RGD Reference Report - Lipoprotein lipase: structure, function, regulation, and role in disease. - Rat Genome Database

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Lipoprotein lipase: structure, function, regulation, and role in disease.

Authors: Mead, JR  Irvine, SA  Ramji, DP 
Citation: Mead JR, etal., J Mol Med 2002 Dec;80(12):753-69. Epub 2002 Oct 24.
RGD ID: 1357916
Pubmed: PMID:12483461   (View Abstract at PubMed)
DOI: DOI:10.1007/s00109-002-0384-9   (Journal Full-text)

Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation. Research carried out over the past two decades have not only established a central role for LPL in the overall lipid metabolism and transport but have also identified additional, non-catalytic functions of the enzyme. Furthermore, abnormalities in LPL function have been found to be associated with a number of pathophysiological conditions, including atherosclerosis, chylomicronaemia, obesity, Alzheimer's disease, and dyslipidaemia associated with diabetes, insulin resistance, and infection. Advances have also been made in relating the various domains in the protein to different functions, and in understanding the mechanisms that are responsible for the changes in LPL expression seen in response to nutritional and other physiological changes, and during disease. This review summarises recent findings in relation to the structure, function, and regulation of LPL along with its important role in disease.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Lpl  (lipoprotein lipase)

Genes (Mus musculus)
Lpl  (lipoprotein lipase)

Genes (Homo sapiens)
LPL  (lipoprotein lipase)


Additional Information