RGD Reference Report - Extrapituitary expression of the rat V1b vasopressin receptor gene. - Rat Genome Database

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Extrapituitary expression of the rat V1b vasopressin receptor gene.

Authors: Lolait, SJ  O'Carroll, AM  Mahan, LC  Felder, CC  Button, DC  Young, WS  Mezey, E  Brownstein, MJ 
Citation: Lolait SJ, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):6783-7.
RGD ID: 61542
Pubmed: PMID:7624319   (View Abstract at PubMed)
PMCID: PMC41413   (View Article at PubMed Central)

[Arg8]vasopressin (AVP) stimulates adrenocorticotropic hormone release from the anterior pituitary by acting on the V1b AVP receptor. This receptor can be distinguished from the vascular/hepatic V1a and renal V2 AVP receptors by its differential binding affinities for structural analogous of AVP. Recent studies have shown that the cloned V1a and V2 receptors are structurally related. We have isolated a clone encoding the V1b receptor from a rat pituitary cDNA library using polymerase chain reaction (PCR)-based methodology. The rat V1b receptor is a protein of 421 amino acids that has 37-50% identity with the V1a and V2 receptors. Homology is particularly high in the seven putative membrane-spanning domains of these guanine nucleotide-binding protein-coupled receptors. Expression of the recombinant receptor in mammalian cells shows the same binding specificity for AVP agonists and antagonists as the rat pituitary V1b receptor. AVP-stimulated phosphotidylinositol hydrolysis and intracellular Ca2+ mobilization in Chinese hamster ovary or COS-7 cells expressing the cloned receptor suggest second messenger signaling through phospholipase C. RNA blot analysis, reverse transcription PCR, and in situ hybridization studies reveal that V1b receptor mRNA is expressed in the majority of pituitary corticotropes as well as in multiple brain regions and a number of peripheral tissues, including kidney, thymus, heart, lung, spleen, uterus, and breast. Thus, the V1b receptor must mediate some of the diverse biological effects of AVP in the pituitary as well as other organs.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AvpRattemperature homeostasis  TAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Avpr1bRatpeptide hormone binding  IMP  RGD 
AvpRatV1B vasopressin receptor binding  IMP  RGD 
Avpr1bRatvasopressin receptor activity  IMP  RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AVPR1BHumanvasopressin signaling pathway   ISOAvpr1b (Rattus norvegicus) RGD 
Avpr1bMousevasopressin signaling pathway   ISOAvpr1b (Rattus norvegicus) RGD 
Avpr1bRatvasopressin signaling pathway   TAS  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Avp  (arginine vasopressin)
Avpr1b  (arginine vasopressin receptor 1B)

Genes (Mus musculus)
Avpr1b  (arginine vasopressin receptor 1B)

Genes (Homo sapiens)
AVPR1B  (arginine vasopressin receptor 1B)


Additional Information