EGF (epidermal growth factor) - Rat Genome Database

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Gene: EGF (epidermal growth factor) Chlorocebus sabaeus
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Symbol: EGF
Name: epidermal growth factor
RGD ID: 18687900
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); cell population proliferation (ortholog); cerebellar granule cell precursor proliferation (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pro-epidermal growth factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,484,638 - 36,584,482 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
cleft palate  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
gastric ulcer  (ISO)
Genetic Predisposition to Disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
high grade glioma  (ISO)
inclusion body myopathy with Paget disease of bone and frontotemporal dementia  (ISO)
juvenile rheumatoid arthritis  (ISO)
kidney disease  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Metaplasia  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
oligodendroglioma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
primary hypomagnesemia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal hypomagnesemia 3  (ISO)
renal hypomagnesemia 4  (ISO)
renal hypomagnesemia 5 with ocular involvement  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
shigellosis  (ISO)
Tympanic Membrane Perforation  (ISO)
Wounds and Injuries  (ISO)
Zollinger-Ellison syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
branching morphogenesis of an epithelial tube  (IEA,ISO)
canonical Wnt signaling pathway  (IEA)
cell population proliferation  (IEA,ISO)
cerebellar granule cell precursor proliferation  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
ERBB2-EGFR signaling pathway  (IEA)
ERK1 and ERK2 cascade  (IEA)
kidney development  (ISO)
mammary gland alveolus development  (IEA,ISO)
negative regulation of cholesterol efflux  (IEA)
negative regulation of secretion  (IEA)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (IEA,ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of epithelial tube formation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of hyaluronan biosynthetic process  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of phosphorylation  (IEA)
positive regulation of protein localization to early endosome  (IEA)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (IEA)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA)
regulation of calcium ion import  (IEA)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of protein localization to cell surface  (IEA)
regulation of protein transport  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
EGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,810,110 - 57,911,361 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,484,638 - 36,584,482 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,912,883 - 110,013,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,912,883 - 110,013,766 (+)EnsemblGRCh38hg38GRCh38
GRCh374110,834,039 - 110,934,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,053,499 - 111,152,868 (+)NCBINCBI36Build 36hg18NCBI36
Build 344111,191,653 - 111,291,023NCBI
Celera4108,127,771 - 108,227,842 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,566,131 - 106,666,223 (+)NCBIHuRef
CHM1_14110,810,552 - 110,910,629 (+)NCBICHM1_1
T2T-CHM13v2.04113,214,975 - 113,315,858 (+)NCBIT2T-CHM13v2.0
Egf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,471,223 - 129,548,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,471,214 - 129,548,965 (-)EnsemblGRCm39 Ensembl
GRCm383129,677,574 - 129,755,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,677,565 - 129,755,316 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,380,493 - 129,458,240 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,669,600 - 129,747,338 (-)NCBIMGSCv36mm8
Celera3136,187,440 - 136,268,006 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.5NCBI
Egf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,893,660 - 220,976,331 (-)NCBIGRCr8
mRatBN7.22218,219,408 - 218,302,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,219,415 - 218,302,064 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,907,754 - 225,986,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,807,431 - 223,886,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,665,094 - 218,744,036 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0268,820,616 - 68,895,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0288,549,746 - 88,621,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0274,746,752 - 74,783,449 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02253,481,574 - 253,482,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,103,900 - 227,195,062 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,090,579 - 227,181,742 (-)NCBI
Celera2210,511,076 - 210,588,041 (-)NCBICelera
RH 3.4 Map21556.7RGD
Cytogenetic Map2q43NCBI
Egf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496328,075 - 401,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955496325,954 - 401,430 (-)NCBIChiLan1.0ChiLan1.0
EGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,005,905 - 108,105,686 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,299,162 - 108,398,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,410,724 - 102,509,691 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,977,565 - 113,075,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,977,565 - 113,076,460 (+)Ensemblpanpan1.1panPan2
EGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,073,541 - 30,166,904 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,073,950 - 30,166,295 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,863,120 - 11,956,432 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,294,579 - 30,388,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,294,820 - 30,388,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,288,558 - 30,381,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,031,820 - 30,125,429 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,723,676 - 9,817,337 (-)NCBIUU_Cfam_GSD_1.0
Egf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,767,839 - 10,855,510 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365631,058,803 - 1,181,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,234,386 - 112,330,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,235,607 - 112,330,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,384,625 - 120,413,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q2.3-q2.7NCBI


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
58 21 20 21 21 57 20

Sequence


Ensembl Acc Id: ENSCSAT00000001946   ⟹   ENSCSAP00000000280
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl757,811,728 - 57,911,516 (+)Ensembl
RefSeq Acc Id: XM_007999539   ⟹   XP_007997730
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1757,810,110 - 57,911,361 (+)NCBI
Vero_WHO_p1.0NW_02366603736,484,638 - 36,584,482 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037990891   ⟹   XP_037846819
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603736,484,638 - 36,583,533 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007997730 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846819 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000280.1
RefSeq Acc Id: XP_007997730   ⟸   XM_007999539
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QV91 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000000280   ⟸   ENSCSAT00000001946
RefSeq Acc Id: XP_037846819   ⟸   XM_037990891
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QV91 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003916 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001946.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  Cueball_EGF_LRP_Nidogen UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Pro-epidermal_GF UniProtKB/TrEMBL
KEGG Report csab:103236114 UniProtKB/TrEMBL
NCBI Gene EGF ENTREZGENE
PANTHER PRO-EPIDERMAL GROWTH FACTOR UniProtKB/TrEMBL
  VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PIRSF Pro-epidermal_growth_factor UniProtKB/TrEMBL
PRINTS EGFTGF UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0A0D9QV91 ENTREZGENE, UniProtKB/TrEMBL