Guca1a (guanylate cyclase activator 1A) - Rat Genome Database

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Gene: Guca1a (guanylate cyclase activator 1A) Rattus norvegicus
Analyze
Symbol: Guca1a
Name: guanylate cyclase activator 1A
RGD ID: 1308712
Description: Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Involved in positive regulation of cGMP-mediated signaling and positive regulation of guanylate cyclase activity. Located in membrane; photoreceptor inner segment; and photoreceptor outer segment. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A); PARTICIPATES IN calcium/calcium-mediated signaling pathway; visual phototransduction pathway; INTERACTS WITH bisphenol A; dexamethasone; glyphosate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanylate cyclase activator 1a (retina); guanylyl cyclase-activating protein 1; LOC301233
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2913,587,695 - 13,598,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,588,525 - 13,598,565 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,168,815 - 22,178,406 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0927,232,681 - 27,242,268 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0925,532,230 - 25,541,815 (+)NCBIRnor_WKY
Rnor_6.0915,609,804 - 15,620,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,609,804 - 15,620,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,530,794 - 14,541,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,046,617 - 9,056,984 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.199,044,401 - 9,054,301 (+)NCBI
Celera911,338,757 - 11,349,075 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2. The localization of guanylyl cyclase-activating proteins in the mammalian retina. Cuenca N, etal., Invest Ophthalmol Vis Sci. 1998 Jun;39(7):1243-50.
3. p19 detected in the rat retina and pineal gland is a guanylyl cyclase-activating protein (GCAP). Dejda A, etal., Acta Biochim Pol. 2002;49(4):899-905.
4. Negatively calcium-modulated membrane guanylate cyclase signaling system in the rat olfactory bulb. Duda T, etal., Biochemistry. 2001 Apr 17;40(15):4654-62.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, etal., Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1. Payne AM, etal., Hum Mol Genet. 1998 Feb;7(2):273-7.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11493703   PMID:15173221   PMID:15336959   PMID:19332500   PMID:22183407  


Genomics

Comparative Map Data
Guca1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2913,587,695 - 13,598,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,588,525 - 13,598,565 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,168,815 - 22,178,406 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0927,232,681 - 27,242,268 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0925,532,230 - 25,541,815 (+)NCBIRnor_WKY
Rnor_6.0915,609,804 - 15,620,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,609,804 - 15,620,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,530,794 - 14,541,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,046,617 - 9,056,984 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.199,044,401 - 9,054,301 (+)NCBI
Celera911,338,757 - 11,349,075 (+)NCBICelera
Cytogenetic Map9q12NCBI
GUCA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38642,173,364 - 42,180,056 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl642,173,364 - 42,181,338 (+)EnsemblGRCh38hg38GRCh38
GRCh37642,141,102 - 42,147,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map6p21.1NCBI
HuRef641,841,195 - 41,865,841 (+)NCBIHuRef
CHM1_1642,125,607 - 42,150,271 (+)NCBICHM1_1
T2T-CHM13v2.0642,001,569 - 42,008,260 (+)NCBIT2T-CHM13v2.0
Guca1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,705,482 - 47,724,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,705,483 - 47,711,509 (-)EnsemblGRCm39 Ensembl
GRCm381747,394,557 - 47,413,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,394,558 - 47,400,584 (-)EnsemblGRCm38mm10GRCm38
MGSCv371747,531,507 - 47,537,533 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361746,857,749 - 46,863,775 (-)NCBIMGSCv36mm8
Celera1750,829,365 - 50,835,380 (-)NCBICelera
Cytogenetic Map17CNCBI
Guca1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,376,091 - 8,382,640 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,370,553 - 8,382,640 (+)NCBIChiLan1.0ChiLan1.0
GUCA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1643,045,278 - 43,069,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,045,307 - 43,070,520 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0641,693,593 - 41,774,591 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Guca1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,258,921 - 46,269,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,691,045 - 17,701,859 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647617,690,484 - 17,701,288 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,282,700 - 37,296,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1737,282,630 - 37,296,713 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,752,943 - 42,760,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,972,216 - 29,984,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,972,862 - 29,977,487 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604442,195,158 - 42,201,833 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Guca1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,089,026 - 17,094,231 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,089,061 - 17,105,538 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Guca1a
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:128
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000020902, ENSRNOT00000065904
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat

Markers in Region
RH135391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,598,310 - 13,598,527 (+)MAPPERmRatBN7.2
Rnor_6.0915,619,775 - 15,619,991NCBIRnor6.0
Rnor_5.0914,540,765 - 14,540,981UniSTSRnor5.0
RGSC_v3.499,056,730 - 9,056,946UniSTSRGSC3.4
Celera911,348,821 - 11,349,037UniSTS
RH 3.4 Map960.2UniSTS
Cytogenetic Map9q12UniSTS
RH138598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,594,428 - 13,594,558 (+)MAPPERmRatBN7.2
Rnor_6.0915,615,893 - 15,616,022NCBIRnor6.0
Rnor_5.0914,536,883 - 14,537,012UniSTSRnor5.0
RGSC_v3.499,052,848 - 9,052,977UniSTSRGSC3.4
Celera911,344,939 - 11,345,068UniSTS
RH 3.4 Map945.4UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium
Low 15 11
Below cutoff 3 4 15 15 4 15 1 1 37 6 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020902   ⟹   ENSRNOP00000020902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl913,588,525 - 13,598,565 (+)Ensembl
Rnor_6.0 Ensembl915,609,804 - 15,620,029 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065904   ⟹   ENSRNOP00000062988
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl915,610,438 - 15,619,811 (+)Ensembl
RefSeq Acc Id: NM_001106887   ⟹   NP_001100357
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2913,588,525 - 13,598,565 (+)NCBI
Rnor_6.0915,609,804 - 15,620,029 (+)NCBI
Rnor_5.0914,530,794 - 14,541,020 (+)NCBI
RGSC_v3.499,046,617 - 9,056,984 (+)RGD
Celera911,338,757 - 11,349,075 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244428   ⟹   XP_006244490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2913,587,695 - 13,598,566 (+)NCBI
Rnor_6.0915,610,202 - 15,620,030 (+)NCBI
Rnor_5.0914,530,794 - 14,541,020 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083176   ⟹   XP_038939104
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2913,595,800 - 13,598,566 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100357 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244490 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939104 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18878 (Get FASTA)   NCBI Sequence Viewer  
  EDM18879 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100357   ⟸   NM_001106887
- UniProtKB: D3ZII9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244490   ⟸   XM_006244428
- Peptide Label: isoform X1
- UniProtKB: D3ZII9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062988   ⟸   ENSRNOT00000065904
RefSeq Acc Id: ENSRNOP00000020902   ⟸   ENSRNOT00000020902
RefSeq Acc Id: XP_038939104   ⟸   XM_039083176
- Peptide Label: isoform X2
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZII9-F1-model_v2 AlphaFold D3ZII9 1-202 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308712 AgrOrtholog
BioCyc Gene G2FUF-28261 BioCyc
Ensembl Genes ENSRNOG00000015402 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020902 ENTREZGENE
  ENSRNOP00000020902.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020902 ENTREZGENE
  ENSRNOT00000020902.7 UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  GUCA1A UniProtKB/TrEMBL
  Recoverin UniProtKB/TrEMBL
KEGG Report rno:301233 UniProtKB/TrEMBL
NCBI Gene 301233 ENTREZGENE
PANTHER PTHR23055 UniProtKB/TrEMBL
  PTHR23055:SF13 UniProtKB/TrEMBL
Pfam EF-hand_8 UniProtKB/TrEMBL
  EF_hand_5 UniProtKB/TrEMBL
PhenoGen Guca1a PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt D3ZII9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Guca1a  guanylate cyclase activator 1A  Guca1a  guanylate cyclase activator 1a (retina)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Guca1a  guanylate cyclase activator 1a (retina)   Guca1a_predicted  guanylate cyclase activator 1a (retina) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Guca1a_predicted  guanylate cyclase activator 1a (retina) (predicted)      Symbol and Name status set to approved 70820 APPROVED