,653 - 27,478,333 (+)ENTREZGENE
CHM1_12030,543,895 - 30,593,543 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002110   ⟹   NP_002101
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,101,856 (+)NCBI
GRCh372030,639,991 - 30,689,659 (+)ENTREZGENE
Build 362030,103,718 - 30,153,320 (+)NCBI Archive
HuRef2027,428,653 - 27,478,333 (+)ENTREZGENE
CHM1_12030,543,895 - 30,593,543 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001165603   ⟸   NM_001172132
- Peptide Label: isoform e
- UniProtKB: A8K4G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001165604   ⟸   NM_001172133
- Peptide Label: isoform b
- UniProtKB: P08631 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_002101   ⟸   NM_002110
- Peptide Label: isoform a
- UniProtKB: P08631 (UniProtKB/Swiss-Prot),   F6SF04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001165600   ⟸   NM_001172129
- Peptide Label: isoform b
- UniProtKB: P08631 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001165601   ⟸   NM_001172130
- Peptide Label: isoform c
- UniProtKB: P08631 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001165602   ⟸   NM_001172131
- Peptide Label: isoform d
- UniProtKB: P08631 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000427757   ⟸   ENST00000518730
RefSeq Acc Id: ENSP00000365012   ⟸   ENST00000375852
RefSeq Acc Id: ENSP00000365022   ⟸   ENST00000375862
RefSeq Acc Id: ENSP00000429848   ⟸   ENST00000520553
RefSeq Acc Id: ENSP00000486627   ⟸   ENST00000629881
RefSeq Acc Id: ENSP00000441169   ⟸   ENST00000538448
RefSeq Acc Id: ENSP00000420457   ⟸   ENST00000486475
RefSeq Acc Id: ENSP00000262651   ⟸   ENST00000262651
Protein Domains
Protein kinase   SH2   SH3

Promoters
RGD ID:6798804
Promoter ID:HG_KWN:39014
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000375852,   ENST00000375862,   NM_001172133,   OTTHUMT00000078605,   UC002WXI.1,   UC010GDY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362030,103,474 - 30,103,974 (+)MPROMDB
RGD ID:13206637
Promoter ID:EPDNEW_H26899
Type:initiation region
Name:HCK_1
Description:HCK proto-oncogene, Src family tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26900  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,242 - 32,052,302EPDNEW
RGD ID:13206639
Promoter ID:EPDNEW_H26900
Type:initiation region
Name:HCK_2
Description:HCK proto-oncogene, Src family tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26899  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382032,052,506 - 32,052,566EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001172133.1(HCK):c.773-671C>A single nucleotide variant Lung cancer [RCV000101532] Chr20:32085957 [GRCh38]
Chr20:30673760 [GRCh37]
Chr20:20q11.21
uncertain significance
GRCh38/hg38 20q11.21(chr20:31289875-32302312)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052792]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052792]|See cases [RCV000052792] Chr20:31289875..32302312 [GRCh38]
Chr20:29877678..30890115 [GRCh37]
Chr20:29341339..30353776 [NCBI36]
Chr20:20q11.21
uncertain significance
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12
pathogenic
GRCh38/hg38 20q11.21(chr20:31254983-32575288)x3 copy number gain See cases [RCV000134504] Chr20:31254983..32575288 [GRCh38]
Chr20:29842786..31163090 [GRCh37]
Chr20:29306447..30626751 [NCBI36]
Chr20:20q11.21
pathogenic
GRCh38/hg38 20q11.21(chr20:31254983-33473080)x3 copy number gain See cases [RCV000135358] Chr20:31254983..33473080 [GRCh38]
Chr20:29842786..32060886 [GRCh37]
Chr20:29306447..31524547 [NCBI36]
Chr20:20q11.21
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q11.21-11.23(chr20:32062768-35906606)x3 copy number gain See cases [RCV000141833] Chr20:32062768..35906606 [GRCh38]
Chr20:30650571..34494528 [GRCh37]
Chr20:30114232..33957942 [NCBI36]
Chr20:20q11.21-11.23
pathogenic
GRCh37/hg19 20p12.1-q11.21(chr20:17705775-31600738)x3 copy number gain See cases [RCV000240436] Chr20:17705775..31600738 [GRCh37]
Chr20:20p12.1-q11.21
pathogenic
GRCh37/hg19 20p11.21-q11.21(chr20:24162775-31820857)x3 copy number gain See cases [RCV000448977] Chr20:24162775..31820857 [GRCh37]
Chr20:20p11.21-q11.21
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
Single allele duplication not provided [RCV000677978] Chr20:17705775..31600738 [GRCh37]
Chr20:20p12.1-q11.21
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_002110.4(HCK):c.1555G>T (p.Glu519Ter) single nucleotide variant not provided [RCV000997767] Chr20:32101493 [GRCh38]
Chr20:30689296 [GRCh37]
Chr20:20q11.21
likely pathogenic
GRCh37/hg19 20q11.21-11.23(chr20:29833608-35087952)x3 copy number gain not provided [RCV000849735] Chr20:29833608..35087952 [GRCh37]
Chr20:20q11.21-11.23
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4840 AgrOrtholog
COSMIC HCK COSMIC
Ensembl Genes ENSG00000101336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000262651 UniProtKB/TrEMBL
  ENSP00000365012 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000365022 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSP00000420457 UniProtKB/TrEMBL
  ENSP00000427757 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429848 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000486627 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000262651 UniProtKB/TrEMBL
  ENST00000375852 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000375862 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENST00000486475 UniProtKB/TrEMBL
  ENST00000518730 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000520553 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000629881 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000101336 GTEx
HGNC ID HGNC:4840 ENTREZGENE
Human Proteome Map HCK Human Proteome Map
InterPro HCK_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3055 UniProtKB/Swiss-Prot
NCBI Gene 3055 ENTREZGENE
OMIM 142370 OMIM
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29216 PharmGKB
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K4G3 ENTREZGENE, UniProtKB/TrEMBL
  F6SF04 ENTREZGENE
  H0Y3C5_HUMAN UniProtKB/TrEMBL
  H7BXG4_HUMAN UniProtKB/TrEMBL
  H7C5P9_HUMAN UniProtKB/TrEMBL
  HCK_HUMAN UniProtKB/Swiss-Prot
  J3KPD6_HUMAN UniProtKB/TrEMBL
  P08631 ENTREZGENE
UniProt Secondary A8K1I1 UniProtKB/Swiss-Prot
  B4DQB6 UniProtKB/Swiss-Prot
  E1P5M2 UniProtKB/Swiss-Prot
  Q29RX1 UniProtKB/Swiss-Prot
  Q2VPE2 UniProtKB/Swiss-Prot
  Q504R5 UniProtKB/Swiss-Prot
  Q5T7K1 UniProtKB/Swiss-Prot
  Q5T7K2 UniProtKB/Swiss-Prot
  Q96CC0 UniProtKB/Swiss-Prot
  Q9H5Y5 UniProtKB/Swiss-Prot
  Q9NUA4 UniProtKB/Swiss-Prot
  Q9UMJ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 HCK  HCK proto-oncogene, Src family tyrosine kinase    hemopoietic cell kinase  Symbol and/or name change 5135510 APPROVED