EGF (epidermal growth factor) - Rat Genome Database
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Gene: EGF (epidermal growth factor) Homo sapiens
Analyze
Symbol: EGF
Name: epidermal growth factor
RGD ID: 736832
HGNC Page HGNC
Description: Exhibits Ras guanyl-nucleotide exchange factor activity and growth factor activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of cellular metabolic process; and regulation of cellular protein localization. Localizes to extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; lupus nephritis; neurodegenerative disease (multiple); pancreatic cancer (multiple); and pancreatitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-urogastrone; HOMG4; pro-epidermal growth factor; URG
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4109,912,883 - 110,013,766 (+)EnsemblGRCh38hg38GRCh38
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,834,040 - 110,934,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
adenocarcinoma  (EXP)
AIDS-Associated Nephropathy  (IEP)
Alzheimer's disease  (IEP)
autistic disorder  (EXP)
Breast Neoplasms  (EXP)
cleft palate  (EXP)
dermatitis  (EXP)
Diabetic Nephropathies  (IEP)
Disease Progression  (EXP)
endometrial cancer  (IAGP)
Endometrial Neoplasms  (IEP)
Experimental Liver Cirrhosis  (EXP)
gallbladder cancer  (IAGP,IEP)
gastric ulcer  (EXP)
Genetic Predisposition to Disease  (EXP)
glioblastoma  (EXP,IAGP)
Helicobacter Infections  (IEP)
hepatocellular carcinoma  (EXP,IAGP)
hereditary renal cell carcinoma  (IAGP)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (IEP)
juvenile rheumatoid arthritis  (EXP)
kidney disease  (EXP)
lung adenocarcinoma  (IAGP)
lung non-small cell carcinoma  (IDA,IEP)
lupus nephritis  (IEP)
malignant glioma  (IAGP)
Metaplasia  (EXP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP)
Neoplastic Cell Transformation  (EXP)
oligodendroglioma  (IAGP)
ovarian cancer  (IEP)
pancreatic cancer  (IEP,TAS)
pancreatic ductal carcinoma  (IEP)
pancreatitis  (IEP)
Parkinson's disease  (IEP)
perinatal necrotizing enterocolitis  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (EXP)
primary hypomagnesemia  (IAGP)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (EXP)
renal hypomagnesemia 3  (IAGP)
renal hypomagnesemia 4  (IAGP)
renal hypomagnesemia 5 with ocular involvement  (IAGP)
Reperfusion Injury  (EXP,IDA)
schizophrenia  (IEP)
shigellosis  (ISO)
Tympanic Membrane Perforation  (IDA)
Wounds and Injuries  (EXP,ISO)
Zollinger-Ellison syndrome  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-ginsenoside Rg3  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (EXP)
(R)-noradrenaline  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
2',3'-dideoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydrocoumarin  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,5-dianilinophthalimide  (ISO)
4-tert-Octylphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-chrysenamine  (ISO)
8-Br-cAMP  (ISO)
8-Hydroxyguanosine  (ISO)
acetaldehyde  (EXP)
actinomycin D  (ISO)
afatinib  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
amsacrine  (EXP)
Anacardic acid  (EXP)
androgen antagonist  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asparagine  (ISO)
atrazine  (EXP)
bacitracin  (ISO)
bafilomycin A1  (ISO)
baicalein  (EXP)
baicalin  (EXP)
belinostat  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (EXP)
butan-1-ol  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
canertinib  (EXP)
capsaicin  (EXP,ISO)
chelerythrine  (EXP)
chlorogenic acid  (EXP)
chloroquine  (EXP,ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
Clivoline  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (EXP)
crizotinib  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP)
dactolisib  (EXP)
daunorubicin  (EXP)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (EXP)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (EXP,ISO)
ethanolamine  (EXP)
etoposide  (EXP)
farnesol  (EXP)
finasteride  (ISO)
flurbiprofen  (ISO)
flutamide  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
galangin  (EXP)
gallic acid  (EXP)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geranylgeraniol  (EXP)
glafenine  (ISO)
glucose  (EXP)
glutathione  (ISO)
Glutethimide  (ISO)
Goe 6976  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
heparin  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxamic acid  (ISO)
ibuprofen  (EXP)
icariside II  (EXP)
indometacin  (EXP,ISO)
inulin  (EXP)
ionomycin  (EXP)
ketoconazole  (EXP)
L-arginine  (ISO)
L-aspartic acid  (ISO)
L-isoleucine  (ISO)
L-leucine  (ISO)
L-lysine  (ISO)
L-methionine  (ISO)
L-phenylalanine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
leupeptin  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
lovastatin  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
magnesium dichloride  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mestranol  (ISO)
methoxyacetic acid  (EXP)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (EXP)
mibolerone  (ISO)
midostaurin  (EXP)
mifepristone  (EXP,ISO)
mitomycin C  (EXP)
ML-7  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
muramyl dipeptide  (ISO)
myricetin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nafenopin  (ISO)
naringin  (EXP)
nefazodone  (ISO)
nevirapine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
Niclosamide  (EXP)
nimesulide  (ISO)
nitrofen  (ISO)
nocodazole  (EXP)
okadaic acid  (ISO)
omeprazole  (ISO)
oridonin  (EXP)
ornithine  (ISO)
Osajin  (EXP)
osimertinib  (EXP)
oxidopamine  (ISO)
p-chloromercuribenzoic acid  (EXP)
p-tert-Amylphenol  (ISO)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
perifosine  (EXP)
permethrin  (ISO)
peroxides  (ISO)
phenanthrolines  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
Pomiferin  (EXP)
primaquine  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
pterostilbene  (EXP)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
Ro 31-8220  (ISO)
Rosavin  (EXP)
rotenone  (EXP,ISO)
rutin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
sorafenib  (EXP)
stattic  (EXP)
staurosporine  (EXP,ISO)
sulfasalazine  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
Swertiamarin  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
tephrosin  (EXP)
teriflunomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
tyrosine  (ISO)
tyrphostin AG 1478  (EXP,ISO)
urethane  (ISO)
valine  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (EXP,ISO)
XL147  (ISO)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (IEA)
activation of MAPKK activity  (IEA)
activation of transmembrane receptor protein tyrosine kinase activity  (IEA)
angiogenesis  (IDA)
branching morphogenesis of an epithelial tube  (IEA)
epidermal growth factor receptor signaling pathway  (IDA,TAS)
epidermal growth factor receptor signaling pathway via MAPK cascade  (IMP)
ERBB2 signaling pathway  (TAS)
ERK1 and ERK2 cascade  (IDA)
kidney development  (ISO)
mammary gland alveolus development  (IEA)
MAPK cascade  (TAS)
membrane organization  (TAS)
negative regulation of cholesterol efflux  (IEA)
negative regulation of epidermal growth factor receptor signaling pathway  (TAS)
negative regulation of ERBB signaling pathway  (TAS)
negative regulation of Notch signaling pathway  (TAS)
negative regulation of secretion  (IDA)
peptidyl-tyrosine phosphorylation  (IEA)
platelet degranulation  (TAS)
positive regulation of canonical Wnt signaling pathway  (IDA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of cerebellar granule cell precursor proliferation  (IEA)
positive regulation of DNA binding  (ISS)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of endothelial cell migration  (IDA)
positive regulation of endothelial cell proliferation  (IDA)
positive regulation of epidermal growth factor-activated receptor activity  (IDA,IMP,TAS)
positive regulation of epithelial tube formation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of hyaluronan biosynthetic process  (IDA)
positive regulation of MAP kinase activity  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of mitotic nuclear division  (IDA)
positive regulation of peptidyl-threonine phosphorylation  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IGI)
positive regulation of phosphorylation  (IDA)
positive regulation of protein kinase B signaling  (IDA,TAS)
positive regulation of protein localization to early endosome  (IDA)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (IDA)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA)
regulation of calcium ion import  (IDA)
regulation of cell motility  (TAS)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of protein localization to cell surface  (IDA)
regulation of protein secretion  (ISO)
regulation of protein transport  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISS)
signal transduction  (TAS)

Cellular Component

References

References - curated
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Additional References at PubMed
PMID:300079   PMID:1281549   PMID:1334406   PMID:1372091   PMID:1501243   PMID:1522591   PMID:1639032   PMID:2789514   PMID:2790960   PMID:3486749   PMID:3491360   PMID:6290982  
PMID:6382023   PMID:6603475   PMID:7540053   PMID:7558411   PMID:7615511   PMID:7640657   PMID:7730382   PMID:7736574   PMID:8077234   PMID:8123596   PMID:8413296   PMID:8419140  
PMID:8639530   PMID:8796265   PMID:8845374   PMID:9020193   PMID:9135143   PMID:9188692   PMID:9356464   PMID:9482941   PMID:9544989   PMID:9661876   PMID:9687510   PMID:9712850  
PMID:9925763   PMID:10085134   PMID:10199559   PMID:10436156   PMID:10559227   PMID:10567358   PMID:10579352   PMID:10648629   PMID:10734310   PMID:10748174   PMID:10788520   PMID:10913131  
PMID:10973965   PMID:11438527   PMID:11751923   PMID:11786904   PMID:11796824   PMID:11823423   PMID:11844511   PMID:11894095   PMID:11896055   PMID:11903419   PMID:11914075   PMID:11925427  
PMID:11950840   PMID:11971908   PMID:11994282   PMID:12009575   PMID:12093292   PMID:12138086   PMID:12141529   PMID:12163055   PMID:12163506   PMID:12202942   PMID:12218189   PMID:12297050  
PMID:12368284   PMID:12388817   PMID:12397374   PMID:12425525   PMID:12477932   PMID:12508124   PMID:12531699   PMID:12540376   PMID:12593796   PMID:12620237   PMID:12637502   PMID:12643788  
PMID:12667326   PMID:12672817   PMID:12722480   PMID:12768436   PMID:12788694   PMID:12795334   PMID:12879019   PMID:12954631   PMID:12960147   PMID:14507446   PMID:14520709   PMID:14523024  
PMID:14560030   PMID:14614718   PMID:14651960   PMID:14662770   PMID:14665621   PMID:14676838   PMID:15003992   PMID:15063762   PMID:15081423   PMID:15087376   PMID:15129177   PMID:15175028  
PMID:15180992   PMID:15183666   PMID:15192046   PMID:15194442   PMID:15252009   PMID:15256384   PMID:15260478   PMID:15272014   PMID:15329330   PMID:15373781   PMID:15373782   PMID:15373802  
PMID:15475003   PMID:15481560   PMID:15485655   PMID:15485674   PMID:15488707   PMID:15489334   PMID:15491342   PMID:15509542   PMID:15536154   PMID:15574420   PMID:15611079   PMID:15613483  
PMID:15620700   PMID:15622242   PMID:15659382   PMID:15663953   PMID:15675968   PMID:15729146   PMID:15735691   PMID:15748906   PMID:15798095   PMID:15802268   PMID:15837620   PMID:15860930  
PMID:15886816   PMID:15901830   PMID:15913871   PMID:15950078   PMID:15950906   PMID:15962011   PMID:15982634   PMID:16019439   PMID:16033767   PMID:16115648   PMID:16134968   PMID:16210470  
PMID:16214932   PMID:16248985   PMID:16274239   PMID:16274250   PMID:16282324   PMID:16314496   PMID:16316319   PMID:16332692   PMID:16344560   PMID:16407418   PMID:16407834   PMID:16413767  
PMID:16428382   PMID:16436184   PMID:16502470   PMID:16584205   PMID:16636672   PMID:16691190   PMID:16728406   PMID:16762922   PMID:16788380   PMID:16820871   PMID:16837648   PMID:16847055  
PMID:16872636   PMID:16885506   PMID:16939220   PMID:16946702   PMID:16969495   PMID:16979250   PMID:17123472   PMID:17175377   PMID:17204151   PMID:17223314   PMID:17227756   PMID:17311928  
PMID:17316357   PMID:17324121   PMID:17334773   PMID:17349580   PMID:17392355   PMID:17397984   PMID:17433039   PMID:17453000   PMID:17479438   PMID:17545148   PMID:17562024   PMID:17567965  
PMID:17573555   PMID:17578349   PMID:17612563   PMID:17617058   PMID:17626784   PMID:17634901   PMID:17661145   PMID:17673689   PMID:17697999   PMID:17762162   PMID:17851837   PMID:17852426  
PMID:17897319   PMID:17898861   PMID:17912028   PMID:17940864   PMID:17943082   PMID:17950068   PMID:17962208   PMID:17968796   PMID:17986122   PMID:17991726   PMID:17991733   PMID:18006148  
PMID:18036246   PMID:18080773   PMID:18088275   PMID:18094008   PMID:18096367   PMID:18156174   PMID:18187620   PMID:18212060   PMID:18271526   PMID:18271972   PMID:18276761   PMID:18292095  
PMID:18325497   PMID:18349392   PMID:18365874   PMID:18382118   PMID:18398039   PMID:18434322   PMID:18441095   PMID:18463167   PMID:18467441   PMID:18483390   PMID:18485152   PMID:18487214  
PMID:18490463   PMID:18511414   PMID:18519765   PMID:18543351   PMID:18567582   PMID:18583979   PMID:18632979   PMID:18676680   PMID:18722344   PMID:18722874   PMID:18757521   PMID:18773861  
PMID:18813355   PMID:18831963   PMID:18844210   PMID:18990689   PMID:19010984   PMID:19011936   PMID:19014905   PMID:19020743   PMID:19032382   PMID:19056867   PMID:19064572   PMID:19073827  
PMID:19074885   PMID:19081071   PMID:19086053   PMID:19087984   PMID:19110611   PMID:19124506   PMID:19127217   PMID:19141999   PMID:19144868   PMID:19167371   PMID:19170196   PMID:19172394  
PMID:19179548   PMID:19203995   PMID:19236842   PMID:19336395   PMID:19380191   PMID:19388850   PMID:19403524   PMID:19415484   PMID:19453261   PMID:19460345   PMID:19470771   PMID:19484147  
PMID:19488063   PMID:19491269   PMID:19492417   PMID:19520791   PMID:19531499   PMID:19544388   PMID:19549686   PMID:19549816   PMID:19592671   PMID:19604397   PMID:19608641   PMID:19619867  
PMID:19624835   PMID:19625176   PMID:19634110   PMID:19670348   PMID:19692168   PMID:19708171   PMID:19727227   PMID:19749156   PMID:19817957   PMID:19823871   PMID:19834535   PMID:19840254  
PMID:19840943   PMID:19853299   PMID:19880507   PMID:19887603   PMID:19895983   PMID:19896111   PMID:19900104   PMID:19913121   PMID:19920151   PMID:19921131   PMID:19951549   PMID:19953086  
PMID:19996314   PMID:20033794   PMID:20036812   PMID:20092031   PMID:20101173   PMID:20108217   PMID:20126978   PMID:20157331   PMID:20158379   PMID:20164030   PMID:20169434   PMID:20197289  
PMID:20201065   PMID:20201926   PMID:20203692   PMID:20207214   PMID:20302655   PMID:20303009   PMID:20332099   PMID:20351270   PMID:20353436   PMID:20362419   PMID:20364107   PMID:20375273  
PMID:20379614   PMID:20388803   PMID:20398806   PMID:20412119   PMID:20418097   PMID:20423485   PMID:20424473   PMID:20429940   PMID:20430735   PMID:20444693   PMID:20453000   PMID:20466569  
PMID:20472833   PMID:20487573   PMID:20498653   PMID:20514023   PMID:20564212   PMID:20587610   PMID:20598233   PMID:20606012   PMID:20621058   PMID:20628086   PMID:20628624   PMID:20631636  
PMID:20634891   PMID:20644561   PMID:20674545   PMID:20690902   PMID:20714325   PMID:20727496   PMID:20727996   PMID:20800603   PMID:20818748   PMID:20819124   PMID:20830310   PMID:20832399  
PMID:20851879   PMID:20854793   PMID:20889718   PMID:20963824   PMID:20969541   PMID:21029725   PMID:21048224   PMID:21062739   PMID:21082674   PMID:21087604   PMID:21099256   PMID:21123997  
PMID:21186997   PMID:21187523   PMID:21209099   PMID:21212517   PMID:21224998   PMID:21236296   PMID:21247755   PMID:21273531   PMID:21274378   PMID:21309478   PMID:21358296   PMID:21376205  
PMID:21436680   PMID:21439278   PMID:21533003   PMID:21567271   PMID:21678081   PMID:21752154   PMID:21822280   PMID:21868386   PMID:21872446   PMID:21873635   PMID:21971700   PMID:21982438  
PMID:22022452   PMID:22033246   PMID:22070650   PMID:22087246   PMID:22122913   PMID:22129558   PMID:22236006   PMID:22279551   PMID:22293333   PMID:22298428   PMID:22308022   PMID:22401280  
PMID:22403631   PMID:22404757   PMID:22413835   PMID:22416276   PMID:22433566   PMID:22457050   PMID:22479527   PMID:22479638   PMID:22493503   PMID:22503865   PMID:22504456   PMID:22505024  
PMID:22532606   PMID:22534548   PMID:22574813   PMID:22578596   PMID:22621366   PMID:22668508   PMID:22677173   PMID:22701712   PMID:22721997   PMID:22727668   PMID:22729867   PMID:22732145  
PMID:22745586   PMID:22773267   PMID:22782629   PMID:22797360   PMID:22829589   PMID:22829952   PMID:22852842   PMID:22925500   PMID:22951723   PMID:22990108   PMID:23007402   PMID:23090954  
PMID:23188118   PMID:23201894   PMID:23219876   PMID:23228281   PMID:23229345   PMID:23376485   PMID:23382691   PMID:23403233   PMID:23419149   PMID:23457387   PMID:23466131   PMID:23533145  
PMID:23542467   PMID:23577098   PMID:23597562   PMID:23608378   PMID:23631828   PMID:23645212   PMID:23689072   PMID:23711349   PMID:23731208   PMID:23810060   PMID:23843455   PMID:23844832  
PMID:23869217   PMID:23869762   PMID:23872928   PMID:23899513   PMID:23902938   PMID:23912699   PMID:23936413   PMID:23963773   PMID:23986482   PMID:24036907   PMID:24039773   PMID:24043306  
PMID:24045955   PMID:24160245   PMID:24203464   PMID:24252043   PMID:24261581   PMID:24268047   PMID:24346284   PMID:24370903   PMID:24399467   PMID:24465796   PMID:24502269   PMID:24505297  
PMID:24556756   PMID:24608429   PMID:24681947   PMID:24703510   PMID:24704591   PMID:24721622   PMID:24740103   PMID:24754849   PMID:24764222   PMID:24769208   PMID:24789460   PMID:24816468  
PMID:24850273   PMID:24906407   PMID:24928511   PMID:24945674   PMID:24969217   PMID:24976124   PMID:24994936   PMID:25024430   PMID:25028172   PMID:25048022   PMID:25062045   PMID:25080504  
PMID:25089940   PMID:25117311   PMID:25122478   PMID:25124796   PMID:25130271   PMID:25222228   PMID:25239885   PMID:25241761   PMID:25269647   PMID:25299191   PMID:25339576   PMID:25367123  
PMID:25422324   PMID:25453753   PMID:25483192   PMID:25533808   PMID:25537294   PMID:25576358   PMID:25589361   PMID:25618241   PMID:25619714   PMID:25666946   PMID:25678558   PMID:25680408  
PMID:25690652   PMID:25724945   PMID:25739869   PMID:25773758   PMID:25779663   PMID:25781916   PMID:25783158   PMID:25854398   PMID:25872475   PMID:25888933   PMID:25907508   PMID:25909813  
PMID:25925840   PMID:25927412   PMID:25964549   PMID:26004531   PMID:26009168   PMID:26015066   PMID:26048984   PMID:26050642   PMID:26057128   PMID:26064965   PMID:26072068   PMID:26079101  
PMID:26110767   PMID:26209696   PMID:26243309   PMID:26280537   PMID:26366788   PMID:26382850   PMID:26398511   PMID:26399281   PMID:26485166   PMID:26518873   PMID:26545991   PMID:26609808  
PMID:26620571   PMID:26646272   PMID:26686751   PMID:26691015   PMID:26774845   PMID:26830684   PMID:26841646   PMID:26854475   PMID:26861207   PMID:26876200   PMID:26892017   PMID:27023845  
PMID:27044757   PMID:27068127   PMID:27101391   PMID:27109354   PMID:27129300   PMID:27163529   PMID:27179806   PMID:27208428   PMID:27285994   PMID:27314851   PMID:27317648   PMID:27321088  
PMID:27369075   PMID:27485121   PMID:27506295   PMID:27585367   PMID:27657362   PMID:27709733   PMID:27755861   PMID:27797381   PMID:27829223   PMID:27867015   PMID:27888616   PMID:27988512  
PMID:28019699   PMID:28076931   PMID:28219779   PMID:28290610   PMID:28349272   PMID:28397482   PMID:28455445   PMID:28474333   PMID:28486782   PMID:28535417   PMID:28558652   PMID:28629477  
PMID:28640887   PMID:28690151   PMID:28746211   PMID:28791994   PMID:28843157   PMID:28844984   PMID:28849196   PMID:28904952   PMID:28906376   PMID:28934307   PMID:28972165   PMID:28978320  
PMID:28986522   PMID:28988771   PMID:29039605   PMID:29122663   PMID:29125273   PMID:29277356   PMID:29315755   PMID:29414320   PMID:29504253   PMID:29523688   PMID:29721775   PMID:29734654  
PMID:29749533   PMID:29843550   PMID:29845760   PMID:29884818   PMID:29895402   PMID:29928795   PMID:29948307   PMID:29977916   PMID:30083275   PMID:30165102   PMID:30171075   PMID:30177836  
PMID:30185207   PMID:30226622   PMID:30261040   PMID:30287279   PMID:30321499   PMID:30357416   PMID:30431382   PMID:30586319   PMID:30633190   PMID:30677083   PMID:30770752   PMID:30779072  
PMID:30783937   PMID:30968148   PMID:31053624   PMID:31197039   PMID:31202974   PMID:31232037   PMID:31358848   PMID:31372646   PMID:31495334   PMID:31601953   PMID:31605630   PMID:31906817  
PMID:31915155   PMID:31924381   PMID:32296183   PMID:32300175   PMID:32332599   PMID:32350443  


Genomics

Comparative Map Data
EGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4109,912,883 - 110,013,766 (+)EnsemblGRCh38hg38GRCh38
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,834,040 - 110,934,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,746 (+)NCBICHM1_1
Egf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39mm39
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIGRCm37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBImm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
Egf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
Celera2210,511,076 - 210,588,041 (-)NCBICelera
Cytogenetic Map2q21NCBI
RH 3.4 Map21556.7RGD
Egf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496328,075 - 401,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955496325,954 - 401,430 (-)NCBIChiLan1.0ChiLan1.0
EGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14112,977,565 - 113,075,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,977,565 - 113,076,460 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04102,410,724 - 102,509,691 (+)NCBIMhudiblu_PPA_v0panPan3
EGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3230,073,950 - 30,166,295 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13230,073,541 - 30,166,904 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Egf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365631,058,803 - 1,181,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,365 - 112,330,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI
EGF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBI
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)Ensembl

Position Markers
D4S2623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374110,889,706 - 110,889,990UniSTSGRCh37
GRCh374110,889,785 - 110,889,990UniSTSGRCh37
Build 364111,109,155 - 111,109,439RGDNCBI36
Celera4108,183,432 - 108,183,712RGD
Celera4108,183,511 - 108,183,712UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map4qUniSTS
Cytogenetic Map4q25UniSTS
HuRef4106,621,811 - 106,622,091UniSTS
HuRef4106,621,890 - 106,622,091UniSTS
Marshfield Genetic Map4114.04UniSTS
Marshfield Genetic Map4114.04RGD
TNG Radiation Hybrid Map467970.0UniSTS
deCODE Assembly Map4113.7UniSTS
Whitehead-RH Map4566.7UniSTS
Whitehead-YAC Contig Map4 UniSTS
SHGC4-992  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374110,833,069 - 110,833,265UniSTSGRCh37
Build 364111,052,518 - 111,052,714RGDNCBI36
Celera4108,126,800 - 108,126,996RGD
Cytogenetic Map4q25UniSTS
HuRef4106,565,160 - 106,565,356UniSTS
TNG Radiation Hybrid Map468025.0UniSTS
GeneMap99-G3 RH Map46272.0UniSTS
EGF_435  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374110,932,717 - 110,933,445UniSTSGRCh37
Build 364111,152,166 - 111,152,894RGDNCBI36
Celera4108,226,441 - 108,227,169RGD
HuRef4106,664,822 - 106,665,550UniSTS
D4S2350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374110,848,789 - 110,849,043UniSTSGRCh37
Build 364111,068,238 - 111,068,492RGDNCBI36
Celera4108,142,520 - 108,142,774RGD
Cytogenetic Map4q25UniSTS
HuRef4106,580,899 - 106,581,153UniSTS
Whitehead-RH Map4568.4UniSTS
Whitehead-YAC Contig Map4 UniSTS
D4S3145  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374110,932,721 - 110,932,829UniSTSGRCh37
Build 364111,152,170 - 111,152,278RGDNCBI36
Celera4108,226,445 - 108,226,553RGD
Cytogenetic Map4q25UniSTS
HuRef4106,664,826 - 106,664,934UniSTS
TNG Radiation Hybrid Map467984.0UniSTS
GeneMap99-G3 RH Map46279.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1443
Count of miRNA genes:738
Interacting mature miRNAs:820
Transcripts:ENST00000265171, ENST00000502579, ENST00000502723, ENST00000503392, ENST00000504633, ENST00000509793, ENST00000509996, ENST00000511228, ENST00000537316, ENST00000540840, ENST00000541061, ENST00000544918
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 7 3 5 18 3 1 740 750 8 138 13 34 16 730
Low 608 1080 907 187 400 48 1548 705 1001 209 796 1289 149 1 25 758 2
Below cutoff 1624 1735 588 208 1064 204 1850 730 2635 61 580 236 8 1022 1193 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001178130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001178131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005262796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011531707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017007855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001741156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001741157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF023155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI628974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ131611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY506357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY548762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA437074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU446298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB227969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB349864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ346088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265171   ⟹   ENSP00000265171
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,912,883 - 110,013,766 (+)Ensembl
RefSeq Acc Id: ENST00000502579
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,968,805 - 109,976,171 (+)Ensembl
RefSeq Acc Id: ENST00000502723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,940,776 - 109,943,972 (+)Ensembl
RefSeq Acc Id: ENST00000503392   ⟹   ENSP00000421384
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,913,241 - 110,011,501 (+)Ensembl
RefSeq Acc Id: ENST00000504633
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,959,134 - 109,963,206 (+)Ensembl
RefSeq Acc Id: ENST00000509793   ⟹   ENSP00000424316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,912,884 - 110,011,994 (+)Ensembl
RefSeq Acc Id: ENST00000509996
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,980,677 - 110,011,689 (+)Ensembl
RefSeq Acc Id: ENST00000511228
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,980,641 - 109,987,855 (+)Ensembl
RefSeq Acc Id: ENST00000537316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4110,004,501 - 110,011,491 (+)Ensembl
RefSeq Acc Id: ENST00000540840
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4110,004,501 - 110,012,220 (+)Ensembl
RefSeq Acc Id: ENST00000541061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,976,087 - 109,977,536 (+)Ensembl
RefSeq Acc Id: ENST00000544918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4110,004,247 - 110,011,598 (+)Ensembl
RefSeq Acc Id: ENST00000652245   ⟹   ENSP00000498337
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4109,912,889 - 110,013,755 (+)Ensembl
RefSeq Acc Id: NM_001178130   ⟹   NP_001171601
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,013,766 (+)NCBI
GRCh374110,834,040 - 110,934,118 (+)ENTREZGENE
HuRef4106,566,131 - 106,666,223 (+)ENTREZGENE
CHM1_14110,810,552 - 110,910,746 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001178131   ⟹   NP_001171602
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,013,766 (+)NCBI
GRCh374110,834,040 - 110,934,118 (+)ENTREZGENE
HuRef4106,566,131 - 106,666,223 (+)ENTREZGENE
CHM1_14110,810,552 - 110,910,746 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357021   ⟹   NP_001343950
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,013,766 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001963   ⟹   NP_001954
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,013,766 (+)NCBI
GRCh374110,834,040 - 110,934,118 (+)ENTREZGENE
Build 364111,053,499 - 111,152,868 (+)NCBI Archive
HuRef4106,566,131 - 106,666,223 (+)ENTREZGENE
CHM1_14110,810,552 - 110,910,746 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005262796   ⟹   XP_005262853
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
GRCh374110,834,040 - 110,934,118 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011531707   ⟹   XP_011530009
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,913,373 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007845   ⟹   XP_016863334
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007846   ⟹   XP_016863335
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007847   ⟹   XP_016863336
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007848   ⟹   XP_016863337
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007849   ⟹   XP_016863338
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007850   ⟹   XP_016863339
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007851   ⟹   XP_016863340
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,012,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007853   ⟹   XP_016863342
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 109,999,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007854   ⟹   XP_016863343
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 109,977,553 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017007855   ⟹   XP_016863344
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 109,980,086 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001741156
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,008,230 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001741157
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,883 - 110,011,308 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001954   ⟸   NM_001963
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P01133 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001171601   ⟸   NM_001178130
- Peptide Label: isoform 2 precursor
- UniProtKB: P01133 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001171602   ⟸   NM_001178131
- Peptide Label: isoform 3 precursor
- UniProtKB: P01133 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005262853   ⟸   XM_005262796
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011530009   ⟸   XM_011531707
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016863334   ⟸   XM_017007845
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016863335   ⟸   XM_017007846
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016863339   ⟸   XM_017007850
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016863336   ⟸   XM_017007847
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016863338   ⟸   XM_017007849
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016863340   ⟸   XM_017007851
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016863337   ⟸   XM_017007848
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016863342   ⟸   XM_017007853
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_016863344   ⟸   XM_017007855
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_016863343   ⟸   XM_017007854
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: NP_001343950   ⟸   NM_001357021
- Peptide Label: isoform 4 precursor
- Sequence:
RefSeq Acc Id: ENSP00000421384   ⟸   ENST00000503392
RefSeq Acc Id: ENSP00000498337   ⟸   ENST00000652245
RefSeq Acc Id: ENSP00000424316   ⟸   ENST00000509793
RefSeq Acc Id: ENSP00000265171   ⟸   ENST00000265171
Protein Domains
EGF-like

Promoters
RGD ID:6868270
Promoter ID:EPDNEW_H7300
Type:initiation region
Name:EGF_1
Description:epidermal growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7301  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,912,884 - 109,912,944EPDNEW
RGD ID:6868272
Promoter ID:EPDNEW_H7301
Type:initiation region
Name:EGF_2
Description:epidermal growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7300  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384109,980,705 - 109,980,765EPDNEW
RGD ID:6802178
Promoter ID:HG_KWN:48911
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001178130,   NM_001178131,   NM_001963
Position:
Human AssemblyChrPosition (strand)Source
Build 364111,053,366 - 111,053,866 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001963.6(EGF):c.3209C>T (p.Pro1070Leu) single nucleotide variant Hypomagnesemia 4, renal [RCV000018089] Chr4:110004540 [GRCh38]
Chr4:110925696 [GRCh37]
Chr4:4q25
pathogenic
NM_001963.6(EGF):c.3454_3468del (p.Ser1152_Ser1156del) deletion not provided [RCV000722513] Chr4:110011282..110011296 [GRCh38]
Chr4:110932438..110932452 [GRCh37]
Chr4:4q25
uncertain significance
GRCh38/hg38 4q25(chr4:109800241-109990141)x3 copy number gain See cases [RCV000051633] Chr4:109800241..109990141 [GRCh38]
Chr4:110721397..110911297 [GRCh37]
Chr4:110940846..111130746 [NCBI36]
Chr4:4q25
uncertain significance
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
GRCh38/hg38 4q24-25(chr4:105778347-110206873)x3 copy number gain See cases [RCV000051777] Chr4:105778347..110206873 [GRCh38]
Chr4:106699504..111128029 [GRCh37]
Chr4:106918953..111347478 [NCBI36]
Chr4:4q24-25
pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
NM_001963.4(EGF):c.478C>T (p.Pro160Ser) single nucleotide variant Malignant melanoma [RCV000060893] Chr4:109943404 [GRCh38]
Chr4:110864560 [GRCh37]
Chr4:111084009 [NCBI36]
Chr4:4q25
not provided
NM_001963.6(EGF):c.-382A>G single nucleotide variant Hypomagnesemia 4, renal [