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Gene: Lpl (lipoprotein lipase) Rattus norvegicus
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Symbol: Lpl
Name: lipoprotein lipase
Description: Exhibits lipoprotein lipase activity and triglyceride binding activity. Involved in several processes, including negative regulation of cellular response to insulin stimulus; response to cold; and triglyceride biosynthetic process. Localizes to the extracellular space. Used to study abdominal obesity-metabolic syndrome 1; familial hyperlipidemia; non-alcoholic fatty liver disease; and obesity. Biomarker of end stage renal failure; focal segmental glomerulosclerosis; non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; (RS)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC93586
Orthologs:
Homo sapiens (human) : LPL (lipoprotein lipase)  HGNC  Alliance
Mus musculus (house mouse) : Lpl (lipoprotein lipase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lpl (lipoprotein lipase)
Pan paniscus (bonobo/pygmy chimpanzee) : LPL (lipoprotein lipase)
Canis lupus familiaris (dog) : LPL (lipoprotein lipase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lpl (lipoprotein lipase)
Sus scrofa (pig) : LPL (lipoprotein lipase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01622,537,687 - 22,561,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,537,056 - 22,561,496 (-)Ensembl
Rnor_5.01622,432,084 - 22,455,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,533,105 - 22,556,905 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11622,532,512 - 22,556,890 (-)NCBI
Celera1620,988,473 - 21,012,282 (-)NCBICelera
Cytogenetic Map16p14NCBI
RH 3.4 Map16252.82RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lpl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3017
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.