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Gene: Lpl (lipoprotein lipase) Mus musculus
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Symbol: Lpl
Name: lipoprotein lipase
Description: Exhibits lipoprotein lipase activity. Involved in several processes, including positive regulation of cytokine secretion; positive regulation of macrophage derived foam cell differentiation; and triglyceride catabolic process. Localizes to cell surface and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; limb; lung; and sensory organ. Used to study familial lipoprotein lipase deficiency. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (20S)-ginsenoside Rh1; (RS)-coclaurine; (RS)-norcoclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: O 1-4-5; phospholipase A1
Orthologs:
Homo sapiens (human) : LPL (lipoprotein lipase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lpl (lipoprotein lipase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lpl (lipoprotein lipase)
Pan paniscus (bonobo/pygmy chimpanzee) : LPL (lipoprotein lipase)
Canis lupus familiaris (dog) : LPL (lipoprotein lipase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lpl (lipoprotein lipase)
Sus scrofa (pig) : LPL (lipoprotein lipase)
Chlorocebus sabaeus (African green monkey) : LPL (lipoprotein lipase)
Heterocephalus glaber (naked mole-rat) : Lpl (lipoprotein lipase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl868,880,491 - 68,907,448 (+)EnsemblGRCm38mm10GRCm38
GRCm38868,880,555 - 68,906,932 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37871,404,454 - 71,430,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36871,809,543 - 71,835,921 (+)NCBImm8
Celera871,423,790 - 71,450,108 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lpl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10876
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.