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Gene: Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Description: Exhibits aromatase activity. Involved in several processes, including animal organ development; carboxylic acid metabolic process; and cellular hormone metabolic process. Localizes to several cellular components, including the dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; female reproductive organ cancer (multiple); polycystic ovary syndrome; and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1); PARTICIPATES IN aromatase inhibitor pathway; estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (S)-naringenin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aromatase; Cyp19; Cyp19a; CYPXIX; cytochrome P-450AROM; cytochrome P450 19 aromatase; cytochrome P450 19A1; cytochrome P450 19A1-like; cytochrome P450 family 19 subfamily a; cytochrome P450, 19, aromatase; cytochrome P450, subfamily 19; estrogen synthase; estrogen synthetase; LOC100359906; P-450AROM; p450arom
Orthologs:
Homo sapiens (human) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102023780 (aromatase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Canis lupus familiaris (dog) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101954950 (aromatase)
Sus scrofa (pig) : CYP19A2 (cytochrome P450 19A2)
Chlorocebus sabaeus (African green monkey) : CYP19A1 (cytochrome P450 family 19 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101702005 (aromatase)
more info ...
Is Marker For: QTLs:   GLUCO126_H  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0858,744,849 - 58,772,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,321,085 - 57,348,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1857,671,013 - 57,691,109 (-)NCBI
Celera854,044,272 - 54,071,684 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp19a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2457
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.