Dhx36 (DEAH (Asp-Glu-Ala-His) box polypeptide 36) - Rat Genome Database
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Gene: Dhx36 (DEAH (Asp-Glu-Ala-His) box polypeptide 36) Mus musculus
Analyze
Symbol: Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
RGD ID: 1318733
MGI Page MGI
Description: Exhibits DNA helicase activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in several processes, including G-quadruplex DNA unwinding; positive regulation of cell differentiation; and regulation of gene expression. Localizes to cytosol. Is expressed in telencephalon. Orthologous to human DHX36 (DEAH-box helicase 36); INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810407E23Rik; AI452301; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; AU022184; Ddx36; DEAD/H box polypeptide 36; DEAH box protein 36; mKIAA1488; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39362,375,436 - 62,414,464 (-)NCBIGRCm39mm39
GRCm38362,468,015 - 62,507,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl362,468,013 - 62,507,004 (-)EnsemblGRCm38mm10GRCm38
MGSCv37362,272,564 - 62,310,910 (-)NCBIGRCm37mm9NCBIm37
MGSCv36362,558,012 - 62,594,917 (-)NCBImm8
Celera362,146,120 - 62,183,742 (-)NCBICelera
Cytogenetic Map3E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (ISO)
cell differentiation  (IEA)
cellular response to arsenite ion  (ISO)
cellular response to heat  (ISO)
cellular response to UV  (ISO)
defense response to virus  (IEA)
G-quadruplex DNA unwinding  (IDA,ISO)
immune system process  (IEA)
innate immune response  (IEA)
multicellular organism development  (IEA)
negative regulation of translation  (ISO)
ossification  (IMP)
positive regulation of cardioblast differentiation  (IMP)
positive regulation of cytoplasmic translation  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hematopoietic progenitor cell differentiation  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IMP)
positive regulation of interferon-alpha production  (ISO)
positive regulation of intracellular mRNA localization  (ISO)
positive regulation of mRNA 3'-end processing  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (IMP)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of telomere maintenance via telomere lengthening  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
regulation of embryonic development  (IMP)
regulation of mRNA stability  (ISO)
regulation of transcription by RNA polymerase III  (ISO)
regulation of transcription from RNA polymerase II promoter involved in spermatogenesis  (IMP)
regulation of translation  (IEA)
response to exogenous dsRNA  (IMP)
response to virus  (IMP)
RNA secondary structure unwinding  (ISO)
spermatogenesis  (IDA)
telomerase RNA stabilization  (ISO)

Cellular Component

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12198572   PMID:12477932   PMID:15328020   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:21266579   PMID:21267068   PMID:21590736   PMID:21677750   PMID:21703541   PMID:21873635   PMID:22422825   PMID:22922362   PMID:24457600   PMID:25611385   PMID:25737280   PMID:26489465  
PMID:30333137   PMID:31138677   PMID:32325033  


Genomics

Comparative Map Data
Dhx36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39362,375,436 - 62,414,464 (-)NCBIGRCm39mm39
GRCm38362,468,015 - 62,507,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl362,468,013 - 62,507,004 (-)EnsemblGRCm38mm10GRCm38
MGSCv37362,272,564 - 62,310,910 (-)NCBIGRCm37mm9NCBIm37
MGSCv36362,558,012 - 62,594,917 (-)NCBImm8
Celera362,146,120 - 62,183,742 (-)NCBICelera
Cytogenetic Map3E1NCBI
DHX36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3154,272,546 - 154,324,487 (-)EnsemblGRCh38hg38GRCh38
GRCh383154,272,546 - 154,324,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373153,993,452 - 154,042,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363155,476,152 - 155,524,971 (-)NCBINCBI36hg18NCBI36
Build 343155,476,159 - 155,524,973NCBI
Celera3152,414,134 - 152,462,946 (-)NCBI
Cytogenetic Map3q25.2NCBI
HuRef3151,388,213 - 151,437,233 (-)NCBIHuRef
CHM1_13153,956,666 - 154,005,426 (-)NCBICHM1_1
Dhx36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02152,785,844 - 152,824,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2152,785,844 - 152,824,547 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02172,178,850 - 172,217,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42152,122,767 - 152,161,219 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12152,075,160 - 152,111,181 (-)NCBI
Celera2141,195,467 - 141,233,553 (-)NCBICelera
Cytogenetic Map2q31NCBI
Dhx36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554485,634,072 - 5,676,319 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554485,634,072 - 5,676,272 (-)NCBIChiLan1.0ChiLan1.0
DHX36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13158,885,041 - 158,935,952 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3158,885,541 - 158,935,871 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03151,331,468 - 151,382,406 (-)NCBIMhudiblu_PPA_v0panPan3
DHX36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2348,407,316 - 48,456,654 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12348,404,351 - 48,456,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dhx36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365191,946,684 - 1,987,036 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1394,298,790 - 94,350,312 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11394,298,790 - 94,350,333 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213102,367,281 - 102,396,208 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHX36
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11536,387,242 - 36,438,133 (+)NCBI
ChlSab1.1 Ensembl1536,387,228 - 36,437,606 (+)Ensembl
Dhx36
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473031,857,157 - 31,913,985 (-)NCBI

Position Markers
AU022184  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38362,470,301 - 62,470,410UniSTSGRCm38
MGSCv37362,274,223 - 62,274,332UniSTSGRCm37
Celera362,147,779 - 62,147,888UniSTS
Cytogenetic Map3E1UniSTS
Whitehead/MRC_RH3562.41UniSTS
UniSTS:234697  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38362,468,156 - 62,468,372UniSTSGRCm38
MGSCv37362,272,078 - 62,272,294UniSTSGRCm37
Celera362,145,634 - 62,145,850UniSTS
Cytogenetic Map3E1UniSTS
BE115449  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38362,472,948 - 62,473,101UniSTSGRCm38
MGSCv37362,276,870 - 62,277,023UniSTSGRCm37
Celera362,150,426 - 62,150,579UniSTS
Cytogenetic Map3E1UniSTS
UniSTS:225146  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38362,497,536 - 62,497,697UniSTSGRCm38
MGSCv37362,301,458 - 62,301,619UniSTSGRCm37
Celera362,175,055 - 62,175,216UniSTS
Cytogenetic Map3E1UniSTS
AU022184  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38362,470,169 - 62,470,388UniSTSGRCm38
MGSCv37362,274,091 - 62,274,310UniSTSGRCm37
Celera362,147,647 - 62,147,866UniSTS
Cytogenetic Map3E1UniSTS
Whitehead/MRC_RH3563.26UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3752111468809613Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33188340565883548Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33358101667581166Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33384462467844807Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33384462467844807Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33426332068263320Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33466868268668682Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33550000069500000Mouse
14746977Manh53_mmandible shape 53 (mouse)33601785970017859Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33712559368809613Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33979668173796810Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33979668173796810Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33979668173796810Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33979668173796810Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884389Skwq10_mskull length QTL 10, 16 week (mouse)34400000065400000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4945016083450160Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34958758483587697Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34958758483587697Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35271817686718412Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35271817686718412Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35271817686718412Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35301585087015850Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:238
Interacting mature miRNAs:264
Transcripts:ENSMUST00000029336, ENSMUST00000160858, ENSMUST00000162070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029336   ⟹   ENSMUSP00000029336
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl362,468,013 - 62,507,004 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160858
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl362,470,645 - 62,472,587 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162070
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl362,484,190 - 62,488,625 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192223
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl362,497,933 - 62,502,133 (-)Ensembl
RefSeq Acc Id: NM_028136   ⟹   NP_082412
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39362,376,063 - 62,414,409 (-)NCBI
GRCm38362,468,642 - 62,506,988 (-)NCBI
MGSCv37362,272,564 - 62,310,910 (-)RGD
Celera362,146,120 - 62,183,742 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036163348   ⟹   XP_036019241
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39362,375,436 - 62,414,453 (-)NCBI
RefSeq Acc Id: XR_004941401
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39362,375,436 - 62,414,464 (-)NCBI
RefSeq Acc Id: XR_004941402
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39362,375,436 - 62,414,464 (-)NCBI
RefSeq Acc Id: XR_004941403
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39362,375,436 - 62,414,464 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_082412   ⟸   NM_028136
- UniProtKB: Q8VHK9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000029336   ⟸   ENSMUST00000029336
RefSeq Acc Id: XP_036019241   ⟸   XM_036163348
- Peptide Label: isoform X1
Promoters
RGD ID:6833655
Promoter ID:MM_KWN:34461
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000064088
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36362,310,651 - 62,311,151 (-)MPROMDB
RGD ID:6880776
Promoter ID:EPDNEW_M3839
Type:initiation region
Name:Dhx36_1
Description:Mus musculus DEAH (Asp-Glu-Ala-His) box polypeptide 36 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38362,506,988 - 62,507,048EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919412 AgrOrtholog
Ensembl Genes ENSMUSG00000027770 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000029336 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029336 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1605 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase-assoc_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72162 UniProtKB/Swiss-Prot
MGD MGI:1919412 ENTREZGENE
NCBI Gene 72162 ENTREZGENE
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OB_NTP_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dhx36 PhenoGen
PROSITE DEAH_ATP_HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.224233 ENTREZGENE
UniProt A0JLR3_MOUSE UniProtKB/TrEMBL
  B2RQS6_MOUSE UniProtKB/TrEMBL
  DHX36_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3X8Y4 UniProtKB/Swiss-Prot
  Q6ZPP7 UniProtKB/Swiss-Prot
  Q9CSE8 UniProtKB/Swiss-Prot