Leukc2 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Leukc2 (Leukocyte quantity QTL 2) Rattus norvegicus

Symbol: Leukc2
Name: Leukocyte quantity QTL 2
RGD ID: 5135226
Previously known as: eosinophilia 2; eos2
Trait: eosinophil quantity   (VT:0002602)    
Measurement Type: blood eosinophil count   (CMO:0000033)    
LOD Score: LRS: 7.1
P Value: Not Available
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82120,039,407 - 151,869,825RGD_MAPPER_PIPELINE
mRatBN7.22118,111,229 - 149,559,726RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02121,750,419 - 155,965,721RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02141,390,480 - 175,354,471RGDRnor5.0
RGSC_v3.42121,545,310 - 155,102,371RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: ACI/NSlc MES/Slc 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2RatEosinophilia  IAGP 5135221 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2Ratincreased eosinophil cell number  IDA 5135221 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2Ratblood eosinophil count  IDA 5135221 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2Ratcontrol condition  IDA 5135221 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2Ratautomated blood cell counting method  IDA 5135221 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2RatACI/NSlc  IEA 5135221 RGD 
Leukc2RatMES/Slc  IEA 5135221 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Leukc2Rateosinophil quantity  IDA 5135221 RGD 


#
Reference Title
Reference Citation
1. A locus for eosinophilia in the MES rat is on Chromosome 19. Li G, etal., Mamm Genome. 2005 Jul;16(7):516-23.


1 to 20 of 288 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
41366851Rbmxl1-ps1Rbmx like 1, pseudogene 12118217422118225582Rat
6504224Pramel7-ps1preferentially expressed antigen in melanoma-like 7, pseudogene 12118236522118237038Rat
2323451Rnps1-ps2RNA binding protein with serine rich domain 1, pseudogene 22118373339118374187Rat
41327895Gabarapl2-ps3GABA type A receptor associated protein like 2, pseudogene 32118499300118500311Rat
41355076Rnu6-1158RNA, U6 small nuclear 11582118570694118570798Rat
1561719Atp11bATPase phospholipid transporting 11B (putative)2118585348118691076Rat
1309668Dcun1d1defective in cullin neddylation 1 domain containing 12118721275118772606Rat
1310615Mccc1methylcrotonyl-CoA carboxylase subunit 12118799147118851181Rat
1585492Ccdc144bcoiled-coil domain containing 144B2118862790118924638Rat
727973Acad9acyl-CoA dehydrogenase family, member 92118943170118966150Rat
2323100Zfp267zinc finger protein 2672119017280119035885Rat
41098583Surf6-ps3surfeit 6, pseudogene 32119017398119027282Rat
1304917Arslarylsulfatase L2119038803119047579Rat
728380Qrfprpyroglutamylated RFamide peptide receptor2119053083119096864Rat
41370461Pou5f1-ps3POU class 5 homeobox 1, pseudogene 32119087448119088134Rat
2120Anxa5annexin A52119314007119344703Rat
11384727Smim43small integral membrane protein 432119380454119385966Rat
1307888Exosc9exosome component 92119416028119426981Rat
621059Ccna2cyclin A22119427239119433645Rat
1309264Bbs7Bardet-Biedl syndrome 72119434760119474665Rat

1 to 20 of 288 rows
1 to 20 of 383 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
41358D2Rat2171392118111229118111368Ratregion
5029863AW5308731572118258177118258334Ratregion
5030343AI7152961992118689951118690150Ratregion
5084576AA9457161662118690858118691024Ratregion
5078512RH1403851902118721709118721899Ratregion
5044102RH1304112132118722390118722646Ratregion
5044102RH1304112132118722433118722646Ratregion
5035466AW5320872112118724204118724415Ratregion
5084710AI1026902102118724677118724887Ratregion
550223724.MMHAP12FLH3.seq1882118753830118754018Ratregion
5030305BF3967351852118755658118755843Ratregion
5499783UniSTS:2346592212118763445118763666Ratregion
60339D2Got751452118768579118768724Ratregion
5048244RH1327911802118772548118772728Ratregion
5073100RH1372378532118799312118800165Ratregion
5053319RH1425794522118800899118801351Ratregion
5032897RH1368881882118965805118965993Ratregion
5086191AI1787641522118966360118966512Ratregion
5030209AW5320751512119031693119031844Ratregion
5072414RH1368352472119035477119035724Ratregion
1 to 20 of 383 rows

Flank 1: (D2Rat217)
Rat AssemblyChrPosition (strand)Source
GRCr82120,039,407 - 120,039,546 (+)Marker Load Pipeline
mRatBN7.22118,111,229 - 118,111,368 (+)MAPPER
Rnor_6.02121,750,419 - 121,750,557NCBI
Rnor_5.02141,390,480 - 141,390,618UniSTS
RGSC_v3.42121,545,310 - 121,545,449RGD
RGSC_v3.42121,545,311 - 121,545,449UniSTS
RGSC_v3.12121,490,272 - 121,490,411RGD
Celera2113,142,302 - 113,142,440UniSTS
SHRSP x BN Map243.3798RGD
SHRSP x BN Map243.3798UniSTS
Flank 2: (D2Rat38)
Rat AssemblyChrPosition (strand)Source
GRCr82151,869,660 - 151,869,825 (+)Marker Load Pipeline
mRatBN7.22149,559,561 - 149,559,726 (+)MAPPER
Rnor_6.02155,965,557 - 155,965,721NCBI
Rnor_5.02175,354,307 - 175,354,471UniSTS
RGSC_v3.42155,101,972 - 155,102,371RGD
RGSC_v3.42155,102,058 - 155,102,222UniSTS
RGSC_v3.12155,052,021 - 155,052,185RGD
Celera2143,979,588 - 143,979,752UniSTS
RH 3.4 Map2972.8RGD
RH 3.4 Map2972.8UniSTS
RH 2.0 Map2698.5RGD
SHRSP x BN Map260.5198RGD
FHH x ACI Map267.7299RGD
Cytogenetic Map2q31UniSTS


1 to 10 of 97 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549841Bp256Blood pressure QTL 2560.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2137219876142323610Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
12879830Bw178Body weight QTL 1780.001body mass (VT:0001259)body weight (CMO:0000012)2137219876142323610Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
12879831Cm82Cardiac mass QTL 820.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2137219876142323610Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat

1 to 10 of 97 rows


Note Type Note Reference
qtl_general explains 5% of the total variance with an additive effect of 83.4 by the MES allele 5135221
qtl_general software used: Map Manager QTXb20 5135221
qtl_general lineage: 7 eosinophilic male rats from F9 and F10 generation were backcrossed to MES/Slc 5135221
qtl_general measurement method: blood samples were collected from the jugular vein of 12 weeks old rats anesthetized with ether; number of leukocytes was counted by an automated cell counter and differential leukocyte counts (%) were determined on blood film stained with Wright's stain 5135221
qtl_general number of animals used: 328 backcross rats 5135221
qtl_statistics LRS: 7.1 5135221