RGD Reference Report - Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. - Rat Genome Database

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Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease.

Authors: Chen-Plotkin, AS  Hu, WT  Siderowf, A  Weintraub, D  Goldmann Gross, R  Hurtig, HI  Xie, SX  Arnold, SE  Grossman, M  Clark, CM  Shaw, LM  McCluskey, L  Elman, L  Van Deerlin, VM  Lee, VM  Soares, H  Trojanowski, JQ 
Citation: Chen-Plotkin AS, etal., Ann Neurol. 2011 Apr;69(4):655-63. doi: 10.1002/ana.22271. Epub 2010 Nov 29.
RGD ID: 10059679
Pubmed: PMID:21520231   (View Abstract at PubMed)
PMCID: PMC3155276   (View Article at PubMed Central)
DOI: DOI:10.1002/ana.22271   (Journal Full-text)

OBJECTIVE: Most people with Parkinson disease (PD) eventually develop cognitive impairment (CI). However, neither the timing of onset nor the severity of cognitive symptoms can be accurately predicted. We sought plasma-based biomarkers for CI in PD. METHODS: A discovery cohort of 70 PD patients was recruited. Cognitive status was evaluated with the Mattis Dementia Rating Scale-2 (DRS) at baseline and on annual follow-up visits, and baseline plasma levels of 102 proteins were determined with a bead-based immunoassay. Using linear regression, we identified biomarkers of CI in PD, that is, proteins whose levels correlated with cognitive performance at baseline and/or cognitive decline at follow-up. We then replicated the association between cognitive performance and levels of the top biomarker, using a different technical platform, with a separate cohort of 113 PD patients. RESULTS: Eleven proteins exhibited plasma levels correlating with baseline cognitive performance in the discovery cohort. The best candidate was epidermal growth factor (EGF, p < 0.001); many of the other 10 analytes covaried with EGF across samples. Low levels of EGF not only correlated with poor cognitive test scores at baseline, but also predicted an 8-fold greater risk of cognitive decline to dementia-range DRS scores at follow-up for those with intact baseline cognition. A weaker, but still significant, relationship between plasma EGF levels and cognitive performance was found in an independent replication cohort of 113 PD patients. INTERPRETATION: Our data suggest that plasma EGF may be a biomarker for progression to CI in PD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease disease_progressionIEP 10059679 RGD 
Parkinson's disease disease_progressionISOEGF (Homo sapiens)10059679; 10059679 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egf  (epidermal growth factor)

Genes (Mus musculus)
Egf  (epidermal growth factor)

Genes (Homo sapiens)
EGF  (epidermal growth factor)


Additional Information