Mgst2 (microsomal glutathione S-transferase 2) - Rat Genome Database

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Gene: Mgst2 (microsomal glutathione S-transferase 2) Rattus norvegicus
Analyze
Symbol: Mgst2
Name: microsomal glutathione S-transferase 2
RGD ID: 1311218
Description: Enables glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in response to lipopolysaccharide and response to organonitrogen compound. Located in cytoplasm. Orthologous to human MGST2 (microsomal glutathione S-transferase 2); PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295037
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22135,679,524 - 135,715,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,269,446 - 142,291,715 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02140,381,704 - 140,403,975 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02135,013,740 - 135,035,919 (+)NCBIRnor_WKY
Rnor_6.02140,708,396 - 140,727,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,180,714 - 160,202,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,546,939 - 140,568,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12140,497,066 - 140,518,579 (+)NCBI
Celera2130,188,760 - 130,210,429 (+)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
atrazine  (EXP)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP,ISO)
nickel atom  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. Ma KF, etal., World J Gastroenterol. 2008 May 7;14(17):2748-56.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schroder O, etal., Biochem Biophys Res Commun. 2003 Dec 12;312(2):271-6.
9. The role of glutathione-S-transferase in anti-cancer drug resistance. Townsend DM and Tew KD, Oncogene 2003 Oct 20;22(47):7369-75.
10. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, etal., Pharmacology. 2007;80(1):11-20. Epub 2007 May 10.
Additional References at PubMed
PMID:8703034   PMID:9092565   PMID:9278457   PMID:23409838   PMID:26066610  


Genomics

Comparative Map Data
Mgst2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22135,679,524 - 135,715,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,269,446 - 142,291,715 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02140,381,704 - 140,403,975 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02135,013,740 - 135,035,919 (+)NCBIRnor_WKY
Rnor_6.02140,708,396 - 140,727,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,180,714 - 160,202,851 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,546,939 - 140,568,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12140,497,066 - 140,518,579 (+)NCBI
Celera2130,188,760 - 130,210,429 (+)NCBICelera
Cytogenetic Map2q26NCBI
MGST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,665,819 - 139,754,618 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4139,665,768 - 139,740,745 (+)EnsemblGRCh38hg38GRCh38
GRCh374140,586,973 - 140,661,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,806,372 - 140,844,857 (+)NCBINCBI36Build 36hg18NCBI36
Build 344140,944,526 - 140,983,009NCBI
Celera4137,919,740 - 137,958,224 (+)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,315,768 - 136,391,008 (+)NCBIHuRef
CHM1_14140,564,114 - 140,639,227 (+)NCBICHM1_1
T2T-CHM13v2.04142,985,421 - 143,060,389 (+)NCBIT2T-CHM13v2.0
Mgst2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39351,544,179 - 51,590,096 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl351,567,781 - 51,590,098 (+)EnsemblGRCm39 Ensembl
GRCm38351,636,912 - 51,682,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl351,660,360 - 51,682,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37351,465,115 - 51,486,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36351,749,166 - 51,770,603 (+)NCBIMGSCv36mm8
Celera351,392,546 - 51,414,043 (+)NCBICelera
Cytogenetic Map3CNCBI
Mgst2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554284,014,810 - 4,037,901 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554284,006,054 - 4,049,497 (-)NCBIChiLan1.0ChiLan1.0
MGST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14143,338,016 - 143,412,966 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4143,338,016 - 143,412,966 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04132,031,087 - 132,106,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MGST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,067,062 - 3,070,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,314,243 - 3,335,238 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0193,136,172 - 3,157,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,122,591 - 3,157,324 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,069,101 - 3,090,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,429,861 - 3,450,892 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,793,259 - 3,814,268 (-)NCBIUU_Cfam_GSD_1.0
Mgst2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530150,548,928 - 50,578,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365357,995,248 - 8,015,463 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365357,995,185 - 8,015,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl887,327,425 - 87,390,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1887,318,180 - 87,394,563 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MGST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1786,629,691 - 86,666,912 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl786,629,642 - 86,666,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603766,152,315 - 66,189,340 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477719,901,862 - 19,927,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477719,902,013 - 19,924,272 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mgst2
171 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:92
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000017785
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat

Markers in Region
RH142268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,714,946 - 135,715,702 (+)MAPPERmRatBN7.2
Rnor_6.02140,726,500 - 140,727,255NCBIRnor6.0
Rnor_5.02160,201,970 - 160,202,725UniSTSRnor5.0
RGSC_v3.42140,567,735 - 140,568,490UniSTSRGSC3.4
Celera2130,209,548 - 130,210,303UniSTS
RH 3.4 Map2848.3UniSTS
Cytogenetic Map2q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 54 41 16 41 37 11
Low 42 3 3 8 11 58 35 4 8
Below cutoff 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000088846   ⟹   ENSRNOP00000068920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,695 - 135,715,807 (+)Ensembl
Rnor_6.0 Ensembl2140,708,397 - 140,727,281 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100251   ⟹   ENSRNOP00000078333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,557 - 135,715,828 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101526   ⟹   ENSRNOP00000081569
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,557 - 135,715,618 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118372   ⟹   ENSRNOP00000090331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,693,557 - 135,714,999 (+)Ensembl
RefSeq Acc Id: NM_001106430   ⟹   NP_001099900
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22135,693,556 - 135,715,828 (+)NCBI
Rnor_6.02140,708,396 - 140,727,381 (+)NCBI
Rnor_5.02160,180,714 - 160,202,851 (+)NCBI
RGSC_v3.42140,546,939 - 140,568,616 (+)RGD
Celera2130,188,760 - 130,210,429 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102006   ⟹   XP_038957934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22135,685,451 - 135,715,827 (+)NCBI
RefSeq Acc Id: XM_039102007   ⟹   XP_038957935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22135,679,524 - 135,715,827 (+)NCBI
RefSeq Acc Id: XM_039102008   ⟹   XP_038957936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22135,693,616 - 135,712,391 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099900   ⟸   NM_001106430
- UniProtKB: A0A8I5ZLK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068920   ⟸   ENSRNOT00000088846
RefSeq Acc Id: XP_038957935   ⟸   XM_039102007
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957934   ⟸   XM_039102006
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957936   ⟸   XM_039102008
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000078333   ⟸   ENSRNOT00000100251
RefSeq Acc Id: ENSRNOP00000081569   ⟸   ENSRNOT00000101526
RefSeq Acc Id: ENSRNOP00000090331   ⟸   ENSRNOT00000118372

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU12-F1-model_v2 AlphaFold A0A0G2JU12 1-128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311218 AgrOrtholog
BioCyc Gene G2FUF-53123 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
Ensembl Genes ENSRNOG00000061857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068920.2 UniProtKB/TrEMBL
  ENSRNOP00000078333 ENTREZGENE
  ENSRNOP00000078333.1 UniProtKB/TrEMBL
  ENSRNOP00000081569.1 UniProtKB/TrEMBL
  ENSRNOP00000090331.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088846.2 UniProtKB/TrEMBL
  ENSRNOT00000100251 ENTREZGENE
  ENSRNOT00000100251.1 UniProtKB/TrEMBL
  ENSRNOT00000101526.1 UniProtKB/TrEMBL
  ENSRNOT00000118372.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.550 UniProtKB/TrEMBL
InterPro 5_LipOase_AP UniProtKB/TrEMBL
  MAPEG-like_dom UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/TrEMBL
NCBI Gene 295037 ENTREZGENE
Pfam MAPEG UniProtKB/TrEMBL
PharmGKB MGST2 RGD
PhenoGen Mgst2 PhenoGen
PRINTS 5LPOXGNASEAP UniProtKB/TrEMBL
Superfamily-SCOP SSF161084 UniProtKB/TrEMBL
UniProt A0A0G2JU12_RAT UniProtKB/TrEMBL
  A0A8I5ZLK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSH5_RAT UniProtKB/TrEMBL
  A0A8I6ADF7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mgst2  microsomal glutathione S-transferase 2   Mgst2_predicted  microsomal glutathione S-transferase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mgst2_predicted  microsomal glutathione S-transferase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED