Avp (arginine vasopressin) - Rat Genome Database

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Gene: Avp (arginine vasopressin) Rattus norvegicus
Symbol: Avp
Name: arginine vasopressin
RGD ID: 2184
Description: Enables V1A vasopressin receptor binding activity; V1B vasopressin receptor binding activity; and neuropeptide hormone activity. Involved in several processes, including grooming behavior; maternal aggressive behavior; and maternal behavior. Located in dendrite; extracellular space; and secretory granule. Is active in neuronal dense core vesicle. Used to study diabetes insipidus; hyperglycemia; portal hypertension; temporal lobe epilepsy; and type 1 diabetes mellitus. Biomarker of hypertension; neurohypophyseal diabetes insipidus; type 2 diabetes mellitus; and vascular dementia. Human ortholog(s) of this gene implicated in diabetes insipidus and neurohypophyseal diabetes insipidus. Orthologous to human AVP (arginine vasopressin); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 1; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (R)-noradrenaline; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADH; antidiuretic hormone; Arginine vasopressin (Diabetes insipidus); arginine vasopressin (Diabetes insipidus) same as Di (conflicting physical mapping); arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping); AVP-NPII; DI; prepropressophysin; preprovasopressin-neurophysin; Vas; vasopressin; vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin prepropeptide; VP
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Avpdi  
Genetic Models: BRAT-Avpdi/BluHsdRrrc BRAT-Avpdi/BluHsd
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83138,246,544 - 138,248,522 (-)NCBIGRCr8
mRatBN7.23117,793,447 - 117,805,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,793,457 - 117,795,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,687,900 - 121,689,880 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,285,159 - 130,287,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,944,031 - 127,946,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,117,482 - 123,119,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,117,492 - 123,119,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,615,610 - 129,627,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,205,007 - 118,206,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,110,580 - 118,112,558 (-)NCBI
Celera3116,604,316 - 116,606,294 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
actinomycin D  (EXP)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
AM-251  (EXP)
ammonium chloride  (EXP)
apomorphine  (ISO)
arachidonic acid  (EXP)
arachidonyl-2'-chloroethylamide  (EXP)
Aroclor 1254  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
butan-1-ol  (EXP)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carvedilol  (EXP,ISO)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
corticosterone  (EXP)
cyanamide  (EXP)
desflurane  (ISO)
desmopressin  (ISO)
dexamethasone  (EXP)
diethylstilbestrol  (EXP)
diprotium oxide  (EXP)
doxorubicin  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP)
enzacamene  (EXP)
ethanol  (EXP)
fluoxetine  (EXP)
fluvoxamine  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
Hexamethonium  (EXP)
hydrochlorothiazide  (ISO)
hydroxyflutamide  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
isoflurane  (ISO)
ketoconazole  (EXP)
labetalol  (ISO)
linsidomine  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
Mesna  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
metoclopramide  (ISO)
microcystin RR  (ISO)
mifepristone  (EXP)
Muraglitazar  (EXP)
naloxone  (ISO)
nicardipine  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nitric oxide  (EXP)
oryzalin  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenylephrine  (EXP)
phosphatidic acid  (EXP)
prazosin  (EXP)
progesterone  (EXP)
propofol  (ISO)
prostaglandin E2  (EXP)
raloxifene  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
sodium chloride  (EXP,ISO)
sotrastaurin  (ISO)
streptozocin  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tris(picolinato)chromium  (EXP)
urea  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
water  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
polyuria  (IAGP)

References - curated
# Reference Title Reference Citation
1. Sustained elevated levels of circulating vasopressin selectively stimulate the proliferation of kidney tubular cells via the activation of V2 receptors. Alonso G, etal., Endocrinology. 2008 Sep 11.
2. Intrahypothalamic angiogenesis induced by osmotic stimuli correlates with local hypoxia: a potential role of confined vasoconstriction induced by dendritic secretion of vasopressin. Alonso G, etal., Endocrinology. 2008 Sep;149(9):4279-88. Epub 2008 May 15.
3. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
4. Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. Bosch OJ and Neumann ID, Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17139-44. Epub 2008 Oct 27.
5. Utility of AVP gene testing in familial neurohypophyseal diabetes insipidus. Chitturi S, etal., Clin Endocrinol (Oxf). 2008 May 20.
6. Activation of ventrolateral medulla neurons by arginine vasopressin via V1A receptors produces inhibition on respiratory-related hypoglossal nerve discharge in the rat. Chuang CW, etal., Chin J Physiol. 2005 Sep 30;48(3):144-54.
7. Vasopressin and oxytocin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats. Ciosek J J Physiol Pharmacol 2002 Sep;53(3):423-37.
8. Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure. Cowley AW Jr, etal., Am J Physiol 1998 Nov;275(5 Pt 2):R1420-4.
9. Time course of c-fos, vasopressin and oxytocin mRNA expression in the hypothalamus following long-term dehydration. da Silveira LT, etal., Cell Mol Neurobiol. 2007 Aug;27(5):575-84.
10. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. De Mota N, etal., Proc Natl Acad Sci U S A 2004 Jul 13;101(28):10464-9. Epub 2004 Jul 01.
11. Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats. Ebner K, etal., Eur J Neurosci 2002 Jan;15(2):384-8.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Geddes BJ, etal., Nat Med. 1997 Dec;3(12):1402-4. doi: 10.1038/nm1297-1402.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy. Gulec G and Noyan B, Neuroreport. 2002 Nov 15;13(16):2045-8.
16. Restriction of Drinking Water Abrogates Splanchnic Vasodilation and Portal Hypertension in Portal Vein-Ligated Rats. Heinemann A, etal., Pharmacology. 2008 Nov 6;83(1):26-32.
17. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
18. Co-expression of vasopressin and androgen-binding protein in the rat hypothalamus. Jirikowski GF, etal., J Chem Neuroanat. 2005 Jun;29(4):233-7. Epub 2005 Mar 17.
19. A paradigm for effective resolution of interpersonal conflict. Jones MA, etal., Nurs Manage. 1990 Feb;21(2):64B, 64F, 64J-64L.
20. Increased expression of renal aquaporin water channels in spontaneously hypertensive rats. Lee J, etal., Kidney Blood Press Res. 2006;29(1):18-23. Epub 2006 Mar 22.
21. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences Li DQ, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 Sep;37(5):468-71.
22. Vasopressin induces vascular superoxide via endothelin-1 in mineralocorticoid hypertension. Li L, etal., Hypertension. 2003 Mar;41(3 Pt 2):663-8. Epub 2002 Dec 16.
23. Extrapituitary expression of the rat V1b vasopressin receptor gene. Lolait SJ, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):6783-7.
24. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Lukas M, etal., Neuropharmacology. 2009 Jun 26.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Local synthesis of the rat Vasopressin precursor in dendrites of in vitro cultured nerve cells. Mohr E and Richter D, Brain Res Mol Brain Res. 2003 Jun 10;114(2):115-22.
27. Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide. Montero S, etal., J Appl Physiol. 2006 Jun;100(6):1902-9. Epub 2006 Feb 23.
28. A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain. Moon BH, etal., Toxicol Appl Pharmacol. 2008 Sep 11.
29. Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct. Mori T, etal., Hypertension 2002 Feb;39(2 Pt 2):465-9.
30. Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation. Nakatani Y, etal., Biochem Biophys Res Commun. 2007 Mar 16;354(3):676-80. Epub 2007 Jan 17.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats. Nephew BC and Bridges RS, Pharmacol Biochem Behav. 2008 Nov;91(1):77-83. Epub 2008 Jun 29.
33. Heterologous expression of human vasopressin-neurophysin precursors in a pituitary cell line: defective transport of a mutant protein from patients with familial diabetes insipidus. Olias G, etal., DNA Cell Biol 1996 Nov;15(11):929-35.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Vasopressin and angiotensin receptors of the medial septal area in the control of mean arterial pressure induced by vasopressin. Pavan de Arruda Camargo GM, etal., J Renin Angiotensin Aldosterone Syst. 2008 Sep;9(3):133-8.
36. Vasopressin interactions with oxytocin in the control of female sexual behavior. Pedersen CA and Boccia ML, Neuroscience. 2006;139(3):843-51. Epub 2006 Feb 20.
37. Sodium excretion in response to vasopressin and selective vasopressin receptor antagonists. Perucca J, etal., J Am Soc Nephrol. 2008 Sep;19(9):1721-31. Epub 2008 Jul 2.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats. Promeneur D, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F370-82.
40. The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation. Rehbein M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):695-704.
41. Increased circulating vasopressin may account for ethanol-induced hypertension in rats. Resstel LB, etal., Am J Hypertens. 2008 Aug;21(8):930-5. Epub 2008 May 8.
42. Adrenal hypersensitivity precedes chronic hypercorticism in streptozotocin-induced diabetes mice. Revsin Y, etal., Endocrinology. 2008 Jul;149(7):3531-9. Epub 2008 Apr 17.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Comprehensive gene review and curation RGD comprehensive gene curation
47. Arginine-vasopressin modulates intracellular pH via V1 and V2 receptors in renal collecting duct cells. Rivarola V, etal., Cell Physiol Biochem. 2007;20(5):549-58.
48. Nocturnal polyuria with abnormal circadian rhythm of plasma arginine vasopressin in post-stroke patients. Sakakibara R, etal., Intern Med. 2005 Apr;44(4):281-4.
49. Inherited hypothalamic diabetes insipidus in the Brattleboro strain of rats. Saul GB 2nd, etal., J Hered 1968 Mar-Apr;59(2):113-7.
50. Early locomotor and social effects in vasopressin deficient neonatal rats. Schank JC Behav Brain Res. 2008 Aug 22.
51. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Schmale H and Richter D, Nature. 1984 Apr 19-25;308(5961):705-9. doi: 10.1038/308705a0.
52. Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE. Schmitz E, etal., DNA Cell Biol 1991 Mar;10(2):81-91.
53. A rat kidney tubule suspension for the study of vasopressin-induced shuttling of AQP2 water channels. Shaw S and Marples D, Am J Physiol Renal Physiol 2002 Nov;283(5):F1160-6.
54. Arginine vasopressin increases glutamate release and intracellular Ca2+ concentration in hippocampal and cortical astrocytes through two distinct receptors. Syed N, etal., J Neurochem. 2007 Oct;103(1):229-37.
55. Nitric oxide in the renal medulla protects from vasopressin-induced hypertension. Szentivanyi M Jr, etal., Hypertension 2000 Mar;35(3):740-5.
56. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
57. Vasopressin increases type IV collagen production through the induction of transforming growth factor-beta secretion in rat mesangial cells. Tahara A, etal., Pharmacol Res. 2008 Feb;57(2):142-50. Epub 2008 Jan 20.
58. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy. Tahara A, etal., Vascul Pharmacol. 2007 Jun;46(6):463-9. Epub 2007 Mar 1.
59. Familial hypothalamic diabetes insipidus in rats. VALTIN H, etal., Nature. 1962 Dec 15;196:1109-10.
60. Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin. Veenema AH, etal., Eur J Neurosci. 2006 Sep;24(6):1711-20.
61. Apoptosis of supraoptic AVP neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats. Wang Y, etal., BMC Neurosci. 2008 Jun 25;9:54.
62. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
63. Selective contributions of the medial preoptic nucleus to testosterone-dependant regulation of the paraventricular nucleus of the hypothalamus and the HPA axis. Williamson M and Viau V, Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1020-30. Epub 2008 Aug 6.
64. Close association of severe hyponatremia with exaggerated release of arginine vasopressin in elderly subjects with secondary adrenal insufficiency. Yatagai T, etal., Eur J Endocrinol. 2003 Feb;148(2):221-6.
65. Enhanced expressions of arginine vasopressin (Avp) in the hypothalamic paraventricular and supraoptic nuclei of type 2 diabetic rats. Yi SS, etal., Neurochem Res. 2008 May;33(5):833-41. Epub 2007 Oct 17.
66. Nicotine self-administration differentially regulates hypothalamic corticotropin-releasing factor and arginine vasopressin mRNAs and facilitates stress-induced neuronal activation. Yu G, etal., J Neurosci. 2008 Mar 12;28(11):2773-82.
67. Differential kinetics of oxytocin and vasopressin heteronuclear RNA expression in the rat supraoptic nucleus in response to chronic salt loading in vivo. Yue C, etal., J Neuroendocrinol. 2008 Feb;20(2):227-32. Epub 2007 Dec 14.
68. Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus. Zemo DA and McCabe JT, Neuropeptides 2001 Jun-Aug;35(3-4):181-8.
69. Two ancient neuropeptides, PACAP and AVP, modulate motivated behavior at synapses in the extrahypothalamic brain: a study in contrast. Zhang L and Eiden LE, Cell Tissue Res. 2019 Jan;375(1):103-122. doi: 10.1007/s00441-018-2958-z. Epub 2018 Dec 5.
Additional References at PubMed
PMID:891987   PMID:1706268   PMID:3956504   PMID:5150741   PMID:6315416   PMID:6526016   PMID:6591192   PMID:6641941   PMID:6689019   PMID:7036996   PMID:11704564   PMID:11911858  
PMID:12151754   PMID:12167608   PMID:12225866   PMID:12532400   PMID:12535168   PMID:12574437   PMID:12624936   PMID:12722640   PMID:12763250   PMID:12764115   PMID:12814355   PMID:12953161  
PMID:12974298   PMID:14530975   PMID:14563696   PMID:14614081   PMID:14960343   PMID:15075200   PMID:15166125   PMID:15193530   PMID:15241560   PMID:15342744   PMID:15632412   PMID:15838302  
PMID:16192392   PMID:16357095   PMID:16459202   PMID:16848219   PMID:16875693   PMID:16884741   PMID:17258819   PMID:17316791   PMID:17363455   PMID:17524563   PMID:17541259   PMID:17826907  
PMID:17901225   PMID:18001282   PMID:18048495   PMID:18052969   PMID:18180322   PMID:18310451   PMID:18402937   PMID:18509102   PMID:18538351   PMID:18579701   PMID:18667481   PMID:19059464  
PMID:19077445   PMID:19091909   PMID:19120141   PMID:19180911   PMID:19207829   PMID:19229989   PMID:19246538   PMID:19258490   PMID:19285113   PMID:19383875   PMID:19460853   PMID:19463813  
PMID:19519660   PMID:19520128   PMID:20015289   PMID:20051497   PMID:20079382   PMID:20182426   PMID:20298693   PMID:20374286   PMID:20621145   PMID:20946941   PMID:21061153   PMID:21073007  
PMID:21171363   PMID:21266716   PMID:21287975   PMID:21478090   PMID:21535246   PMID:21677651   PMID:21849630   PMID:21858088   PMID:21920364   PMID:22005685   PMID:22079778   PMID:22100184  
PMID:22197269   PMID:22266748   PMID:22522466   PMID:22527858   PMID:22651925   PMID:22677202   PMID:22801106   PMID:22831701   PMID:22960410   PMID:23085097   PMID:23523151   PMID:23551170  
PMID:23580725   PMID:24037803   PMID:24317347   PMID:24342802   PMID:24505289   PMID:24623760   PMID:24627106   PMID:24766650   PMID:25001964   PMID:25117459   PMID:25127982   PMID:25377918  
PMID:25446223   PMID:25451978   PMID:25462910   PMID:25823554   PMID:25834057   PMID:25854851   PMID:25961839   PMID:26503226   PMID:26578428   PMID:26651338   PMID:26791475   PMID:26923576  
PMID:26939727   PMID:27066536   PMID:27829122   PMID:28235136   PMID:28340511   PMID:28579251   PMID:28759308   PMID:28934194   PMID:29183979   PMID:29212780   PMID:29446159   PMID:29524562  
PMID:30166555   PMID:30334404   PMID:30633838   PMID:30951747   PMID:31677199   PMID:31820102   PMID:33048914   PMID:33422647   PMID:34006875   PMID:34713515   PMID:34748241   PMID:34926704  
PMID:35007255   PMID:36934678   PMID:37224632  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83138,246,544 - 138,248,522 (-)NCBIGRCr8
mRatBN7.23117,793,447 - 117,805,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,793,457 - 117,795,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,687,900 - 121,689,880 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,285,159 - 130,287,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,944,031 - 127,946,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,117,482 - 123,119,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,117,492 - 123,119,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,615,610 - 129,627,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,205,007 - 118,206,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,110,580 - 118,112,558 (-)NCBI
Celera3116,604,316 - 116,606,294 (-)NCBICelera
Cytogenetic Map3q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38203,082,556 - 3,084,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,082,556 - 3,084,724 (-)EnsemblGRCh38hg38GRCh38
GRCh37203,063,202 - 3,065,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,011,202 - 3,013,370 (-)NCBINCBI36Build 36hg18NCBI36
Build 34203,011,202 - 3,013,370NCBI
Celera203,125,188 - 3,127,356 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,011,450 - 3,013,197 (-)NCBIHuRef
CHM1_1203,057,749 - 3,065,399 (-)NCBICHM1_1
T2T-CHM13v2.0203,113,454 - 3,115,623 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392130,422,540 - 130,424,508 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,422,540 - 130,424,474 (-)EnsemblGRCm39 Ensembl
GRCm382130,580,620 - 130,582,588 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,580,620 - 130,582,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,406,413 - 130,408,277 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,272,118 - 130,273,982 (-)NCBIMGSCv36mm8
Celera2131,805,101 - 131,806,965 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2214,050,125 - 4,055,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,046,950 - 4,052,045 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,169,094 - 3,172,900 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1202,934,408 - 2,937,077 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12418,183,057 - 18,184,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,183,057 - 18,184,883 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,011,435 - 18,013,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02418,601,989 - 18,603,744 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,601,989 - 18,603,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,195,309 - 18,197,064 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,307,955 - 18,309,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,635,781 - 18,637,537 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1732,581,234 - 32,583,185 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,581,234 - 32,583,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,950,915 - 36,952,826 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1233,761,066 - 33,764,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,761,140 - 33,763,172 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,750,976 - 10,753,915 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247414,208,329 - 4,210,071 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,208,305 - 4,210,097 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Avp
65 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:23
Interacting mature miRNAs:24
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q41-q42UniSTS

Genetic Models
This gene Avp is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 11 1
Low 6 41 8
Below cutoff 21 6 7 2 5 16 4 15 2 2


RefSeq Acc Id: ENSRNOT00000028833   ⟹   ENSRNOP00000028833
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,793,457 - 117,795,425 (-)Ensembl
Rnor_6.0 Ensembl3123,117,492 - 123,119,460 (-)Ensembl
RefSeq Acc Id: NM_016992   ⟹   NP_058688
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr83138,246,544 - 138,248,522 (-)NCBI
mRatBN7.23117,793,447 - 117,795,425 (-)NCBI
Rnor_6.03123,117,482 - 123,119,460 (-)NCBI
Rnor_5.03129,615,610 - 129,627,147 (-)NCBI
RGSC_v3.43118,205,007 - 118,206,985 (-)RGD
Celera3116,604,316 - 116,606,294 (-)RGD
RefSeq Acc Id: NP_058688   ⟸   NM_016992
- Peptide Label: preproprotein
- UniProtKB: P01186 (UniProtKB/Swiss-Prot),   A6HQA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028833   ⟸   ENSRNOT00000028833

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01186-F1-model_v2 AlphaFold P01186 1-168 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692438
Promoter ID:EPDNEW_R2961
Type:single initiation site
Description:arginine vasopressin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,119,471 - 123,119,531EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2184 AgrOrtholog
BioCyc Gene G2FUF-47852 BioCyc
Ensembl Genes ENSRNOG00000021229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006166 UniProtKB/Swiss-Prot
  ENSRNOG00060006535 UniProtKB/Swiss-Prot
  ENSRNOG00060017663 UniProtKB/Swiss-Prot
  ENSRNOG00065014579 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028833 ENTREZGENE
  ENSRNOT00000028833.6 UniProtKB/Swiss-Prot
  ENSRNOT00055009991 UniProtKB/Swiss-Prot
  ENSRNOT00060010701 UniProtKB/Swiss-Prot
  ENSRNOT00060030207 UniProtKB/Swiss-Prot
  ENSRNOT00065024085 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neurhyp_horm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurhyp_horm_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurohypophysial_hormone_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Avp PhenoGen
PIRSF Nonapeptide_hormone_precursor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021229 RatGTEx
  ENSRNOG00055006166 RatGTEx
  ENSRNOG00060006535 RatGTEx
  ENSRNOG00060017663 RatGTEx
  ENSRNOG00065014579 RatGTEx
SMART SM00003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Neurophysin II UniProtKB/TrEMBL, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Avp  arginine vasopressin      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Avp  arginine vasopressin      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs renal medullary blood flow is reduced by the infusion of vasopressin V1 receptor agonist (V1AG) which results in a rise of arterial pressure 628560
gene_expression synthesized in and secreted by the suprachiasmatic nucleus (SCN) in a circadian pattern 628560
gene_expression expressed in the inner medulla 628560
gene_pathway gene expression in the SCN is mediated by MAPK signaling pathway 628560
gene_process regulates water balance and intracellular pH 69915
gene_process regulates water balance and intracellular pH 628560
gene_process contracts smooth muscle during parturition and lactation 69915
gene_process contracts smooth muscle during parturition and lactation 628560
gene_process involved in complex sexual and maternal behaviour 69915
gene_process involved in complex sexual and maternal behaviour 628560
gene_process involved in the regulation cardiovascular functions 69915
gene_process involved in the regulation cardiovascular functions 628560
gene_process stimulates two HCO3-transporters and Na+/H+ exchanger 69915
gene_process stimulates two HCO3-transporters and Na+/H+ exchanger 628560
gene_process regulates Aqp2 mediated osmotic permeability of collecting duct epithelium in kidneys; causes shuttling of water channel protein AQP2 from intacellular vesicles to apical plasma membrane in principal cells 628560
gene_process activates adenylyl cyclase via V2 receptors and increases cAMP which leads to increased water permeability of the cell membrane and activation of the aquaporin shuttle system in IMCDs 628560
gene_process small increase in the expression produces chronic elevation of renal medullary [NO] which resulted in the increased expression of eNOS in the medullary collecting ducts 628560
gene_process a potent circulatory vasoconstrictor peptide whose excess increases the arterial pressure but is not responsible for hypertension as it cannot reduce the renal medullary blood flow substantially 628560
gene_process mobilizes Ca2+ through vasopressin V2-like receptors to produce nitric oxide (NO) in epithelial collecting duct cells of the inner medulla (IMCDs) 628560
gene_process reduces the rate of fluid excretion and reduces renal medullary blood flow 628566
gene_process reduces the rate of fluid excretion and reduces renal medullary blood flow 628569
gene_process involved in the regulation of brain water content and cerebral edema 728880
gene_regulation activated by the protein kinase C activator, phorbol 12-myristate 13-acetate 628560
gene_regulation sodium channel blocker, tetrodotoxin (TTX), greatly decreases heteronuclear RNA levels and suppresses rhythmicity 628560