Exhibits Ras guanyl-nucleotide exchange factor activity and growth factor activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of cellular metabolic process; and regulation of cellular protein localization. Localizes to extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; lupus nephritis; neurodegenerative disease (multiple); pancreatic cancer (multiple); and pancreatitis.
EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein], ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]] more ...
[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA] more ...
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]], Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]] more ...
bisindolylmaleimide I inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA], bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein]
[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA] more ...
[Bucladesine co-treated with 1-Methyl-3-isobutylxanthine co-treated with EGF protein co-treated with FGF2 protein co-treated with NGF protein co-treated with BDNF protein] results in increased expression of ENO2 mRNA more ...
1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [EGF results in increased phosphorylation of MAPK1 protein]], 1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [EGF results in increased phosphorylation of MAPK3 protein]]
EGF protein inhibits the reaction [naphthol AS-E phosphate inhibits the reaction [[monobutyryl cyclic AMP co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased phosphorylation of and results in increased activity of MAPK1 protein]], EGF protein inhibits the reaction [naphthol AS-E phosphate inhibits the reaction [[monobutyryl cyclic AMP co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine], Selenium inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine]
afatinib inhibits the reaction [EGF protein results in increased expression of EHMT2 protein], afatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein] more ...
[Tretinoin co-treated with EGF protein co-treated with NOG protein] results in increased expression of SOX10 mRNA, [Tretinoin co-treated with EGF protein] results in increased expression of NKX2-2 mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of EGF mRNA
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine]
baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EGF mRNA
EGF protein promotes the reaction [Benzoapyrene results in increased expression of CYP1B1 mRNA], EGF protein promotes the reaction [Benzoapyrene results in increased expression of CYP1B1 protein]
AHR protein affects the reaction [Benzoapyrene inhibits the reaction [EGF protein binds to EGFR protein]], Benzoapyrene inhibits the reaction [EGF protein binds to EGFR protein]
Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]], Benzoic Acid analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of EGF mRNA
[Bucladesine co-treated with 1-Methyl-3-isobutylxanthine co-treated with EGF protein co-treated with FGF2 protein co-treated with NGF protein co-treated with BDNF protein] results in increased expression of ENO2 mRNA more ...
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of EGF mRNA
chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]], chelerythrine inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde]
chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] more ...
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA], Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA] more ...
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
Selenium inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine], Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EGF mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of EGF mRNA
Enzyme Inhibitors inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Enzyme Inhibitors inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein], Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein]
galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ...
[Genistein co-treated with vinclozolin] results in decreased expression of EGF mRNA, Genistein inhibits the reaction [EGF protein results in decreased secretion of REN protein]
[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ...
[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ...
2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF], perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]
Hydroxamic Acids analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]], Hydroxamic Acids analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine]
Leflunomide inhibits the reaction [EGF protein results in increased activity of ELK1 protein], Leflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein], EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein]
[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of EGF mRNA
methoxyacetic acid promotes the reaction [EGF protein results in increased activity of ELK1 protein], U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]]
methyl-beta-cyclodextrin inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]
midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]
Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]] more ...
EGF protein inhibits the reaction [naphthol AS-E phosphate inhibits the reaction [[monobutyryl cyclic AMP co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased phosphorylation of and results in increased activity of MAPK1 protein]], EGF protein inhibits the reaction [naphthol AS-E phosphate inhibits the reaction [[monobutyryl cyclic AMP co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine], Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of Peroxides]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein affects the localization of RELA protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein], Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]]
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein], Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA], Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
Okadaic Acid inhibits the reaction [EGF protein results in decreased activity of ACO1 protein], Okadaic Acid inhibits the reaction [EGF protein results in decreased activity of IREB2 protein]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine]
[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of EGF mRNA
[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EGF mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of EGF mRNA, [EGF protein co-treated with HGF protein] promotes the reaction [Acetaminophen results in decreased expression of CYP1A2 mRNA]
perifosine inhibits the reaction [cyadox results in increased expression of EGF], perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]
EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA], EGF protein inhibits the reaction [Permethrin results in increased expression of CYP3A23-3A1 mRNA]
Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of Peroxides], Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]
Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein], Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]
Phenobarbital inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Phenobarbital inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein], oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of EGF mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA
2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] more ...
PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]
Selenium inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine], Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]
[EGF protein results in decreased expression of EGFR protein] inhibits the reaction [sodium arsenite results in increased activity of MAPK1 protein] more ...
EGF protein promotes the reaction [sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD1 protein]] more ...
Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein], stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] more ...
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein], EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
AHR protein affects the reaction [benzaanthracene inhibits the reaction [EGF protein binds to EGFR protein]], benzaanthracene inhibits the reaction [EGF protein binds to EGFR protein]
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] more ...
[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EGF mRNA
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine]
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine, Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine]
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA, [Genistein co-treated with vinclozolin] results in decreased expression of EGF mRNA
[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EGF mRNA
wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein], wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose]
Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]
Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]
Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775]
