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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfmultiple interactionsEXP 6480464CTDbisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein]; Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein]; TAPI-2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein]; Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein; Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]PMID:12947092
Egfincreases expressionISOEGF (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of EGF proteinPMID:19447859
Egfmultiple interactionsISOEgf (Mus musculus)6480464CTDTetradecanoylphorbol Acetate inhibits the reaction [EGF protein binds to EGFR protein]PMID:6309801
Egfmultiple interactionsISOEGF (Homo sapiens)6480464CTDpterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein]PMID:19447859
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