Dhx36 (DEAH-box helicase 36) - Rat Genome Database

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Gene: Dhx36 (DEAH-box helicase 36) Rattus norvegicus
Analyze
Symbol: Dhx36
Name: DEAH-box helicase 36
RGD ID: 1308767
Description: Enables pre-miRNA binding activity. Involved in positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; and positive regulation of intracellular mRNA localization. Located in axon; dendrite; and perikaryon. Orthologous to human DHX36 (DEAH-box helicase 36); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; G4R1; LOC310461; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82149,006,089 - 149,044,192 (-)NCBIGRCr8
mRatBN7.22146,856,469 - 146,894,577 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2146,856,469 - 146,894,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2153,533,266 - 153,574,345 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02151,638,135 - 151,676,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02146,270,518 - 146,308,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02152,785,844 - 152,824,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2152,785,844 - 152,824,547 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02172,178,850 - 172,217,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42152,122,767 - 152,161,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12152,075,160 - 152,111,181 (-)NCBI
Celera2141,195,467 - 141,233,553 (-)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (ISO,ISS)
cell differentiation  (IEA)
cellular response to arsenite ion  (ISO)
cellular response to heat  (ISO)
cellular response to UV  (ISO,ISS)
defense response to virus  (IEA)
DNA duplex unwinding  (IEA)
G-quadruplex DNA unwinding  (ISO,ISS)
innate immune response  (IEA)
negative regulation of translation  (ISO,ISS)
ossification  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
positive regulation of cardioblast differentiation  (ISO,ISS)
positive regulation of cytoplasmic translation  (ISO,ISS)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of hematopoietic progenitor cell differentiation  (ISO,ISS)
positive regulation of interferon-alpha production  (ISO)
positive regulation of intracellular mRNA localization  (IMP)
positive regulation of mRNA 3'-end processing  (ISO,ISS)
positive regulation of myeloid dendritic cell cytokine production  (ISO)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of telomere maintenance via telomere lengthening  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transcription initiation by RNA polymerase II  (ISO,ISS)
regulation of embryonic development  (ISO,ISS)
regulation of mRNA stability  (ISO,ISS)
regulation of transcription by RNA polymerase III  (ISO,ISS)
response to exogenous dsRNA  (ISO)
response to virus  (ISO)
RNA secondary structure unwinding  (ISO,ISS)
spermatogenesis  (ISO,ISS)
telomerase RNA stabilization  (ISO)

Cellular Component
axon  (IDA)
chromosome, telomeric region  (ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoplasmic stress granule  (ISO)
cytosol  (ISO,ISS)
dendrite  (IDA)
mitochondrion  (IEA,ISO)
nuclear speck  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,ISO,ISS)
perikaryon  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134. Bicker S, etal., Genes Dev. 2013 May 1;27(9):991-6. doi: 10.1101/gad.211243.112.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14731398   PMID:16150737   PMID:18279852   PMID:18570454   PMID:18842585   PMID:18854321   PMID:20472641   PMID:20696886   PMID:21149580   PMID:21266579   PMID:21586581   PMID:21590736  
PMID:21703541   PMID:21846770   PMID:21993297   PMID:22238380   PMID:22422825   PMID:22658674   PMID:22681889   PMID:24151078   PMID:24369427   PMID:25579584   PMID:25611385   PMID:26489465  
PMID:27940037  


Genomics

Comparative Map Data
Dhx36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82149,006,089 - 149,044,192 (-)NCBIGRCr8
mRatBN7.22146,856,469 - 146,894,577 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2146,856,469 - 146,894,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2153,533,266 - 153,574,345 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02151,638,135 - 151,676,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02146,270,518 - 146,308,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02152,785,844 - 152,824,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2152,785,844 - 152,824,547 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02172,178,850 - 172,217,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42152,122,767 - 152,161,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12152,075,160 - 152,111,181 (-)NCBI
Celera2141,195,467 - 141,233,553 (-)NCBICelera
Cytogenetic Map2q31NCBI
DHX36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383154,272,546 - 154,324,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3154,272,546 - 154,324,487 (-)EnsemblGRCh38hg38GRCh38
GRCh373153,990,335 - 154,042,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363155,476,152 - 155,524,971 (-)NCBINCBI36Build 36hg18NCBI36
Build 343155,476,159 - 155,524,973NCBI
Celera3152,414,134 - 152,462,946 (-)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3151,388,213 - 151,437,233 (-)NCBIHuRef
CHM1_13153,956,666 - 154,005,426 (-)NCBICHM1_1
T2T-CHM13v2.03157,046,825 - 157,098,745 (-)NCBIT2T-CHM13v2.0
Dhx36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39362,375,436 - 62,414,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl362,375,434 - 62,414,425 (-)EnsemblGRCm39 Ensembl
GRCm38362,468,015 - 62,507,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl362,468,013 - 62,507,004 (-)EnsemblGRCm38mm10GRCm38
MGSCv37362,272,564 - 62,310,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36362,558,012 - 62,594,917 (-)NCBIMGSCv36mm8
Celera362,146,120 - 62,183,742 (-)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.97NCBI
Dhx36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554485,634,072 - 5,676,319 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554485,634,072 - 5,676,272 (-)NCBIChiLan1.0ChiLan1.0
DHX36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22152,190,111 - 152,241,082 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13152,194,843 - 152,245,768 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03151,331,468 - 151,382,406 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13158,885,041 - 158,935,952 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3158,885,541 - 158,935,871 (-)Ensemblpanpan1.1panPan2
DHX36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12348,404,351 - 48,456,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2348,407,316 - 48,456,654 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2348,271,774 - 48,335,495 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02349,034,891 - 49,086,747 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2349,036,423 - 49,086,673 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12348,615,676 - 48,679,491 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02348,671,780 - 48,735,432 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02348,954,309 - 49,018,059 (-)NCBIUU_Cfam_GSD_1.0
Dhx36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560287,746,909 - 87,787,083 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365191,946,652 - 1,987,070 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365191,946,684 - 1,987,036 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1394,298,794 - 94,350,308 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11394,298,790 - 94,350,333 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213102,367,281 - 102,396,208 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHX36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11536,387,242 - 36,438,133 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1536,387,228 - 36,437,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660419,049,856 - 9,103,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhx36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473031,855,992 - 31,914,253 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473031,857,157 - 31,913,985 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dhx36
203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:562
Count of miRNA genes:264
Interacting mature miRNAs:338
Transcripts:ENSRNOT00000019824
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat

Markers in Region
RH128402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22146,856,637 - 146,856,834 (+)MAPPERmRatBN7.2
Rnor_6.02152,786,013 - 152,786,209NCBIRnor6.0
Rnor_5.02172,179,019 - 172,179,215UniSTSRnor5.0
RGSC_v3.42152,122,936 - 152,123,132UniSTSRGSC3.4
Celera2141,195,636 - 141,195,832UniSTS
RH 3.4 Map18390.0UniSTS
RH 3.4 Map2957.4UniSTS
Cytogenetic Map2q31UniSTS
AU022184  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22146,858,763 - 146,858,872 (+)MAPPERmRatBN7.2
Rnor_6.02152,788,139 - 152,788,247NCBIRnor6.0
Rnor_5.02172,181,145 - 172,181,253UniSTSRnor5.0
RGSC_v3.42152,125,062 - 152,125,170UniSTSRGSC3.4
Celera2141,197,762 - 141,197,870UniSTS
Cytogenetic Map2q31UniSTS
BE115449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22146,863,018 - 146,863,168 (+)MAPPERmRatBN7.2
Rnor_6.02152,792,393 - 152,792,542NCBIRnor6.0
Rnor_5.02172,185,399 - 172,185,548UniSTSRnor5.0
RGSC_v3.42152,129,316 - 152,129,465UniSTSRGSC3.4
Celera2141,202,016 - 141,202,165UniSTS
RH 3.4 Map2960.3UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 54 38 19 38 8 9 74 34 39 11 8
Low 5 3 3 3 2 1 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019824   ⟹   ENSRNOP00000019824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2146,856,469 - 146,894,572 (-)Ensembl
Rnor_6.0 Ensembl2152,785,844 - 152,824,547 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118321   ⟹   ENSRNOP00000086951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2146,856,469 - 146,894,572 (-)Ensembl
RefSeq Acc Id: NM_001107678   ⟹   NP_001101148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82149,006,089 - 149,044,191 (-)NCBI
mRatBN7.22146,856,469 - 146,894,572 (-)NCBI
Rnor_6.02152,785,844 - 152,824,547 (-)NCBI
Rnor_5.02172,178,850 - 172,217,986 (-)NCBI
RGSC_v3.42152,122,767 - 152,161,219 (-)RGD
Celera2141,195,467 - 141,233,553 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761047   ⟹   XP_008759269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82149,010,687 - 149,044,192 (-)NCBI
mRatBN7.22146,862,811 - 146,894,577 (-)NCBI
Rnor_6.02152,791,525 - 152,824,549 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005500288
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82149,006,203 - 149,044,192 (-)NCBI
mRatBN7.22146,856,583 - 146,894,576 (-)NCBI
RefSeq Acc Id: XR_351724
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82149,006,203 - 149,044,192 (-)NCBI
mRatBN7.22146,856,583 - 146,894,576 (-)NCBI
Rnor_6.02152,785,958 - 152,824,549 (-)NCBI
Rnor_5.02172,178,850 - 172,217,986 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001101148   ⟸   NM_001107678
- UniProtKB: D4A2Z8 (UniProtKB/TrEMBL),   A0A8I6A6W1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759269   ⟸   XM_008761047
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000019824   ⟸   ENSRNOT00000019824
RefSeq Acc Id: ENSRNOP00000086951   ⟸   ENSRNOT00000118321
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2Z8-F1-model_v2 AlphaFold D4A2Z8 1-1000 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691355
Promoter ID:EPDNEW_R1879
Type:multiple initiation site
Name:Dhx36_1
Description:DEAH-box helicase 36
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02152,824,520 - 152,824,580EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308767 AgrOrtholog
BioCyc Gene G2FUF-52943 BioCyc
Ensembl Genes ENSRNOG00000014599 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00060004440 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019824 ENTREZGENE
  ENSRNOT00000019824.7 UniProtKB/Swiss-Prot
  ENSRNOT00000118321.1 UniProtKB/TrEMBL
  ENSRNOT00060007457 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.1080 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEAD-box_helicase_OB_fold UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1605 UniProtKB/Swiss-Prot
  HA2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase-assoc_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310461 UniProtKB/Swiss-Prot
NCBI Gene 310461 ENTREZGENE
PANTHER ATP-DEPENDENT DNA/RNA HELICASE DHX36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HA2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OB_NTP_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dhx36 PhenoGen
PROSITE DEAH_ATP_HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014599 RatGTEx
  ENSRNOG00060004440 RatGTEx
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A6W1 ENTREZGENE, UniProtKB/TrEMBL
  D4A2Z8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Dhx36  DEAH-box helicase 36  Dhx36  DEAH (Asp-Glu-Ala-His) box polypeptide 36  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dhx36  DEAH (Asp-Glu-Ala-His) box polypeptide 36   Dhx36_predicted  DEAH (Asp-Glu-Ala-His) box polypeptide 36 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dhx36_predicted  DEAH (Asp-Glu-Ala-His) box polypeptide 36 (predicted)      Symbol and Name status set to approved 70820 APPROVED