EGF (epidermal growth factor) - Rat Genome Database
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Gene: EGF (epidermal growth factor) Sus scrofa
Analyze
Symbol: EGF
Name: epidermal growth factor
RGD ID: 13916117
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN activation of MAPK activity (ortholog); activation of MAPKK activity (ortholog); branching morphogenesis of an epithelial tube (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: pro-epidermal growth factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,365 - 112,330,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
cleft palate  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
gastric ulcer  (ISO)
Genetic Predisposition to Disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
high grade glioma  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Metaplasia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
oligodendroglioma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
primary hypomagnesemia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal hypomagnesemia 3  (ISO)
renal hypomagnesemia 4  (ISO)
renal hypomagnesemia 5 with ocular involvement  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
shigellosis  (ISO)
Tympanic Membrane Perforation  (ISO)
Wounds and Injuries  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (IEA,ISO)
activation of MAPKK activity  (IEA,ISO)
angiogenesis  (IEA)
branching morphogenesis of an epithelial tube  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (ISO)
epidermal growth factor receptor signaling pathway via MAPK cascade  (IEA,ISS)
ERK1 and ERK2 cascade  (IEA)
kidney development  (ISO)
mammary gland alveolus development  (IEA,ISO)
negative regulation of cholesterol efflux  (IEA,ISO)
negative regulation of secretion  (IEA)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cerebellar granule cell precursor proliferation  (IEA,ISO)
positive regulation of DNA binding  (IEA,ISO,ISS)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA replication  (IEA,ISS)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epidermal growth factor-activated receptor activity  (IEA)
positive regulation of epithelial tube formation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of hyaluronan biosynthetic process  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA)
positive regulation of phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (IEA)
positive regulation of protein localization to early endosome  (IEA)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (IEA)
positive regulation of transcription, DNA-templated  (IEA)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA,ISO)
regulation of calcium ion import  (IEA)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of protein localization to cell surface  (IEA)
regulation of protein secretion  (ISO)
regulation of protein transport  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:2015058   PMID:9741816   PMID:11518619   PMID:17020010   PMID:17913840   PMID:20168049   PMID:24002665   PMID:24012778   PMID:27119729   PMID:31430961  


Genomics

Comparative Map Data
EGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,365 - 112,330,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI
EGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4109,912,883 - 110,013,766 (+)EnsemblGRCh38hg38GRCh38
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374110,834,039 - 110,934,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,746 (+)NCBICHM1_1
Egf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39mm39
GRCm39 Ensembl3129,471,214 - 129,548,965 (-)Ensembl
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIGRCm37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBImm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
Egf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22218,219,408 - 218,302,370 (-)NCBI
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
Celera2210,511,076 - 210,588,041 (-)NCBICelera
RH 3.4 Map21556.7RGD
Cytogenetic Map2q21NCBI
Egf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496328,075 - 401,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955496325,954 - 401,430 (-)NCBIChiLan1.0ChiLan1.0
EGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14112,977,565 - 113,075,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,977,565 - 113,076,460 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04102,410,724 - 102,509,691 (+)NCBIMhudiblu_PPA_v0panPan3
EGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3230,073,950 - 30,166,295 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13230,073,541 - 30,166,904 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Egf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365631,058,803 - 1,181,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBI
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)Ensembl


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 1
Low 10 2 3 3 21 2 1
Below cutoff 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010002   ⟹   ENSSSCP00000009740
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,236,822 - 112,330,046 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000032398   ⟹   ENSSSCP00000028117
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,234,365 - 112,329,839 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046113   ⟹   ENSSSCP00000045709
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,235,098 - 112,330,046 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000052170   ⟹   ENSSSCP00000042767
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,235,098 - 112,330,046 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000054613   ⟹   ENSSSCP00000037992
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8112,235,847 - 112,330,046 (-)Ensembl
RefSeq Acc Id: NM_214020   ⟹   NP_999185
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18112,235,843 - 112,330,012 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100461   ⟹   XP_020956120
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021100462   ⟹   XP_020956121
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002346366
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020956121   ⟸   XM_021100462
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020956120   ⟸   XM_021100461
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999185   ⟸   NM_214020
- Peptide Label: precursor
- UniProtKB: Q00968 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000037992   ⟸   ENSSSCT00000054613
RefSeq Acc Id: ENSSSCP00000009740   ⟸   ENSSSCT00000010002
RefSeq Acc Id: ENSSSCP00000042767   ⟸   ENSSSCT00000052170
RefSeq Acc Id: ENSSSCP00000045709   ⟸   ENSSSCT00000046113
RefSeq Acc Id: ENSSSCP00000028117   ⟸   ENSSSCT00000032398
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020390 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009740 UniProtKB/TrEMBL
  ENSSSCP00000028117 UniProtKB/TrEMBL
  ENSSSCP00000037992 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000042767 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000045709 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070034152 UniProtKB/TrEMBL
  ENSSSCP00070034180 UniProtKB/TrEMBL
  ENSSSCP00070034193 UniProtKB/TrEMBL
  ENSSSCP00070034203 UniProtKB/TrEMBL
  ENSSSCP00070034206 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010002 UniProtKB/TrEMBL
  ENSSSCT00000032398 UniProtKB/TrEMBL
  ENSSSCT00000046113 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000052170 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000054613 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070040698 UniProtKB/TrEMBL
  ENSSSCT00070040735 UniProtKB/TrEMBL
  ENSSSCT00070040748 UniProtKB/TrEMBL
  ENSSSCT00070040759 UniProtKB/TrEMBL
  ENSSSCT00070040763 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro-epidermal_GF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397083 UniProtKB/Swiss-Prot
NCBI Gene EGF ENTREZGENE
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Pro-epidermal_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0F6QEH3_PIG UniProtKB/TrEMBL
  A0A287A231_PIG UniProtKB/TrEMBL
  A0A287AFY5_PIG UniProtKB/TrEMBL
  A0A287AP83_PIG UniProtKB/TrEMBL
  A0A4X1UXX0_PIG UniProtKB/TrEMBL
  A0A4X1UZ77_PIG UniProtKB/TrEMBL
  A0A4X1UZH2_PIG UniProtKB/TrEMBL
  A0A4X1UZL4_PIG UniProtKB/TrEMBL
  EGF_PIG UniProtKB/Swiss-Prot
  F1S137_PIG UniProtKB/TrEMBL
  I3LVG5_PIG UniProtKB/TrEMBL
  Q00968 ENTREZGENE
  Q9XT78_PIG UniProtKB/TrEMBL
  Q9XT79_PIG UniProtKB/TrEMBL
UniProt Secondary O62759 UniProtKB/Swiss-Prot
  Q9BDQ0 UniProtKB/Swiss-Prot
VGNC ID VGNC:98921 ENTREZGENE