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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3017
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:47776
Term: very-low-density lipoprotein triglyceride
Definition: Triglycerides which are contained in very low density lipoproteins (VLDL).
Chemical ID: MESH:C030106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lplincreases activityISOLPL (Homo sapiens)6480464CTDvery low density lipoprotein triglyceride results in increased activity of LPL proteinPMID:12573449
Lplincreases hydrolysisISOLPL (Homo sapiens)6480464CTDLPL protein results in increased hydrolysis of very low density lipoprotein triglyceridePMID:18435438
Lplmultiple interactionsISOLPL (Homo sapiens)6480464CTD[LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride] which results in increased abundance of Fatty Acids, Unsaturated; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]; very low density lipoprotein triglyceride affects the reaction [LPL protein results in decreased activity of TNF protein]PMID:12573449 PMID:15994321 PMID:18435438
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