Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3017
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lplincreases expressionISOLPL (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNAPMID:22645054
Lplmultiple interactionsISOLpl (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with perfluorooctanoic acid] results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein]; [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPL mRNA; [2-ethylhexyldiphenylphosphate co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA; [Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with perfluorooctanoic acid] results in increased expression of LPL mRNA; [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA; [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL protein; [Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPL mRNA; [Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPL mRNA; Acrylamide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPL mRNA]; bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]; Rosiglitazone promotes the reaction [[Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; rotenoisin A inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL protein]; T 0070907 inhibits the reaction [[Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPL mRNA]; T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPL mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]PMID:16054899 PMID:22197818 PMID:23086663 PMID:26820058 PMID:27273607 PMID:29094436 PMID:30409764 PMID:30446312 PMID:30665118 PMID:34302803 PMID:36764644
Lplmultiple interactionsISOLPL (Homo sapiens)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Dexamethasone] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Firemaster 550] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Firemaster 550] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Troglitazone] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with Troglitazone co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol F co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [bisphenol F co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [bisphenol S co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of LPL protein; [bisphenol S co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA; [Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LPL mRNA; [Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA; [Rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA; [Rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL protein; [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA; [Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] affects the expression of LPL mRNA; aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA]; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; Rosiglitazone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; T 0070907 inhibits the reaction [[Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA]; T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LPL mRNA]; TGFB1 protein inhibits the reaction [[Rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LPL mRNA]PMID:19186324 PMID:20206132 PMID:22645054 PMID:23086663 PMID:27003841 PMID:28437481 PMID:28628672 PMID:33836827 PMID:33865937 PMID:34575692
Go Back to source page   Continue to Ontology report