Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) Rattus norvegicus
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
RGD ID: 2457
Description: Enables aromatase activity. Involved in several processes, including carboxylic acid metabolic process; gonad development; and limbic system development. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1); PARTICIPATES IN aromatase inhibitor pathway; estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (E)-thiamethoxam.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aromatase; Cyp19; Cyp19a; CYPXIX; cytochrome P-450AROM; cytochrome P450 19 aromatase; cytochrome P450 19A1; cytochrome P450 19A1-like; cytochrome P450 family 19 subfamily a; cytochrome P450, 19, aromatase; cytochrome P450, subfamily 19; estrogen synthase; estrogen synthetase; LOC100359906; P-450AROM; p450arom
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   GLUCO126_H  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2854,552,978 - 54,580,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,553,165 - 54,580,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,087,103 - 60,114,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0858,366,113 - 58,393,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,230,358 - 56,257,810 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,744,849 - 58,772,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,321,085 - 57,348,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1857,671,013 - 57,691,109 (-)NCBI
Celera854,044,272 - 54,071,684 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-thiamethoxam  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-benzofuran  (ISO)
1-naphthylamine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-Bis(3-hydroxybenzyl)butane-1,4-diol  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-dibromophenol  (ISO)
2-bromophenol  (ISO)
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7-hydroxyflavanone  (ISO)
7-hydroxyflavone  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (EXP,ISO)
acetaldehyde  (ISO)
afimoxifene  (ISO)
Aflatoxicol  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
albuterol  (ISO)
aldrin  (ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
aminoglutethimide  (ISO)
amitraz  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
amoxicillin  (ISO)
amphetamine  (ISO)
anastrozole  (ISO)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (EXP,ISO)
androstane-3,17-diol  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
bazedoxifene  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzofurans  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bicalutamide  (EXP)
bifenthrin  (EXP,ISO)
bifonazole  (ISO)
biochanin A  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bitertanol  (EXP)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbendazim  (ISO)
carmustine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
Chorionic gonadotropin  (EXP)
chromium(6+)  (EXP)
chrysin  (ISO)
citalopram  (ISO)
clotrimazole  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyanamide  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cyhexatin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (ISO)
cyproterone  (ISO)
D-aspartic acid  (EXP,ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (EXP)
dicofol  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
E-4031  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (ISO)
Enterolactone  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP,ISO)
equol  (ISO)
erlotinib hydrochloride  (ISO)
erythrosin B  (EXP)
estriol  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (ISO)
exemestane  (ISO)
farnesol  (EXP)
fenarimol  (ISO)
fenbuconazole  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP)
finasteride  (EXP,ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavone  (ISO)
flavones  (ISO)
flavonoids  (EXP,ISO)
fluconazole  (ISO)
flufenoxuron  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvoxamine  (ISO)
formestane  (EXP,ISO)
fulvestrant  (EXP,ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
Geniposidic acid  (EXP)
genistein  (EXP,ISO)
glyphosate  (EXP,ISO)
heptachlor  (ISO)
herbicide  (EXP,ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (ISO)
HT-2 toxin  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
indirubin  (ISO)
indometacin  (EXP,ISO)
iodoacetic acid  (ISO)
iprodione  (ISO)
isoliquiritigenin  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
lamotrigine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
letrozole  (EXP,ISO)
leuprolide  (ISO)
levetiracetam  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
mestranol  (ISO)
metformin  (EXP)
methadone  (ISO)
methomyl  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nandrolone  (ISO)
naphthalene  (ISO)
nicotine  (EXP,ISO)
Niflumic acid  (ISO)
nimesulide  (EXP,ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleuropein  (ISO)
Oxadiazon  (ISO)
oxcarbazepine  (ISO)
oxiconazole  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion-methyl  (ISO)
paroxetine  (ISO)
pasireotide  (EXP)
pentachlorophenol  (ISO)
perflubron  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirimicarb  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
plumbagin  (EXP)
potassium dichromate  (EXP,ISO)
prochloraz  (EXP,ISO)
procymidone  (EXP)
profenofos  (EXP)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propazine  (ISO)
propiconazole  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP,ISO)
pyrene  (ISO)
quercetin  (EXP,ISO)
quinalphos  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rolipram  (ISO)
rose bengal  (EXP)
rotenone  (ISO)
rottlerin  (ISO)
rutin  (EXP)
SB-239063  (EXP)
SC-58125  (ISO)
semicarbazide  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simazine  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
terbutylazine  (EXP)
testolactone  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
thiacloprid  (ISO)
thiamethoxam  (EXP,ISO)
tiagabine  (ISO)
titanium dioxide  (EXP,ISO)
toxaphene  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
triclosan  (EXP)
triflusulfuron-methyl  (ISO)
triphenylstannane  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
U-73122  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (EXP)
vorozole  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEP)
androgen catabolic process  (ISO)
androgen metabolic process  (IEA,IMP,ISO)
bile acid metabolic process  (IEP)
biphenyl metabolic process  (IEP)
bone development  (IEP)
C21-steroid hormone metabolic process  (IDA)
calcineurin-mediated signaling  (IMP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to hydrostatic pressure  (IEP)
dibenzo-p-dioxin metabolic process  (IEP)
estrogen biosynthetic process  (IDA)
female genitalia development  (IEA,ISO)
female gonad development  (IBA,IEA,ISO)
granulocyte differentiation  (IEP)
hippocampus development  (IEP)
hypothalamus development  (IEP)
luteinization  (IEP)
male gonad development  (IEP)
mammary gland development  (IEA,ISO)
melatonin metabolic process  (IEP)
negative regulation of bone resorption  (IMP)
negative regulation of chronic inflammatory response  (IEA,ISO)
negative regulation of macrophage chemotaxis  (IEA,ISO)
phthalate metabolic process  (IEP)
positive regulation of estradiol secretion  (ISO)
prostate gland growth  (IEA,ISO)
regulation of synapse structure or activity  (IMP)
response to cesium ion  (IEP)
response to estradiol  (IBA,IEP)
response to estrogen  (IEP)
response to herbicide  (IEP)
response to ionizing radiation  (IEP)
response to metal ion  (IEP)
response to organic cyclic compound  (IEP)
response to testosterone  (IEP)
response to xenobiotic stimulus  (IEP)
testosterone biosynthetic process  (IEA,ISO)
uterus development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats. Aloisi AM, etal., Mol Pain. 2010 Oct 26;6:69.
2. Age- and cell-related gene expression of aromatase and estrogen receptors in the rat testis. Bois C, etal., J Mol Endocrinol. 2010 Sep;45(3):147-59. Epub 2010 Jun 16.
3. Regulation of aromatase gene expression in purified germ cells of adult male rats: effects of transforming growth factor beta, tumor necrosis factor alpha, and cyclic adenosine 3',5'-monosphosphate. Bourguiba S, etal., Biol Reprod. 2003 Aug;69(2):592-601. Epub 2003 Apr 16.
4. Diabetes alters aromatase enzyme levels in gonadal tissues of rats. Burul-Bozkurt N, etal., Naunyn Schmiedebergs Arch Pharmacol. 2010 Jul;382(1):33-41. Epub 2010 Apr 29.
5. Aromatase expression in male germ cells. Carreau S, etal., J Steroid Biochem Mol Biol 2001 Dec;79(1-5):203-8.
6. Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats. Carretero J, etal., Pituitary 2002 Jan;5(1):5-10.
7. Brain aromatase expression after experimental stroke: topography and time course. Carswell HV, etal., J Steroid Biochem Mol Biol. 2005 Jun;96(1):89-91.
8. Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. Catalano S, etal., J Biol Chem. 2010 Feb 19;285(8):5581-93. Epub 2009 Dec 21.
9. Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. Ceccarelli I, etal., J Cell Physiol. 2009 Oct;221(1):1-4.
10. Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells. Chabrolle C, etal., Reprod Biol Endocrinol. 2008 Mar 19;6:11.
11. Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats. Colciago A, etal., Brain Res Dev Brain Res. 2005 Mar 31;155(2):107-16.
12. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the offspring. Colciago A, etal., Toxicol Appl Pharmacol. 2009 Aug 15;239(1):46-54. Epub 2009 May 21.
13. Maternal malnutrition during lactation affects folliculogenesis, gonadotropins, and leptin receptors in adult rats. da Silva Faria T, etal., Nutrition. 2010 Oct;26(10):1000-7. Epub 2009 Dec 16.
14. The differential effects of the gonadotropin receptors on aromatase expression in primary cultures of immature rat granulosa cells are highly dependent on the density of receptors expressed and the activation of the inositol phosphate cascade. Donadeu FX and Ascoli M, Endocrinology. 2005 Sep;146(9):3907-16. Epub 2005 May 26.
15. Increased endogenous estrogen synthesis leads to the sequential induction of prostatic inflammation (prostatitis) and prostatic pre-malignancy. Ellem SJ, etal., Am J Pathol. 2009 Sep;175(3):1187-99. doi: 10.2353/ajpath.2009.081107. Epub 2009 Aug 21.
16. Inhibition of rat granulosa cell differentiation by overexpression of Galphaq. Escamilla-Hernandez R, etal., Endocrine. 2008 Feb;33(1):21-31. Epub 2008 Apr 10.
17. Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation. Escamilla-Hernandez R, etal., Mol Endocrinol. 2008 Aug;22(8):1842-52. Epub 2008 Jun 5.
18. Aromatase gene expression and regulation in the female rat pituitary. Galmiche G, etal., Ann N Y Acad Sci. 2006 Jul;1070:286-92.
19. The expression of aromatase in gonadotropes is regulated by estradiol and gonadotropin-releasing hormone in a manner that differs from the regulation of luteinizing hormone. Galmiche G, etal., Endocrinology. 2006 Sep;147(9):4234-44. Epub 2006 Jun 8.
20. Aromatase Is Increased in Astrocytes in the Presence of Elevated Pressure. Gatson JW, etal., Endocrinology. 2010 Nov 3.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells. Gonzalez A, etal., Br J Cancer. 2007 Sep 17;97(6):755-60. Epub 2007 Aug 14.
23. Testicular steroidogenesis is not altered by 137 cesium Chernobyl fallout, following in utero or post-natal chronic exposure. Grignard E, etal., C R Biol. 2010 May;333(5):416-23. Epub 2010 Apr 24.
24. Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat. Grignard E, etal., Int J Toxicol. 2008 Jul-Aug;27(4):323-8.
25. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Gulyaeva LF, etal., Adv Exp Med Biol. 2008;617:359-66.
26. Short term hypothyroidism affects ovarian function in the cycling rat. Hapon MB, etal., Reprod Biol Endocrinol. 2010 Feb 11;8:14.
27. Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA. Hickey GJ, etal., Mol Endocrinol 1990 Jan;4(1):3-12.
28. Sex-dependent aromatase activity in rat offspring after pre- and postnatal exposure to triphenyltin chloride. Hobler C, etal., Toxicology. 2010 Oct 29;276(3):198-205. Epub 2010 Aug 12.
29. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Hojo Y, etal., Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):865-70. Epub 2003 Dec 23.
30. [Study on the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) and susceptibility to breast cancer in Chinese women] Hu MB, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Apr;27(4):351-5.
31. CYP19 haplotypes increase risk for Alzheimer's disease. Huang R and Poduslo SE, J Med Genet. 2006 Aug;43(8):e42.
32. Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Ito Y, etal., Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11673-7.
33. Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats. Jablonska O, etal., Int J Androl. 2010 Jan 4.
34. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
35. The aromatase inhibitor letrozole reduces adhesion formation after intraperitoneal surgery in a rat uterine horn model. Keskin HL, etal., Eur J Obstet Gynecol Reprod Biol. 2013 Apr;167(2):199-204. doi: 10.1016/j.ejogrb.2012.12.002. Epub 2013 Feb 8.
36. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
37. Effects of maternal exposure to low doses of DES on testicular steroidogenesis and spermatogenesis in male rat offspring. Kobayashi T, etal., J Reprod Dev. 2009 Dec;55(6):629-37. Epub 2009 Sep 7.
38. Calcineurin and CRTC2 mediate FSH and TGFß1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. Lai WA, etal., J Mol Endocrinol. 2014 Oct;53(2):259-70. doi: 10.1530/JME-14-0048. Epub 2014 Jul 23.
39. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
40. Changes in histone modification and DNA methylation of the StAR and Cyp19a1 promoter regions in granulosa cells undergoing luteinization during ovulation in rats. Lee L, etal., Endocrinology. 2013 Jan;154(1):458-70. doi: 10.1210/en.2012-1610. Epub 2012 Nov 26.
41. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Lin W, etal., Am J Pathol. 2011 Mar;178(3):1233-44. doi: 10.1016/j.ajpath.2010.11.056.
42. [Expression of steroidogenic enzymes in the rat model of polycystic ovary syndrome]. Lin W, etal., Sheng Li Xue Bao. 2013 Apr 25;65(2):171-7.
43. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Liu Z, etal., Mol Endocrinol. 2009 May;23(5):649-61. Epub 2009 Feb 5.
44. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30.
45. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. Maliqueo M, etal., Endocrinology. 2013 Jan;154(1):434-45. doi: 10.1210/en.2012-1693. Epub 2012 Nov 26.
46. Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. Manigrasso MB, etal., Am J Physiol Renal Physiol. 2012 May 1;302(9):F1203-9. doi: 10.1152/ajprenal.00569.2011. Epub 2012 Feb 1.
47. Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway. McDonald CA, etal., Mol Endocrinol. 2006 Mar;20(3):608-18. Epub 2005 Nov 3.
48. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
49. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
50. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Miller WR, etal., Oncologist. 2008 Aug;13(8):829-37. Epub 2008 Aug 11.
51. Promotion of bladder cancer development and progression by androgen receptor signals. Miyamoto H, etal., J Natl Cancer Inst. 2007 Apr 4;99(7):558-68.
52. Functional relationship between fibroblast growth factor-8 and bone morphogenetic proteins in regulating steroidogenesis by rat granulosa cells. Miyoshi T, etal., Mol Cell Endocrinol. 2010 Aug 30;325(1-2):84-92. Epub 2010 Apr 29.
53. Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures. Munetsuna E, etal., Endocrinology. 2009 Sep;150(9):4260-9. Epub 2009 Jun 4.
54. A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. Nakamura E, etal., Endocrinology. 2010 Nov;151(11):5506-18. Epub 2010 Sep 1.
55. Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer. Napoli N, etal., Bone. 2013 Aug;55(2):309-14. doi: 10.1016/j.bone.2013.04.021. Epub 2013 May 1.
56. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
57. Development of relevant assay system to identify steroidogenic enzyme inhibitors. Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7.
58. Aromatase expression in endometriosis. Noble LS, etal., J Clin Endocrinol Metab. 1996 Jan;81(1):174-9.
59. Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. O'Grady SP, etal., Syst Biol Reprod Med. 2010 Aug;56(4):292-302.
60. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
61. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
62. Increased aromatase expression in the hippocampus of spontaneously hypertensive rats: effects of estradiol administration. Pietranera L, etal., Neuroscience. 2010 Nov 27.
63. Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Pinilla L, etal., Endocrinology. 2009 Jun;150(6):2889-97. Epub 2009 Feb 19.
64. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis. Riancho JA, etal., J Clin Endocrinol Metab. 2007 Feb;92(2):660-5. Epub 2006 Nov 21.
69. Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study. Riancho JA, etal., Osteoarthritis Cartilage. 2010 Jul;18(7):927-33. doi: 10.1016/j.joca.2010.04.002. Epub 2010 Apr 22.
70. Expression of the P450 side-chain cleavage and adrenodoxin genes begins during early stages of adrenal cortex development. Rogler LE and Pintar JE, Mol Endocrinol. 1993 Mar;7(3):453-61.
71. Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate. Ryu JY, etal., J Toxicol Environ Health A. 2008;71(23):1542-9.
72. The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures. Santamaría CG, etal., Toxicol Lett. 2019 Mar 15;303:48-54. doi: 10.1016/j.toxlet.2018.12.016. Epub 2018 Dec 30.
73. Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma. Santen RJ, etal., Ann Intern Med. 1982 Jan;96(1):94-101.
74. Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons. Schaeffer V, etal., Glia. 2010 Jan 15;58(2):169-80.
75. Expression of functional aromatase in the epididymis: role of androgens and LH in modulation of expression and activity. Shayu D and Rao AJ, Mol Cell Endocrinol. 2006 Apr 25;249(1-2):40-50. Epub 2006 Mar 29.
76. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. Slominski AT, etal., PLoS One. 2009;4(2):e4309. Epub 2009 Feb 3.
77. Protective Role of Testosterone in Ischemia-Reperfusion-induced Acute Kidney Injury. Soljancic A, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 3.
78. Estrogen receptor ss activity modulates synaptic signaling and structure. Srivastava DP, etal., J Neurosci. 2010 Oct 6;30(40):13454-60.
79. Infravesical obstruction in aromatase over expressing transgenic male mice with increased ratio of serum estrogen-to-androgen concentration. Streng T, etal., J Urol. 2002 Jul;168(1):298-302.
80. Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior. Takeda T, etal., J Pharmacol Exp Ther. 2009 Jun;329(3):1091-9. Epub 2009 Mar 10.
81. Effect of Insulin-Like Growth Factor-Binding Protein 7 on Steroidogenesis in Granulosa Cells Derived from Equine Chorionic Gonadotropin-Primed Immature Rat Ovaries. Tamura K, etal., Biol Reprod. 2007 May 23;.
82. Understanding the Effects of Atrazine on Steroidogenesis IN RAT GRANULOSA and H295R Adrenal Cortical Carcinoma Cells. Tinfo NS, etal., Reprod Toxicol. 2010 Nov 29.
83. Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPbeta in reperfusion injury-induced ischemic rat hippocampus. Ugur PK, etal., Eur J Pharmacol. 2010 Nov 27.
84. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
85. Aromatization of androgens is important for skeletal maintenance of aged male rats. Vanderschueren D, etal., Calcif Tissue Int. 1996 Sep;59(3):179-83.
86. A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro. Wang H, etal., Mol Hum Reprod. 2011 Jun;17(6):386-91. doi: 10.1093/molehr/gar007. Epub 2011 Jan 31.
87. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
88. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Xia X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):54-9. doi: 10.3969/j.issn.1672-7347.2013.01.010.
89. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
90. Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague-Dawley rats following combined oral exposure to benzopyrene and di-(2-ethylhexyl) phthalate. Xu C, etal., Toxicol Lett. 2010 Dec 15;199(3):323-32.
91. Perinatal exposure to bisphenol-A changes N-methyl-D-aspartate receptor expression in the hippocampus of male rat offspring. Xu XH, etal., Environ Toxicol Chem. 2010 Jan;29(1):176-81.
92. Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors. Zhou L, etal., Exp Neurol. 2007 Jan;203(1):72-81. Epub 2006 Sep 26.
Additional References at PubMed
PMID:2340950   PMID:7669221   PMID:8809197   PMID:9618522   PMID:9687153   PMID:11356695   PMID:14736734   PMID:15364411   PMID:15525594   PMID:16723702   PMID:16770574   PMID:17116232  
PMID:17227882   PMID:17693615   PMID:17804753   PMID:17909262   PMID:18097519   PMID:18287941   PMID:18296822   PMID:18313839   PMID:18401595   PMID:19129847   PMID:19583995   PMID:19698287  
PMID:19838799   PMID:20064538   PMID:20112740   PMID:20214950   PMID:20385561   PMID:20568448   PMID:21392135   PMID:21471296   PMID:21635821   PMID:21932034   PMID:23020785   PMID:23225240  
PMID:23405234   PMID:23606751   PMID:24287798   PMID:24518793   PMID:24556528   PMID:24679120   PMID:24718039   PMID:25036039   PMID:25447050   PMID:26054748   PMID:26482249   PMID:28822806  
PMID:28964927   PMID:29121167   PMID:29880879   PMID:29898754   PMID:30817060   PMID:32632943   PMID:34215832   PMID:36857632  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2854,552,978 - 54,580,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,553,165 - 54,580,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,087,103 - 60,114,553 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0858,366,113 - 58,393,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,230,358 - 56,257,810 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,744,849 - 58,772,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,321,085 - 57,348,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1857,671,013 - 57,691,109 (-)NCBI
Celera854,044,272 - 54,071,684 (-)NCBICelera
Cytogenetic Map8q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381551,208,057 - 51,338,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,208,057 - 51,338,601 (-)EnsemblGRCh38hg38GRCh38
GRCh371551,500,254 - 51,630,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361549,288,961 - 49,418,086 (-)NCBINCBI36Build 36hg18NCBI36
Celera1528,393,650 - 28,524,194 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1528,330,314 - 28,460,872 (-)NCBIHuRef
CHM1_11551,618,344 - 51,748,904 (-)NCBICHM1_1
T2T-CHM13v2.01549,015,801 - 49,146,366 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39954,073,221 - 54,175,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,073,221 - 54,175,394 (-)EnsemblGRCm39 Ensembl
GRCm38954,165,937 - 54,268,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,165,937 - 54,268,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,013,744 - 54,041,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,964,074 - 53,991,581 (-)NCBIMGSCv36mm8
Celera951,408,025 - 51,435,376 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.49NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554093,266,233 - 3,313,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,198,622 - 3,313,072 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11544,628,633 - 44,758,666 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01530,152,924 - 30,282,854 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11548,486,688 - 48,616,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1548,486,688 - 48,521,554 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13016,954,020 - 17,056,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,957,215 - 16,988,353 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,883,348 - 16,914,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03017,098,681 - 17,221,672 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3017,101,433 - 17,133,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13017,024,100 - 17,055,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03017,141,587 - 17,173,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03017,248,285 - 17,280,035 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864095,258,165 - 95,328,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647113,107,603 - 13,136,910 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647113,107,603 - 13,136,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1120,367,667 - 120,695,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,652,172 - 120,695,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21133,903,926 - 133,936,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12632,074,260 - 32,164,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,132,425 - 32,164,277 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048109,028,218 - 109,061,355 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247319,053,803 - 9,100,212 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,053,644 - 9,100,212 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cyp19a1
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:125
Interacting mature miRNAs:139
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300150Cm3Cardiac mass QTL 33.97heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)85423781455523877Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,580,298 - 54,580,749 (+)MAPPERmRatBN7.2
Rnor_6.0858,771,949 - 58,772,399NCBIRnor6.0
Rnor_5.0857,348,022 - 57,348,472UniSTSRnor5.0
Celera854,071,225 - 54,071,675UniSTS
SHRSP x BN Map839.17RGD
SHRSP x BN Map839.17UniSTS
FHH x ACI Map847.98RGD
Cytogenetic Map8q23-q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,580,498 - 54,580,715 (+)MAPPERmRatBN7.2
Rnor_6.0858,772,149 - 58,772,365NCBIRnor6.0
Rnor_5.0857,348,222 - 57,348,438UniSTSRnor5.0
Celera854,071,425 - 54,071,641UniSTS
Cytogenetic Map8q23-q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,555,121 - 54,555,308 (+)MAPPERmRatBN7.2
Rnor_6.0858,746,804 - 58,746,990NCBIRnor6.0
Rnor_5.0857,323,040 - 57,323,226UniSTSRnor5.0
RGSC_v3.4857,653,139 - 57,653,325UniSTSRGSC3.4
Celera854,046,227 - 54,046,413UniSTS
RH 3.4 Map8598.7UniSTS
Cytogenetic Map8q23-q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,553,027 - 54,553,228 (+)MAPPERmRatBN7.2
Rnor_6.0858,744,712 - 58,744,912NCBIRnor6.0
Rnor_5.0857,320,948 - 57,321,148UniSTSRnor5.0
RGSC_v3.4857,651,047 - 57,651,247UniSTSRGSC3.4
Celera854,044,135 - 54,044,335UniSTS
RH 3.4 Map8597.4UniSTS
Cytogenetic Map8q23-q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 4
Low 20 4 17 4 1 1 38 7 16 9 1
Below cutoff 3 10 24 24 2 24 7 8 24 3 14 2 7


RefSeq Acc Id: ENSRNOT00000000212   ⟹   ENSRNOP00000000212
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl854,553,165 - 54,580,378 (-)Ensembl
Rnor_6.0 Ensembl858,744,849 - 58,772,408 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099462   ⟹   ENSRNOP00000080443
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl854,553,934 - 54,580,758 (-)Ensembl
RefSeq Acc Id: NM_017085   ⟹   NP_058781
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2854,552,978 - 54,580,375 (-)NCBI
Rnor_6.0858,744,849 - 58,772,408 (-)NCBI
Rnor_5.0857,321,085 - 57,348,481 (-)NCBI
Celera854,044,272 - 54,071,684 (-)RGD
Protein Sequences
Protein RefSeqs NP_058781 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABK88260 (Get FASTA)   NCBI Sequence Viewer  
  ABO65256 (Get FASTA)   NCBI Sequence Viewer  
  EDL95528 (Get FASTA)   NCBI Sequence Viewer  
  EDL95529 (Get FASTA)   NCBI Sequence Viewer  
  P22443 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058781   ⟸   NM_017085
- UniProtKB: F1LPY2 (UniProtKB/TrEMBL),   A6J4K5 (UniProtKB/TrEMBL),   A0A8I5ZQN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000212   ⟸   ENSRNOT00000000212
RefSeq Acc Id: ENSRNOP00000080443   ⟸   ENSRNOT00000099462

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22443-F1-model_v2 AlphaFold P22443 1-508 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2457 AgrOrtholog
BioCyc Gene G2FUF-30406 BioCyc
Ensembl Genes ENSRNOG00000000196 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000212 ENTREZGENE
  ENSRNOP00000000212.7 UniProtKB/TrEMBL
  ENSRNOP00000080443.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000212 ENTREZGENE
  ENSRNOT00000000212.8 UniProtKB/TrEMBL
  ENSRNOT00000099462.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25147 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp19a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CP19A_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Cyp19a1  cytochrome P450, family 19, subfamily a, polypeptide 1  LOC100359906  cytochrome P450 19A1-like  Data Merged 737654 PROVISIONAL
2010-05-06 LOC100359906  cytochrome P450 19A1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cyp19a1  cytochrome P450, family 19, subfamily a, polypeptide 1  Cyp19  cytochrome P450, subfamily 19  Symbol and Name updated 1299863 APPROVED
2002-11-06 Cyp19  cytochrome P450, subfamily 19    Cytochrome P450, 19, aromatase  Name updated 625702 APPROVED
2002-06-10 Cyp19  Cytochrome P450, 19, aromatase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may functionally produce pituitary adenomas 1298840
gene_expression expressed in pituitary adenomas 1298840
gene_expression expressed in ovarian tissues 1298838
gene_expression protein expressed in Leydig cells, germ cells and elongated spermatids 1298839
gene_regulation transcription is regulated by androgens, cytokines and growth factors 1298839
gene_regulation biosynthesis is regulated by cAMP-dependent mechanisms during preovulation and by cAMP-independent mechanisms after leutinization in granulosa cells 1298838