Mmp1 (matrix metallopeptidase 1) - Rat Genome Database

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Gene: Mmp1 (matrix metallopeptidase 1) Rattus norvegicus
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Symbol: Mmp1
Name: matrix metallopeptidase 1
RGD ID: 1307917
Description: Exhibits peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Localizes to cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1); PARTICIPATES IN atherosclerosis pathway; endothelin signaling pathway; syndecan signaling pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; alpha-naphthoflavone; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Clgn; fibroblast collagenase; interstitial collagenase; LOC300339; matrix metallopeptidase 1 (interstitial collagenase); matrix metallopeptidase 1a; matrix metallopeptidase 1a (interstitial collagenase); matrix metalloproteinase 1; matrix metalloproteinase 1a (interstitial collagenase); matrix metalloproteinase-1; MMP-1; Mmp1a; myocardial collagenase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,658,588 - 4,679,099 (+)NCBI
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.085,703,206 - 5,723,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.085,706,054 - 5,726,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,333,773 - 4,354,284 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,333,814 - 4,353,725 (+)NCBI
Celera86,218,410 - 6,238,921 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Adult Cerebral Astrocytoma  (ISO)
Airway Obstruction  (ISO)
Amaurosis Fugax  (ISO)
amyotrophic lateral sclerosis  (ISO)
Aneurysm  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cervical cancer  (ISO)
cholesteatoma of middle ear  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Periodontitis  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Nephrotic Syndrome with or without Ocular Abnormalities  (ISO)
congestive heart failure  (IDA,ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
degenerative disc disease  (IDA)
dermatomyositis  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Emphysema  (ISO)
end stage renal disease  (ISO)
epidermolysis bullosa dystrophica  (ISO)
esophagus adenocarcinoma  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (IDA,IEP)
Experimental Autoimmune Uveitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Fetal Hypoxia  (IEP)
glomerulosclerosis  (IDA,IEP)
Head and Neck Neoplasms  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Hyperplasia  (IDA)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
Kidney Neoplasms  (ISO)
Knee Osteoarthritis  (IEP)
liver cirrhosis  (IDA,IEP)
localized scleroderma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
obstructive lung disease  (ISO)
ocular hypertension  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
ovarian cancer  (ISO)
periodontitis  (ISO)
polymyositis  (ISO)
preterm premature rupture of the membranes  (ISO)
primary open angle glaucoma  (ISO)
psoriatic arthritis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IDA)
pulmonary hypertension  (IDA)
recessive dystrophic epidermolysis bullosa  (ISS)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
rheumatoid arthritis  (ISO)
scoliosis  (IEP)
Sepsis  (IEP)
skin melanoma  (ISO)
stomach carcinoma  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
tendinitis  (IEP)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (IDA)
urinary bladder cancer  (ISO)
varicose veins  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,4-dichloroaniline  (ISO)
3-hydroxypicolinic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetaldehyde  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP,ISO)
aluminium oxide  (ISO)
amitrole  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
Arg-Gly-Asp  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
azithromycin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzylpenicillin  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bufalin  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carazolol  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
chromium atom  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
Deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dichloromethane  (ISO)
dieckol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
endosulfan  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
famotidine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gadodiamide hydrate  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
glucose  (ISO)
Heliotrine  (ISO)
hemin  (ISO)
heparin  (ISO)
herbimycin  (ISO)
histamine  (ISO)
homocysteine  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
ilomastat  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
L-cystathionine  (ISO)
L-cysteine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP,ISO)
lucanthone  (ISO)
luteolin  (ISO)
LY294002  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
Methanandamide  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mibolerone  (ISO)
mifepristone  (ISO)
moxifloxacin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
norfloxacin  (ISO)
NSC 23766  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
platycodin D  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
ruthenium red  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
selumetinib  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thymidine  (ISO)
thymine  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
urethane  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
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Additional References at PubMed
PMID:8605638   PMID:9920899   PMID:11113146   PMID:12118097   PMID:12477932   PMID:14504039   PMID:15652546   PMID:15863497   PMID:16047157   PMID:17275272   PMID:17607299   PMID:17989988  
PMID:19022250   PMID:19250650   PMID:20923679   PMID:21342246   PMID:21637818   PMID:23086831   PMID:23845380   PMID:25073870   PMID:26087281   PMID:26191209   PMID:27339256   PMID:28220578  
PMID:28626073   PMID:32538742  


Genomics

Comparative Map Data
Mmp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,658,588 - 4,679,099 (+)NCBI
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.085,703,206 - 5,723,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.085,706,054 - 5,726,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,333,773 - 4,354,284 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,333,814 - 4,353,725 (+)NCBI
Celera86,218,410 - 6,238,921 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11102,789,919 - 102,798,160 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11102,789,401 - 102,798,160 (-)EnsemblGRCh38hg38GRCh38
GRCh3811102,789,919 - 102,798,160 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,660,650 - 102,668,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,165,861 - 102,174,104 (-)NCBINCBI36hg18NCBI36
Build 3411102,165,860 - 102,174,104NCBI
Celera1199,822,300 - 99,830,624 (-)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,588,616 - 98,596,940 (-)NCBIHuRef
CHM1_111102,543,487 - 102,551,813 (-)NCBICHM1_1
Mmp1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,464,141 - 7,476,870 (+)NCBIGRCm39mm39
GRCm39 Ensembl97,464,141 - 7,476,857 (+)Ensembl
GRCm3897,464,141 - 7,476,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,464,141 - 7,476,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,464,141 - 7,476,869 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,464,141 - 7,476,856 (+)NCBImm8
Cytogenetic Map9A1NCBI
MMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111101,221,393 - 101,230,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,221,393 - 101,230,104 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01197,730,545 - 97,739,190 (-)NCBIMhudiblu_PPA_v0panPan3
MMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,978,385 - 28,986,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,978,473 - 28,986,648 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,926,897 - 28,935,120 (+)NCBI
ROS_Cfam_1.0529,029,643 - 29,038,059 (+)NCBI
UMICH_Zoey_3.1529,064,653 - 29,073,076 (+)NCBI
UNSW_CanFamBas_1.0528,944,064 - 28,952,288 (+)NCBI
UU_Cfam_GSD_1.0529,119,065 - 29,127,510 (+)NCBI
Mmp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,361,179 - 86,368,526 (-)NCBI
SpeTri2.0NW_0049365515,167,909 - 5,175,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,411,065 - 33,454,000 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,411,738 - 33,420,205 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,358,454 - 37,367,107 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,167,507 - 94,177,357 (-)NCBI
ChlSab1.1 Ensembl194,167,219 - 94,176,767 (-)Ensembl
Mmp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462487871,642 - 79,660 (+)NCBI

Position Markers
AU049293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.284,663,853 - 4,664,063 (+)MAPPER
Rnor_6.085,708,472 - 5,708,681NCBIRnor6.0
Rnor_5.085,711,320 - 5,711,529UniSTSRnor5.0
RGSC_v3.484,339,039 - 4,339,248UniSTSRGSC3.4
Celera86,223,676 - 6,223,885UniSTS
Cytogenetic Map8q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124608226Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125942267Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8210812847108128Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8210812847108128Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8210812847108128Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8210812847108128Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:53
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000012595
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium
Low 2 1 8
Below cutoff 7 2 9 2 11 19 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012595   ⟹   ENSRNOP00000012595
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl85,703,206 - 5,723,591 (+)Ensembl
RefSeq Acc Id: NM_001134530   ⟹   NP_001128002
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.284,658,588 - 4,679,099 (+)NCBI
Rnor_6.085,703,206 - 5,723,593 (+)NCBI
Rnor_5.085,706,054 - 5,726,441 (+)NCBI
RGSC_v3.484,333,773 - 4,354,284 (+)RGD
Celera86,218,410 - 6,238,921 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128002 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69019 (Get FASTA)   NCBI Sequence Viewer  
  P81563 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001128002   ⟸   NM_001134530
- Peptide Label: precursor
- UniProtKB: B5DFD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012595   ⟸   ENSRNOT00000012595
Protein Domains
ZnMc

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307917 AgrOrtholog
Ensembl Genes ENSRNOG00000032353 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012595 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012595 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin/matrixin UniProtKB/TrEMBL
  Hemopexin/matrixin_CS UniProtKB/TrEMBL
  Hemopexin/matrixin_repeat UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A_matrix_cons-reg UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
KEGG Report rno:300339 UniProtKB/TrEMBL
NCBI Gene 300339 ENTREZGENE
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PhenoGen Mmp1 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Hemopexin UniProtKB/TrEMBL
  PGBD_like UniProtKB/TrEMBL
UniProt B5DFD5 ENTREZGENE, UniProtKB/TrEMBL
  MMP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-04 Mmp1  matrix metallopeptidase 1  Mmp1  matrix metallopeptidase 1 (interstitial collagenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-27 Mmp1  matrix metallopeptidase 1 (interstitial collagenase)  Mmp1a  matrix metallopeptidase 1a (interstitial collagenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mmp1a  matrix metallopeptidase 1a (interstitial collagenase)   Mmp1a_predicted  matrix metallopeptidase 1a (interstitial collagenase) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Mmp1a_predicted  matrix metallopeptidase 1a (interstitial collagenase) (predicted)    matrix metalloproteinase 1a (interstitial collagenase) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Mmp1a_predicted  matrix metalloproteinase 1a (interstitial collagenase) (predicted)      Symbol and Name status set to approved 70820 APPROVED