17alpha-ethynylestradiol increases expression ISO RGD:3238 6480464 Ethinyl Estradiol results in increased expression of OXT mRNA CTD PMID:15834898 , PMID:17351261 17alpha-ethynylestradiol decreases expression ISO RGD:3238 6480464 Ethinyl Estradiol results in decreased expression of OXT mRNA CTD PMID:27571134 17beta-estradiol multiple interactions ISO RGD:3238 6480464 [Estradiol co-treated with OXT protein] results in increased expression of SLC5A5 mRNA more ... CTD PMID:16954431 more ... 17beta-estradiol increases expression ISO RGD:3238 6480464 Estradiol results in increased expression of OXT mRNA CTD PMID:17010207 more ... 17beta-estradiol multiple interactions ISO RGD:11040 6480464 [Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA, ESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA] CTD PMID:12834440 2,4-D decreases secretion ISO RGD:3238 6480464 2, 4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein CTD PMID:20122984 4-tert-Octylphenol increases expression ISO RGD:3238 6480464 4-tert-octylphenol results in increased expression of OXT mRNA CTD PMID:23664861 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid multiple interactions ISO RGD:3238 6480464 pyridoxal phosphate-6-azophenyl-2' more ... CTD PMID:11102496 8-OH-DPAT multiple interactions ISO RGD:3238 6480464 [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form, Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form] CTD PMID:22265196 ammonium chloride affects expression ISO RGD:3238 6480464 Ammonium Chloride affects the expression of OXT mRNA CTD PMID:16483693 ATP multiple interactions ISO RGD:3238 6480464 Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein] more ... CTD PMID:11102496 ATP increases secretion ISO RGD:3238 6480464 Adenosine Triphosphate results in increased secretion of OXT protein CTD PMID:11102496 benzo[a]pyrene increases expression ISO RGD:3238 6480464 Benzo(a)pyrene results in increased expression of OXT mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression ISO RGD:11040 6480464 Benzo(a)pyrene results in decreased expression of OXT mRNA CTD PMID:22228805 bisphenol A decreases expression ISO RGD:11040 6480464 bisphenol A results in decreased expression of OXT mRNA CTD PMID:22707478 bisphenol A affects expression ISO RGD:3238 6480464 bisphenol A affects the expression of OXT mRNA CTD PMID:27571134 bisphenol A decreases expression ISO RGD:3238 6480464 bisphenol A results in decreased expression of OXT mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:3238 6480464 bisphenol A results in increased expression of OXT mRNA CTD PMID:17010207 , PMID:23664861 butyric acid increases expression ISO RGD:11040 6480464 Butyric Acid results in increased expression of OXT mRNA CTD PMID:22687346 calcium atom multiple interactions EXP 6480464 OXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium] CTD PMID:12700192 calcium atom multiple interactions ISO RGD:3238 6480464 [Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein CTD PMID:22028774 calcium(0) multiple interactions EXP 6480464 OXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium] CTD PMID:12700192 calcium(0) multiple interactions ISO RGD:3238 6480464 [Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein CTD PMID:22028774 chlorpyrifos increases expression ISO RGD:11040 6480464 Chlorpyrifos results in increased expression of OXT protein CTD PMID:19165396 chlorpyrifos decreases expression ISO RGD:11040 6480464 Chlorpyrifos results in decreased expression of OXT mRNA CTD PMID:25889763 clofibrate multiple interactions ISO RGD:11040 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA] CTD PMID:17585979 clozapine affects response to substance EXP 6480464 OXT protein affects the susceptibility to Clozapine CTD PMID:20196918 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA] CTD PMID:18936084 copper atom decreases expression ISO RGD:3238 6480464 Copper results in decreased expression of OXT mRNA CTD PMID:30556269 copper(0) decreases expression ISO RGD:3238 6480464 Copper results in decreased expression of OXT mRNA CTD PMID:30556269 cortisol affects abundance EXP 6480464 OXT protein affects the abundance of Hydrocortisone CTD PMID:16554389 decabromodiphenyl ether increases expression ISO RGD:3238 6480464 decabromobiphenyl ether results in increased expression of OXT mRNA CTD PMID:23914054 diethylstilbestrol increases expression ISO RGD:3238 6480464 Diethylstilbestrol results in increased expression of OXT mRNA CTD PMID:17010207 flavonoids increases expression ISO RGD:3238 6480464 Flavonoids results in increased expression of OXT mRNA CTD PMID:18035473 fluoxetine decreases expression ISO RGD:3238 6480464 Fluoxetine results in decreased expression of OXT mRNA CTD PMID:17033635 lithium atom increases expression ISO RGD:3238 6480464 Lithium results in increased expression of OXT mRNA CTD PMID:11739594 lithium atom increases secretion ISO RGD:3238 6480464 Lithium results in increased secretion of OXT protein CTD PMID:11739594 lithium hydride increases secretion ISO RGD:3238 6480464 Lithium results in increased secretion of OXT protein CTD PMID:11739594 lithium hydride increases expression ISO RGD:3238 6480464 Lithium results in increased expression of OXT mRNA CTD PMID:11739594 methamphetamine multiple interactions ISO RGD:3238 6480464 [Methamphetamine co-treated with SCH 23390] affects the expression of OXT mRNA CTD PMID:19564919 methamphetamine affects expression ISO RGD:3238 6480464 Methamphetamine affects the expression of OXT mRNA CTD PMID:19564919 Nonylphenol increases expression ISO RGD:3238 6480464 nonylphenol results in increased expression of OXT mRNA CTD PMID:17010207 p-tert-Amylphenol increases expression ISO RGD:3238 6480464 4-tert-octylphenol results in increased expression of OXT mRNA CTD PMID:23664861 paclitaxel increases expression ISO RGD:3238 6480464 Paclitaxel analog results in increased expression of OXT mRNA, Paclitaxel results in increased expression of OXT mRNA CTD PMID:15585946 paracetamol multiple interactions ISO RGD:11040 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of OXT mRNA] CTD PMID:17585979 phenylephrine multiple interactions ISO RGD:3238 6480464 Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein] more ... CTD PMID:11102496 phenylephrine increases secretion ISO RGD:3238 6480464 Phenylephrine results in increased secretion of OXT protein CTD PMID:15149956 prazosin increases expression ISO RGD:3238 6480464 Prazosin results in increased expression of OXT protein CTD PMID:1791990 progesterone multiple interactions ISO RGD:3238 6480464 Progesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA] CTD PMID:17400809 progesterone multiple interactions ISO RGD:11040 6480464 [Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA, ESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA] CTD PMID:12834440 pyridaben decreases expression ISO RGD:11040 6480464 pyridaben results in decreased expression of OXT mRNA CTD PMID:22563483 SCH 23390 multiple interactions ISO RGD:3238 6480464 [Methamphetamine co-treated with SCH 23390] affects the expression of OXT mRNA CTD PMID:19564919 SCH 23390 affects expression ISO RGD:3238 6480464 SCH 23390 affects the expression of OXT mRNA CTD PMID:19564919 serotonin increases secretion ISO RGD:11040 6480464 OXT protein results in increased secretion of Serotonin CTD PMID:19228979 thapsigargin multiple interactions ISO RGD:3238 6480464 [Thapsigargin results in increased transport of Calcium] which results in increased secretion of OXT protein CTD PMID:22028774 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of OXT mRNA CTD PMID:29154799 valproic acid affects expression ISO RGD:11040 6480464 Valproic Acid affects the expression of OXT mRNA CTD PMID:17292431
Biological Process drinking behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 eating behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 female pregnancy IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 G protein-coupled receptor signaling pathway TAS 2290271 Reactome Reactome:R-HSA-388396 grooming behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 heart development IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 hyperosmotic salinity response IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 male mating behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 maternal aggressive behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 maternal behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 memory IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 negative regulation of blood pressure IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 negative regulation of gastric acid secretion IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 negative regulation of urine volume IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of blood pressure IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of cold-induced thermogenesis ISS UniProtKB:P35454 2290271 (PMID:18071238) YuBioLab PMID:18071238 positive regulation of cytosolic calcium ion concentration IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of female receptivity IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of hindgut contraction IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of norepinephrine secretion IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of ossification IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of penile erection IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of prostaglandin secretion IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of renal sodium excretion IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of synapse assembly IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of synaptic transmission IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 positive regulation of uterine smooth muscle contraction IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 regulation of heart rate IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 regulation of sensory perception of pain IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to activity IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to amphetamine IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to cAMP IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to cocaine IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to electrical stimulus IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to estradiol IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to ether IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to food IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to glucocorticoid IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to peptide hormone IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to progesterone IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to prostaglandin E IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to retinoic acid IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 response to sucrose IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 signal transduction TAS 2290271 (PMID:10218979) PINC PMID:10218979 sleep IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 social behavior IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 sperm ejaculation IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 Cellular Component extracellular region TAS 2290271 Reactome Reactome:R-HSA-379048 more ... extracellular space IBA PANTHER:PTN000913415 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 secretory granule IBA PANTHER:PTN000913415 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 terminal bouton IEA UniProtKB:P01179 , ensembl:ENSRNOP000000288292290271 Ensembl GO_REF:0000107 Molecular Function neurohypophyseal hormone activity IEA InterPro:IPR000981 more ... 2290271 InterPro GO_REF:0000002 neuropeptide hormone activity IBA PANTHER:PTN000913415 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 oxytocin receptor binding IBA PANTHER:PTN000188232 , RGD:3238 2290271 (PMID:21873635) GO_Central PMID:21873635
Gene-Chemical Interaction Annotations
