GUCA1A (guanylate cyclase activator 1A) - Rat Genome Database

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Gene: GUCA1A (guanylate cyclase activator 1A) Chlorocebus sabaeus
Analyze
Symbol: GUCA1A
Name: guanylate cyclase activator 1A
RGD ID: 18557005
Description: ENCODES a protein that exhibits calcium ion binding (inferred); calcium sensitive guanylate cyclase activator activity (inferred); guanylate cyclase regulator activity (inferred); INVOLVED IN positive regulation of cGMP-mediated signaling (ortholog); positive regulation of guanylate cyclase activity (ortholog); ASSOCIATED WITH cone dystrophy (ortholog); cone-rod dystrophy (ortholog); cone-rod dystrophy 14 (ortholog); FOUND IN photoreceptor inner segment (ortholog); photoreceptor outer segment (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanylyl cyclase-activating protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,972,216 - 29,984,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,972,862 - 29,977,487 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604442,195,158 - 42,201,833 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GUCA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,972,216 - 29,984,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,972,862 - 29,977,487 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604442,195,158 - 42,201,833 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GUCA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38642,173,364 - 42,180,056 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl642,173,364 - 42,181,338 (+)EnsemblGRCh38hg38GRCh38
GRCh37642,141,102 - 42,147,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map6p21.1NCBI
HuRef641,841,195 - 41,865,841 (+)NCBIHuRef
CHM1_1642,125,607 - 42,150,271 (+)NCBICHM1_1
T2T-CHM13v2.0642,001,569 - 42,008,260 (+)NCBIT2T-CHM13v2.0
Guca1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,080,782 - 21,096,221 (+)NCBIGRCr8
mRatBN7.2913,588,988 - 13,598,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,588,525 - 13,598,565 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,168,815 - 22,178,406 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,232,681 - 27,242,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,532,230 - 25,541,815 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,609,804 - 15,620,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,609,804 - 15,620,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,530,794 - 14,541,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,046,617 - 9,056,984 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.199,044,401 - 9,054,301 (+)NCBI
Celera911,338,757 - 11,349,075 (+)NCBICelera
Cytogenetic Map9q12NCBI
Guca1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,376,091 - 8,382,640 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,370,553 - 8,382,640 (+)NCBIChiLan1.0ChiLan1.0
GUCA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,669,264 - 56,676,039 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,539,219 - 52,545,995 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,693,593 - 41,774,591 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,045,278 - 43,069,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,045,307 - 43,070,520 (+)Ensemblpanpan1.1panPan2
Guca1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,258,921 - 46,269,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,691,045 - 17,701,859 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,690,484 - 17,701,288 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,282,700 - 37,296,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1737,282,630 - 37,296,713 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,752,943 - 42,760,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Guca1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,089,026 - 17,094,231 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,089,061 - 17,105,538 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 4 11 22
Below cutoff 20 6 29

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000009469   ⟹   ENSCSAP00000007584
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1729,972,862 - 29,977,487 (-)Ensembl
RefSeq Acc Id: XM_007972576   ⟹   XP_007970767
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,972,216 - 29,978,899 (-)NCBI
Vero_WHO_p1.0NW_02366604442,195,158 - 42,201,833 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007970767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007584
  ENSCSAP00000007584.1
Reference Protein Sequences
RefSeq Acc Id: XP_007970767   ⟸   XM_007972576
- UniProtKB: A0A0D9RG45 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000007584   ⟸   ENSCSAT00000009469


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009469.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Recoverin UniProtKB/TrEMBL
KEGG Report csab:103221501 UniProtKB/TrEMBL
NCBI Gene GUCA1A ENTREZGENE
PANTHER PTHR23055 UniProtKB/TrEMBL
  PTHR23055:SF13 UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A0D9RG45 ENTREZGENE, UniProtKB/TrEMBL