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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2785
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hck
Name: HCK proto-oncogene, Src family tyrosine kinase
Acc ID: CHEBI:78543
Term: ponatinib
Definition: A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline.
Chemical ID: MESH:C545373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hckdecreases activityISORGD:7324716480464CTDponatinib results in decreased activity of HCK protein

PMID:19878872
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