Egf (epidermal growth factor) - Rat Genome Database

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Gene: Egf (epidermal growth factor) Mus musculus
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Symbol: Egf
Name: epidermal growth factor
RGD ID: 10510
MGI Page MGI
Description: Enables epidermal growth factor receptor binding activity; receptor ligand activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including ERBB2-EGFR signaling pathway; negative regulation of cholesterol efflux; and positive regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of cell population proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Located in plasma membrane. Is active in extracellular space. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI790464; pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18238  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,471,214 - 129,548,965 (-)EnsemblGRCm39 Ensembl
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBIMGSCv36mm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
cleft palate  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
high grade glioma  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Metaplasia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
oligodendroglioma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
pneumonia  (IDA)
pre-malignant neoplasm  (ISO)
primary hypomagnesemia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal hypomagnesemia 3  (ISO)
renal hypomagnesemia 4  (ISO)
renal hypomagnesemia 5 with ocular involvement  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
shigellosis  (IDA)
Tympanic Membrane Perforation  (ISO)
Wounds and Injuries  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2',3'-dideoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydrocoumarin  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5-dianilinophthalimide  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
8-Hydroxyguanosine  (ISO)
acetaldehyde  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amsacrine  (ISO)
androgen antagonist  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asparagine  (ISO)
atrazine  (ISO)
bacitracin  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (ISO)
belinostat  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoic acid  (EXP)
berberine  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
canertinib  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
CHIR 99021  (ISO)
chlordecone  (EXP)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
Clivoline  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP,ISO)
cortisol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
cytochalasin D  (EXP)
D-glucose  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP,ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
ethanolamine  (ISO)
etoposide  (ISO)
farnesol  (ISO)
finasteride  (ISO)
flurbiprofen  (EXP)
flutamide  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geranylgeraniol  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (ISO)
Glutethimide  (ISO)
glycidol  (EXP,ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
heparin  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (EXP)
ibuprofen  (ISO)
icariside II  (ISO)
ICI-164384  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ionomycin  (ISO)
ketoconazole  (ISO)
L-arginine  (ISO)
L-aspartic acid  (ISO)
L-isoleucine  (ISO)
L-leucine  (ISO)
L-lysine  (ISO)
L-methionine  (ISO)
L-phenylalanine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
leupeptin  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
Maduramicin  (ISO)
magnesium dichloride  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mestranol  (ISO)
methoxyacetic acid  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (ISO)
mibolerone  (EXP)
midostaurin  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
ML-7  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
muramyl dipeptide  (EXP)
myricetin  (EXP)
N(6)-butyryl-cAMP  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nafenopin  (ISO)
naringin  (ISO)
nefazodone  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
nitenpyram  (ISO)
nitrofen  (ISO)
nocodazole  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oridonin  (ISO)
ornithine  (ISO)
Osajin  (ISO)
osimertinib  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
pamidronate  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perifosine  (ISO)
permethrin  (ISO)
peroxides  (ISO)
phenanthrolines  (ISO)
phencyclidine  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
primaquine  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
Ro 31-8220  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sepantronium  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Sodium salicylate  (EXP)
sorafenib  (ISO)
sotorasib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
sulfasalazine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
Swertiamarin  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tephrosin  (ISO)
teriflunomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triphenyl phosphate  (ISO)
tyrosine  (ISO)
tyrphostin AG 1478  (EXP,ISO)
urethane  (EXP)
valine  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
XL147  (EXP)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
branching morphogenesis of an epithelial tube  (IDA)
cell population proliferation  (IGI)
cerebellar granule cell precursor proliferation  (IDA)
epidermal growth factor receptor signaling pathway  (IBA,IDA,IGI,ISO)
epithelial cell proliferation  (IGI)
ERBB2-EGFR signaling pathway  (IDA,ISO)
ERK1 and ERK2 cascade  (ISO)
kidney development  (ISO)
mammary gland alveolus development  (IGI)
negative regulation of cholesterol efflux  (IDA)
negative regulation of secretion  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,IDA,IGI,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (IDA)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IGI)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of MAPK cascade  (IBA,IDA,ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein localization to early endosome  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IDA)
regulation of calcium ion import  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (IDA)
regulation of protein localization to cell surface  (ISO)
regulation of protein transport  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues. Abraham JA, etal., Biochem Biophys Res Commun 1993 Jan 15;190(1):125-33.
2. Serum levels of epidermal growth factor, transforming growth factor, and c-erbB2 in ovarian cancer. Balcan E, etal., Int J Gynecol Cancer. 2012 Sep;22(7):1138-42. doi: 10.1097/IGC.0b013e31825b7dcc.
3. Serum calprotectin, CD26 and EGF to establish a panel for the diagnosis of lung cancer. Blanco-Prieto S, etal., PLoS One. 2015 May 18;10(5):e0127318. doi: 10.1371/journal.pone.0127318. eCollection 2015.
4. [Effects of Wenshen Jianpi Recipe on chronic wound healing in rats]. Cao YQ, etal., Zhong Xi Yi Jie He Xue Bao. 2005 May;3(3):220-4.
5. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Chen-Plotkin AS, etal., Ann Neurol. 2011 Apr;69(4):655-63. doi: 10.1002/ana.22271. Epub 2010 Nov 29.
6. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Cibrian D, etal., Clin Sci (Lond). 2006 May;110(5):563-73.
7. Association between functional EGF+61 polymorphism and glioma risk. Costa BM, etal., Clin Cancer Res. 2007 May 1;13(9):2621-6. doi: 10.1158/1078-0432.CCR-06-2606.
8. Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. da Silveira Fd, etal., J Cancer Res Clin Oncol. 2012 Aug;138(8):1347-54. doi: 10.1007/s00432-012-1203-5. Epub 2012 Apr 6.
9. Cytokine profiling in patients with VCP-associated disease. Dec E, etal., Clin Transl Sci. 2014 Feb;7(1):29-32. doi: 10.1111/cts.12117. Epub 2013 Oct 3.
10. Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia. Dominguez JA, etal., Shock. 2011 Oct;36(4):381-9.
11. Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth factor for prevention of experimental necrotizing enterocolitis. Dvorak B, etal., J Pediatr Gastroenterol Nutr. 2008 Jul;47(1):11-8. doi: 10.1097/MPG.0b013e3181788618.
12. [Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma]. Dznelashvili N, etal., Georgian Med News. 2014 Oct;(235):17-24.
13. Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival. Einarsdóttir K, etal., Br J Cancer. 2009 Apr 21;100(8):1358-64. doi: 10.1038/sj.bjc.6604984. Epub 2009 Mar 24.
14. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Futamura T, etal., Mol Psychiatry. 2002;7(7):673-82.
15. Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. Groenestege WM, etal., J Clin Invest. 2007 Aug;117(8):2260-7.
16. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
17. Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients. Hochstrasser T, etal., Curr Alzheimer Res. 2012 Oct;9(8):982-9.
18. The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression. Jurkowska G, etal., Adv Med Sci. 2014 Sep;59(2):221-6. doi: 10.1016/j.advms.2014.01.006. Epub 2014 Jun 9.
19. Changes in hepatic cell junctions structure during experimental necrotizing enterocolitis: effect of EGF treatment. Khailova L, etal., Pediatr Res. 2009 Aug;66(2):140-4.
20. A functional polymorphism in the epidermal growth factor gene is associated with risk for glioma in a Chinese population. Li Y, etal., Genet Test Mol Biomarkers. 2012 May;16(5):449-52. doi: 10.1089/gtmb.2011.0258. Epub 2011 Nov 22.
21. Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study. Liangos O, etal., Biomarkers. 2010 Aug;15(5):436-45.
22. Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy. Lindenmeyer MT, etal., J Am Soc Nephrol. 2007 Jun;18(6):1765-76. Epub 2007 May 2.
23. Clinical Implication of EGF A61G Polymorphism in the Risk of Non Small Cell Lung Adenocarcinoma Patients: A Case Control Study. Masroor M, etal., Asian Pac J Cancer Prev. 2015;16(17):7529-34.
24. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
25. MGDs mouse GO annotations MGD data from the GO Consortium
26. MGD IEA MGD IEA
27. Epidermal Growth Factor Receptor-Responsive Indoleamine 2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri Infection. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Epidermal Growth Factor Serum Levels and the 61 G/A Polymorphism in Patients with Acute Pancreatitis. Papachristou GI, etal., Dig Dis Sci. 2010 Feb 3.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma. Pryczynicz A, etal., Anticancer Res. 2008 Mar-Apr;28(2B):1399-404.
33. Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis. Reich HN, etal., J Mol Diagn. 2011 Mar;13(2):143-51.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. A Phase III Clinical Trial of the Epidermal Growth Factor Vaccine CIMAvax-EGF as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients. Rodriguez PC, etal., Clin Cancer Res. 2016 Aug 1;22(15):3782-90. doi: 10.1158/1078-0432.CCR-15-0855. Epub 2016 Feb 29.
38. CIMAvax-EGF: A New Therapeutic Vaccine for Advanced Non-Small Cell Lung Cancer Patients. Saavedra D and Crombet T, Front Immunol. 2017 Mar 13;8:269. doi: 10.3389/fimmu.2017.00269. eCollection 2017.
39. Salivary and gastric epidermal growth factor in patients with Zollinger-Ellison syndrome: its protective potential. Sarosiek J, etal., Am J Gastroenterol. 2000 May;95(5):1158-65.
40. Identification and partial characterization of multiple forms of biologically active EGF in rat milk. Schaudies RP, etal., Am J Physiol. 1990 Dec;259(6 Pt 1):G1056-61.
41. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
42. A urinary biomarker profile for children with HIV-associated renal diseases. Soler-Garcia AA, etal., Kidney Int. 2009 Jul;76(2):207-14. Epub 2009 Apr 8.
43. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. Tanabe KK, etal., JAMA. 2008 Jan 2;299(1):53-60. doi: 10.1001/jama.2007.65.
44. Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. Vishnoi M, etal., Hum Immunol. 2008 Jun;69(6):360-7. Epub 2008 May 6.
45. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
46. Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China. Wu J, etal., Genet Test Mol Biomarkers. 2013 Aug;17(8):595-600. doi: 10.1089/gtmb.2013.0031. Epub 2013 Jun 22.
47. The immunohistochemical expressions of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer. Yamanaka Y Nippon Ika Daigaku Zasshi. 1992 Feb;59(1):51-61.
48. Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer, and chronic cholecystitis. Yukawa M, etal., Hum Pathol. 1993 Jan;24(1):37-40.
Additional References at PubMed
PMID:1349842   PMID:1426645   PMID:1442934   PMID:1445923   PMID:1577403   PMID:1578263   PMID:1617215   PMID:1676977   PMID:1716634   PMID:1726866   PMID:1728582   PMID:1731873  
PMID:1764058   PMID:1783375   PMID:1898268   PMID:1968405   PMID:2542863   PMID:2574151   PMID:2663575   PMID:2676841   PMID:2885848   PMID:2897103   PMID:3076779   PMID:3871506  
PMID:3871525   PMID:4636327   PMID:4750422   PMID:6248866   PMID:6304537   PMID:6315413   PMID:6315706   PMID:6602382   PMID:7523515   PMID:7538664   PMID:7544156   PMID:7588322  
PMID:7590736   PMID:7595133   PMID:7608209   PMID:7640657   PMID:7641815   PMID:7678348   PMID:7724532   PMID:7743917   PMID:7751935   PMID:7752576   PMID:7781894   PMID:7819439  
PMID:7881126   PMID:7910583   PMID:7932371   PMID:7951532   PMID:7956906   PMID:8013342   PMID:8026321   PMID:8034329   PMID:8036006   PMID:8063822   PMID:8071311   PMID:8076525  
PMID:8086337   PMID:8231109   PMID:8240367   PMID:8266997   PMID:8292539   PMID:8344470   PMID:8349621   PMID:8364887   PMID:8378774   PMID:8395365   PMID:8419117   PMID:8449508  
PMID:8504737   PMID:8565823   PMID:8593821   PMID:8600155   PMID:8604219   PMID:8660964   PMID:8661727   PMID:8702723   PMID:8706788   PMID:8770913   PMID:8800404   PMID:8833158  
PMID:8901048   PMID:8901633   PMID:8906120   PMID:8937653   PMID:8940071   PMID:9022052   PMID:9030684   PMID:9165054   PMID:9261927   PMID:9264259   PMID:9275222   PMID:9281334  
PMID:9285326   PMID:9305636   PMID:9305638   PMID:9367891   PMID:9367982   PMID:9390635   PMID:9403069   PMID:9504046   PMID:9529375   PMID:9832315   PMID:9890455   PMID:10027293  
PMID:10082370   PMID:10331984   PMID:10349636   PMID:10441734   PMID:10521784   PMID:10700187   PMID:10753509   PMID:10926756   PMID:10964941   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11336639   PMID:11387238   PMID:11399798   PMID:11438495   PMID:11518516   PMID:11553295   PMID:11707574   PMID:11773073   PMID:11822870   PMID:11823423   PMID:11825889   PMID:11841993  
PMID:11884396   PMID:11909964   PMID:11940581   PMID:11956170   PMID:12162747   PMID:12372343   PMID:12399441   PMID:12426576   PMID:12466851   PMID:12477932   PMID:12495619   PMID:12520078  
PMID:12700634   PMID:12714603   PMID:12761849   PMID:12837294   PMID:12878679   PMID:12880367   PMID:12919676   PMID:12960147   PMID:12967642   PMID:14514757   PMID:14514962   PMID:14561752  
PMID:14627991   PMID:14643177   PMID:14662770   PMID:14668448   PMID:14712229   PMID:14747473   PMID:14964469   PMID:15051883   PMID:15103386   PMID:15149844   PMID:15156153   PMID:15314086  
PMID:15375216   PMID:15380929   PMID:15456865   PMID:15489334   PMID:15509736   PMID:15522985   PMID:15525267   PMID:15572151   PMID:15633125   PMID:15652340   PMID:15695332   PMID:15747579  
PMID:15790735   PMID:15799028   PMID:15811345   PMID:15831470   PMID:15987744   PMID:16014027   PMID:16019431   PMID:16054021   PMID:16141072   PMID:16141073   PMID:16339969   PMID:16400024  
PMID:16517600   PMID:16574995   PMID:16675530   PMID:16727441   PMID:16773716   PMID:17223098   PMID:17626015   PMID:17673689   PMID:17991704   PMID:18069687   PMID:18165319   PMID:18287559  
PMID:18441095   PMID:18691227   PMID:18838072   PMID:19081071   PMID:19196031   PMID:19218245   PMID:19273609   PMID:19328792   PMID:19330341   PMID:19341767   PMID:19474150   PMID:19500387  
PMID:19571236   PMID:19629819   PMID:19710174   PMID:19723622   PMID:20032199   PMID:20037141   PMID:20080754   PMID:20087964   PMID:20095053   PMID:20133770   PMID:20208556   PMID:20371608  
PMID:20392696   PMID:20444693   PMID:20462955   PMID:20472833   PMID:20606012   PMID:20705924   PMID:20714325   PMID:20843830   PMID:20870721   PMID:20878766   PMID:20881363   PMID:21098035  
PMID:21186272   PMID:21209099   PMID:21293035   PMID:21350188   PMID:21464922   PMID:21512138   PMID:21624348   PMID:21660950   PMID:21666233   PMID:21767580   PMID:21873635   PMID:22035642  
PMID:22160594   PMID:22294205   PMID:22426781   PMID:22493503   PMID:22514047   PMID:22682244   PMID:22798669   PMID:22822073   PMID:23135700   PMID:23168795   PMID:23241343   PMID:23362023  
PMID:23377280   PMID:23629862   PMID:23669345   PMID:23669645   PMID:23787120   PMID:23831329   PMID:23843455   PMID:23896528   PMID:23982810   PMID:24126105   PMID:24126741   PMID:24215827  
PMID:24227310   PMID:24337738   PMID:24389165   PMID:24492000   PMID:24628338   PMID:24825892   PMID:24907656   PMID:24952961   PMID:24967966   PMID:25260751   PMID:25410786   PMID:25504289  
PMID:25641696   PMID:25730472   PMID:25782989   PMID:25925840   PMID:26022336   PMID:26492470   PMID:26574435   PMID:26764350   PMID:26930157   PMID:27096934   PMID:27109378   PMID:28290610  
PMID:28305731   PMID:28818950   PMID:28827448   PMID:29058721   PMID:29438518   PMID:29532549   PMID:29638228   PMID:29862299   PMID:30084919   PMID:31221639   PMID:31638299   PMID:31754329  
PMID:32301281   PMID:32325033   PMID:32478376   PMID:32531471   PMID:32553120   PMID:32708917   PMID:32719388   PMID:33009641   PMID:35442545   PMID:36915679   PMID:37138025   PMID:37977137  


Genomics

Comparative Map Data
Egf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,471,214 - 129,548,965 (-)EnsemblGRCm39 Ensembl
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBIMGSCv36mm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
EGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,912,883 - 110,013,766 (+)EnsemblGRCh38hg38GRCh38
GRCh374110,834,039 - 110,934,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36Build 36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,629 (+)NCBICHM1_1
T2T-CHM13v2.04113,214,975 - 113,315,858 (+)NCBIT2T-CHM13v2.0
Egf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,893,660 - 220,976,331 (-)NCBIGRCr8
mRatBN7.22218,219,408 - 218,302,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,219,415 - 218,302,064 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,907,754 - 225,986,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,807,431 - 223,886,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,665,094 - 218,744,036 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
Celera2210,511,076 - 210,588,041 (-)NCBICelera
RH 3.4 Map21556.7RGD
Cytogenetic Map2q43NCBI
Egf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496328,075 - 401,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955496325,954 - 401,430 (-)NCBIChiLan1.0ChiLan1.0
EGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,005,905 - 108,105,686 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,299,162 - 108,398,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,410,724 - 102,509,691 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,977,565 - 113,075,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,977,565 - 113,076,460 (+)Ensemblpanpan1.1panPan2
EGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,073,541 - 30,166,904 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,073,950 - 30,166,295 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,863,120 - 11,956,432 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,294,579 - 30,388,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,294,820 - 30,388,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,288,558 - 30,381,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,031,820 - 30,125,429 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,723,676 - 9,817,337 (-)NCBIUU_Cfam_GSD_1.0
Egf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,767,839 - 10,855,510 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365631,058,803 - 1,181,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,386 - 112,330,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI
EGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,484,638 - 36,584,482 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Egf
2618 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:170
Interacting mature miRNAs:203
Transcripts:ENSMUST00000029653
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3124993649137205761Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse

Markers in Region
J00380  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383129,678,023 - 129,678,214UniSTSGRCm38
MGSCv373129,380,941 - 129,381,132UniSTSGRCm37
Celera3136,187,888 - 136,188,079UniSTS
Cytogenetic Map3G3UniSTS
cM Map365.2UniSTS
Whitehead_YAC1 UniSTS
Egf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv373129,380,602 - 129,380,791UniSTSGRCm37
Celera3136,187,549 - 136,187,738UniSTS
Cytogenetic Map3G3UniSTS
cM Map365.2UniSTS
AI790464  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383129,677,917 - 129,678,004UniSTSGRCm38
MGSCv373129,380,835 - 129,380,922UniSTSGRCm37
Celera3136,187,782 - 136,187,869UniSTS
Cytogenetic Map3G3UniSTS
cM Map365.2UniSTS
Whitehead/MRC_RH31469.31UniSTS
Whitehead/MRC_RH31468.75UniSTS
Egf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
cM Map365.2UniSTS
Egf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383129,677,684 - 129,677,873UniSTSGRCm38
MGSCv373129,380,602 - 129,380,791UniSTSGRCm37
Celera3136,187,549 - 136,187,738UniSTS
Cytogenetic Map3G3UniSTS
cM Map365.2UniSTS
Egf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Egf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Egf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001310737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001329594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006500990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001783650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB635280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP761200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X08047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000029653   ⟹   ENSMUSP00000029653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,471,214 - 129,548,965 (-)Ensembl
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197079   ⟹   ENSMUSP00000143075
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,471,227 - 129,518,736 (-)Ensembl
GRCm38.p6 Ensembl3129,677,578 - 129,725,087 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197250
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,471,986 - 129,475,195 (-)Ensembl
GRCm38.p6 Ensembl3129,678,337 - 129,681,546 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197713   ⟹   ENSMUSP00000143108
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,493,110 - 129,518,735 (-)Ensembl
GRCm38.p6 Ensembl3129,699,461 - 129,725,086 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,530,571 - 129,548,965 (-)Ensembl
GRCm38.p6 Ensembl3129,736,922 - 129,755,316 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198816
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,529,099 - 129,548,965 (-)Ensembl
GRCm38.p6 Ensembl3129,735,450 - 129,755,316 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199209
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,479,834 - 129,486,731 (-)Ensembl
GRCm38.p6 Ensembl3129,686,185 - 129,693,082 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199272
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,486,013 - 129,488,926 (-)Ensembl
GRCm38.p6 Ensembl3129,692,364 - 129,695,277 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199615   ⟹   ENSMUSP00000142497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,471,229 - 129,518,726 (-)Ensembl
GRCm38.p6 Ensembl3129,677,580 - 129,725,077 (-)Ensembl
RefSeq Acc Id: NM_001310737   ⟹   NP_001297666
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,226 - 129,518,735 (-)NCBI
GRCm383129,677,577 - 129,725,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001329594   ⟹   NP_001316523
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,226 - 129,518,735 (-)NCBI
GRCm383129,677,577 - 129,725,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010113   ⟹   NP_034243
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,226 - 129,548,971 (-)NCBI
GRCm383129,677,577 - 129,755,322 (-)NCBI
MGSCv373129,380,493 - 129,458,240 (-)RGD
Celera3136,187,440 - 136,268,006 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006500990   ⟹   XP_006501053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,223 - 129,548,891 (-)NCBI
GRCm383129,677,574 - 129,755,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240010   ⟹   XP_011238312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,223 - 129,548,891 (-)NCBI
GRCm383129,677,574 - 129,755,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240011   ⟹   XP_011238313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,223 - 129,548,891 (-)NCBI
GRCm383129,677,574 - 129,755,098 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001783650
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,223 - 129,548,891 (-)NCBI
GRCm383129,696,818 - 129,755,098 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004941276
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,223 - 129,548,891 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004941277
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,471,223 - 129,548,891 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034243   ⟸   NM_010113
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q569W5 (UniProtKB/Swiss-Prot),   E9QNX6 (UniProtKB/Swiss-Prot),   Q6P9J2 (UniProtKB/Swiss-Prot),   P01132 (UniProtKB/Swiss-Prot),   Q8VD07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501053   ⟸   XM_006500990
- Peptide Label: isoform X3
- UniProtKB: Q8VD07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238313   ⟸   XM_011240011
- Peptide Label: isoform X2
- UniProtKB: Q8VD07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238312   ⟸   XM_011240010
- Peptide Label: isoform X1
- UniProtKB: Q8VD07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001297666   ⟸   NM_001310737
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JF92 (UniProtKB/TrEMBL),   Q3UWD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316523   ⟸   NM_001329594
- Peptide Label: isoform 3
- UniProtKB: A0A0G2JDT8 (UniProtKB/TrEMBL),   Q3UWD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000143075   ⟸   ENSMUST00000197079
RefSeq Acc Id: ENSMUSP00000143108   ⟸   ENSMUST00000197713
RefSeq Acc Id: ENSMUSP00000029653   ⟸   ENSMUST00000029653
RefSeq Acc Id: ENSMUSP00000142497   ⟸   ENSMUST00000199615
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01132-F1-model_v2 AlphaFold P01132 1-1217 view protein structure

Promoters
RGD ID:6833679
Promoter ID:MM_KWN:36075
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:UC008RIG.1,   UC008RII.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363129,427,936 - 129,428,502 (-)MPROMDB
RGD ID:6833681
Promoter ID:MM_KWN:36077
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_010113,   UC008RIJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363129,458,036 - 129,458,536 (-)MPROMDB
RGD ID:6882344
Promoter ID:EPDNEW_M4623
Type:multiple initiation site
Name:Egf_1
Description:Mus musculus epidermal growth factor , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383129,725,086 - 129,725,146EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95290 AgrOrtholog
Ensembl Genes ENSMUSG00000028017 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029653 ENTREZGENE
  ENSMUST00000029653.7 UniProtKB/Swiss-Prot
  ENSMUST00000197079 ENTREZGENE
  ENSMUST00000197079.5 UniProtKB/TrEMBL
  ENSMUST00000197713.2 UniProtKB/TrEMBL
  ENSMUST00000199615 ENTREZGENE
  ENSMUST00000199615.5 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro-epidermal_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95290 ENTREZGENE
NCBI Gene 13645 ENTREZGENE
PANTHER PRO-EPIDERMAL GROWTH FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EGF RGD
PhenoGen Egf PhenoGen
PIRSF Pro-epidermal_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EGFTGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JF92 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JFB8_MOUSE UniProtKB/TrEMBL
  E9QNX6 ENTREZGENE
  EGF_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UWD7 ENTREZGENE, UniProtKB/TrEMBL
  Q569W5 ENTREZGENE
  Q6P9J2 ENTREZGENE
  Q8VD07 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9QNX6 UniProtKB/Swiss-Prot
  Q569W5 UniProtKB/Swiss-Prot
  Q6P9J2 UniProtKB/Swiss-Prot