Arglu1 (arginine and glutamate rich 1) - Rat Genome Database

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Gene: Arglu1 (arginine and glutamate rich 1) Rattus norvegicus
Analyze
Symbol: Arglu1
Name: arginine and glutamate rich 1
RGD ID: 1310061
Description: Predicted to be located in cytosol. Predicted to be active in mitochondrion and nucleoplasm. Orthologous to human ARGLU1 (arginine and glutamate rich 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arginine and glutamate-rich protein 1; LOC290912; MGC109359; MGC156517; RGD1310061; similar to hypothetical protein FLJ10154
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81687,455,097 - 87,479,148 (+)NCBIGRCr8
mRatBN7.21680,753,300 - 80,777,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1680,753,315 - 80,777,349 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1686,032,336 - 86,056,378 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01689,484,947 - 89,508,989 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01684,729,373 - 84,753,409 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01686,600,877 - 86,625,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1686,600,877 - 86,625,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01686,014,418 - 86,038,237 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41686,143,399 - 86,181,601 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11686,129,438 - 86,167,640 (+)NCBI
Celera1678,531,608 - 78,555,458 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
mitochondrion  (IBA,ISO)
nucleoplasm  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:25468996  


Genomics

Comparative Map Data
Arglu1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81687,455,097 - 87,479,148 (+)NCBIGRCr8
mRatBN7.21680,753,300 - 80,777,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1680,753,315 - 80,777,349 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1686,032,336 - 86,056,378 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01689,484,947 - 89,508,989 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01684,729,373 - 84,753,409 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01686,600,877 - 86,625,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1686,600,877 - 86,625,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01686,014,418 - 86,038,237 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41686,143,399 - 86,181,601 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11686,129,438 - 86,167,640 (+)NCBI
Celera1678,531,608 - 78,555,458 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
ARGLU1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813106,541,673 - 106,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13106,541,673 - 106,568,137 (-)EnsemblGRCh38hg38GRCh38
GRCh3713107,194,021 - 107,220,485 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613105,993,663 - 106,018,515 (-)NCBINCBI36Build 36hg18NCBI36
Celera1388,039,892 - 88,064,742 (-)NCBICelera
Cytogenetic Map13q33.3NCBI
HuRef1387,787,076 - 87,811,929 (-)NCBIHuRef
CHM1_113107,164,330 - 107,189,194 (-)NCBICHM1_1
T2T-CHM13v2.013105,762,093 - 105,788,553 (-)NCBIT2T-CHM13v2.0
Arglu1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3988,716,307 - 8,741,818 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl88,715,075 - 8,740,521 (-)EnsemblGRCm39 Ensembl
GRCm3888,666,297 - 8,690,550 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl88,665,075 - 8,690,521 (-)EnsemblGRCm38mm10GRCm38
MGSCv3788,666,576 - 8,690,537 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3688,666,548 - 8,690,493 (-)NCBIMGSCv36mm8
Celera88,839,215 - 8,862,964 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map83.57NCBI
Arglu1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554044,962,000 - 4,980,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554044,962,000 - 4,980,226 (+)NCBIChiLan1.0ChiLan1.0
ARGLU1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214108,040,331 - 108,065,175 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113106,720,660 - 106,745,507 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01387,683,306 - 87,708,108 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113106,823,229 - 106,847,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13106,823,229 - 106,847,933 (-)Ensemblpanpan1.1panPan2
ARGLU1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12255,616,498 - 55,640,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2255,616,977 - 55,639,784 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2255,374,265 - 55,397,955 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02256,128,655 - 56,152,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2256,126,981 - 56,152,126 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12255,721,376 - 55,745,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02255,708,193 - 55,731,591 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02255,746,940 - 55,770,656 (-)NCBIUU_Cfam_GSD_1.0
Arglu1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945190,819,302 - 190,846,313 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364725,105,269 - 5,134,313 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364725,105,836 - 5,131,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARGLU1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1174,239,419 - 74,267,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11174,241,089 - 74,267,416 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21181,617,834 - 81,644,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARGLU1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1384,958,279 - 84,983,102 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604641,521,231 - 41,546,048 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arglu1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247935,059,644 - 5,085,572 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247935,059,826 - 5,083,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arglu1
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:76
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000057347
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH128419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21680,776,999 - 80,777,205 (+)MAPPERmRatBN7.2
Rnor_6.01686,624,734 - 86,624,939NCBIRnor6.0
Rnor_5.01686,037,887 - 86,038,092UniSTSRnor5.0
RGSC_v3.41686,181,251 - 86,181,456UniSTSRGSC3.4
Celera1678,555,108 - 78,555,313UniSTS
RH 3.4 Map16787.9UniSTS
RH 3.4 Map16786.1UniSTS
Cytogenetic Map16q12.5UniSTS
FLJ10154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21680,776,562 - 80,776,724 (+)MAPPERmRatBN7.2
Rnor_6.01686,624,297 - 86,624,458NCBIRnor6.0
Rnor_5.01686,037,450 - 86,037,611UniSTSRnor5.0
RGSC_v3.41686,180,814 - 86,180,975UniSTSRGSC3.4
Celera1678,554,671 - 78,554,832UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000057347   ⟹   ENSRNOP00000054160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1680,753,315 - 80,777,349 (+)Ensembl
Rnor_6.0 Ensembl1686,600,877 - 86,625,083 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088161   ⟹   ENSRNOP00000071691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1686,624,391 - 86,624,524 (+)Ensembl
RefSeq Acc Id: NM_001024972   ⟹   NP_001020143
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81687,455,113 - 87,479,148 (+)NCBI
mRatBN7.21680,753,315 - 80,777,350 (+)NCBI
Rnor_6.01686,600,877 - 86,625,084 (+)NCBI
Rnor_5.01686,014,418 - 86,038,237 (+)NCBI
RGSC_v3.41686,143,399 - 86,181,601 (+)RGD
Celera1678,531,608 - 78,555,458 (+)RGD
Sequence:
RefSeq Acc Id: XR_010058287
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81687,455,097 - 87,463,990 (+)NCBI
RefSeq Acc Id: NP_001020143   ⟸   NM_001024972
- UniProtKB: A0JPJ8 (UniProtKB/Swiss-Prot),   Q5BJT0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054160   ⟸   ENSRNOT00000057347
RefSeq Acc Id: ENSRNOP00000071691   ⟸   ENSRNOT00000088161

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJT0-F1-model_v2 AlphaFold Q5BJT0 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700250
Promoter ID:EPDNEW_R10774
Type:initiation region
Name:Arglu1_1
Description:arginine and glutamate rich 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01686,600,872 - 86,600,932EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310061 AgrOrtholog
BioCyc Gene G2FUF-10598 BioCyc
Ensembl Genes ENSRNOG00000024142 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055015029 UniProtKB/Swiss-Prot
  ENSRNOG00060004138 UniProtKB/Swiss-Prot
  ENSRNOG00065002524 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057347 ENTREZGENE
  ENSRNOT00000057347.4 UniProtKB/Swiss-Prot
  ENSRNOT00055025702 UniProtKB/Swiss-Prot
  ENSRNOT00060006903 UniProtKB/Swiss-Prot
  ENSRNOT00065003317 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125115 IMAGE-MGC_LOAD
  IMAGE:7315932 IMAGE-MGC_LOAD
InterPro ARGLU1 UniProtKB/Swiss-Prot
KEGG Report rno:290912 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109359 IMAGE-MGC_LOAD
  MGC:156517 IMAGE-MGC_LOAD
NCBI Gene 290912 ENTREZGENE
PANTHER ARGININE AND GLUTAMATE-RICH PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR31711 UniProtKB/Swiss-Prot
Pfam ARGLU UniProtKB/Swiss-Prot
PhenoGen Arglu1 PhenoGen
RatGTEx ENSRNOG00000024142 RatGTEx
  ENSRNOG00055015029 RatGTEx
  ENSRNOG00060004138 RatGTEx
  ENSRNOG00065002524 RatGTEx
UniProt A0JPJ8 ENTREZGENE
  ARGL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JPJ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-01-29 Arglu1  arginine and glutamate rich 1  RGD1310061  similar to hypothetical protein FLJ10154  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310061  similar to hypothetical protein FLJ10154  RGD1310061_predicted  similar to hypothetical protein FLJ10154 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310061_predicted  similar to hypothetical protein FLJ10154 (predicted)  LOC290912_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290912_predicted  similar to hypothetical protein FLJ10154 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL