HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7)

Gene: HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7) Chlorocebus sabaeus

Analyze

Symbol:

HSD17B7

Name:

hydroxysteroid 17-beta dehydrogenase 7

RGD ID:

18698551

Description:

ENCODES a protein that exhibits prolactin receptor binding (ortholog); INVOLVED IN androgen metabolic process (ortholog); brain development (ortholog); cell differentiation (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); parathyroid carcinoma (ortholog); FOUND IN endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

3-keto-steroid reductase; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	1,271,259 - 1,289,232 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	1,273,052 - 1,288,930 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	290,535 - 308,235 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

polycystic ovary syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (ISO)

brain development (ISO)

cell differentiation (ISO)

cholesterol biosynthetic process (IEA,ISO)

embryonic organ development (ISO)

embryonic skeletal system development (ISO)

estrogen biosynthetic process (ISO)

hippocampus development (ISO)

maternal process involved in female pregnancy (ISO)

nervous system development (ISO)

response to estradiol (ISO)

response to organic cyclic compound (ISO)

response to prolactin (ISO)

response to xenobiotic stimulus (ISO)

steroid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

3-keto sterol reductase activity (IEA)

5alpha-androstane-3beta,17beta-diol dehydrogenase activity (IEA)

estradiol 17-beta-dehydrogenase [NAD(P)] activity (IEA)

oxidoreductase activity (IEA)

prolactin receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

cholesterol biosynthetic pathway (ISO)

cholesterol ester storage disease pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HSD17B7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	1,271,259 - 1,289,232 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	1,273,052 - 1,288,930 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	290,535 - 308,235 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HSD17B7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	162,790,702 - 162,812,823 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	162,790,702 - 162,812,823 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	162,760,492 - 162,782,613 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	161,027,120 - 161,049,232 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	159,492,153 - 159,514,265	NCBI
Celera	1	135,864,558 - 135,886,965 (+)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	134,005,589 - 134,028,003 (+)	NCBI		HuRef
CHM1_1	1	164,183,061 - 164,205,170 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	162,134,938 - 162,157,387 (+)	NCBI		T2T-CHM13v2.0

Hsd17b7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	169,777,109 - 169,796,757 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	169,777,104 - 169,796,810 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	169,949,535 - 169,969,242 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	169,949,535 - 169,969,241 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	171,879,668 - 171,899,336 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	171,786,212 - 171,805,880 (-)	NCBI		MGSCv36	mm8
Celera	1	172,391,590 - 172,411,249 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	76.84	NCBI

Hsd17b7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	84,702,875 - 84,722,810 (-)	NCBI		GRCr8
mRatBN7.2	13	82,170,079 - 82,190,018 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	82,173,179 - 82,190,017 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	84,799,751 - 84,816,641 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	86,093,813 - 86,110,564 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	83,324,993 - 83,341,883 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	88,288,116 - 88,308,019 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	88,288,046 - 88,307,988 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	92,914,581 - 92,934,289 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	85,776,077 - 85,792,977 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	85,790,264 - 85,807,165 (-)	NCBI
Celera	13	81,835,166 - 81,852,028 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

Hsd17b7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	13,557,292 - 13,574,593 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	13,555,488 - 13,574,506 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100985156
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	51,005,870 - 51,028,676 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	51,011,219 - 51,034,004 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	38,424,713 - 38,447,193 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	142,001,063 - 142,017,150 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	142,001,162 - 142,022,865 (+)	Ensembl	panpan1.1		panPan2

HSD17B7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	19,975,935 - 19,999,077 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	19,977,086 - 19,999,010 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	20,031,119 - 20,054,229 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	20,059,511 - 20,082,663 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	20,058,310 - 20,082,624 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	20,034,574 - 20,057,608 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	20,386,347 - 20,409,416 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	20,677,507 - 20,700,653 (-)	NCBI		UU_Cfam_GSD_1.0

Hsd17b7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	8,635,691 - 8,660,282 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936831	951,562 - 977,208 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936831	951,603 - 976,159 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	87,720,118 - 87,742,992 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	87,720,747 - 87,743,037 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	95,571,675 - 95,593,948 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hsd17b7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	1,260,223 - 1,283,741 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	1,260,133 - 1,287,565 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	11		10
Low	25	20	50
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007976345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037997648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005240261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000000768 ⟹ ENSCSAP00000015296

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	1,273,052 - 1,288,930 (-)	Ensembl

RefSeq Acc Id:

XM_007976345 ⟹ XP_007974536

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	1,271,259 - 1,289,232 (-)	NCBI
Vero_WHO_p1.0	NW_023666038	290,535 - 308,235 (-)	NCBI

Sequence:

show sequence

AATCTCAGACGCCAGGGCACAGACCCAGTGCGTGTTACTCCTCTCCTAAGAGCTAGGCCGGGTG
ACACGCCCACCAGGATTAAACATCCGCCTTCCAAAGAGCCCTAGGCGGCAGTGACGGACACCTG
CGCTGAGGCGGAGCGAGAAGAGCCTGGCATGGCTCCGGGATTTGCGTCACGCAGCTCCTCCCCT
CGGCCTATCTCACCCGACGCCGACTCTGAGGGCAGGGAGCGGTTGGCGGACTGAGATTGGAGGG
ATCAGCGCAGACTCGATGACGCAACGGGAGGCGGGGCGTGGCCGTACTCTGATTGGTGATGGGT
GAGGTGGGCCCGGCTGCGGCCCGAAATCTTAGGACTTCCGAAAGCAGCGGCGGCGTTTGCTTCA
CTGCTTGGAAGTGTGAATGCGCGAAGATGCGAAAGGTGGTTTTGATCACCGGCGCGAGCAGTGG
CATTGGCCTGGCCCTCTGCAAGCGGCTGCTGGCGGAAGATGATGAGCTTCATCTGTGTTTGGCG
TGCAGGAATAGGAACAAGGCAGAAGCTGTCCGTGCTTCTCTGCTGGCCTCTCACCCCACTGCTG
AGGTCACCATTGTCCAGGTGGATATCAGCAACCTGCAGTCCGTGTTCCGGGCCTCCAAGGAACT
TAAGCAAAGGTTTCAGAGATTAGACTGTATATATCTAAATGCTGGGATCATGCCTAATCCACAG
CTAAATATCAAAGCACTTTTCTTTGGCCTCTTTTCAAGAAAAGTGATTCATATGTTCTCCACAG
CTGAAGGCCTGCTGACCCAGGGTGATAAGATCACTGCTGATGGACTTCAGGAGGTGTTTGAGAC
CAATGTCTTTGGCCATTTTATCCTGATTCGGGAACTGGAGCCTCTCCTTTGTCACAGTGACAGT
CCATCTCAGCTCATCTGGACATCGTCTCGCAATGCAAGGAAATCTAATTTCAGCCTCGAGGACT
TCCAGCACAGCAAAGGCAAGGAGCCCTACAGTTCTTCCAAATATGCCACTGACCTTCTGAGTGT
AGCTTTGAACAGGAACTTCAACCAGCAGGGTCTGTATTCCAATGTGGTGTGTCCAGGTACAGCA
CTGACCAATTTGACATATGGAATTCTGCCTCCCTTTATATGGACACTGTTGATGCCAGCAATAT
TGCTACTTCGCTTTTTTGCAAACGCATTCACTTTGACACCATACAATGGAACAGAAGCGCTGGT
ATGGCTTTTCCACCAAAAGCCCGAATCTCTCAATCCTCTGATCAAATATCTGAGTGCCACCACT
GGCTTTGGAAGAAATTACATTATGACCCAGAAGATGGACCTAGATGAAGACACTGCTGAAAAAT
TTTATCAAAAGTTACTGGAACTGGAAAAGCACATTAGGGTCACTATTCAAAAGACAGATAATCA
GGCTGGGCACAGTGGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGCGGAAGGATCAC
TTGAGACTAGGAGTTCGAGACCAGCCTGAGAAACATAGTGAGACCCTGTCTCTACAAAAAGAAA
TAAAAAAATTAGCTGGGTGTGGTGGCATGCATCTGTAGTCCCAACTACTCAGGAGGATGAGGTG
GGAGGATCTCTTGAGGCTGGGAGGTGGAGGTTGCAGTGAACTGAGATTGTGCCATTGCACTCCA
GCCTGGGTGACAGCGAGACCCTGTCTCAAAAAATATGTATATTTAAAATATATATATATATAAA
TATATATATATATATAAAAATATATATACATAACCAGAACTGACAATGATACTCTGGAACATTG
CATACCTTCTTGTACATTCTGGGGCATGTGGATTTCTATCATGTTGGATAATATGCATTTGTAA
TAAACTATGAACTATGACTGTC

hide sequence

RefSeq Acc Id:

XM_037997648 ⟹ XP_037853576

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	300,853 - 308,235 (-)	NCBI

RefSeq Acc Id:

XR_005240261

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	299,056 - 308,235 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007974536	(Get FASTA)	NCBI Sequence Viewer
	XP_037853576	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015296
	ENSCSAP00000015296.1

RefSeq Acc Id:	XP_007974536 ⟸ XM_007976345
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9S357 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000015296 ⟸ ENSCSAT00000000768

RefSeq Acc Id:	XP_037853576 ⟸ XM_037997648
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002749	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000768.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	HSD17B7	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	HSD17B7	ENTREZGENE
PANTHER	3-KETO-STEROID REDUCTASE	UniProtKB/TrEMBL
	3-KETO-STEROID REDUCTASE/17-BETA-HYDROXYSTEROID DEHYDROGENASE 7	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9S357	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB