Avp<sup>di</sup> (arginine vasopressin; diabetes insipidus mutant) - Rat Genome Database

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Gene: Avpdi (arginine vasopressin; diabetes insipidus mutant) Rattus norvegicus
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Symbol: Avpdi
Name: arginine vasopressin; diabetes insipidus mutant
RGD ID: 13627261
Description: This spontaneous deletion was identified in Brattleboro rats. It consists of a single nucleotide deletion (c.delG316) in exon 2 of the vasopressin gene which results in an altered vasopressin precursor.
ASSOCIATED WITH polyuria; ASSOCIATED WITH diabetes insipidus; Polyuria; type 1 diabetes mellitus
Type: allele  of Avp  
Previously known as: Avp^[di]
Is Marker For: Strains:   BRAT-Avpdi/BluHsd   BRAT-Avpdi/BluHsdRrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
polyuria  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Geddes BJ, etal., Nat Med. 1997 Dec;3(12):1402-4. doi: 10.1038/nm1297-1402.
2. Identification and sequence analysis of arginine vasopressin mRNA in normal and Brattleboro rat aortic tissue. Méchaly I, etal., Eur J Endocrinol. 1998 Jul;139(1):123-6.
3. Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats. Promeneur D, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F370-82.
4. Inherited hypothalamic diabetes insipidus in the Brattleboro strain of rats. Saul GB 2nd, etal., J Hered 1968 Mar-Apr;59(2):113-7.
5. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Schmale H and Richter D, Nature. 1984 Apr 19-25;308(5961):705-9. doi: 10.1038/308705a0.
6. Familial hypothalamic diabetes insipidus in rats. VALTIN H, etal., Nature. 1962 Dec 15;196:1109-10.

Genomics


Related Rat Strains
The following Strains have been annotated to Avpdi
BRAT-Avpdi/BluHsd     BRAT-Avpdi/BluHsdRrrc    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information