Avp (arginine vasopressin) - Rat Genome Database

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Gene: Avp (arginine vasopressin) Rattus norvegicus
Analyze
Symbol: Avp
Name: arginine vasopressin
RGD ID: 2184
Description: Enables V1A vasopressin receptor binding activity; V1B vasopressin receptor binding activity; and neuropeptide hormone activity. Involved in several processes, including cellular cation homeostasis; mating; and regulation of secretion. Located in dendrite; extracellular space; and secretory granule. Used to study diabetes insipidus; hyperglycemia; portal hypertension; temporal lobe epilepsy; and type 1 diabetes mellitus. Biomarker of hypertension; neurohypophyseal diabetes insipidus; type 2 diabetes mellitus; and vascular dementia. Human ortholog(s) of this gene implicated in diabetes insipidus and neurohypophyseal diabetes insipidus. Orthologous to human AVP (arginine vasopressin); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 1; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (R)-noradrenaline; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ADH; antidiuretic hormone; Arginine vasopressin (Diabetes insipidus); arginine vasopressin (Diabetes insipidus) same as Di (conflicting physical mapping); arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping); AVP-NPII; DI; prepropressophysin; preprovasopressin-neurophysin; Vas; vasopressin; vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin prepropeptide; VP
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Avpdi  
Genetic Models: BRAT-Avpdi/BluHsd BRAT-Avpdi/BluHsdRrrc
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,793,447 - 117,805,091 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3117,793,457 - 117,795,425 (-)Ensembl
Rnor_6.03123,117,482 - 123,119,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,117,492 - 123,119,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,615,610 - 129,627,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,205,007 - 118,206,985 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,110,580 - 118,112,558 (-)NCBI
Celera3116,604,316 - 116,606,294 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
actinomycin D  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (EXP)
ammonium chloride  (EXP)
apomorphine  (ISO)
arachidonic acid  (EXP)
Aroclor 1254  (EXP)
ATP  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
butan-1-ol  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carvedilol  (EXP,ISO)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
corticosterone  (EXP)
cyanamide  (EXP)
desflurane  (ISO)
desmopressin  (ISO)
dexamethasone  (EXP)
diprotium oxide  (EXP)
doxorubicin  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP)
ethanol  (EXP)
fluoxetine  (EXP)
fluvoxamine  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
Hexamethonium  (EXP)
hydrochlorothiazide  (ISO)
hydroxyflutamide  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
isoflurane  (ISO)
labetalol  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
Mesna  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
metoclopramide  (ISO)
microcystin RR  (ISO)
mifepristone  (EXP)
naloxone  (ISO)
Nicardipine  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nitric oxide  (EXP)
oryzalin  (ISO)
paraquat  (ISO)
phenylephrine  (EXP)
phosphatidic acid  (EXP)
prazosin  (EXP)
progesterone  (EXP)
propofol  (ISO)
prostaglandin E2  (EXP)
SCH 23390  (EXP)
scopolamine  (EXP)
sodium chloride  (EXP,ISO)
streptozocin  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tris(picolinato)chromium  (EXP)
urea  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
water  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
ERK1 and ERK2 cascade  (ISO)
grooming behavior  (IMP)
hyperosmotic salinity response  (IEP)
locomotory behavior  (IMP)
maternal aggressive behavior  (IMP)
maternal behavior  (IMP)
multicellular organismal water homeostasis  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of female receptivity  (IMP)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of transmission of nerve impulse  (IMP)
penile erection  (IMP)
positive regulation of cell growth  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cellular pH reduction  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glutamate secretion  (IMP)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of prostaglandin biosynthetic process  (IMP)
positive regulation of systemic arterial blood pressure  (IDA)
positive regulation of vasoconstriction  (IMP)
protein kinase C signaling  (ISO)
protein phosphorylation  (IEA)
regulation of renal sodium excretion  (IMP)
response to ethanol  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to testosterone  (IEP)
signal transduction  (ISO)
smooth muscle contraction  (TAS)
social behavior  (IMP)
temperature homeostasis  (TAS)
vasoconstriction  (IEA)
viral entry into host cell  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
polyuria  (IAGP)
References

References - curated
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14. GOA data from the GO Consortium
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25. MGD data from the GO Consortium
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30. Nakatani Y, etal., Biochem Biophys Res Commun. 2007 Mar 16;354(3):676-80. Epub 2007 Jan 17.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
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34. OMIM Disease Annotation Pipeline
35. Pavan de Arruda Camargo GM, etal., J Renin Angiotensin Aldosterone Syst. 2008 Sep;9(3):133-8.
36. Pedersen CA and Boccia ML, Neuroscience. 2006;139(3):843-51. Epub 2006 Feb 20.
37. Perucca J, etal., J Am Soc Nephrol. 2008 Sep;19(9):1721-31. Epub 2008 Jul 2.
38. Pipeline to import KEGG annotations from KEGG into RGD
39. Promeneur D, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F370-82.
40. Rehbein M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):695-704.
41. Resstel LB, etal., Am J Hypertens. 2008 Aug;21(8):930-5. Epub 2008 May 8.
42. Revsin Y, etal., Endocrinology. 2008 Jul;149(7):3531-9. Epub 2008 Apr 17.
43. RGD automated data pipeline
44. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. RGD automated import pipeline for gene-chemical interactions
46. RGD comprehensive gene curation
47. Rivarola V, etal., Cell Physiol Biochem. 2007;20(5):549-58.
48. Sakakibara R, etal., Intern Med. 2005 Apr;44(4):281-4.
49. Saul GB 2nd, etal., J Hered 1968 Mar-Apr;59(2):113-7.
50. Schank JC Behav Brain Res. 2008 Aug 22.
51. Schmale H and Richter D, Nature. 1984 Apr 19-25;308(5961):705-9. doi: 10.1038/308705a0.
52. Schmitz E, etal., DNA Cell Biol 1991 Mar;10(2):81-91.
53. Shaw S and Marples D, Am J Physiol Renal Physiol 2002 Nov;283(5):F1160-6.
54. Syed N, etal., J Neurochem. 2007 Oct;103(1):229-37.
55. Szentivanyi M Jr, etal., Hypertension 2000 Mar;35(3):740-5.
56. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
57. Tahara A, etal., Pharmacol Res. 2008 Feb;57(2):142-50. Epub 2008 Jan 20.
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61. Wang Y, etal., BMC Neurosci. 2008 Jun 25;9:54.
62. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
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65. Yi SS, etal., Neurochem Res. 2008 May;33(5):833-41. Epub 2007 Oct 17.
66. Yu G, etal., J Neurosci. 2008 Mar 12;28(11):2773-82.
67. Yue C, etal., J Neuroendocrinol. 2008 Feb;20(2):227-32. Epub 2007 Dec 14.
68. Zemo DA and McCabe JT, Neuropeptides 2001 Jun-Aug;35(3-4):181-8.
Additional References at PubMed
PMID:891987   PMID:1706268   PMID:3956504   PMID:5150741   PMID:6315416   PMID:6526016   PMID:6591192   PMID:6641941   PMID:6689019   PMID:7036996   PMID:11704564   PMID:11911858  
PMID:12151754   PMID:12167608   PMID:12225866   PMID:12532400   PMID:12535168   PMID:12574437   PMID:12624936   PMID:12722640   PMID:12763250   PMID:12764115   PMID:12814355   PMID:12953161  
PMID:12974298   PMID:14530975   PMID:14563696   PMID:14614081   PMID:14960343   PMID:15075200   PMID:15166125   PMID:15193530   PMID:15241560   PMID:15342744   PMID:15632412   PMID:15838302  
PMID:16192392   PMID:16357095   PMID:16459202   PMID:16848219   PMID:16875693   PMID:16884741   PMID:17258819   PMID:17316791   PMID:17363455   PMID:17524563   PMID:17541259   PMID:17826907  
PMID:17901225   PMID:18001282   PMID:18048495   PMID:18052969   PMID:18180322   PMID:18310451   PMID:18402937   PMID:18509102   PMID:18538351   PMID:18579701   PMID:18667481   PMID:19059464  
PMID:19077445   PMID:19091909   PMID:19120141   PMID:19180911   PMID:19207829   PMID:19229989   PMID:19246538   PMID:19258490   PMID:19285113   PMID:19383875   PMID:19460853   PMID:19463813  
PMID:19519660   PMID:19520128   PMID:20015289   PMID:20051497   PMID:20079382   PMID:20182426   PMID:20298693   PMID:20374286   PMID:20621145   PMID:20946941   PMID:21061153   PMID:21073007  
PMID:21171363   PMID:21266716   PMID:21287975   PMID:21478090   PMID:21535246   PMID:21677651   PMID:21849630   PMID:21858088   PMID:21920364   PMID:22005685   PMID:22079778   PMID:22100184  
PMID:22197269   PMID:22266748   PMID:22522466   PMID:22527858   PMID:22651925   PMID:22677202   PMID:22801106   PMID:22831701   PMID:22960410   PMID:23085097   PMID:23523151   PMID:23551170  
PMID:23580725   PMID:24037803   PMID:24317347   PMID:24342802   PMID:24505289   PMID:24623760   PMID:24627106   PMID:25001964   PMID:25117459   PMID:25127982   PMID:25377918   PMID:25446223  
PMID:25451978   PMID:25462910   PMID:25823554   PMID:25834057   PMID:25854851   PMID:25961839   PMID:26503226   PMID:26578428   PMID:26651338   PMID:26791475   PMID:26923576   PMID:26939727  
PMID:27066536   PMID:27829122   PMID:28235136   PMID:28340511   PMID:28579251   PMID:28759308   PMID:28934194   PMID:29183979   PMID:29212780   PMID:29446159   PMID:29524562   PMID:30166555  
PMID:30334404   PMID:30633838   PMID:30951747   PMID:31677199   PMID:31820102   PMID:33048914   PMID:34006875  


Genomics

Comparative Map Data
Avp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,793,447 - 117,805,091 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3117,793,457 - 117,795,425 (-)Ensembl
Rnor_6.03123,117,482 - 123,119,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,117,492 - 123,119,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,615,610 - 129,627,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,205,007 - 118,206,985 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,110,580 - 118,112,558 (-)NCBI
Celera3116,604,316 - 116,606,294 (-)NCBICelera
Cytogenetic Map3q36NCBI
AVP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,082,556 - 3,084,724 (-)EnsemblGRCh38hg38GRCh38
GRCh38203,082,556 - 3,093,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,063,202 - 3,065,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,011,202 - 3,013,370 (-)NCBINCBI36hg18NCBI36
Build 34203,011,202 - 3,013,370NCBI
Celera203,125,188 - 3,127,356 (-)NCBI
Cytogenetic Map20p13NCBI
HuRef203,011,450 - 3,013,197 (-)NCBIHuRef
CHM1_1203,057,749 - 3,065,399 (-)NCBICHM1_1
Avp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,422,540 - 130,424,508 (-)NCBIGRCm39mm39
GRCm39 Ensembl2130,422,540 - 130,424,474 (-)Ensembl
GRCm382130,580,620 - 130,582,588 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,580,620 - 130,582,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,406,413 - 130,408,277 (-)NCBIGRCm37mm9NCBIm37
MGSCv362130,272,118 - 130,273,982 (-)NCBImm8
Celera2131,805,101 - 131,806,965 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
AVP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1202,934,408 - 2,937,077 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0203,169,094 - 3,172,900 (-)NCBIMhudiblu_PPA_v0panPan3
AVP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,183,057 - 18,184,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,183,057 - 18,184,883 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,011,435 - 18,013,192 (+)NCBI
ROS_Cfam_1.02418,601,989 - 18,603,744 (+)NCBI
UMICH_Zoey_3.12418,195,309 - 18,197,064 (+)NCBI
UNSW_CanFamBas_1.02418,307,955 - 18,309,707 (+)NCBI
UU_Cfam_GSD_1.02418,635,781 - 18,637,537 (+)NCBI
AVP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,581,230 - 32,583,427 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,581,234 - 32,583,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,950,915 - 36,952,826 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247178
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,761,066 - 33,764,608 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl233,761,140 - 33,763,172 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607110,750,976 - 10,753,915 (+)NCBIVero_WHO_p1.0
Avp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247414,208,305 - 4,210,097 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q41-q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat


Genetic Models
This gene Avp is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:23
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000028833
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 1
Low 6 41 8
Below cutoff 21 6 7 2 5 16 4 15 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028833   ⟹   ENSRNOP00000028833
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,793,457 - 117,795,425 (-)Ensembl
Rnor_6.0 Ensembl3123,117,492 - 123,119,460 (-)Ensembl
RefSeq Acc Id: NM_016992   ⟹   NP_058688
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23117,793,447 - 117,795,425 (-)NCBI
Rnor_6.03123,117,482 - 123,119,460 (-)NCBI
Rnor_5.03129,615,610 - 129,627,147 (-)NCBI
RGSC_v3.43118,205,007 - 118,206,985 (-)RGD
Celera3116,604,316 - 116,606,294 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104238   ⟹   XP_038960166
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23117,793,447 - 117,805,091 (-)NCBI
RefSeq Acc Id: XM_039104239   ⟹   XP_038960167
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23117,793,447 - 117,805,091 (-)NCBI
RefSeq Acc Id: XM_039104240   ⟹   XP_038960168
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23117,793,447 - 117,805,091 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058688   ⟸   NM_016992
- Peptide Label: preproprotein
- UniProtKB: P01186 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028833   ⟸   ENSRNOT00000028833
RefSeq Acc Id: XP_038960168   ⟸   XM_039104240
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960167   ⟸   XM_039104239
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960166   ⟸   XM_039104238
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692438
Promoter ID:EPDNEW_R2961
Type:single initiation site
Name:Avp_1
Description:arginine vasopressin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,119,471 - 123,119,531EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2184 AgrOrtholog
Ensembl Genes ENSRNOG00000021229 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028833 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028833 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.9.10 UniProtKB/Swiss-Prot
InterPro Neurhyp_horm UniProtKB/Swiss-Prot
  Neurhyp_horm_dom_sf UniProtKB/Swiss-Prot
  Neurohypophysial_hormone_CS UniProtKB/Swiss-Prot
KEGG Report rno:24221 UniProtKB/Swiss-Prot
NCBI Gene 24221 ENTREZGENE
PANTHER PTHR11681 UniProtKB/Swiss-Prot
Pfam Hormone_4 UniProtKB/Swiss-Prot
  Hormone_5 UniProtKB/Swiss-Prot
PhenoGen Avp PhenoGen
PIRSF Nonapeptide_hormone_precursor UniProtKB/Swiss-Prot
PRINTS NEUROPHYSIN UniProtKB/Swiss-Prot
PROSITE NEUROHYPOPHYS_HORM UniProtKB/Swiss-Prot
SMART SM00003 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49606 UniProtKB/Swiss-Prot
UniProt NEU2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Avp  arginine vasopressin      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Avp  arginine vasopressin      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs renal medullary blood flow is reduced by the infusion of vasopressin V1 receptor agonist (V1AG) which results in a rise of arterial pressure 628560
gene_expression synthesized in and secreted by the suprachiasmatic nucleus (SCN) in a circadian pattern 628560
gene_expression expressed in the inner medulla 628560
gene_pathway gene expression in the SCN is mediated by MAPK signaling pathway 628560
gene_process regulates water balance and intracellular pH 69915
gene_process regulates water balance and intracellular pH 628560
gene_process contracts smooth muscle during parturition and lactation 69915
gene_process contracts smooth muscle during parturition and lactation 628560
gene_process involved in complex sexual and maternal behaviour 69915
gene_process involved in complex sexual and maternal behaviour 628560
gene_process involved in the regulation cardiovascular functions 69915
gene_process involved in the regulation cardiovascular functions 628560
gene_process stimulates two HCO3-transporters and Na+/H+ exchanger 69915
gene_process stimulates two HCO3-transporters and Na+/H+ exchanger 628560
gene_process regulates Aqp2 mediated osmotic permeability of collecting duct epithelium in kidneys; causes shuttling of water channel protein AQP2 from intacellular vesicles to apical plasma membrane in principal cells 628560
gene_process activates adenylyl cyclase via V2 receptors and increases cAMP which leads to increased water permeability of the cell membrane and activation of the aquaporin shuttle system in IMCDs 628560
gene_process small increase in the expression produces chronic elevation of renal medullary [NO] which resulted in the increased expression of eNOS in the medullary collecting ducts 628560
gene_process a potent circulatory vasoconstrictor peptide whose excess increases the arterial pressure but is not responsible for hypertension as it cannot reduce the renal medullary blood flow substantially 628560
gene_process mobilizes Ca2+ through vasopressin V2-like receptors to produce nitric oxide (NO) in epithelial collecting duct cells of the inner medulla (IMCDs) 628560
gene_process reduces the rate of fluid excretion and reduces renal medullary blood flow 628566
gene_process reduces the rate of fluid excretion and reduces renal medullary blood flow 628569
gene_process involved in the regulation of brain water content and cerebral edema 728880
gene_regulation activated by the protein kinase C activator, phorbol 12-myristate 13-acetate 628560
gene_regulation sodium channel blocker, tetrodotoxin (TTX), greatly decreases heteronuclear RNA levels and suppresses rhythmicity 628560