Lpl (lipoprotein lipase) - Rat Genome Database

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Gene: Lpl (lipoprotein lipase) Rattus norvegicus
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Symbol: Lpl
Name: lipoprotein lipase
RGD ID: 3017
Description: Enables lipoprotein lipase activity and triglyceride binding activity. Involved in several processes, including lipid catabolic process; negative regulation of cellular response to insulin stimulus; and triglyceride biosynthetic process. Located in extracellular space. Used to study abdominal obesity-metabolic syndrome 1; familial hyperlipidemia; metabolic dysfunction-associated steatotic liver disease; and obesity. Biomarker of end stage renal disease; focal segmental glomerulosclerosis; metabolic dysfunction-associated steatotic liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3,4-thiadiazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93586; phospholipase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81625,596,205 - 25,621,928 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1625,596,211 - 25,622,107 (-)EnsemblGRCr8
mRatBN7.21620,830,055 - 20,853,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,829,465 - 20,855,249 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1624,205,897 - 24,229,703 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01627,628,201 - 27,652,035 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01623,571,205 - 23,595,012 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01622,537,687 - 22,561,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)Ensemblrn6Rnor6.0
Rnor_5.01622,432,084 - 22,455,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41622,533,105 - 22,556,905 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1620,988,473 - 21,012,282 (-)NCBICelera
RGSC_v3.11622,532,512 - 22,556,890 (-)NCBI
RH 3.4 Map16252.82RGD
Cytogenetic Map16p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IDA)
Alcoholic Liver Diseases  (IEP)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
basal cell carcinoma  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
celiac disease  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
Chronic Intermittent Hypoxia  (IEP)
Colonic Neoplasms  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (IEP,ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial combined hyperlipidemia  (ISO)
Familial Hyperchylomicronemia Syndrome  (ISO)
familial hyperlipidemia  (IDA,ISO)
familial lipase maturation factor 1 deficiency  (ISO)
familial lipoprotein lipase deficiency  (ISO,ISS)
focal segmental glomerulosclerosis  (IEP)
genetic disease  (ISO)
hepatitis C  (ISO)
hereditary spastic paraplegia 53  (ISO)
Hyperapobetalipoproteinemia  (ISO)
Hypercholesterolemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (IDA,ISO)
Insulin Resistance  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA,IEP)
muscular disease  (ISO)
Myeloperoxidase Deficiency  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
obesity  (IDA,IEP,ISO)
pancreatitis  (ISO)
Prostatic Neoplasms  (ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+/-)-Aegeline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(R)-noradrenaline  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,1-dichloroethene  (ISO)
1,3,4-thiadiazole  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-butoxyethanol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
9,10-epoxy-12-octadecenoic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
Benoxacor  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromuconazole  (EXP)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 12177  (EXP)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-V  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chlorogenic acid  (EXP)
chlorpyrifos  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
CL316243  (EXP)
clofibrate  (EXP,ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cytochalasin B  (ISO)
D-gluconic acid  (EXP)
D-glucose  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
efavirenz  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
etofibrate  (EXP)
fenofibrate  (EXP,ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemfibrozil  (EXP,ISO)
genistein  (EXP,ISO)
ginsenoside Rb2  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 7647  (ISO)
heparin  (EXP,ISO)
Heptachlor epoxide  (ISO)
hesperetin  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
insulin  (ISO)
inulin  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lidocaine  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
maneb  (ISO)
mangiferin  (ISO)
melatonin  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
metolachlor  (ISO)
mifepristone  (EXP,ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
morphine  (ISO)
myricetin  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-phosphocreatine  (EXP)
naringin  (EXP)
nelfinavir  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nitrendipine  (EXP)
ochratoxin A  (ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
orlistat  (EXP,ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (ISO)
perfluorobutyric acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
Phenylamil  (ISO)
phenylephrine  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phoxim  (ISO)
picrotoxin  (EXP)
piperine  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium chloride  (EXP,ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propranolol  (EXP)
pyrazinecarboxamide  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salvianolic acid A  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
stavudine  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrahydrocurcumin  (EXP)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolclofos-methyl  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
triticonazole  (EXP)
troglitazone  (EXP,ISO)
undecane  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vorinostat  (ISO)
yohimbine  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to fatty acid  (IEA,ISO)
cellular response to nutrient  (IEA,ISO)
cholesterol homeostasis  (IBA,IEA,ISO)
chylomicron remodeling  (IEA,ISO,ISS)
fatty acid biosynthetic process  (IBA,IEA,ISO)
fatty acid metabolic process  (IEA,ISO,ISS)
high-density lipoprotein particle remodeling  (IBA)
lipid catabolic process  (IDA,IEA)
lipid metabolic process  (IEA)
low-density lipoprotein particle mediated signaling  (IEA,ISO)
negative regulation of cellular response to insulin stimulus  (IMP)
positive regulation of adipose tissue development  (IEA,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of cholesterol storage  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
retinoid metabolic process  (IEA,ISO)
triglyceride biosynthetic process  (IMP)
triglyceride catabolic process  (IBA,IEA,ISO,ISS)
triglyceride homeostasis  (IEA,ISO)
triglyceride metabolic process  (IEA,ISO)
very-low-density lipoprotein particle clearance  (IEA,ISO)
very-low-density lipoprotein particle remodeling  (IBA,IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl-CoA desaturase-1, lipase activity, leptin and resistin. Al-Muzafar HM and Amin KA, Exp Ther Med. 2018 Oct;16(4):2938-2948. doi: 10.3892/etm.2018.6563. Epub 2018 Aug 2.
2. Changes in white adipose tissue metabolism induced by resveratrol in rats. Alberdi G, etal., Nutr Metab (Lond). 2011 May 10;8(1):29. doi: 10.1186/1743-7075-8-29.
3. Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance. Annuzzi G, etal., Nutr Metab Cardiovasc Dis. 2008 Oct;18(8):531-8. Epub 2008 Mar 5.
4. Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats. Ayyasamy R and Leelavinothan P, Pharm Biol. 2016 Nov;54(11):2521-2527. doi: 10.3109/13880209.2016.1168852. Epub 2016 May 9.
5. Lipoprotein lipase mutations and Alzheimer's disease. Baum L, etal., Am J Med Genet. 1999 Apr 16;88(2):136-9.
6. A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology. Blain JF, etal., Eur J Neurosci. 2006 Sep;24(5):1245-51. doi: 10.1111/j.1460-9568.2006.05007.x. Epub 2006 Sep 8.
7. Streptozotocin-induced diabetes decreases mammary gland lipoprotein lipase activity and messenger ribonucleic acid in pregnant and nonpregnant rats. Blanco-Dolado L, etal., Int J Exp Diabetes Res 2002;3(1):61-8.
8. Effect of DanQi Pill on PPARa, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease. Chang H, etal., BMC Complement Altern Med. 2016 Mar 22;16:103. doi: 10.1186/s12906-016-1083-3.
9. Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study. Chen P, etal., J Biomed Sci. 2005;12(4):651-8. Epub 2005 Nov 10.
10. Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase. Cheng Y and Hauton D, Biochim Biophys Acta. 2008 Oct;1781(10):618-26. doi: 10.1016/j.bbalip.2008.07.006. Epub 2008 Aug 5.
11. Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus. Cho YS, etal., Exp Mol Med. 2008 Oct 31;40(5):523-32.
12. Catalytic triad residue mutation (Asp156----Gly) causing familial lipoprotein lipase deficiency. Co-inheritance with a nonsense mutation (Ser447----Ter) in a Turkish family. Faustinella F, etal., J Biol Chem 1991 Aug 5;266(22):14418-24.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats. Gomes Natal DI, etal., Nutrition. 2016 Sep;32(9):1011-8. doi: 10.1016/j.nut.2016.02.008. Epub 2016 Mar 4.
16. Lipoprotein lipase (LPL) is associated with neurite pathology and its levels are markedly reduced in the dentate gyrus of Alzheimer's disease brains. Gong H, etal., J Histochem Cytochem. 2013 Dec;61(12):857-68. doi: 10.1369/0022155413505601. Epub 2013 Sep 4.
17. Exercise prevents HFD- and OVX-induced type 2 diabetes risk factors by decreasing fat storage and improving fuel utilization. Gorres-Martens BK, etal., Physiol Rep. 2018 Jul;6(13):e13783. doi: 10.14814/phy2.13783.
18. Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. Hokanson JE, etal., Am J Hum Genet 1999 Feb;64(2):608-18.
19. Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study. Izar MC, etal., Atherosclerosis. 2009 May;204(1):165-70. Epub 2008 Aug 14.
20. ShRNA-mediated gene silencing of lipoprotein lipase improves insulin sensitivity in L6 skeletal muscle cells. Jan M and Medh JD, Biochem Biophys Res Commun. 2015 Jun 19;462(1):33-7. doi: 10.1016/j.bbrc.2015.04.098. Epub 2015 Apr 27.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
23. PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Laplante M, etal., Diabetes 2003 Feb;52(2):291-9.
24. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. Levak-Frank S, etal., J Clin Invest 1995 Aug;96(2):976-86.
25. Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model. López YR, etal., Curr Drug Deliv. 2016;13(1):158-69.
26. [Gene expression of hormone sensitive lipase and lipoprotein lipase in obesity-prone and obesity-resistant rats induced by high-fat diet] Ma W, etal., Wei Sheng Yan Jiu. 2007 May;36(3):320-2.
27. Antihyperlipidemic and antiapoptotic potential of zingerone on alcohol induced hepatotoxicity in experimental rats. Mani V, etal., Chem Biol Interact. 2017 Jun 25;272:197-206. doi: 10.1016/j.cbi.2017.04.019. Epub 2017 Apr 22.
28. Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease. Martin-Rehrmann MD, etal., Neurosci Lett. 2002 Aug 9;328(2):109-12.
29. Lipoprotein lipase: structure, function, regulation, and role in disease. Mead JR, etal., J Mol Med 2002 Dec;80(12):753-69. Epub 2002 Oct 24.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Apolipoprotein E and lipoprotein lipase increase triglyceride-rich particle binding but decrease particle penetration in arterial wall. Mullick AE, etal., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2080-5.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 -455T>C polymorphisms on the susceptibility to diabetic nephropathy. Ng MC, etal., Clin Genet. 2006 Jul;70(1):20-8.
34. Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference. Niu YG and Evans RD, Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1106-16. Epub 2008 Sep 9.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. Papassotiropoulos A, etal., J Clin Psychiatry. 2005 Jul;66(7):940-7.
37. Apolipoprotein E and lipoprotein lipase gene polymorphisms interaction on the atherogenic combined expression of hypertriglyceridemia and hyperapobetalipoproteinemia phenotypes. Perron P, etal., J Endocrinol Invest. 2007 Jul-Aug;30(7):551-7.
38. Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Picard F, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E412-8.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Anti-obesity effects of tea from Mangifera indica L. leaves of the Ubá variety in high-fat diet-induced obese rats. Ramírez NM, etal., Biomed Pharmacother. 2017 Jul;91:938-945. doi: 10.1016/j.biopha.2017.05.015. Epub 2017 May 13.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Protein restriction and AST-120 improve lipoprotein lipase and VLDL receptor in focal glomerulosclerosis. Sato T, etal., Kidney Int. 2003 Nov;64(5):1780-6.
46. The H+ allele of the lipoprotein lipase (LPL) HindIII intronic polymorphism and the risk for sporadic late-onset Alzheimer's disease. Scacchi R, etal., Neurosci Lett. 2004 Sep 2;367(2):177-80. doi: 10.1016/j.neulet.2004.05.111.
47. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Scribner KA, etal., Metabolism. 2000 Sep;49(9):1106-10.
48. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
49. Strong Association of Lipid Metabolism Related MicroRNA Binding Sites Polymorphisms with the Risk of Late Onset Alzheimer's Disease. Tan L, etal., Curr Neurovasc Res. 2017;14(1):3-10. doi: 10.2174/1567202613666161027101100.
50. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
51. Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression. Vaziri ND, etal., Clin Exp Nephrol. 2012 Apr;16(2):238-43. Epub 2011 Oct 19.
52. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Wang H, etal., Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.
53. Pathogenesis of Abnormal Hepatic Lipid Metabolism Induced by Chronic Intermittent Hypoxia in Rats and the Therapeutic Effect of N-Acetylcysteine. Wang H, etal., Med Sci Monit. 2018 Jul 3;24:4583-4591. doi: 10.12659/MSM.907228.
54. Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes. Wang XL, etal., Circulation. 1996 Apr 1;93(7):1339-45.
55. The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme. Wu G, etal., J Biol Chem. 2003 Apr 4;278(14):11925-30. Epub 2003 Jan 27.
56. The hormonal responses of lipoprotein lipase activity and lipolysis in adipose tissue differ depending on the stage of the estrous cycle in female rats. Yamaguchi M, etal., Int J Obes Relat Metab Disord 2002 May;26(5):610-7.
57. [Preventive and therapeutic effects of compound ginkgo extract in rats with nonalcoholic steatohepatitis induced by high-fat, high-fructose diet]. Yang Q, etal., Zhonghua Gan Zang Bing Za Zhi. 2016 Nov 20;24(11):852-858.
58. A novel substitution at the translation initiator codon (ATG-->ATC) of the lipoprotein lipase gene is mainly responsible for lipoprotein lipase deficiency in a patient with severe hypertriglyceridemia and recurrent pancreatitis. Yu XH, etal., Biochem Biophys Res Commun. 2006 Mar 3;341(1):82-7. Epub 2006 Jan 9.
59. Pyrazinamide induced hepatic injury in rats through inhibiting the PPARa pathway. Zhang Y, etal., J Appl Toxicol. 2016 Dec;36(12):1579-1590. doi: 10.1002/jat.3319. Epub 2016 Apr 12.
60. [Modulating effects of shenmai injection on serum lipids in rats with hyperlipemia]. Zhu TL, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2016 Mar 8;32(3):230-233. doi: 10.13459/j.cnki.cjap.2016.03.011.
Additional References at PubMed
PMID:182536   PMID:1339374   PMID:1485686   PMID:2110364   PMID:2233752   PMID:2340307   PMID:2563260   PMID:3973011   PMID:7592706   PMID:10085125   PMID:10858435   PMID:11342582  
PMID:11809775   PMID:11882325   PMID:11896485   PMID:11897675   PMID:12032167   PMID:12573449   PMID:12815182   PMID:12967632   PMID:15178420   PMID:15328075   PMID:15489334   PMID:15670333  
PMID:15681706   PMID:15887043   PMID:15947029   PMID:16166565   PMID:16179346   PMID:16502470   PMID:16807550   PMID:17018885   PMID:17088546   PMID:17170230   PMID:17244606   PMID:17259660  
PMID:17451160   PMID:17628524   PMID:17709442   PMID:17890220   PMID:17942824   PMID:18583709   PMID:19088434   PMID:20497648   PMID:20620994   PMID:21147877   PMID:21646389   PMID:21986524  
PMID:22226882   PMID:22870821   PMID:22963823   PMID:23012479   PMID:23176178   PMID:23376485   PMID:23471235   PMID:23816988   PMID:24115032   PMID:25149060   PMID:25589507   PMID:26586663  
PMID:27035287   PMID:27578112   PMID:28986359   PMID:29794473   PMID:30559189   PMID:30660685   PMID:31108749   PMID:38114521  


Genomics

Comparative Map Data
Lpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81625,596,205 - 25,621,928 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1625,596,211 - 25,622,107 (-)EnsemblGRCr8
mRatBN7.21620,830,055 - 20,853,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,829,465 - 20,855,249 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1624,205,897 - 24,229,703 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01627,628,201 - 27,652,035 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01623,571,205 - 23,595,012 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01622,537,687 - 22,561,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)Ensemblrn6Rnor6.0
Rnor_5.01622,432,084 - 22,455,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41622,533,105 - 22,556,905 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1620,988,473 - 21,012,282 (-)NCBICelera
RGSC_v3.11622,532,512 - 22,556,890 (-)NCBI
RH 3.4 Map16252.82RGD
Cytogenetic Map16p14NCBI
LPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38819,939,253 - 19,967,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl819,901,717 - 19,967,259 (+)Ensemblhg38GRCh38
GRCh37819,796,764 - 19,824,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36819,840,862 - 19,869,050 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34819,841,057 - 19,869,049NCBI
Celera818,759,678 - 18,787,858 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef818,336,820 - 18,365,002 (+)NCBIHuRef
CHM1_1819,998,390 - 20,026,574 (+)NCBICHM1_1
T2T-CHM13v2.0820,204,296 - 20,232,297 (+)NCBIT2T-CHM13v2.0
Lpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,333,207 - 69,359,584 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl869,333,143 - 69,360,100 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38868,880,555 - 68,906,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl868,880,491 - 68,907,448 (+)Ensemblmm10GRCm38
MGSCv37871,404,454 - 71,430,831 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36871,809,543 - 71,835,921 (+)NCBIMGSCv36mm8
Celera871,423,790 - 71,450,108 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
Lpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,646,084 - 43,673,967 (+)Ensembl
ChiLan1.0NW_00495540343,646,084 - 43,672,116 (+)NCBIChiLan1.0ChiLan1.0
LPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2738,421,240 - 38,449,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1814,146,772 - 14,174,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0819,164,541 - 19,193,100 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1816,113,415 - 16,142,113 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,113,415 - 16,142,966 (+)EnsemblpanPan2panpan1.1
LPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,078,306 - 37,102,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,079,756 - 37,102,700 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2537,670,851 - 37,695,657 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02537,307,488 - 37,333,689 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,305,811 - 37,333,670 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,243,904 - 37,268,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,086,270 - 37,110,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,256,141 - 37,280,964 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494314,462,292 - 14,486,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365554,084,099 - 4,108,365 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365554,084,099 - 4,108,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,104,772 - 4,135,814 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1144,104,761 - 4,134,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap14q12-q14NCBI
LPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,009,049 - 18,038,315 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl818,009,093 - 18,038,598 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605224,205,476 - 24,235,020 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475815,651,992 - 15,680,762 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475815,652,553 - 15,680,107 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Lpl
242 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:171
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000016543
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH94806  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81625,597,632 - 25,597,928 (+)Marker Load Pipeline
mRatBN7.21620,830,885 - 20,831,182 (+)MAPPERmRatBN7.2
Rnor_6.01622,538,518 - 22,538,814NCBIRnor6.0
Rnor_5.01622,432,915 - 22,433,211UniSTSRnor5.0
RGSC_v3.41622,533,936 - 22,534,232UniSTSRGSC3.4
Celera1620,989,304 - 20,989,600UniSTS
RH 3.4 Map16252.82UniSTS
Cytogenetic Map16p14UniSTS
RH94543  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81625,596,915 - 25,597,095 (+)Marker Load Pipeline
mRatBN7.21620,830,169 - 20,830,349 (+)MAPPERmRatBN7.2
Rnor_6.01622,537,802 - 22,537,981NCBIRnor6.0
Rnor_5.01622,432,199 - 22,432,378UniSTSRnor5.0
RGSC_v3.41622,533,220 - 22,533,399UniSTSRGSC3.4
Celera1620,988,588 - 20,988,767UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 62 59 6 326 162 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016543   ⟹   ENSRNOP00000016543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1625,596,211 - 25,622,107 (-)Ensembl
mRatBN7.2 Ensembl1620,829,465 - 20,855,249 (-)Ensembl
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)Ensembl
RefSeq Acc Id: NM_012598   ⟹   NP_036730
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,596,801 - 25,620,601 (-)NCBI
mRatBN7.21620,830,055 - 20,853,855 (-)NCBI
Rnor_6.01622,537,687 - 22,561,487 (-)NCBI
Rnor_5.01622,432,084 - 22,455,950 (-)NCBI
RGSC_v3.41622,533,105 - 22,556,905 (-)RGD
Celera1620,988,473 - 21,012,282 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275054   ⟹   XP_063131124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,596,205 - 25,621,928 (-)NCBI
RefSeq Acc Id: NP_036730   ⟸   NM_012598
- Peptide Label: precursor
- UniProtKB: Q06000 (UniProtKB/Swiss-Prot),   A6KFI9 (UniProtKB/TrEMBL),   A0A8L2Q8D2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016543   ⟸   ENSRNOT00000016543
RefSeq Acc Id: XP_063131124   ⟸   XM_063275054
- Peptide Label: isoform X1
- UniProtKB: Q06000 (UniProtKB/Swiss-Prot),   A0A8L2Q8D2 (UniProtKB/TrEMBL),   A6KFI9 (UniProtKB/TrEMBL)
Protein Domains
PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06000-F1-model_v2 AlphaFold Q06000 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700057
Promoter ID:EPDNEW_R10581
Type:single initiation site
Name:Lpl_1
Description:lipoprotein lipase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01622,561,504 - 22,561,564EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3017 AgrOrtholog
BioCyc Gene G2FUF-11698 BioCyc
BioCyc Pathway LIPAS-PWY [triacylglycerol degradation] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
BioCyc Pathway Image LIPAS-PWY BioCyc
  PWY-8052 BioCyc
Ensembl Genes ENSRNOG00000012181 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016543 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
  PLAT/LH2 domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106121 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Lipase/vitellogenin UniProtKB/Swiss-Prot
  Lipase_LIPH UniProtKB/Swiss-Prot
  Lipase_N UniProtKB/Swiss-Prot
  Lipo_Lipase UniProtKB/Swiss-Prot
  PLAT/LH2_dom UniProtKB/Swiss-Prot
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot
  TAG_lipase UniProtKB/Swiss-Prot
KEGG Report rno:24539 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93586 IMAGE-MGC_LOAD
NCBI Gene 24539 ENTREZGENE
PANTHER PTHR11610 UniProtKB/Swiss-Prot
  PTHR11610:SF3 UniProtKB/Swiss-Prot
Pfam Lipase UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
PharmGKB LPL RGD
PhenoGen Lpl PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot
PRINTS LIPOLIPASE UniProtKB/Swiss-Prot
  TAGLIPASE UniProtKB/Swiss-Prot
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012181 RatGTEx
SMART LH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
TIGR TC204043
UniProt A0A8L2Q8D2 ENTREZGENE, UniProtKB/TrEMBL
  A6KFI9 ENTREZGENE, UniProtKB/TrEMBL
  LIPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lpl  Lipoprotein lipase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in hyperinsulinemia 70246
gene_function hydrolyzes circulating plasma triglycerides 70246
gene_process involved in diet-induced insulin resistance 70246
gene_regulation expression is decreased by insulin deficiency 729358