Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1); PARTICIPATES IN atherosclerosis pathway; endothelin signaling pathway; syndecan signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; alpha-naphthoflavone.
[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MMP1 mRNA and epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased expression of MMP1 protein]
Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA and Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein
ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein] and ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]] more ...
Glucose inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and Glucose inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA] and alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]]
[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA and Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of and results in increased activity of MMP1 protein] more ...
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of MMP1 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MMP1 mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of MMP1 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MMP1 mRNA
Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP1 mRNA] and SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP1 mRNA]
Genistein inhibits the reaction [Chromium results in increased expression of MMP1 mRNA] and herbimycin inhibits the reaction [Chromium results in increased expression of MMP1 mRNA]
Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA] and Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]
Glucose inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and Glucose inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]
Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA] and Mifepristone inhibits the reaction [Dexamethasone results in decreased secretion of MMP1 protein]
diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of MMP1 mRNA] and diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]
[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA and carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA]
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP1 mRNA] and Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]
Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]
Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA] and Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]
Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA] and Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]
Cystathionine inhibits the reaction [Formaldehyde results in increased expression of MMP1 protein] and Cysteine inhibits the reaction [Formaldehyde results in increased expression of MMP1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein] and U 0126 inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]
Glucose inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and Glucose inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein] and Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein
HU 308 inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and HU 308 inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]
Hydrogen Peroxide inhibits the reaction [ursonic acid results in decreased expression of MMP1 mRNA] and loliolide inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP1 mRNA]
ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein] and ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA]
[[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of MMP1 mRNA and Ascorbic Acid inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP1 mRNA]
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of MMP1 mRNA
[Lipopolysaccharides co-treated with Zymosan] results in decreased activity of MMP1 protein and [Lipopolysaccharides co-treated with Zymosan] results in increased activity of MMP1 protein
[sodium arsenite co-treated with Lipopolysaccharides] results in decreased expression of MMP1 mRNA and SERPINH1 protein promotes the reaction [[sodium arsenite co-treated with Lipopolysaccharides] results in decreased expression of MMP1 mRNA]
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of MMP1 mRNA and [manganese chloride results in increased abundance of Manganese] which results in increased expression of MMP1 mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of MMP1 mRNA and [manganese chloride results in increased abundance of Manganese] which results in increased expression of MMP1 mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of MMP1 mRNA and [manganese chloride results in increased abundance of Manganese] which results in increased expression of MMP1 mRNA
[mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETS1 protein results in increased expression of MMP1 mRNA] more ...
Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA] and Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA and Tetradecanoylphorbol Acetate results in increased expression of MMP1 protein
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] and herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] and herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]
[Protein Kinase Inhibitors results in decreased activity of PTK2 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]
pyrrolidine dithiocarbamic acid inhibits the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of MMP1 protein]] and pyrrolidine dithiocarbamic acid promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]]
NFE2L2 protein affects the reaction [ruscogenin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]] and ruscogenin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]
[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA and Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
SB 203580 inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of and results in increased activity of MMP1 protein] more ...
[LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with EGF protein co-treated with FGF2 protein] results in increased expression of MMP1 mRNA
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]] more ...
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of MMP1 mRNA more ...
[sodium arsenite co-treated with Lipopolysaccharides] results in decreased expression of MMP1 mRNA and SERPINH1 protein promotes the reaction [[sodium arsenite co-treated with Lipopolysaccharides] results in decreased expression of MMP1 mRNA]
Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP1 protein] and Sodium Azide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP1 mRNA]
[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein and Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein]
CAT protein affects the reaction [trichostatin A promotes the reaction [SOD2 protein results in increased expression of MMP1 mRNA]] and trichostatin A promotes the reaction [SOD2 protein results in increased expression of MMP1 mRNA]
Hydrogen Peroxide inhibits the reaction [ursonic acid results in decreased expression of MMP1 mRNA] and ursonic acid results in decreased activity of and results in decreased secretion of MMP1 protein
varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] and varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]
[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of MMP1 mRNA and [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of MMP1 mRNA
Prognostic significance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in voided urine samples from patients with transitional cell carcinoma of the bladder.
A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support.
[The expressions of TNF-alpha and MMP-9 in serum and MMP-1 mRNA in the bone tissue in chronic obstructive pulmonary disease patients of cold dryness syndrome in northwest China].
Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices.
Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy.
Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease.
Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region.
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
[Effects of yiqi huoxue compound combined with exercise therapy on MMP-1 and collagen type III expressions of cardiac muscle in chronic heart failure rats].
Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population.
Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics.
Elevation of serum levels of metalloproteinase-1, tissue inhibitor of metalloproteinase-1 and type IV collagen, and plasma levels of metalloproteinase-9 in polycystic kidney disease.
A polymorphism at -1607 2G in the matrix metalloproteinase-1 (MMP-1) increased risk of sudden deafness in Korean population but not at -519A/G in MMP-1.
Collagenase, gelatinase, and proteoglycanase messenger ribonucleic acid expression and activity during luteal development, maintenance, and regression in the pseudopregnant rat ovary.
Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells.
Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury.
[Effects of electroacupuncture at Jiaji (EX-B 2) on extracellular matrix MMP-1, MMP-3 and TIMP-1 levels in the degenerated cervical intervertebral disc in rats].
[Precondition with doxycycline administration abates ischemia/reperfusion injury and reduces the expression of matrix metalloproteinase-1/9 in myocardium in rat in vivo].
Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis.
Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and -9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats.
Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis.
[Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases].
