Egf (epidermal growth factor) - Rat Genome Database
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Gene: Egf (epidermal growth factor) Rattus norvegicus
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Symbol: Egf
Name: epidermal growth factor
RGD ID: 2542
Description: Exhibits epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; and positive regulation of nitrogen compound metabolic process. Localizes to extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: pro-epidermal growth factor
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
Celera2210,511,076 - 210,588,041 (-)NCBICelera
Cytogenetic Map2q21NCBI
RH 3.4 Map21556.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
cleft palate  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
gastric ulcer  (ISO)
Genetic Predisposition to Disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
malignant glioma  (ISO)
Metaplasia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
oligodendroglioma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (IDA)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
primary hypomagnesemia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal hypomagnesemia 3  (ISO)
renal hypomagnesemia 4  (ISO)
renal hypomagnesemia 5 with ocular involvement  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
shigellosis  (ISO)
Tympanic Membrane Perforation  (ISO)
Wounds and Injuries  (IEP,ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2',3'-dideoxyadenosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydrocoumarin  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,5-dianilinophthalimide  (EXP)
4-tert-Octylphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (ISO)
8-Br-cAMP  (ISO)
8-Hydroxyguanosine  (EXP)
acetaldehyde  (ISO)
actinomycin D  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
amsacrine  (ISO)
Anacardic acid  (ISO)
androgen antagonist  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asparagine  (EXP)
atrazine  (ISO)
bacitracin  (EXP)
bafilomycin A1  (EXP)
baicalein  (ISO)
baicalin  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
butan-1-ol  (EXP)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
canertinib  (ISO)
capsaicin  (EXP,ISO)
chelerythrine  (ISO)
chlorogenic acid  (ISO)
chloroquine  (EXP,ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
Clivoline  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (EXP)
cytochalasin D  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
DDE  (EXP)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (EXP,ISO)
ethanolamine  (ISO)
etoposide  (ISO)
farnesol  (ISO)
finasteride  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
fructose  (EXP)
fulvestrant  (EXP,ISO)
galangin  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geranylgeraniol  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
Glutethimide  (EXP)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
ketoconazole  (ISO)
L-arginine  (EXP)
L-aspartic acid  (EXP)
L-isoleucine  (EXP)
L-leucine  (EXP)
L-lysine  (EXP)
L-methionine  (EXP)
L-phenylalanine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
leupeptin  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
magnesium dichloride  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mestranol  (EXP)
methoxyacetic acid  (ISO)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (ISO)
mibolerone  (ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
ML-7  (EXP)
monensin A  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
muramyl dipeptide  (ISO)
myricetin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nafenopin  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nocodazole  (ISO)
okadaic acid  (EXP)
omeprazole  (ISO)
oridonin  (ISO)
ornithine  (EXP)
Osajin  (ISO)
osimertinib  (ISO)
oxidopamine  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perifosine  (ISO)
permethrin  (EXP)
peroxides  (EXP)
phenanthrolines  (EXP)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
primaquine  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
prostaglandin D2  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
Ro 31-8220  (EXP)
Rosavin  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Sodium salicylate  (ISO)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (EXP,ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
Swertiamarin  (EXP)
tamoxifen  (ISO)
taurine  (EXP)
tephrosin  (ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tyrosine  (EXP)
tyrphostin AG 1478  (EXP,ISO)
urethane  (ISO)
valine  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
XL147  (ISO)
Y-27632  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (ISO)
activation of MAPKK activity  (ISO)
angiogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
epidermal growth factor receptor signaling pathway  (IDA,ISO)
epidermal growth factor receptor signaling pathway via MAPK cascade  (ISO,ISS)
ERK1 and ERK2 cascade  (ISO)
intracellular signal transduction  (TAS)
kidney development  (IEP)
mammary gland alveolus development  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of secretion  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA binding  (ISO,ISS)
positive regulation of DNA biosynthetic process  (IDA)
positive regulation of DNA replication  (ISO,ISS)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epidermal growth factor-activated receptor activity  (ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to early endosome  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
regulation of calcium ion import  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of protein secretion  (IMP)
regulation of protein transport  (IDA)
regulation of receptor signaling pathway via JAK-STAT  (ISO,ISS)
signal transduction  (IEA)

Cellular Component

Molecular Function

References

References - curated
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67. Yukawa M, etal., Hum Pathol. 1993 Jan;24(1):37-40.
68. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
Additional References at PubMed
PMID:3000782   PMID:3262867   PMID:6315706   PMID:7641815   PMID:7678348   PMID:7736574   PMID:8240367   PMID:8702723   PMID:9030684   PMID:10027293   PMID:10331984   PMID:10559227  
PMID:11278445   PMID:11867627   PMID:11940581   PMID:12115579   PMID:12456804   PMID:12579338   PMID:12700634   PMID:12834262   PMID:14523024   PMID:14559717   PMID:14561752   PMID:14630916  
PMID:14712229   PMID:15051883   PMID:15156153   PMID:15254973   PMID:15331766   PMID:15361518   PMID:15380929   PMID:15509736   PMID:15611079   PMID:15695332   PMID:15701816   PMID:15793571  
PMID:15803132   PMID:15831470   PMID:15968738   PMID:16126730   PMID:16314496   PMID:16332692   PMID:16339969   PMID:16502470   PMID:16760267   PMID:16885413   PMID:16944045   PMID:17203207  
PMID:17324121   PMID:17349580   PMID:17626015   PMID:17631610   PMID:17897319   PMID:17962899   PMID:17975113   PMID:17982486   PMID:18332871   PMID:18401831   PMID:18441095   PMID:18567582  
PMID:18722344   PMID:18848961   PMID:19056867   PMID:19433789   PMID:19996314   PMID:20037141   PMID:20142421   PMID:20208556   PMID:20302655   PMID:20353436   PMID:20388803   PMID:20967565  
PMID:21082674   PMID:21186272   PMID:21187008   PMID:22298428   PMID:22514047   PMID:22645946   PMID:22732145   PMID:22926925   PMID:23376485   PMID:23467299   PMID:23533145   PMID:23599382  
PMID:23821047   PMID:23932386   PMID:24763928   PMID:24967966   PMID:25309082   PMID:25678558   PMID:25920966  


Genomics

Comparative Map Data
Egf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
Celera2210,511,076 - 210,588,041 (-)NCBICelera
Cytogenetic Map2q21NCBI
RH 3.4 Map21556.7RGD
EGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4109,912,883 - 110,013,766 (+)EnsemblGRCh38hg38GRCh38
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,834,040 - 110,934,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,746 (+)NCBICHM1_1
Egf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39mm39
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIGRCm37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBImm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
EGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,365 - 112,330,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI
EGF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBI
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)Ensembl

Position Markers
D2Rat61  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0268,865,414 - 68,866,454NCBIRnor6.0
Rnor_5.0288,594,475 - 88,595,515UniSTSRnor5.0
RGSC_v3.42227,150,051 - 227,150,248RGDRGSC3.4
RGSC_v3.42227,150,052 - 227,150,249UniSTSRGSC3.4
RGSC_v3.12227,136,731 - 227,136,928RGD
Celera2210,543,293 - 210,543,469UniSTS
Cytogenetic Map2q42-q43UniSTS
RH 3.4 Map21546.8UniSTS
RH 3.4 Map21546.8RGD
RH 2.0 Map21129.9RGD
SHRSP x BN Map288.6498RGD
FHH x ACI Map2101.7399RGD
RH133380  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02234,159,671 - 234,159,888NCBIRnor6.0
Rnor_6.02235,049,473 - 235,049,690NCBIRnor6.0
Rnor_5.0274,870,658 - 74,870,875UniSTSRnor5.0
Rnor_5.02253,481,697 - 253,481,914UniSTSRnor5.0
RGSC_v3.42227,104,023 - 227,104,240UniSTSRGSC3.4
Celera2210,511,199 - 210,511,416UniSTS
Cytogenetic Map2q42-q43UniSTS
RH 3.4 Map21556.0UniSTS
RH94666  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02235,177,882 - 235,178,146NCBIRnor6.0
Rnor_6.0268,819,745 - 68,820,009NCBIRnor6.0
Rnor_5.0288,548,875 - 88,549,139UniSTSRnor5.0
Rnor_5.0274,745,886 - 74,746,150UniSTSRnor5.0
RGSC_v3.42227,195,669 - 227,195,933UniSTSRGSC3.4
Celera2210,588,648 - 210,588,912UniSTS
Cytogenetic Map2q42-q43UniSTS
RH 3.4 Map21556.7UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)23127638105149020Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)2944467968866454Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22328064775687607Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)223837491149614623Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491169852800Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)223837491169852800Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)223837719169852670Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22618609783819822Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22618609783819822Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226186097135654963Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226186097142053534Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)227161361148295267Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)227161361148295267Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)227161361148295267Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227161361148295267Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22776030172760301Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23127237976272379Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23408817591101903Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23513320280133202Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)236245223112175725Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240171834105089682Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240171834105089682Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916169852800Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916195645082Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243133606217498545Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243133606217498545Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243141290114164944Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243141290114164944Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243141290154583160Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight as a percentage of body weight (CMO:0000654)24314978885642672Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243149788198704485Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246537589217498710Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25443669875687607Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256244671217498710Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25771560378466260Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25834410075687607Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260131410135646395Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)260325352106432915Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)260325352106432915Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)260325352147522851Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)260325686105059293Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261924251106924251Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828049217498710Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828236243550655Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)26886541480632096Rat
1581576Pur7Proteinuria QTL 70.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)26886541480632096Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)268865414169852800Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)26886645480631953Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)268866454149614466Rat


Related Rat Strains
The following Strains have been annotated to Egf
W

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:60
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000046113
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17
Low 3 27 15 11 15 8 11 4 6 7 8 8
Below cutoff 41 28 24 8 24 69 12 31 3

Sequence


Reference Sequences
RefSeq Acc Id: NM_012842   ⟹   NP_036974
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0268,820,616 - 68,895,537 (+)NCBI
Rnor_5.0288,549,746 - 88,621,570 (+)NCBI
Rnor_5.02253,481,574 - 253,482,579 (-)NCBI
RGSC_v3.42227,103,900 - 227,195,062 (-)RGD
Celera2210,511,076 - 210,588,041 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036974   ⟸   NM_012842
- Peptide Label: precursor
- UniProtKB: P07522 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
EGF-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691200
Promoter ID:EPDNEW_R1722
Type:single initiation site
Name:Egf_1
Description:epidermal growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1723  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0268,820,617 - 68,820,677EPDNEW
RGD ID:13691201
Promoter ID:EPDNEW_R1723
Type:single initiation site
Name:Egf_2
Description:epidermal growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1722  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0268,820,963 - 68,821,023EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2542 AgrOrtholog
Ensembl Genes ENSRNOG00000053979 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073099 UniProtKB/TrEMBL
  ENSRNOP00000074125 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075379 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083713 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000087007 UniProtKB/TrEMBL
  ENSRNOT00000089504 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623849 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro-epidermal_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25313 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72539 IMAGE-MGC_LOAD
NCBI Gene 25313 ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EGF RGD
PhenoGen Egf PhenoGen
PIRSF Pro-epidermal_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220642
UniGene Rn.6075 ENTREZGENE
UniProt A0A0G2K4M4_RAT UniProtKB/TrEMBL
  A0A0G2K7A3_RAT UniProtKB/TrEMBL
  A0A0G2KAF5_RAT UniProtKB/TrEMBL
  EGF_RAT UniProtKB/Swiss-Prot
  J9SG97_RAT UniProtKB/TrEMBL
  P07522 ENTREZGENE
UniProt Secondary Q63183 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Egf  epidermal growth factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression lacking in the stroma of dorsal and ventral lobes of young prostates but present in both the stroma and epithelium of aging prostates 70812
gene_expression present in many body fluids, especially in maternal milk including colostrum 70301
gene_physical_interaction present in the fetal and neonatal GI tract 70301
gene_physical_interaction stimulates several proteins to bind to 14-3-3 in the PI-3- kinase dependent pathway 629545
gene_process responsible for proliferation and differentiation of epithelial cells 70301
gene_process responsible for proliferation and differentiation of epithelial cells 70812
gene_process responsible for the healing of damaged gastrointestinal mucosa 70301
gene_process responsible for the healing of damaged gastrointestinal mucosa 70812
gene_process induces the activation of Mapk in lacrimal gland acinar cells 629545