Afg2a (AFG2 AAA ATPase homolog A)

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Gene: Afg2a (AFG2 AAA ATPase homolog A) Rattus norvegicus

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Symbol:

Afg2a (Ensembl: Spata5)

Name:

AFG2 AAA ATPase homolog A (Ensembl:spermatogenesis associated 5)

RGD ID:

1310478

Description:

Predicted to enable ATP hydrolysis activity and preribosome binding activity. Predicted to be involved in brain development and ribosomal large subunit biogenesis. Predicted to be located in spindle. Predicted to be active in cytoplasm. Orthologous to human AFG2A (AFG2 AAA ATPase homolog A); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ATPase family gene 2 protein homolog A; ATPase family protein 2 homolog; LOC361935; ribosome biogenesis protein SPATA5; Spata5; spermatogenesis associated 5; spermatogenesis-associated protein 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AFG2A (AFG2 AAA ATPase homolog A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Afg2a (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Afg2a (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AFG2A (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AFG2A (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Afg2a (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AFG2A (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AFG2A (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Afg2a (AFG2 AAA ATPase homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AFG2A (AFG2 AAA ATPase homolog A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Afg2a (AFG2 AAA ATPase homolog A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AFG2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5776	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cdc-48.3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	spata5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	122,234,619 - 122,425,808 (+)	NCBI		GRCr8
mRatBN7.2	2	120,306,417 - 120,497,707 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,705 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	126,869,277 - 127,060,635 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	124,981,783 - 125,173,154 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	119,610,740 - 119,802,117 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	124,149,872 - 124,341,138 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	124,149,872 - 124,341,131 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	143,758,068 - 143,950,578 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	123,962,875 - 124,154,127 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	123,913,002 - 124,104,391 (+)	NCBI
Celera	2	115,253,057 - 115,441,808 (+)	NCBI		Celera
Cytogenetic Map	2	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

genetic disease (ISO)

neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

bortezomib (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

dioxygen (ISO)

enzyme inhibitor (ISO)

fipronil (EXP)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glycidyl methacrylate (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

leflunomide (ISO)

methotrexate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

propiconazole (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

T-2 toxin (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP,ISO)

Triptolide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

ribosomal large subunit biogenesis (ISO)

Cellular Component

cytoplasm (IBA,ISO)

spindle (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA)

preribosome binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:26299366	PMID:29343804

Genomics

Comparative Map Data

Afg2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	122,234,619 - 122,425,808 (+)	NCBI		GRCr8
mRatBN7.2	2	120,306,417 - 120,497,707 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,705 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	126,869,277 - 127,060,635 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	124,981,783 - 125,173,154 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	119,610,740 - 119,802,117 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	124,149,872 - 124,341,138 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	124,149,872 - 124,341,131 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	143,758,068 - 143,950,578 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	123,962,875 - 124,154,127 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	123,913,002 - 124,104,391 (+)	NCBI
Celera	2	115,253,057 - 115,441,808 (+)	NCBI		Celera
Cytogenetic Map	2	q25	NCBI

AFG2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	122,923,078 - 123,319,433 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	122,923,070 - 123,319,433 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	123,844,233 - 124,240,588 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	124,063,675 - 124,460,055 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	124,201,833 - 124,593,407	NCBI
Celera	4	121,227,068 - 121,623,149 (+)	NCBI		Celera
Cytogenetic Map	4	q28.1	NCBI
HuRef	4	119,570,673 - 119,967,245 (+)	NCBI		HuRef
CHM1_1	4	123,820,765 - 124,217,279 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	126,227,197 - 126,623,517 (+)	NCBI		T2T-CHM13v2.0

Afg2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	37,474,052 - 37,633,245 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	37,474,045 - 37,633,245 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	37,419,903 - 37,579,096 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	37,419,896 - 37,579,096 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	37,319,202 - 37,478,017 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	37,611,847 - 37,770,640 (+)	NCBI		MGSCv36	mm8
Celera	3	37,295,123 - 37,453,242 (+)	NCBI		Celera
Cytogenetic Map	3	B	NCBI
cM Map	3	18.46	NCBI

Afg2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	17,524,583 - 17,823,108 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955428	17,525,388 - 17,823,478 (-)	NCBI	ChiLan1.0	ChiLan1.0

AFG2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	120,699,939 - 121,092,742 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	120,965,751 - 121,358,911 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	115,101,064 - 115,489,360 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	126,245,508 - 126,632,165 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	126,256,152 - 126,631,500 (+)	Ensembl	panpan1.1		panPan2

AFG2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	17,020,337 - 17,371,396 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	16,994,661 - 17,463,151 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	17,233,899 - 17,584,562 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	17,132,668 - 17,484,528 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	19	17,090,290 - 17,440,587 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	17,368,198 - 17,719,114 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	17,839,642 - 18,190,985 (-)	NCBI		UU_Cfam_GSD_1.0

Afg2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	64,912,369 - 65,214,617 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936662	1,958,268 - 2,208,207 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936662	1,886,176 - 1,929,097 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936662	1,957,364 - 2,207,410 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AFG2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	100,917,319 - 101,241,099 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	100,918,331 - 101,241,099 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	108,342,977 - 108,446,111 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AFG2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	70,188,246 - 70,585,022 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	49,158,187 - 49,516,718 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Afg2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624777	3,342,271 - 3,639,118 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624777	3,342,437 - 3,710,544 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Afg2a
421 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	19
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000023584
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	102803808	147803808	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	118111229	157142209	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	143657569	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	104559726	149559726	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	118111229	149559726	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	118189491	163189491	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	112103657	148076632	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	114654253	159654253	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat

Markers in Region

D2Rat218

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,346,103 - 120,346,217 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,189,562 - 124,189,675	NCBI	Rnor6.0
Rnor_5.0	2	143,797,758 - 143,797,871	UniSTS	Rnor5.0
RGSC_v3.4	2	124,002,564 - 124,002,678	RGD	RGSC3.4
RGSC_v3.4	2	124,002,565 - 124,002,678	UniSTS	RGSC3.4
RGSC_v3.1	2	123,952,334 - 123,952,447	RGD
Celera	2	115,292,631 - 115,292,744	UniSTS
RH 3.4 Map	2	673.2	UniSTS
RH 3.4 Map	2	673.2	RGD
SHRSP x BN Map	2	44.6298	UniSTS
SHRSP x BN Map	2	44.6298	RGD
Cytogenetic Map	2	q25	UniSTS

D3Got115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,490,082 - 120,490,284 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,333,512 - 124,333,713	NCBI	Rnor6.0
Rnor_5.0	2	143,942,966 - 143,943,167	UniSTS	Rnor5.0
RGSC_v3.4	2	124,146,514 - 124,146,716	RGD	RGSC3.4
RGSC_v3.4	2	124,146,515 - 124,146,716	UniSTS	RGSC3.4
RGSC_v3.1	2	124,096,779 - 124,096,980	RGD
Celera	2	115,434,266 - 115,434,467	UniSTS
RH 3.4 Map	2	676.7	UniSTS
RH 3.4 Map	2	676.7	RGD
RH 2.0 Map	2	593.2	RGD
Cytogenetic Map	2	q25	UniSTS

BF404163

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,391,886 - 120,391,985 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,235,343 - 124,235,441	NCBI	Rnor6.0
Rnor_5.0	2	143,844,225 - 143,844,323	UniSTS	Rnor5.0
RGSC_v3.4	2	124,048,346 - 124,048,444	UniSTS	RGSC3.4
Celera	2	115,337,372 - 115,337,470	UniSTS
RH 3.4 Map	2	674.2	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH136733

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,422,221 - 120,422,340 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,265,670 - 124,265,788	NCBI	Rnor6.0
Rnor_5.0	2	143,874,760 - 143,874,878	UniSTS	Rnor5.0
RGSC_v3.4	2	124,078,673 - 124,078,791	UniSTS	RGSC3.4
Celera	2	115,368,070 - 115,368,188	UniSTS
RH 3.4 Map	2	675.2	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH126301

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	120,310,928 - 120,311,132 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	124,154,389 - 124,154,592	NCBI	Rnor6.0
Rnor_5.0	2	143,762,585 - 143,762,788	UniSTS	Rnor5.0
RGSC_v3.4	2	123,967,392 - 123,967,595	UniSTS	RGSC3.4
Celera	2	115,257,578 - 115,257,781	UniSTS
Cytogenetic Map	2	q25	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023584 ⟹ ENSRNOP00000023584

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,697 (+)	Ensembl
Rnor_6.0 Ensembl	2	124,149,872 - 124,341,124 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078650 ⟹ ENSRNOP00000071455

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,705 (+)	Ensembl
Rnor_6.0 Ensembl	2	124,150,224 - 124,341,131 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119204 ⟹ ENSRNOP00000086493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	120,306,412 - 120,497,702 (+)	Ensembl

RefSeq Acc Id:

NM_001415082 ⟹ NP_001402011

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	122,234,883 - 122,425,808 (+)	NCBI
mRatBN7.2	2	120,306,760 - 120,497,707 (+)	NCBI

RefSeq Acc Id:

XM_008760933 ⟹ XP_008759155

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	122,234,619 - 122,425,808 (+)	NCBI
mRatBN7.2	2	120,306,437 - 120,497,707 (+)	NCBI
Rnor_6.0	2	124,150,209 - 124,341,137 (+)	NCBI

Sequence:

show sequence

GTTTTATCCCCGTGCCGCGCACGTTGAGCCGGCTTTGGGCTGCTTTTCTCCGACAGCCTGCGGT
CATGTCTTCCAAGAAGAACAGAAAGCGACAGAAAGAGGGCGCGGAGGGGACCTCGCCCTCGCTC
TCTGCGGCTTCGTCTCGCTCGGGGACCTCGACTCCTCTCGCTCAGCCGAACGTGGCGGCGCCGG
GGATGTTGGTGGTGACCAACTTTCTTGAGAAAGATGGCAAAGTTCCTAAGACATTCCAGAATTC
CCTAGTTCATCTTGGACTTAACACTATGAAGTCTGCAAACATATGTATAGGTCGACCAGTGCTC
CTTACCAGTTTGGATGGAAAGCAGGAGGTTTATACAGCCTGGCCAGTTGCAGGATTTCCTGGAG
GCAAGGTTGGTCTAAGTGAAATGGCACAGAAGAATGTGGGTGTGAAAGCTGGTGAGACCATCCG
GGTCCAACCTCTTTTGGGTGCTGTACTTCAGGCCCAGGAAATGGACTTGGCACTGAGTGACAAA
GATAAGGAAATTAATGAAGAAGAACTGACTGGTTGTATTCTGAGAAAACTAGATGGCAAGATTG
TTTTACCAGGCAACTTTCTGTACTGTACATTCTATGGACGACTCTGCAAGTTACAAGTGTTGCA
AGTAAAAGGGACAGATGGCACAACATTGGGAAAGCCTCAGAGCTCCTCTGGCACTGATGTCCAT
GGAATGGCCTCTGAGCAGTCTAGCATGGAAAGCAGTGATGTGGATATTTCATTCCAGCTAAGCC
AGTTAGATCTGAAAGAACCTCAGAGCCCAGCATCACAGAGTACTCCCTGTAAACCCATCAATGA
CAGAACTATGAATAAAGCTGGTGAAGTTTTGTTGGATGTTACACAGAGCCCTAGGGATGGAAGT
GGACTTGGACTAGAGGAAATCACAGGGCTTAAGTGTAGTTTTGATTCATCCAAAGAAGGAAATA
CACAACCTATCAGTGAAGAGAAACTACTAAAATCTACTAGTGCAGGTGCAAAGAACAATACTGA
TACTTTTTATTTTATTTCTTCAACAACAAGAATCAATCTTCGAAAAATTTGTACAAATTCAAAA
GAACAAGACAGTCAGTTCAAAGTAACTTATGACATGATTGGAGGCTTAAACAGTCAGCTGAAAG
CAATAAGAGAAATAATTGAACTGCCTCTCAAGCAGCCTGAACTTTTCAAGAGTTACGGAATTCC
AGCACCTAGAGGGTTATTACTCTATGGTCCTCCAGGTACCGGAAAGACAATGATTGCTAGGGCT
GTTGCTAATGAAGTTGGAGCTTATGTTTCTGTAATTAATGGTCCTGAAATTATAAGCAAATTCT
ATGGTGAGACTGAAGCAAGGTTACGCCAGATATTTGCTGAAGCCACTCTACGGCATCCATCGAT
TATTTTTATTGATGAGCTGGATGCACTTTGCCCTAAAAGAGAAGGAGCTCAAAGTGAAGTGGAA
AAGAGAGTTGTAGCTTCGCTCTTAACATTGATGGATGGCATTGGCTCAGAAGGAAGTGAAGGAC
GGGTATTAGTCCTTGGGGCCACAAATCGCCCTCAAGCGCTAGATGCTGCACTCAGAAGACCTGG
GCGATTTGATAAAGAGATTGAGATTGGCATTCCTAATGCCCAAGACCGGCTTGATATTCTCCAG
AAACTACTCCGAAGGGTGCCACACTTACTCACCAAAGCTGAGCTTCTGAGATTGGCAAATAATG
CCCATGGTTATGTTGGCGCAGACTTGAAAGCCTTGTGTAATGAAGCAGGTCTGTATGCCTTGCG
AAGAGTCCTGAGGAAACAGCCTAATCTCCCTGATAGCAAGGTGGCTGGCATGGTGAAGATTACC
CTAAATGATTTCTTACAGGGGATGAATGATATCAGGCCTAGTGCTATGAGAGAGGTAGCAATTG
ATGTCCCAAATGTATCCTGGTCAGATATTGGAGGACTGGAAAATATCAAACTGAAATTGAAACA
GGCTGTGGAATGGCCCTTGAAACATCCTAAGTCTTTCAGCAGAATGGGTATTCAGCCACCTAAA
GGAGTTCTCTTGTATGGGCCTCCTGGATGCTCAAAAACAATGATAGCAAAGGCTTTGGCCAATG
AAAGTGGGTTGAACTTTCTAGCTATAAAGGGGCCTGAATTAATGAATAAGTATGTTGGTGAATC
TGAAAGAGCAGTTAGAGAGGTATTCCGTAAAGCAAGAGCAGTGGCACCTTCCATTATCTTTTTT
GATGAACTTGATGCCTTGGCTGTTGAAAGGGGCAGTTCTTCAGGTGCCGGGAATGTTGCAGATC
GTGTTTTGGCTCAGCTGTTAACGGAAATGGATGGAATTGAACAGCTAAAAAATGTGACAGTTTT
GGCAGCTACTAATCGCCCAGATAGAATAGACAAGGCTCTGATGAGGCCTGGAAGAATTGACAGG
ATCATTTATGTGCCCTTACCGGATGCAGCAACAAGAAGGGAAATACTGAACTTGCAGTTCCACT
CAATGCCAATCAGTAACGAGGTTGACCTGGATGAACTGGTCCTCCAAACTGACACCTACTCAGG
AGCAGAGATCATAGCAGTCTGCAAGGAGGCCGCTCTCCTAGCTCTGGAAGAAAACATTAAAGCT
GACTGCATTATGAAGAGGCATTTCACTCAAGCCTTGAGCATTGTGACACCCAGAATCCCGGAGT
CACTGAGGCGCTTTTATGAAGATTACCAAGAGAAGAGTGGGTTACACATGGTCTAAGAAATACC
TATGTGCATATATTTTCTAGAAAAAAGTTTGTATTCAAATTTTGTCTTGAGAGTGTTTACGGTT
TCTTAATAGGTAAATGTTTGAAATCCTCACTGGAGTTGAAGAGCCAAATGTTTTGAGTCATTCT
AGTACAATAAACATTTCTCCGGGCATGTGTTCAAACCA

hide sequence

RefSeq Acc Id:

XM_008760934 ⟹ XP_008759156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	122,234,619 - 122,425,687 (+)	NCBI
mRatBN7.2	2	120,306,417 - 120,497,488 (+)	NCBI
Rnor_6.0	2	124,149,877 - 124,340,866 (+)	NCBI

Sequence:

show sequence

TTGAGCTGGAATTTCCATTTGACAGTTTAGTGGAGCTGACTGACCTCCACGGGTCTGGGACAGA
GAGGAGAAACTTTTCGACTTTTTTTTTTTTTTGTTGCTGTTGTTACTTTAATCCGACCCATATT
TGCTTCGAGAGTAGGCAAAGCAGCGGAACAGCCGAAGTTCACTTTCCAAGGGCTCATAACGTAA
ACGGCGGTTCCTATGCCTAGGCGGTCTTTCTTTACGCAACGGTGTTTTGCGAGACCCTCGCTAA
TCACCTCAGCCTCGCCGGCTGCGCTGTACGTGGGGCATTACGGCGGTGCGCCGAGCCGCTGACC
TCTGACCCGGAAGTTTTATCCCCGTGCCGCGCACGTTGAGCCGGCTTTGGGCTGCTTTTCTCCG
ACAGCCTGCGGTCATGTCTTCCAAGAAGAACAGAAAGCGACAGAAAGAGGGCGCGGAGGGGACC
TCGCCCTCGCTCTCTGCGGCTTCGTCTCGCTCGGGGACCTCGACTCCTCTCGCTCAGCCGAACG
TGGCGGCGCCGGGGATGTTGGTGGTGACCAACTTTCTTGAGAAAGTAGATGGCAAAGTTCCTAA
GACATTCCAGAATTCCCTAGTTCATCTTGGACTTAACACTATGAAGTCTGCAAACATATGTATA
GGTCGACCAGTGCTCCTTACCAGTTTGGATGGAAAGCAGGAGGTTTATACAGCCTGGCCAGTTG
CAGGATTTCCTGGAGGCAAGGTTGGTCTAAGTGAAATGGCACAGAAGAATGTGGGTGTGAAAGC
TGGTGAGACCATCCGGGTCCAACCTCTTTTGGGTGCTGTACTTCAGGCCCAGGAAATGGACTTG
GCACTGAGTGACAAAGATAAGGAAATTAATGAAGAAGAACTGACTGGTTGTATTCTGAGAAAAC
TAGATGGCAAGATTGTTTTACCAGGCAACTTTCTGTACTGTACATTCTATGGACGACTCTGCAA
GTTACAAGTGTTGCAAGTAAAAGGGACAGATGGCACAACATTGGGAAAGCCTCAGAGCTCCTCT
GGCACTGATGTCCATGGAATGGCCTCTGAGCAGTCTAGCATGGAAAGCAGTGATGTGGATATTT
CATTCCAGCTAAGCCAGTTAGATCTGAAAGAACCTCAGAGCCCAGCATCACAGAGTACTCCCTG
TAAACCCATCAATGACAGAACTATGAATAAAGCTGGTGAAGTTTTGTTGGATGTTACACAGAGC
CCTAGGGATGGAAGTGGACTTGGACTAGAGGAAATCACAGGGCTTAAGTGTAGTTTTGATTCAT
CCAAAGAAGGAAATACACAACCTATCAGTGAAGAGAAACTACTAAAATCTACTAGTGCAGGTGC
AAAGAACAATACTGATACTTTTTATTTTATTTCTTCAACAACAAGAATCAATCTTCGAAAAATT
TGTACAAATTCAAAAGAACAAGACAGTCAGTTCAAAGTAACTTATGACATGATTGGAGGCTTAA
ACAGTCAGCTGAAAGCAATAAGAGAAATAATTGAACTGCCTCTCAAGCAGCCTGAACTTTTCAA
GAGTTACGGAATTCCAGCACCTAGAGGGTTATTACTCTATGGTCCTCCAGGTACCGGAAAGACA
ATGATTGCTAGGGCTGTTGCTAATGAAGTTGGAGCTTATGTTTCTGTAATTAATGGTCCTGAAA
TTATAAGCAAATTCTATGGTGAGACTGAAGCAAGGTTACGCCAGATATTTGCTGAAGCCACTCT
ACGGCATCCATCGATTATTTTTATTGATGAGCTGGATGCACTTTGCCCTAAAAGAGAAGGAGCT
CAAAGTGAAGTGGAAAAGAGAGTTGTAGCTTCGCTCTTAACATTGATGGATGGCATTGGCTCAG
AAGGAAGTGAAGGACGGGTATTAGTCCTTGGGGCCACAAATCGCCCTCAAGCGCTAGATGCTGC
ACTCAGAAGACCTGGGCGATTTGATAAAGAGATTGAGATTGGCATTCCTAATGCCCAAGACCGG
CTTGATATTCTCCAGAAACTACTCCGAAGGGTGCCACACTTACTCACCAAAGCTGAGCTTCTGA
GATTGGCAAATAATGCCCATGGTTATGTTGGCGCAGACTTGAAAGCCTTGTGTAATGAAGCAGG
TCTGTATGCCTTGCGAAGAGTCCTGAGGAAACAGCCTAATCTCCCTGATAGCAAGGTGGCTGGC
ATGGTGAAGATTACCCTAAATGATTTCTTACAGGGGATGAATGATATCAGGCCTAGTGCTATGA
GAGAGGTAGCAATTGATGTCCCAAATGTATCCTGGTCAGATATTGGAGGACTGGAAAATATCAA
ACTGAAATTGAAACAGGCTGTGGAATGGCCCTTGAAACATCCTAAGTCTTTCAGCAGAATGGGT
ATTCAGCCACCTAAAGGAGTTCTCTTGTATGGGCCTCCTGGATGCTCAAAAACAATGATAGCAA
AGGCTTTGGCCAATGAAAGTGGGTTGAACTTTCTAGCTATAAAGGGGCCTGAATTAATGAATAA
GTATGTTGGTGAATCTGAAAGAGCAGTTAGAGAGGTATTCCGTAAAGCAAGAGCAGTGGCACCT
TCCATTATCTTTTTTGATGAACTTGATGCCTTGGCTGTTGAAAGGGGCAGTTCTTCAGGTGCCG
GGAATGTTGCAGATCGTGTTTTGGCTCAGCTGTTAACGGAAATGGATGGAATTGAACAGCTAAA
AAATGTGACAGTTTTGGCAGCTACTAATCGCCCAGATAGAATAGACAAGGCTCTGATGAGGCCT
GGAAGAATTGACAGGATCATTTATGTGCCCTTACCGGATGCAGCAACAAGAAGGGAAATACTGA
ACTTGCAGTTCCACTCAATGCCAATCAGTAACGAGGTTGACCTGGATGAACTGGTCCTCCAAAC
TGACACCTACTCAGGAGCAGAGAGTGACAACAGTGCTACAGTTTGAAGGCCAAAATTAGATCAT
AGCAGTCTGCAAGGAGGCCGCTCTCCTAGCTCTGGAAGAAAACATTAAAGCTGACTGCATTATG
AAGAGGCATTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001402011	(Get FASTA)	NCBI Sequence Viewer
	XP_008759155	(Get FASTA)	NCBI Sequence Viewer
	XP_008759156	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01312	(Get FASTA)	NCBI Sequence Viewer
	EDM01313	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023584.5
	ENSRNOP00000071455.1
	ENSRNOP00000086493.1

RefSeq Acc Id:	XP_008759156 ⟸ XM_008760934
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2K0I1 (UniProtKB/TrEMBL), A6II14 (UniProtKB/TrEMBL), D4A6T1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKKNRKRQKEGAEGTSPSLSAASSRSGTSTPLAQPNVAAPGMLVVTNFLEKVDGKVPKTFQN SLVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVKAGETI RVQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVL QVKGTDGTTLGKPQSSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPIN DRTMNKAGEVLLDVTQSPRDGSGLGLEEITGLKCSFDSSKEGNTQPISEEKLLKSTSAGAKNNT DTFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGI PAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPS IIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRP GRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLYAL RRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLK QAVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGE SERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTV LAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYS GAESDNSATV hide sequence

RefSeq Acc Id:	XP_008759155 ⟸ XM_008760933
- Peptide Label:	isoform X1
- UniProtKB:	A6II14 (UniProtKB/TrEMBL), D4A6T1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKKNRKRQKEGAEGTSPSLSAASSRSGTSTPLAQPNVAAPGMLVVTNFLEKDGKVPKTFQNS LVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVKAGETIR VQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQ VKGTDGTTLGKPQSSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPIND RTMNKAGEVLLDVTQSPRDGSGLGLEEITGLKCSFDSSKEGNTQPISEEKLLKSTSAGAKNNTD TFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIP APRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSI IFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRPG RFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLYALR RVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQ AVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES ERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVL AATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSG AEIIAVCKEAALLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHMV hide sequence

Ensembl Acc Id:

ENSRNOP00000023584 ⟸ ENSRNOT00000023584

Ensembl Acc Id:

ENSRNOP00000071455 ⟸ ENSRNOT00000078650

Ensembl Acc Id:

ENSRNOP00000086493 ⟸ ENSRNOT00000119204

RefSeq Acc Id:	NP_001402011 ⟸ NM_001415082
- UniProtKB:	A0A8I6A2A6 (UniProtKB/TrEMBL), A6II14 (UniProtKB/TrEMBL), D4A6T1 (UniProtKB/TrEMBL)

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K0I1-F1-model_v2	AlphaFold	A0A0G2K0I1	1-842	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691301

Promoter ID:

EPDNEW_R1823

Type:

initiation region

Name:

Spata5_1

Description:

spermatogenesis associated 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	124,150,250 - 124,150,310	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310478	AgrOrtholog
BioCyc Gene	G2FUF-53303	BioCyc
Ensembl Genes	ENSRNOG00000017462	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023584.7	UniProtKB/TrEMBL
	ENSRNOT00000078650.2	UniProtKB/TrEMBL
	ENSRNOT00000119204.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	2.40.40.20	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA_ATPase_domain	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	Asp_de-COase-like_fold	UniProtKB/TrEMBL
	ATPase_AAA+_core	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/TrEMBL
	ATPase_AAA_CS	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	361935	ENTREZGENE
PANTHER	AAA-FAMILY ATPASE	UniProtKB/TrEMBL
	ATPASE FAMILY PROTEIN 2 HOMOLOG	UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
PhenoGen	Afg2a	PhenoGen
PROSITE	AAA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017462	RatGTEx
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	Asp_decarb_fold	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2K0I1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A2A6	ENTREZGENE, UniProtKB/TrEMBL
	A6II14	ENTREZGENE, UniProtKB/TrEMBL
	D4A6T1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-04-17	Afg2a	AFG2 AAA ATPase homolog A	Spata5	spermatogenesis associated 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Spata5	spermatogenesis associated 5	Spata5_predicted	spermatogenesis associated 5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Spata5_predicted	spermatogenesis associated 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)