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Gene: Lpl (lipoprotein lipase) Mus musculus
Symbol: Lpl
Name: lipoprotein lipase
Description: Exhibits lipoprotein lipase activity. Involved in several processes, including positive regulation of cytokine secretion; positive regulation of macrophage derived foam cell differentiation; and triglyceride catabolic process. Localizes to cell surface and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; limb; lung; and sensory organ. Used to study familial lipoprotein lipase deficiency. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (20S)-ginsenoside Rh1; (RS)-coclaurine; (RS)-norcoclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: O 1-4-5; phospholipase A1
Homo sapiens (human) : LPL (lipoprotein lipase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lpl (lipoprotein lipase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lpl (lipoprotein lipase)
Pan paniscus (bonobo/pygmy chimpanzee) : LPL (lipoprotein lipase)
Canis lupus familiaris (dog) : LPL (lipoprotein lipase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lpl (lipoprotein lipase)
Sus scrofa (pig) : LPL (lipoprotein lipase)
Chlorocebus sabaeus (African green monkey) : LPL (lipoprotein lipase)
Heterocephalus glaber (naked mole-rat) : Lpl (lipoprotein lipase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl868,880,491 - 68,907,448 (+)EnsemblGRCm38mm10GRCm38
GRCm38868,880,555 - 68,906,932 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37871,404,454 - 71,430,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36871,809,543 - 71,835,921 (+)NCBImm8
Celera871,423,790 - 71,450,108 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lpl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10876
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.