Nudt4 (nudix hydrolase 4) - Rat Genome Database

Name: Nudt4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nudt4 (nudix hydrolase 4) Rattus norvegicus

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Symbol:

Nudt4

Name:

nudix hydrolase 4

RGD ID:

621355

Description:

Predicted to enable pyrophosphatase activity and snoRNA binding activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including NUDT4 (nudix hydrolase 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydolase type II; diphosphoinositol polyphosphate phosphohydrolase 2; DIPP-2; DRCF-5; LOC360416; nucleoside diphosphate-linked moiety X motif 4; nudix (nucleoside diphosphate linked moiety X)-type motif 4; nudix motif 4; nudix-type motif 4; rDIPP2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NUDT4 (nudix hydrolase 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nudt4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nudt4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NUDT4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NUDT4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nudt4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NUDT4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NUDT4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nudt4 (nudix hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NUDT4B (nudix hydrolase 4B)	HGNC	Ensembl, OrthoDB, Panther
Homo sapiens (human):	NUDT11 (nudix hydrolase 11)	HGNC	OrthoDB
Homo sapiens (human):	NUDT10 (nudix hydrolase 10)	HGNC	OrthoDB
Homo sapiens (human):	CHRM1 (cholinergic receptor muscarinic 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	NUDT4 (nudix hydrolase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nudt4 (nudix hydrolase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NUDT4B (nudix hydrolase 4B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nudt4a (nudix (nucleoside diphosphate linked moiety X)-type motif 4a)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	nudt4b (nudix (nucleoside diphosphate linked moiety X)-type motif 4b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Aps	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	DDP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	Y92H12BL.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nudt4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	32,074,978 - 32,091,491 (-)	NCBI		GRCr8
mRatBN7.2	7	30,188,100 - 30,204,615 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	30,188,100 - 30,204,615 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	32,174,576 - 32,191,073 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	34,348,209 - 34,364,896 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	34,123,196 - 34,139,687 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	36,643,916 - 36,660,334 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	36,643,916 - 36,660,141 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	36,695,609 - 36,712,030 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	32,753,728 - 32,769,953 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	32,773,998 - 32,790,224	NCBI
Celera	7	27,261,241 - 27,277,464 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsane (EXP)

arsenic atom (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

bromobenzene (EXP)

buspirone (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

formaldehyde (ISO)

genistein (EXP,ISO)

gentamycin (EXP)

indometacin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

kainic acid (ISO)

ketoconazole (ISO)

leflunomide (ISO)

levofloxacin (EXP)

lithium atom (EXP)

lithium hydride (EXP)

methapyrilene (EXP)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

nefazodone (EXP)

nickel atom (ISO)

nicotine (ISO)

nimesulide (EXP)

paclitaxel (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

titanium dioxide (ISO)

topotecan (ISO)

Tributyltin oxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (EXP,ISO)

urethane (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenosine 5'-(hexahydrogen pentaphosphate) catabolic process (IBA)

diadenosine hexaphosphate catabolic process (IBA)

diadenosine pentaphosphate catabolic process (IBA)

diphosphoinositol polyphosphate metabolic process (IBA)

phosphatidylinositol metabolic process (NAS)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (ISO)

nucleus (IBA)

Molecular Function

5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity (ISO,ISS)

bis(5'-adenosyl)-hexaphosphatase activity (IBA)

bis(5'-adenosyl)-pentaphosphatase activity (IBA)

diphosphoinositol-polyphosphate diphosphatase activity (IBA,ISO,ISS)

endopolyphosphatase activity (IBA)

inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity (IEA)

inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity (IEA)

inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

pyrophosphatase activity (IEA)

RNA binding (IEA)

snoRNA binding (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Molecular cloning of a novel isoform of diphosphoinositol polyphosphate phosphohydrolase: a potential target of lithium therapy.	Hua LV, etal., Neuropsychopharmacology 2001 Jun;24(6):640-51.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10777568	PMID:21070968

Genomics

Comparative Map Data

Nudt4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	32,074,978 - 32,091,491 (-)	NCBI		GRCr8
mRatBN7.2	7	30,188,100 - 30,204,615 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	30,188,100 - 30,204,615 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	32,174,576 - 32,191,073 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	34,348,209 - 34,364,896 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	34,123,196 - 34,139,687 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	36,643,916 - 36,660,334 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	36,643,916 - 36,660,141 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	36,695,609 - 36,712,030 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	32,753,728 - 32,769,953 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	32,773,998 - 32,790,224	NCBI
Celera	7	27,261,241 - 27,277,464 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

NUDT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	93,377,925 - 93,408,146 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	93,377,883 - 93,408,146 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	93,771,701 - 93,801,922 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	92,295,832 - 92,321,155 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	92,274,169 - 92,302,519	NCBI
Celera	12	93,442,852 - 93,467,713 (+)	NCBI		Celera
Cytogenetic Map	12	q22	NCBI
HuRef	12	90,838,980 - 90,863,685 (+)	NCBI		HuRef
CHM1_1	12	93,736,652 - 93,761,972 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	93,358,899 - 93,389,124 (+)	NCBI		T2T-CHM13v2.0

Nudt4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	95,382,869 - 95,400,008 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	95,382,869 - 95,400,008 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	95,547,007 - 95,564,146 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	95,547,007 - 95,564,146 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	95,009,641 - 95,026,801 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	94,976,977 - 94,993,834 (-)	NCBI		MGSCv36	mm8
Celera	10	97,522,698 - 97,539,519 (-)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI
cM Map	10	49.42	NCBI

Nudt4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955405	30,228,072 - 30,234,683 (+)	NCBI	ChiLan1.0	ChiLan1.0

NUDT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	101,420,265 - 101,444,233 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	101,416,726 - 101,440,627 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	90,920,449 - 90,944,338 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	94,323,929 - 94,347,414 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

NUDT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	33,627,441 - 33,644,350 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	33,627,846 - 33,641,795 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	34,078,975 - 34,095,579 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	34,299,028 - 34,315,643 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	34,298,875 - 34,315,304 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	33,577,609 - 33,594,223 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	33,666,908 - 33,683,537 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	33,931,202 - 33,947,815 (+)	NCBI		UU_Cfam_GSD_1.0

Nudt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	26,366,673 - 26,373,448 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936507	9,861,971 - 9,868,763 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NUDT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	89,714,012 - 89,728,260 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	93,643,052 - 93,657,286 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NUDT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	88,779,771 - 88,803,468 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	156,359,494 - 156,383,240 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nudt4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624750	13,474,932 - 13,493,950 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nudt4
137 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	743
Count of miRNA genes:	296
Interacting mature miRNAs:	386
Transcripts:	ENSRNOT00000012363
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	19654317	49753746	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	19654317	49753746	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	19654317	52888450	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	29409683	53612950	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat

Markers in Region

RH129315

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	30,188,142 - 30,188,339 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	36,643,959 - 36,644,155	NCBI	Rnor6.0
Rnor_5.0	7	36,695,652 - 36,695,848	UniSTS	Rnor5.0
RGSC_v3.4	7	32,753,771 - 32,753,967	UniSTS	RGSC3.4
Celera	7	27,261,284 - 27,261,480	UniSTS
Cytogenetic Map	7	q13	UniSTS

RH137140

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	30,188,294 - 30,188,487 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	36,644,111 - 36,644,303	NCBI	Rnor6.0
Rnor_5.0	7	36,695,804 - 36,695,996	UniSTS	Rnor5.0
RGSC_v3.4	7	32,753,923 - 32,754,115	UniSTS	RGSC3.4
Celera	7	27,261,436 - 27,261,628	UniSTS
RH 3.4 Map	7	233.3	UniSTS
Cytogenetic Map	7	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC124896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF253473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JN831161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U95001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012363 ⟹ ENSRNOP00000012363

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	30,188,124 - 30,204,615 (-)	Ensembl
Rnor_6.0 Ensembl	7	36,643,916 - 36,660,141 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104209 ⟹ ENSRNOP00000078797

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	30,188,124 - 30,204,615 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105881 ⟹ ENSRNOP00000077626

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	30,188,100 - 30,193,778 (-)	Ensembl

RefSeq Acc Id:

NM_001399417 ⟹ NP_001386346

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	32,074,978 - 32,091,491 (-)	NCBI
mRatBN7.2	7	30,188,100 - 30,204,615 (-)	NCBI

RefSeq Acc Id:

NM_053598 ⟹ NP_446050

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	32,074,978 - 32,091,491 (-)	NCBI
mRatBN7.2	7	30,188,100 - 30,204,615 (-)	NCBI
Rnor_6.0	7	36,643,916 - 36,660,141 (-)	NCBI
Rnor_5.0	7	36,695,609 - 36,712,030 (-)	NCBI
RGSC_v3.4	7	32,753,728 - 32,769,953 (-)	RGD
Celera	7	27,261,241 - 27,277,464 (-)	RGD

Sequence:

show sequence

CCGGCTCCGGAGCACCGCGACTTCGTTCGGTCCGACTCCCCGGCGGGGTGGCGGCGGCCGGGTC
CCCACGGTGGCGGCCGGAGCAGCGGCTGCAGGAGCCCGGCTCTAGGATGAAGTTCAAGCCCAAC
CAGACGCGGACATACGACCGCGAGGGCTTCAAGAAGCGGGCGGCCTGCCTGTGCTTCCGCAGCG
AGCAGGAGGACGAGGTGCTGTTGGTGAGCAGCAGTCGGTACCCAGACCAATGGATCGTGCCGGG
AGGAGGGGTGGAGCCGGAGGAGGAGCCTGGCGGTGCTGCTGCAAGGGAAGTGTATGAAGAGGCT
GGAGTCAAAGGAAAATTAGGCAGACTCCTGGGAATATTTGAGAATCAAGACCGGAAGCACAGAA
CATATGTTTATGTTCTGACAGTCACTGAAATATTGGAAGACTGGGAAGACTCTGTTAACATAGG
GAGGAAGAGAGAGTGGTTCAAAGTGGAAGACGCAATCAAGGTTCTTCAGTGTCACAAGCCTGTC
CACGCAGAGTACCTGGAAAGGCTGAAGCTGGGGTGTTCTCCGACCAACGGGAATTCCACGGTCC
CTTCCCTCCCAGATAACAATGCCTTGTTTGTGACTGCCGCACCACCCTCTGGGGTGCCATCCAG
TATAAGATAGAGAGCTGGGGCCCCTCCCCCACCGTGTCATGGCACATGTCAGAGGGAGAGAGGC
TTTTTTACTTCTAACACATCTGACTGCTGCTGGCAGACTCTAGATTTGCCATGCAGGGGTTTCA
AATAATTTGCATGTATTTCAGATGCTTTCAACTCTTTTAAAATAAATAACAAAATAGCAAAAAT
ACTTTAAGATGCCAAAGCCATGTGGATTTTTTTTAAAGCCTTAATTGTAAGTCTACCCCATTAC
TTTGGTTCTCATTTTTATAACCTTTCTTAAAATTTCACTTTTGAACACTCAACATTCTATGGTT
TATTTTGACAGATCAACTGGTTGTTGGGTATGTTTTTGCCCTAATATTTTTTTCTTACAGTATC
AAATAGTCACCAAATCTTTGGGAATTAATGAAAAATATTCTTGGTATTTAAAAAAATATATATG
TGCCCCAAAACTTGTTTAAGAGAGTCGCATTCTCTCCACTTGTAAGCTGCAGGTTTGCGCTGAT
TTGTATGGACGGGCCAGTTGCCTTTGACCAAGCACTCAAGTTTACTCTATCCGAGAATTTGTAC
ACAGCAAGAATTATGTCAGTGCACAGGCACTGCCTCCCCTCTGACACGGTGATTCCATATGAAT
CACTCCATTTTTAGGGAAAACTGTCAGGAACTTGCCTGTGGCACCGCACAGCTCATTCTGAAAC
TGTTCAGAGAAGTCTGTTCAGCACGCTCTGCGGCTGCTTCCTCCCTGCTCCTTCCGACACAGAC
TGTGTTAGGGGCCACATTGCTCCCATGGCCAGTGCTCTTCATATTTTCAGTCTAGCAACAACAC
TGTTGACCAGTGGATTAGACTCTAACCTTAGATACAGCAGTCACTGACTGGCATCCAAGGTTAG
ATCACACTAAACAAAATGGCTGTCCTAGGCCTAAGACACTGTCTTGAGTGTCAGTAAGCAGCTT
GTCAGATGAGTGTGAGGGAACTAGAACTATGTTACCTTGTCTTTGTGCTCTCTCAAAACGGGCC
ACCCCATGGAAAAGTACCTACATTTCCTTCAGGAAGTCATGGAGGAAGTGAAGGGGGAGGGGGG
AGAGGAAAAGATCTTTCGCAGTACAGTTAGGACATCTGTAACCTGTTAACCTTTAAATTGTAAT
GTTGCTGCTGCCAATGTCCTTACCTGTAAGGAAGGAAAATGAGATCTCGTGCCCAAATGCAGCA
GAACTAAAAACATTAGGTTACAAAGCAGAAAAACCCAACCAGTAGTGTTCATTCTAAATTATGT
AGCGTAAACAAATGTGATCGTCCAGACCTTTTCTATTTTTCTTTGTACAGAGGTCATGTACTCT
GGGTGTGTTTTAAAAGAAACATTTTAAAGAAACCCACAGATTGACATTTTCTATCTTTTCGTTT
TCTCACGATTCTCTGCAATTTTTCCATGTACTAAACACAACAGAAACTGGACTGTTTTGTATAG
AATACTGCTTCCAGCTAAAACCATCACAAGTGCCCGGGAGTTTATGTGGACATGATAGATACTC
TGGGCGGTAATAATGCATGAACCTGTTTTATAAACTCTTGAACTGTGTATTGCCATGTAAAATA
TGTACAGTATTAATGTCAACCATCTCTTTAAAAGTTAGCCTATGAACATTGTTGTATAATTTCT
TTGGTCAGAAACATTTGGACTAAGTCATGTCACCTGGGTCAGGATTTTCTTCAATGCCGTGTAG
CAAAACTGTCTTTAGTCTATGCAAATAGCGAGTCACTGAGTGTGACAGAATGCAACTTCACTGT
TAAACTTCACCTGAGGGTTCCTCATTCTGGAATCCAGACTGCAAGATTATAAAGGAAAAGACCT
AAGGCAATTCAGTTCTTTTTGCAAATCAATTGAATCCACGAGAGATGTCTACCAGCGAGATGTT
TACCAGCCCAGCCGCCTGCAGCCTGCAGCCTGCTGTGTGTGCTTATTTGTGCGCTGAATAAAAT
GGGGCAGCTAAATTCTCCAGTTCCATATGCCTCCGAAGTTCAAAGAAAAGAAAGCAAAGTAACA
TGTTAGACTTGACTTGTGTGGCGGGGTAAAGAAATGGCATCTTCCCACTAAGAACGAACCATCC
AGTTCTTTTGTCAGTCACACTATGAAACAGGGAAGGTGAAGGGAAGAAATGGTTATGTGTGCAC
GAATCGCTTTGCATGGTCTCATGAGATGGCTGCATTCGAACTGTTTTAAGAATTGTAAGGATCT
TGACTTTTTTACATTTGGAAACATCAAATAAAAACAAACATAATCTGTGAAAAAAAAAAAAAAA
AAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001386346	(Get FASTA)	NCBI Sequence Viewer
	NP_446050	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK29279	(Get FASTA)	NCBI Sequence Viewer
	AFN80335	(Get FASTA)	NCBI Sequence Viewer
	EDM16850	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012363.4
	ENSRNOP00000077626.1
	ENSRNOP00000078797.1
GenBank Protein	Q99MY2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446050 ⟸ NM_053598
- Peptide Label:	isoform 2
- UniProtKB:	Q99MY2 (UniProtKB/Swiss-Prot), A6IG47 (UniProtKB/TrEMBL), A0A8I5ZLI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGVEPEEEPGGAAAR EVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVL QCHKPVHAEYLERLKLGCSPTNGNSTVPSLPDNNALFVTAAPPSGVPSSIR hide sequence

Ensembl Acc Id:

ENSRNOP00000012363 ⟸ ENSRNOT00000012363

Ensembl Acc Id:

ENSRNOP00000077626 ⟸ ENSRNOT00000105881

Ensembl Acc Id:

ENSRNOP00000078797 ⟸ ENSRNOT00000104209

RefSeq Acc Id:	NP_001386346 ⟸ NM_001399417
- Peptide Label:	isoform 1

Protein Domains

Nudix hydrolase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99MY2-F1-model_v2	AlphaFold	Q99MY2	1-179	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621355	AgrOrtholog
BioCyc Gene	G2FUF-34332	BioCyc
Ensembl Genes	ENSRNOG00000009094	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012363.5	UniProtKB/TrEMBL
	ENSRNOT00000104209.1	UniProtKB/TrEMBL
	ENSRNOT00000105881.1	UniProtKB/TrEMBL
Gene3D-CATH	Nucleoside Triphosphate Pyrophosphohydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DDP-like_NUDIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_hydrolase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_hydrolase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_hydrolase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:94267	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	94267	ENTREZGENE
PANTHER	DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 2-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	NUDIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nudt4	PhenoGen
PROSITE	NUDIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUDIX_BOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009094	RatGTEx
Superfamily-SCOP	SSF55811	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YCF8_RAT	UniProtKB/TrEMBL
	A0A8I5ZLI5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q5G6_RAT	UniProtKB/TrEMBL
	A6IG47	ENTREZGENE, UniProtKB/TrEMBL
	NUDT4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-10	Nudt4	nudix hydrolase 4	Nudt4	nudix (nucleoside diphosphate linked moiety X)-type motif 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-02-23	Nudt4	nudix (nucleoside diphosphate linked moiety X)-type motif 4	Nudt4_predicted	nudix (nucleoside diphosphate linked moiety X)-type motif 4 (predicted)	Data merged from RGD:1309814	737654	APPROVED
2005-01-20	Nudt4	nudix (nucleoside diphosphate linked moiety X)-type motif 4		diphosphoinositol polyphosphate phosphohydolase type II	Name updated	1299863	APPROVED
2005-01-12	Nudt4_predicted	nudix (nucleoside diphosphate linked moiety X)-type motif 4 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-08-07	Nudt4	diphosphoinositol polyphosphate phosphohydolase type II			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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