RGD Reference Report - Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus. - Rat Genome Database

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Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus.

Authors: Zemo, DA  McCabe, JT 
Citation: Zemo DA and McCabe JT, Neuropeptides 2001 Jun-Aug;35(3-4):181-8.
RGD ID: 728880
Pubmed: PMID:11884209   (View Abstract at PubMed)
DOI: DOI:10.1054/npep.2001.0864   (Journal Full-text)

The choroid plexus plays a pivotal role in the production of cerebrospinal fluid (CSF). Messenger RNA (mRNA) transcripts encoding arginine vasopressin (AVP) and the vasopressin 1b receptor (V(1b)R) are found in various structures of the central nervous system, including the choroid plexus. The present study measured AVP and V(1b)R mRNA production in response to plasma hyperosmolality. Compared to rats maintained on water, 2% salt-drinking rats had increased levels of AVP and V(1b)R mRNAs in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus and in the choroid plexus. The increase in V(1b)R mRNA in the SON and PVN as a result of plasma hyperosmolality may reflect changes in receptor production that, in turn, have a role in AVP autoregulation of hypothalamic magnocellular neurons. The increase of AVP and V(1b)R mRNAs in the choroid plexus further shows the involvement of AVP in the regulation of brain water content and cerebral edema.



Objects referenced in this article
Gene Avp arginine vasopressin Rattus norvegicus
Gene Avpr1b arginine vasopressin receptor 1B Rattus norvegicus

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