Lpl (lipoprotein lipase) - Rat Genome Database

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Gene: Lpl (lipoprotein lipase) Rattus norvegicus
Analyze
Symbol: Lpl
Name: lipoprotein lipase
RGD ID: 3017
Description: Enables lipoprotein lipase activity and triglyceride binding activity. Involved in several processes, including negative regulation of cellular response to insulin stimulus; response to cold; and triglyceride biosynthetic process. Located in extracellular space. Used to study abdominal obesity-metabolic syndrome 1; familial hyperlipidemia; non-alcoholic fatty liver disease; and obesity. Biomarker of end stage renal disease; focal segmental glomerulosclerosis; non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC93586; phospholipase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,830,055 - 20,853,855 (-)NCBI
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01622,537,687 - 22,561,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01622,432,084 - 22,455,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,533,105 - 22,556,905 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11622,532,512 - 22,556,890 (-)NCBI
Celera1620,988,473 - 21,012,282 (-)NCBICelera
RH 3.4 Map16252.82RGD
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(20S)-ginsenoside Rh1  (ISO)
(R)-noradrenaline  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-butoxyethanol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 12177  (EXP)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-V  (ISO)
chloroform  (EXP)
chlorogenic acid  (EXP)
chlorpyrifos  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
curcumin  (ISO)
cytochalasin B  (ISO)
D-gluconic acid  (EXP)
D-glucose  (ISO)
DDT  (ISO)
deoxycholic acid  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
efavirenz  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
etofibrate  (EXP)
fenofibrate  (EXP,ISO)
fluvastatin  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemfibrozil  (EXP,ISO)
genistein  (EXP,ISO)
ginsenoside Rb2  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucose  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 7647  (ISO)
heparin  (EXP)
Heptachlor epoxide  (ISO)
hesperetin  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
melatonin  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
monocrotophos  (EXP)
morphine  (ISO)
myricetin  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naringin  (EXP)
nelfinavir  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
orlistat  (EXP,ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
Phenylamil  (ISO)
phenylephrine  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
piperine  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium chloride  (EXP,ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propranolol  (EXP)
pyrazinecarboxamide  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rotenone  (EXP)
saquinavir  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
stavudine  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrahydrocurcumin  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (EXP,ISO)
undecane  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
yohimbine  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Al-Muzafar HM and Amin KA, Exp Ther Med. 2018 Oct;16(4):2938-2948. doi: 10.3892/etm.2018.6563. Epub 2018 Aug 2.
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3. Annuzzi G, etal., Nutr Metab Cardiovasc Dis. 2008 Oct;18(8):531-8. Epub 2008 Mar 5.
4. Ayyasamy R and Leelavinothan P, Pharm Biol. 2016 Nov;54(11):2521-2527. doi: 10.3109/13880209.2016.1168852. Epub 2016 May 9.
5. Baum L, etal., Am J Med Genet. 1999 Apr 16;88(2):136-9.
6. Blain JF, etal., Eur J Neurosci. 2006 Sep;24(5):1245-51. doi: 10.1111/j.1460-9568.2006.05007.x. Epub 2006 Sep 8.
7. Blanco-Dolado L, etal., Int J Exp Diabetes Res 2002;3(1):61-8.
8. Chang H, etal., BMC Complement Altern Med. 2016 Mar 22;16:103. doi: 10.1186/s12906-016-1083-3.
9. Chen P, etal., J Biomed Sci. 2005;12(4):651-8. Epub 2005 Nov 10.
10. Cheng Y and Hauton D, Biochim Biophys Acta. 2008 Oct;1781(10):618-26. doi: 10.1016/j.bbalip.2008.07.006. Epub 2008 Aug 5.
11. Cho YS, etal., Exp Mol Med. 2008 Oct 31;40(5):523-32.
12. Faustinella F, etal., J Biol Chem 1991 Aug 5;266(22):14418-24.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. GOA data from the GO Consortium
15. Gomes Natal DI, etal., Nutrition. 2016 Sep;32(9):1011-8. doi: 10.1016/j.nut.2016.02.008. Epub 2016 Mar 4.
16. Gong H, etal., J Histochem Cytochem. 2013 Dec;61(12):857-68. doi: 10.1369/0022155413505601. Epub 2013 Sep 4.
17. Gorres-Martens BK, etal., Physiol Rep. 2018 Jul;6(13):e13783. doi: 10.14814/phy2.13783.
18. Hokanson JE, etal., Am J Hum Genet 1999 Feb;64(2):608-18.
19. Izar MC, etal., Atherosclerosis. 2009 May;204(1):165-70. Epub 2008 Aug 14.
20. Jan M and Medh JD, Biochem Biophys Res Commun. 2015 Jun 19;462(1):33-7. doi: 10.1016/j.bbrc.2015.04.098. Epub 2015 Apr 27.
21. KEGG
22. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
23. Laplante M, etal., Diabetes 2003 Feb;52(2):291-9.
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27. Mani V, etal., Chem Biol Interact. 2017 Jun 25;272:197-206. doi: 10.1016/j.cbi.2017.04.019. Epub 2017 Apr 22.
28. Martin-Rehrmann MD, etal., Neurosci Lett. 2002 Aug 9;328(2):109-12.
29. Mead JR, etal., J Mol Med 2002 Dec;80(12):753-69. Epub 2002 Oct 24.
30. MGD data from the GO Consortium
31. Mullick AE, etal., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2080-5.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Ng MC, etal., Clin Genet. 2006 Jul;70(1):20-8.
34. Niu YG and Evans RD, Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1106-16. Epub 2008 Sep 9.
35. OMIM Disease Annotation Pipeline
36. Papassotiropoulos A, etal., J Clin Psychiatry. 2005 Jul;66(7):940-7.
37. Perron P, etal., J Endocrinol Invest. 2007 Jul-Aug;30(7):551-7.
38. Picard F, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E412-8.
39. Pipeline to import KEGG annotations from KEGG into RGD
40. Pipeline to import SMPDB annotations from SMPDB into RGD
41. Ramírez NM, etal., Biomed Pharmacother. 2017 Jul;91:938-945. doi: 10.1016/j.biopha.2017.05.015. Epub 2017 May 13.
42. RGD automated data pipeline
43. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. RGD automated import pipeline for gene-chemical interactions
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50. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
51. Vaziri ND, etal., Clin Exp Nephrol. 2012 Apr;16(2):238-43. Epub 2011 Oct 19.
52. Wang H, etal., Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.
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Additional References at PubMed
PMID:182536   PMID:1339374   PMID:1485686   PMID:2110364   PMID:2233752   PMID:2340307   PMID:2563260   PMID:3973011   PMID:7592706   PMID:10085125   PMID:10858435   PMID:11342582  
PMID:11809775   PMID:11882325   PMID:11896485   PMID:11897675   PMID:12032167   PMID:12573449   PMID:12815182   PMID:12967632   PMID:15178420   PMID:15328075   PMID:15489334   PMID:15670333  
PMID:15681706   PMID:15887043   PMID:15947029   PMID:16166565   PMID:16179346   PMID:16502470   PMID:16807550   PMID:17018885   PMID:17088546   PMID:17170230   PMID:17244606   PMID:17259660  
PMID:17451160   PMID:17628524   PMID:17709442   PMID:17890220   PMID:17942824   PMID:18583709   PMID:19088434   PMID:20497648   PMID:20620994   PMID:21147877   PMID:21646389   PMID:21986524  
PMID:22226882   PMID:22870821   PMID:22963823   PMID:23012479   PMID:23176178   PMID:23376485   PMID:23471235   PMID:23816988   PMID:24115032   PMID:25149060   PMID:25589507   PMID:26586663  
PMID:27035287   PMID:27578112   PMID:28986359   PMID:29794473   PMID:30559189   PMID:30660685   PMID:31108749  


Genomics

Comparative Map Data
Lpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,830,055 - 20,853,855 (-)NCBI
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01622,537,687 - 22,561,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01622,432,084 - 22,455,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,533,105 - 22,556,905 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11622,532,512 - 22,556,890 (-)NCBI
Celera1620,988,473 - 21,012,282 (-)NCBICelera
RH 3.4 Map16252.82RGD
Cytogenetic Map16p14NCBI
LPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl819,901,717 - 19,967,259 (+)EnsemblGRCh38hg38GRCh38
GRCh38819,939,253 - 19,967,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37819,796,764 - 19,824,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36819,840,862 - 19,869,050 (+)NCBINCBI36hg18NCBI36
Build 34819,841,057 - 19,869,049NCBI
Celera818,759,678 - 18,787,858 (+)NCBI
Cytogenetic Map8p21.3NCBI
HuRef818,336,820 - 18,365,002 (+)NCBIHuRef
CHM1_1819,998,390 - 20,026,574 (+)NCBICHM1_1
Lpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,333,207 - 69,359,584 (+)NCBIGRCm39mm39
GRCm39 Ensembl869,333,143 - 69,360,100 (+)Ensembl
GRCm38868,880,555 - 68,906,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl868,880,491 - 68,907,448 (+)EnsemblGRCm38mm10GRCm38
MGSCv37871,404,454 - 71,430,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36871,809,543 - 71,835,921 (+)NCBImm8
Celera871,423,790 - 71,450,108 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
Lpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,646,084 - 43,673,967 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540343,646,084 - 43,672,116 (+)NCBIChiLan1.0ChiLan1.0
LPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1816,113,415 - 16,142,113 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,113,415 - 16,142,966 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0819,164,541 - 19,193,100 (+)NCBIMhudiblu_PPA_v0panPan3
LPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,078,306 - 37,102,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,079,756 - 37,102,700 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2537,670,851 - 37,695,657 (-)NCBI
ROS_Cfam_1.02537,307,488 - 37,333,689 (-)NCBI
UMICH_Zoey_3.12537,243,904 - 37,268,469 (-)NCBI
UNSW_CanFamBas_1.02537,086,270 - 37,110,850 (-)NCBI
UU_Cfam_GSD_1.02537,256,141 - 37,280,964 (-)NCBI
Lpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494314,462,292 - 14,486,414 (-)NCBI
SpeTri2.0NW_0049365554,084,099 - 4,108,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,104,772 - 4,135,814 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,104,761 - 4,134,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap14q12-q14NCBI
LPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,009,049 - 18,038,315 (+)NCBI
ChlSab1.1 Ensembl818,009,093 - 18,038,598 (+)Ensembl
Vero_WHO_p1.0NW_02366605224,205,476 - 24,235,020 (-)NCBI
Lpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475815,652,553 - 15,680,107 (+)NCBI

Position Markers
RH94806  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,830,885 - 20,831,182 (+)MAPPER
Rnor_6.01622,538,518 - 22,538,814NCBIRnor6.0
Rnor_5.01622,432,915 - 22,433,211UniSTSRnor5.0
RGSC_v3.41622,533,936 - 22,534,232UniSTSRGSC3.4
Celera1620,989,304 - 20,989,600UniSTS
RH 3.4 Map16252.82UniSTS
Cytogenetic Map16p14UniSTS
RH94543  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,830,169 - 20,830,349 (+)MAPPER
Rnor_6.01622,537,802 - 22,537,981NCBIRnor6.0
Rnor_5.01622,432,199 - 22,432,378UniSTSRnor5.0
RGSC_v3.41622,533,220 - 22,533,399UniSTSRGSC3.4
Celera1620,988,588 - 20,988,767UniSTS
Cytogenetic Map16p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16413635523105837Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161730939622744540Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161939818770590230Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161939818770590230Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:171
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000016543
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 45 29 19 29 8 11 41 29 26 11 8
Low 1 12 12 12 33 6 12
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016543   ⟹   ENSRNOP00000016543
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)Ensembl
RefSeq Acc Id: NM_012598   ⟹   NP_036730
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21620,830,055 - 20,853,855 (-)NCBI
Rnor_6.01622,537,687 - 22,561,487 (-)NCBI
Rnor_5.01622,432,084 - 22,455,950 (-)NCBI
RGSC_v3.41622,533,105 - 22,556,905 (-)RGD
Celera1620,988,473 - 21,012,282 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036730   ⟸   NM_012598
- Peptide Label: precursor
- UniProtKB: Q06000 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016543   ⟸   ENSRNOT00000016543
Protein Domains
PLAT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700057
Promoter ID:EPDNEW_R10581
Type:single initiation site
Name:Lpl_1
Description:lipoprotein lipase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01622,561,504 - 22,561,564EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3017 AgrOrtholog
Ensembl Genes ENSRNOG00000012181 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016543 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016543 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106121 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Lipase/vitellogenin UniProtKB/Swiss-Prot
  Lipase_LIPH UniProtKB/Swiss-Prot
  Lipase_N UniProtKB/Swiss-Prot
  Lipo_Lipase UniProtKB/Swiss-Prot
  PLAT/LH2_dom UniProtKB/Swiss-Prot
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot
  TAG_lipase UniProtKB/Swiss-Prot
KEGG Report rno:24539 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93586 IMAGE-MGC_LOAD
NCBI Gene 24539 ENTREZGENE
PANTHER PTHR11610 UniProtKB/Swiss-Prot
  PTHR11610:SF3 UniProtKB/Swiss-Prot
Pfam Lipase UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
PharmGKB LPL RGD
PhenoGen Lpl PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot
PRINTS LIPOLIPASE UniProtKB/Swiss-Prot
  TAGLIPASE UniProtKB/Swiss-Prot
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
SMART LH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
TIGR TC204043
TIGRFAMs lipo_lipase UniProtKB/Swiss-Prot
UniProt LIPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lpl  Lipoprotein lipase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in hyperinsulinemia 70246
gene_function hydrolyzes circulating plasma triglycerides 70246
gene_process involved in diet-induced insulin resistance 70246
gene_regulation expression is decreased by insulin deficiency 729358