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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3017
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:81731
Term: tolclofos-methyl
Definition: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for controlling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.
Chemical ID: MESH:C426783
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lplincreases expressionISOLpl (Mus musculus)6480464CTDtolclofos-methyl results in increased expression of LPL mRNAPMID:33872936
Lplmultiple interactionsISOLpl (Mus musculus)6480464CTDFulvestrant inhibits the reaction [tolclofos-methyl results in increased expression of LPL mRNA]PMID:33872936
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