Hsd17b7 (hydroxysteroid (17-beta) dehydrogenase 7) - Rat Genome Database

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Gene: Hsd17b7 (hydroxysteroid (17-beta) dehydrogenase 7) Rattus norvegicus
Analyze
Symbol: Hsd17b7
Name: hydroxysteroid (17-beta) dehydrogenase 7
RGD ID: 2837
Description: Enables estradiol 17-beta-dehydrogenase [NAD(P)] activity and prolactin receptor binding activity. Involved in several processes, including estrogen biosynthetic process; response to estradiol; and response to prolactin. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Biomarker of polycystic ovary syndrome. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; dihydrotestosterone oxidoreductase; estradiol 17-beta-dehydrogenase 7; hydroxysteroid 17-beta dehydrogenase 7; hydroxysteroid dehydrogenase 17 beta, type 7; PRAP; PRL receptor-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21382,170,079 - 82,190,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,173,179 - 82,190,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,799,751 - 84,816,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,093,813 - 86,110,564 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,324,993 - 83,341,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,288,116 - 88,308,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,288,046 - 88,307,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,914,581 - 92,934,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,776,077 - 85,792,977 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,790,264 - 85,807,165 (-)NCBI
Celera1381,835,166 - 81,852,028 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
auramine O  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
Chorionic gonadotropin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
estrone  (ISO)
finasteride  (EXP)
fipronil  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
luteolinidin  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
obeticholic acid  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phytosterols  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (EXP)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. PRAP, a prolactin receptor associated protein: its gene expression and regulation in the corpus luteum. Duan WR, etal., Endocrinology. 1997 Aug;138(8):3216-21.
2. Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor. Duan WR, etal., J Biol Chem 1996 Jun 28;271(26):15602-7.
3. Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Einbond LS, etal., Fundam Clin Pharmacol. 2009 Jun;23(3):311-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
8. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Liu Z, etal., Mol Endocrinol. 2009 May;23(5):649-61. Epub 2009 Feb 5.
9. Identification and characterization of an abundant phosphoprotein specific to the large luteal cell. McLean MP, etal., Endocrinology. 1990 Apr;126(4):1796-805.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Nokelainen P, etal., Mol Endocrinol. 1998 Jul;12(7):1048-59. doi: 10.1210/mend.12.7.0134.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. Salilew-Wondim D, etal., J Ovarian Res. 2015 Apr 13;8(1):24. doi: 10.1186/s13048-015-0151-5.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12829805   PMID:15731358   PMID:21515572   PMID:26873413   PMID:31587341  


Genomics

Comparative Map Data
Hsd17b7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21382,170,079 - 82,190,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,173,179 - 82,190,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,799,751 - 84,816,641 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,093,813 - 86,110,564 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,324,993 - 83,341,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,288,116 - 88,308,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,288,046 - 88,307,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,914,581 - 92,934,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,776,077 - 85,792,977 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,790,264 - 85,807,165 (-)NCBI
Celera1381,835,166 - 81,852,028 (-)NCBICelera
Cytogenetic Map13q24NCBI
HSD17B7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,790,702 - 162,812,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,790,702 - 162,812,823 (+)EnsemblGRCh38hg38GRCh38
GRCh371162,760,492 - 162,782,613 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,027,120 - 161,049,232 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,492,153 - 159,514,265NCBI
Celera1135,864,558 - 135,886,965 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,005,589 - 134,028,003 (+)NCBIHuRef
CHM1_11164,183,061 - 164,205,170 (+)NCBICHM1_1
T2T-CHM13v2.01162,134,938 - 162,157,387 (+)NCBIT2T-CHM13v2.0
Hsd17b7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,777,109 - 169,796,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,777,104 - 169,796,810 (-)EnsemblGRCm39 Ensembl
GRCm381169,949,535 - 169,969,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,949,535 - 169,969,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv371171,879,668 - 171,899,336 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361171,786,212 - 171,805,880 (-)NCBIMGSCv36mm8
Celera1172,391,590 - 172,411,249 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map176.84NCBI
Hsd17b7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,557,292 - 13,574,593 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546213,555,488 - 13,574,506 (-)NCBIChiLan1.0ChiLan1.0
LOC100985156
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11051,011,219 - 51,034,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01038,424,713 - 38,447,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,001,063 - 142,017,150 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,001,162 - 142,022,865 (+)Ensemblpanpan1.1panPan2
HSD17B7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,975,935 - 19,999,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,977,086 - 19,999,010 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,031,119 - 20,054,229 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03820,059,511 - 20,082,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,058,310 - 20,082,624 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,034,574 - 20,057,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,386,347 - 20,409,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,677,507 - 20,700,653 (-)NCBIUU_Cfam_GSD_1.0
Hsd17b7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050588,635,691 - 8,660,282 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936831951,562 - 977,208 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936831951,603 - 976,159 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,720,118 - 87,742,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1487,720,747 - 87,743,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,571,675 - 95,593,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1201,271,259 - 1,289,232 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl201,273,052 - 1,288,930 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038290,535 - 308,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,260,223 - 1,283,741 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248261,260,133 - 1,287,565 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b7
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:227
Count of miRNA genes:158
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000003812
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH130925  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21382,173,401 - 82,173,578 (+)MAPPERmRatBN7.2
Rnor_6.01388,291,439 - 88,291,615NCBIRnor6.0
Rnor_5.01392,917,904 - 92,918,080UniSTSRnor5.0
RGSC_v3.41385,776,265 - 85,776,441UniSTSRGSC3.4
Celera1381,835,357 - 81,835,533UniSTS
RH 3.4 Map13514.1UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 26 26 55 14 11
Low 2 42 31 15 19 15 8 11 19 21 30 11 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000003812   ⟹   ENSRNOP00000003812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1382,173,179 - 82,190,017 (-)Ensembl
Rnor_6.0 Ensembl1388,288,046 - 88,307,988 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111937   ⟹   ENSRNOP00000095732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1382,173,179 - 82,189,139 (-)Ensembl
RefSeq Acc Id: NM_017235   ⟹   NP_058931
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21382,173,211 - 82,189,963 (-)NCBI
Rnor_6.01388,291,248 - 88,307,988 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
RGSC_v3.41385,776,077 - 85,792,977 (-)RGD
Celera1381,835,166 - 81,852,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250215   ⟹   XP_006250277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21382,170,083 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250216   ⟹   XP_006250278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21382,170,079 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250217   ⟹   XP_006250279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21382,170,079 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Rnor_5.01392,914,581 - 92,934,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598772   ⟹   XP_017454261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21382,170,083 - 82,190,018 (-)NCBI
Rnor_6.01388,288,116 - 88,308,019 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058931   ⟸   NM_017235
- UniProtKB: Q62904 (UniProtKB/Swiss-Prot),   A0A8I6AU17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250279   ⟸   XM_006250217
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHB1 (UniProtKB/TrEMBL),   A6IDN2 (UniProtKB/TrEMBL),   A0A8I6AU17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250278   ⟸   XM_006250216
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHB1 (UniProtKB/TrEMBL),   A6IDN2 (UniProtKB/TrEMBL),   A0A8I6AU17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250277   ⟸   XM_006250215
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHB1 (UniProtKB/TrEMBL),   A6IDN2 (UniProtKB/TrEMBL),   A0A8I6AU17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454261   ⟸   XM_017598772
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AU17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003812   ⟸   ENSRNOT00000003812
RefSeq Acc Id: ENSRNOP00000095732   ⟸   ENSRNOT00000111937

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62904-F1-model_v2 AlphaFold Q62904 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698981
Promoter ID:EPDNEW_R9506
Type:initiation region
Name:Hsd17b7_1
Description:hydroxysteroid (17-beta) dehydrogenase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01388,307,984 - 88,308,044EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2837 AgrOrtholog
BioCyc Gene G2FUF-17488 BioCyc
BioCyc Pathway PWY-6074 [zymosterol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6074 BioCyc
Ensembl Genes ENSRNOG00000002826 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003812 ENTREZGENE
  ENSRNOT00000003812.6 UniProtKB/TrEMBL
  ENSRNOT00000111937 ENTREZGENE
  ENSRNOT00000111937.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106149 IMAGE-MGC_LOAD
InterPro HSD17B7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29540 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93527 IMAGE-MGC_LOAD
NCBI Gene 29540 ENTREZGENE
PANTHER 3-KETO-STEROID REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-KETO-STEROID REDUCTASE/17-BETA-HYDROXYSTEROID DEHYDROGENASE 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b7 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002826 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232143
UniProt A0A0H2UHB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AU17 ENTREZGENE, UniProtKB/TrEMBL
  A6IDN2 ENTREZGENE, UniProtKB/TrEMBL
  A6IDN3_RAT UniProtKB/TrEMBL
  DHB7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b7  hydroxysteroid (17-beta) dehydrogenase 7    hydroxysteroid dehydrogenase 17 beta, type 7  Name updated 1299863 APPROVED
2002-06-10 Hsd17b7  hydroxysteroid dehydrogenase 17 beta, type 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in the effects of PRL on the corpus luteum during pregnancy 69856