RGD Reference Report - The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression. - Rat Genome Database

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The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression.

Authors: Jurkowska, Grażyna  Piotrowska-Staworko, Grażyna  Guzińska-Ustymowicz, Katarzyna  Kemona, Andrzej  Świdnicka-Siergiejko, Agnieszka  Łaszewicz, Wiktor  Dąbrowski, Andrzej 
Citation: Jurkowska G, etal., Adv Med Sci. 2014 Sep;59(2):221-6. doi: 10.1016/j.advms.2014.01.006. Epub 2014 Jun 9.
RGD ID: 38599160
Pubmed: PMID:25051417   (View Abstract at PubMed)
DOI: DOI:10.1016/j.advms.2014.01.006   (Journal Full-text)


PURPOSE: Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gastric expression of growth factors and serum gastrin concentrations.
PATIENTS/METHODS: We examined immunohistochemically gastric EGF and both receptors' expression in: gastric cancer (GC; n=29), chronic gastritis with H. pylori infection (GHp+; n=40) before and after eradication and in patients without H. pylori infection (GHp-; n=42).
RESULTS: Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp- (p<0.05), but were similar to GC. After eradication, EGF and the receptor's expression significantly decreased in the gastric body. Both EGFR and c-erb-B2 expression in the antrum were still higher than in GHp- (p<0.05), and remained comparable to GC.
CONCLUSIONS: In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Helicobacter Infections treatmentIEP 38599160; 38599160; 38599160associated with gastritisRGD 
Helicobacter Infections treatmentISOEGF (Homo sapiens)38599160; 38599160associated with gastritisRGD 
Helicobacter Infections treatmentISOEGFR (Homo sapiens)38599160; 38599160associated with gastritisRGD 
Helicobacter Infections treatmentISOERBB2 (Homo sapiens)38599160; 38599160associated with gastritisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Egf  (epidermal growth factor)
Egfr  (epidermal growth factor receptor)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Genes (Mus musculus)
Egf  (epidermal growth factor)
Egfr  (epidermal growth factor receptor)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Genes (Homo sapiens)
EGF  (epidermal growth factor)
EGFR  (epidermal growth factor receptor)
ERBB2  (erb-b2 receptor tyrosine kinase 2)


Additional Information